Vardenafil HCL phofo

Vardenafil Hydrochloride Video ea phofo-AASraw

Raw Vardenafil HCL Litlhaku tsa Powder Basic

Vardenafil hydrochloride Powder ke eng?

Vardenafil hydrochloride powder, eo hape e bitsoang vardenafil HCL phofo, ke e 'ngoe ea enzyme ea phosphodiesterase mofuta oa 5 (PDE5) li-inhibitors. Enzyme ena e ikarabella bakeng sa ho senyeha ha cyclic guanosine monophosphate (cGMP), molek'hule e bapalang karolo ea bohlokoa ts'ebetsong ea erectile.

Nakong ea ho tsosoa ha thobalano, nitric oxide e lokolloa liseleng tsa erectile tsa penis (corpus cavernosum), e ntan'o susumetsa enzyme ea guanylate cyclase. Enzyme ena e eketsa maemo a cGMP, e leng eona e khathollang lisele tsa mesifa tse boreleli ho corpus cavernosum. Ho phomola ha mesifa ena ho lumella mali a mangata hore a phalle botoneng, e leng se lebisang ho erection.

Ka ho thibela PDE5, AASraw vardenafil hydrochloride phofo e thibela ho senyeha ha cGMP, kahoo ho boloka maemo a phahameng a molek'hule ena le ho lelefatsa liphello tsa eona. Sena se fella ka ho phomola ha mesifa le ho phalla ha mali, kahoo ho thusa ho boloka erection nakong ea thobalano.

Vardenafil hydrochloride Powder e sebetsa joang?

Vardenafil hydrochloride phofo e sebetsa e le inhibitor e khethiloeng ea enzyme e bitsoang phosphodiesterase mofuta oa 5 (PDE5). Mona ke tataiso ea mohato ka mohato hore na e sebetsa joang:

① Khothatso ea thobalano e etsa hore ho tsoe nitric oxide ka har'a corpus cavernosum, sebaka sa botoneng.

②Nitric oxide ena e etsa hore enzyme e bitsoang guanylate cyclase e fetole guanosine triphosphate (GTP) hore e be cyclic guanosine monophosphate (cGMP).

③CGMP e etsa hore mesifa e boreleli e ka har'a corpus cavernosum e phomole, e lumellang methapo ea mali hore e atolohe.

④Ho atolosoa ha methapo ea mali ho eketsa phallo ea mali botoneng, e lebisang ho erection.

⑤Ka tloaelo, enzyme ea PDE5 e senya cGMP, e qetella erection. Vardenafil hydrochloride e sebetsa ka ho thibela ketso ea PDE5, kahoo e lumella cGMP hore e lule nako e telele le ho lelefatsa nako ea ho emisa.

⑥Qetellong, vardenafil hydrochloride e ntlafatsa le ho boloka ts'ebetso ea likokoana-hloko e lebisang ho erection ho arabela ho tsosoa ha thobalano.

Ke habohlokoa ho utloisisa hore vardenafil hydrochloride ha e bake erection ka ho toba. Ho e-na le hoo, e matlafatsa karabelo ea tlhaho ea ’mele ho susumelletseha ho kopanela liphate. Hape, ke habohlokoa ho reka vardenafil hydrochloride powder ho tsoa ho mofani ea ka tšeptjoang joaloka AASraw, e faneng ka vardenafil hcl phofo e hloekileng ka lilemo tse ngata.

Vardenafil VS.Avanafil VS.Tadalafil VS.Sildenafil

Li-inhibitors tse 'nè tse tloaelehileng ka ho fetisisa tsa PDE5 'marakeng ke sildenafil, tadalafil, vardenafil, le avanafil. Meriana ena e mene kaofela ke li-inhibitors tsa PDE5 'me ke mokhoa oa pele oa phekolo bakeng sa ED. Leha ho le joalo, limolek'hule tsa lik'hemik'hale tsa meriana ena e mene lia fapana, e leng se bakang liketso tse sa tšoaneng tsa lik'hemik'hale le tsa 'mele. Ka lebaka leo, ho monya ha bona, ho ajoa, metabolism, le ho tsoa ha bona 'meleng ho fapana, joalo ka litlamorao tsa bona tsa kalafo.

