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Tirzepatide

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mabitso a mang: Tirze phofo, Mounjaro

AASraw ke moetsi ea hloahloa oa peptide Tirzepatide e nang le lab e ikemetseng le fektheri e kholo e le ts'ehetso, tlhahiso eohle e tla etsoa tlas'a taolo ea CGMP le tsamaiso ea tsamaiso ea boleng bo sebetsang hantle. linkhoana.

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Tlhaloso ea Sehlahisoa

Tirzepatide ke eng?

Tirzepatide ke moriana o mocha o amohetsoeng ke FDA bakeng sa kalafo ea lefu la tsoekere la mofuta oa 2. Ka lebaka la thepa ea eona e matla ea ho theola boima ba 'mele, reka tirzepatide hore e sebelisoe kantle ho label bakeng sa kalafo ea botenya.

E sebetsa e le mohanyetsi oa GLP-1 le GIP agonist ho eketsa melemo e ts'oanang e bonoang ka meriana ea GLP-1 joalo ka. semaglutide.Hajoale e sebelisoa e le moriana oa lefu la tsoekere oa mofuta oa bobeli, o ts'oanang le meriana ea GLP-1, 'me e fanoa e le ente ea subcutaneous ea hang ka beke. FDA e amohetse peptide Tirzepatide ka Mots'eanong 2022.

Tirzepatide e sebetsa joang?

Tirzepatide ke peptide ea maiketsetso; le dual gastric inhibitory polypeptide (GIP) le glucagon-like peptide 1 (GLP-1) receptor agonist. E entsoe ka 39 amino acid le ke analoge ea gastric inhibitory polypeptide. Ka mokhoa o ts'oanang, e susumetsa tlhahiso ea insulin ho manyeme mme e lebisa ho phokotso ea hyperglycemia. Ho feta moo, Tirzepatide e boetse e eketsa maemo a adiponectin. Bokhoni ba eona bo habeli ba agonism bo lebisa phokotsong e kholo ea hyperglycemia ho feta li-agonists tsa GLP-1 feela mme e theola takatso ea mosebelisi.

Melemo ea Tirzepatide

Tirzepatide ke receptor e itšetlehileng ka tsoekere ea insulinotropic polypeptide (GIP) le glucagon-like peptide-1 (GLP-1) receptor agonist, e amohetsoeng ke FDA bakeng sa ho alafa lefu la tsoekere la mofuta oa 2. Ho bohlokoa ho hlokomela hore tirzepatide ha e lumelloe ho phekola lefu la tsoekere la mofuta oa 1 mme ha e so ithutoe ho bakuli ba nang le pancreatitis. Tirzepatide ke GIP receptor le GLP-1 receptor agonist, e lebisang ho ntlafatseng taolo ea glycemic ho bakuli ba lefu la tsoekere la mofuta oa 2 le phokotso e kholo ea boima ba 'mele.

Liphetho tsa Tirzepatide

Bakuli ba nang le botenya le mofuta oa lefu la tsoekere la mofuta oa 2 (T2D) kapa ba nang le boima bo feteletseng le T2D ba lahlehetsoe ke boima ba lik'hilograma tse 34.4 (15.7%) ka 10 mg le 15 mg ea tirzepatide (Mounjaro; Eli Lilly le Company), ho latela liphuputso tse tsoang ho SURMOUNT - Teko ea 2 ea lefats'e ea 3. Ka ho khetheha, tirzepatide ka 10 mg e fokolitse boima ba 'mele ka 5% kapa ho feta ho 79.2% ea bakuli le ho fokotsa boima ba' mele ka 12.8%, ha tekanyo ea 15 mg e fokolitse boima ba 'mele ho 82.7% ea bakuli le ho fokotsa boima ba' mele ka 14.7%.

Tirzepatide e sebelisetsoa ho fokotsa boima ba 'mele

Tirzepatide ke ente ea hang ka beke ho fokotsa tsoekere ea mali. Ho tloha ka 2022 e bonts'itse litlamorao tse makatsang tsa ho theola boima ba 'mele mme e maemong a potlakileng bakeng sa tlhahlobo ea eona bakeng sa kalafo ea botenya. Ka karolelano, bakuli ba bone tahlehelo e makatsang ea boima ba 'mele e fetang 20% ​​ea boima ba' mele ba bona ba pele.

Tirzepatide le BPC 157 thusa ka boima ba 'mele ka ho fokotsa ho ja lijo le ho fokotsa lebelo la lijo tse tsamaeang ka har'a tšilo ea lijo. Sena se ka u thusa hore u ikutloe u khotše nako e telele le ho fokotsa lijo tseo u li jang. Liphuputso li bontša hore ketso ena e ka etsahala bokong.

Kamoo e ea sebetsang:

● Fokotsa hore na ho jeoa lijo tse kae.

●E thibela sebete ho etsa le ho ntša tsoekere e ngata haholo.

●E fokotsa lebelo la kamoo lijo li tlohang ka mpeng kateng.