Hlokomela:

Tmax = nako ea ho fihlella khatello e phahameng ea plasma

Cmax = boholo ba khatello ea mali ea plasma

T1/2 = halofo ea bophelo

Tafole ena e akaretsa litšobotsi tsa pharmacokinetic tsa li-inhibitor tse 'nè tsa PDE5 tse tšohloang. Kamehla ke habohlokoa hore bafani ba tlhokomelo ea bophelo ba nahane ka phapang ena ha ba fana ka meriana ena, 'me bakuli ba lokela ho sebelisa meriana ena kamehla tlas'a tlhokomelo ea ngaka. Ho feta moo, ho reka vardenafil hcl phofo ho tsoa ho mofani ea tšeptjoang ea kang AASraw o tiisetsa hore o fumana sehlahisoa sa boleng bo botle le bohloeki. AASraw, e le setsebi sa vardenafil hcl phofo ea mofani oa thepa, e ka fana ka vardenafil hydrochloride phofo ka boleng bo phahameng lefatšeng ka bophara.

U ka khetha li-inhibitors tsa PDE5 joang?

Ho khetha PDE5 inhibitor e nepahetseng ho ka itšetleha ka lintlha tse fapaneng, ho kenyelletsa le bophelo bo botle ba mokuli, boteng ba maemo a mang, mokhoa oa bona oa bophelo, le karabelo ea bona ea motho ka mong meriana. Mona ke tataiso e akaretsang ea ho khetha PDE5 inhibitor bakeng sa litšupiso, empa hopola ho buisana kamehla le mofani oa tlhokomelo ea bophelo ho etsa khetho e nepahetseng bakeng sa litlhoko tsa motho ka mong.

Lintlha: Lintlha tsena tse mabapi le li-inhibitors tsa PDE5 li fanoe molemong oa tlhaiso-leseling e akaretsang feela mme ha li kenye keletso ea bongaka. Khetho ea PDE5 inhibitor e lokela ho lula e etsoa ka ho buisana le mofani oa tlhokomelo ea bophelo ea ka nahanang ka bophelo bo botle ba motho ka kakaretso, meriana e meng e nooang, le mofuta o itseng le ho teba ha ho se sebetse ha erectile. Le hoja meriana ena e ka atleha ho phekola ho se sebetse ha erectile, e boetse e na le litla-morao le likotsi tse ka 'nang tsa e-ba teng,' me ha e tšoanele motho e mong le e mong. Maemo a mang a bophelo bo botle le meriana e meng e ka sebelisana le PDE5 inhibitors, e leng se lebisang ho litlamorao tse mpe tse ka bang teng. Kamehla batla keletso ho mofani oa tlhokomelo ea bophelo bakeng sa lipotso leha e le life tseo u ka bang le tsona mabapi le boemo ba bongaka.

Tekanyo le tsamaiso ea Vardenafil hydrochloride Powder bakeng sa ho buuoa

Tekanyo ea phofo ea vardenafil HCL e ka 'na ea fapana ho itšetlehile ka bophelo bo botle ba motho, karabelo ea phekolo, le meriana e meng eo ba ka e nkang. Mona ke litlhahiso tse akaretsang, empa ho bohlokoa ho latela litaelo tse tobileng tsa mofani oa tlhokomelo ea bophelo.

①Standard dose bakeng sa erectile dho se sebetse

Tekanyo e khothalletsoang ea ho qala ea vardenafil ke 10 mg, e nkiloeng ka molomo hoo e ka bang metsotso ea 60 pele ho thobalano. Tekanyetso e ka eketsoa ho fihla ho 20 mg kapa ea fokotseha ho isa ho 5 mg, ho ipapisitse le katleho le mamello ea motho ka mong. Maqhubu a phahameng a khothaletsoang a dosing ke hang ka letsatsi.

②Bakuli ba nang le moderate hepatic iho senyeha

Bakeng sa bakuli ba nang le bokooa bo itekanetseng ba sebete (Ngoana-Pugh B), tekanyo ea pele ea 5 mg ea vardenafil e khothalletsoa. Tekanyetso e phahameng ho bakuli ba nang le ts'enyo e leka-lekaneng ea sebete ha ea lokela ho feta 10 mg.

③Bakuli ba nang le skamehla renal iho senyeha

Bakeng sa bakuli ba nang le ts'oaetso e matla (CLcr <30 mL / min) ea renal, tekanyo e qalang ea 5 mg ea vardenafil e khothalletsoa.

④Bakuli ba ntse ba tsoela pele stafoleng alpha-blocker tphekolo

Tekanyo e khothalletsoang ea ho qala ea vardenafil bakeng sa bakuli ba fumanang phekolo e tsitsitseng ea alpha-blocker ke 5 mg.

⑤Bakuli ba nang le concomitant uSetšoantšo sa CYP3A4 ili-hibitors

Bakeng sa bakuli ba nkang li-inhibitors tse matla tsa CYP3A4 (tse kang ketoconazole, itraconazole, ritonavir, indinavir, saquinavir le atazanavir), tekanyo ea pele ea 5 mg vardenafil ha ea lokela ho fetisoa.

Notes

Ke habohlokoa ho hlokomela hore ho susumetsa thobalano hoa hlokahala bakeng sa karabelo ea phekolo. Vardenafil ha e eketse takatso ea thobalano 'me e ke ke ea hlahisa erection ntle le ts'usumetso ea thobalano. Ho reka phofo ea vardenafil HCL ho tsoa ho mofani ea ka tšeptjoang ho ka etsa bonnete ba hore u fumana sehlahisoa sa boleng bo phahameng se tla thusa ho finyella katleho e ntle ka ho fetisisa bakeng sa tšebeliso ea eona e reriloeng.AASraw e ikemiselitse ho fana ka boleng ba boleng ba vardenafil hcl phofo lefatšeng ka bophara tlas'a taolo ea CGMP. Haeba u na le litlhoko, AASraw ke khetho e babatsehang ea ho reka vardenafil hcl phofo.

Hokae ho reka Vardenafil hydrochloride Powder?

Vardenafil hydrochloride powder e ka rekoa ho tsoa ho mefuta e fapaneng ea bafani ba marang-rang ba khethehileng ka ho rekisa metsoako ea meriana. Ha u etsa qeto ea ho reka ho tsoa ho mofani oa thepa ea inthaneteng, ho bohlokoa ho netefatsa hore ke mohloli o tšepahalang, ho latela bohlokoa ba boleng le bohloeki ba sehlahisoa bakeng sa lits'ebetso tsa bophelo bo botle. Netefatsa hore morekisi o fana ka litlhaloso tsa sehlahisoa le litokomane tsa netefatso ea boleng, joalo ka Setifikeiti sa Tlhahlobo.

Haeba u batla mohloli o tšepahalang oa ho reka phofo ea vardenafil, AASraw e ka 'na ea e-ba khetho e loketseng.AASraw ke k'hamphani e fanang ka mefuta e mengata ea lihlahisoa tse tala tsa meriana, ho akarelletsa le vardenafil powder. Lihlahisoa tsa bona hangata li sebelisoa ke lilaboratori le litsi tsa lipatlisiso bakeng sa nts'etsopele le tlhahiso ea lihlahisoa tse fapaneng tsa bophelo bo botle.

Raw Vardenafil HCL Tlaleho ea Tlhahlobo ea Phofo-HNMR

HNMR ke eng hona HNMR spectrum e u bolella eng? H Nuclear Magnetic Resonance (NMR) spectroscopy ke mokhoa oa ho hlahloba k'hemistri o sebelisoang ho laola boleng le lipatlisiso bakeng sa ho fumana likahare le bohloeki ba sampuli hammoho le sebopeho sa limolek'hule. Mohlala, NMR e ka sekaseka ka bongata metsoako e nang le metsoako e tsebahalang. Bakeng sa metsoako e sa tsejoeng, NMR e ka sebelisoa ho bapisa le lilaebrari tsa spectral kapa ho fana ka sebopeho sa motheo ka kotloloho. Hang ha sebopeho sa motheo se tsejoa, NMR e ka sebelisoa ho fumana hore na limolek'hule li lumellana joang le tharollo hammoho le ho ithuta thepa ea 'mele boemong ba limolek'hule joalo ka phapanyetsano ea conformational, liphetoho tsa mohato, solubility le diffusion.

Vardenafil Hydrochloride phofo (224785-91-5) -COA

Vardenafil Hydrochloride phofo (224785-91-5) -COA

Mokhoa oa ho reka Vardenafil HCL Powder ho tloha AASraw?

❶Ho ikopanya le rona ka sistimi ea rona ea ho botsa ka lengolo-tsoibila, kapa ho re siela nomoro ea hau ea WhatsApp, moemeli oa rona oa litšebeletso tsa bareki(CSR) o tla ikopanya le uena ka mor'a lihora tse 12.

❷ Ho re fa palo le aterese eo u e botsitseng.

❸ CSR ea rona e tla u fa khotheishene, nako ea ho patala, nomoro ea morao-rao, litsela tsa ho fihla, le letsatsi la ho fihla (ETA).

❹Ho lefa 'me thepa e tla romelloa ka mor'a lihora tse 12.

❺Lintho tse amohetsoeng le ho fana ka maikutlo.

Mongoli oa sengoloa sena:
Ngaka Monique Hong o fumane lengolo UK Imperial College London Faculty of Medicine

Sengoli sa pampiri sa Scientific Journal:
1. Hazem M. Abu Shawish
Lefapha la Khemistri, College of Sciences, Univesithi ea Al-Aqsa, Gaza, Palestine
2. E. BISCHOFF
Ho tsoa Setsing sa Cardiovascular Research II, le Mafapha a Patlisiso ea Lik'hemik'hale, le Nts'etsopele ea Lihlahisoa le Preclinical Pharmacokinetics, BAYER AG Pharmaceutical Business Group, Wuppertal, Germany.
3. MM Mabrouk
Lefapha la k'hemistri ea tlhahlobo ea meriana, lefapha la pharmacy, univesithi ea Tanta, Tanta, Egepeta
4. Engin Yurtcu
Lefapha la Bongaka le Botho ba Basali Sepetleleng sa Bophelo sa Basali sa Zekai Tahir Burak, Ankara, Turkey
5. Silvia Limoncella
Setsi sa Endocrinology, Lefapha la Biomedical, Metabolic le Neural Sciences, Univesithi ea Modena le Reggio Emilia, Modena, Italy.
Ha ho ka tsela leha e le efe ngaka/saense ena e buellang kapa ho buella ho rekoa, thekiso, kapa tšebeliso ea sehlahisoa sena ka lebaka lefe kapa lefe. Aasraw ha e na kamano kapa kamano, ho boleloa kapa ho seng joalo, le ngaka ena. Sepheo sa ho qotsa ngaka ena ke ho ananela, ho ananela le ho babatsa lipatlisiso tse felletseng le mosebetsi oa nts'etsopele o entsoeng ke bo-ramahlale ba sebetsanang le ntho ena.

Reference

[1] Aversa A,Pili M,Francomano D,Bruzziches R,Spera E,La Pera G,Spera G (Phupu 2009). "Litlamorao tsa tsamaiso ea vardenafil ka nako ea morao-rao ea ejaculatory latency ho banna ba nang le ejaculation ea bophelo bohle pele ho nako". International Journal of Impotence Research. 21 (4):221–7. 

[2] Schools of Pharmacy (Glen L.Stimmel,D.,and Mary A.Gutierrez,Pharm.D.) and Medicine (Glen L.Stimmel,Pharm.D.),University of Southern California,Los Angeles,California. "Ho eletsa Bakuli ka Litaba tsa Thobalano: Priapism e Bakiloeng ke Lithethefatsi".Medscape.Retrieved 2010-12-06.

[3] "Kalafo e ncha ea ho se sebetse ha erectile Staxyn e amohetsoe US.– Pharmaceutical Processing”. net.2010-06-21.E bolokoa ho tsoa ea mantlha ka 2012-04-06.

[4] Tucker J,Fischer T,Upjohn L,Mazzera D,Kumar M (Mphalane 2018). "Metsoako e sa Amoheloeng ea Meriana e Kenyellelitsoeng Lijong tsa Lijo tse Amanang le Litemoso tsa Tsamaiso ea Lijo le Lithethefatsi tsa US". Mokhatlo oa JAMA o bulehileng. 1(6): 

[5] Lepor H,Lepor NE,Hill LA,Trohman RG (2008). "Nako ea QT le Khetho ea Alpha-blockers bakeng sa Benign Prostatic Hyperplasia". Litlhahlobo ho Urology. 10 (2):85–91.

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