● 'Mele o ntša insulin ha tsoekere e le holimo.

● 'Mele o ntša tsoekere e ngata maling.

Phapang ke efe pakeng tsa Tirzepatide le Semaglutide?

Tirzepatide e sebetsa ho BOTH GIP le GLP-1 li-receptors, ha Semaglutide e sebetsa feela ho li-receptor tsa GLP-1. Lithethefatsi tsena ka bobeli ke kalafo e sebetsang ea ho theola boima ba 'mele. Tirzepatide ke GIP e sebetsang ka bobeli (insulinotropic polypeptide e itšetlehileng ka tsoekere) le GLP-1.glucagon-joaloka peptide-1) agonist ea li-receptor. Ka bobeli li sehlopheng sa lithethefatsi tse tsejoang e le incretin mimetics empa li na le phapang e itseng.

Liphetoho tsa mokhoa oa bophelo le thibelo ea khalori li tla lebisa liphellong tse molemo ka kakaretso. Melemo ea ho theola boima ba 'mele ke li-comorbidities tse ntlafetseng tsa botenya tse kang lefu la tsoekere, khatello e phahameng ea mali, mali a sa tloaelehang a lipids, le lefu la pelo le ka bonoang ka ho fokotseha ha boima ba 5%.

Litla-morao tsa Tirzepatide

Litla-morao tse tloaelehileng ka ho fetisisa tsa Tirzepatide li kenyelletsa ho nyekeloa ke pelo, letšollo, ho fokotseha ha takatso ea lijo, ho hlatsa, ho patoa, ho senya lijo, le bohloko ba ka mpeng (ka mpeng). Tsena ha se litlamorao tsohle tse ka bang teng tsa Tirzepatide. Buisana le mofani oa tlhokomelo ea bophelo ka litla-morao life kapa life tseo u ka bang le tsona.

Hokae ho Reka Tirzepatide?

AASraw ke sebaka se setle ka ho fetisisa sa ho reka thepa e ngata ea Tirzepatide. Lihlahisoa tsohle tsa rona li tla le Setifikeiti sa Tlhahlobo se ikemetseng, se fanoeng ke motho oa boraro bakeng sa boitsebahatso, bohloeki le ho tsepamisa maikutlo. 'Me re na le Tirzepatide e ngata e rekisoang setokong!

AASraw ke mofani oa thepa ea Tirzepatide le moetsi oa Tirzepatide ea nang le lab e ikemetseng le fektheri e kholo e le ts'ehetso, tlhahiso eohle e tla etsoa tlas'a taolo ea CGMP le tsamaiso ea ho laola boleng ba trackable. Sistimi ea phepelo ea tirzepatide e tsitsitse, 'me liodara tsa mabenkele le li-wholesale lia amoheleha. Haeba u batla ho reka Tirzepatide inthaneteng, amohela ho etela sebaka sa rona sa Marang-rang(aasraw.com).

Tlaleho ea Tlhahlobo ea Tirzepatide-HNMR

HNMR ke eng hona HNMR spectrum e u bolella eng? H Nuclear Magnetic Resonance (NMR) spectroscopy ke mokhoa oa ho hlahloba k'hemistri o sebelisoang ho laola boleng le lipatlisiso bakeng sa ho fumana likahare le bohloeki ba sampuli hammoho le sebopeho sa limolek'hule. Mohlala, NMR e ka sekaseka ka bongata metsoako e nang le metsoako e tsebahalang. Bakeng sa metsoako e sa tsejoeng, NMR e ka sebelisoa ho bapisa le lilaebrari tsa spectral kapa ho fana ka sebopeho sa motheo ka kotloloho. Hang ha sebopeho sa motheo se tsejoa, NMR e ka sebelisoa ho fumana hore na limolek'hule li lumellana joang le tharollo hammoho le ho ithuta thepa ea 'mele boemong ba limolek'hule joalo ka phapanyetsano ea conformational, liphetoho tsa mohato, solubility le diffusion.

Tsela ea ho reka Tirzepatide ho tloha AASraw?

❶Ho ikopanya le rona ka sistimi ea rona ea ho botsa ka lengolo-tsoibila, kapa ho re siela nomoro ea hau ea WhatsApp, moemeli oa rona oa litšebeletso tsa bareki(CSR) o tla ikopanya le uena ka mor'a lihora tse 12.

❷ Ho re fa palo le aterese eo u e botsitseng.

❸ CSR ea rona e tla u fa khotheishene, nako ea ho patala, nomoro ea morao-rao, litsela tsa ho fihla, le letsatsi la ho fihla (ETA).

❹Ho lefa 'me thepa e tla romelloa ka mor'a lihora tse 12.

❺Lintho tse amohetsoeng le ho fana ka maikutlo.

Mongoli oa sengoloa sena:
Ngaka Monique Hong o fumane lengolo UK Imperial College London Faculty of Medicine

Sengoli sa pampiri sa Scientific Journal:
1. Qi Liu
Lefapha la Cardiology, Sepetlele sa Renmin sa Univesithi ea Wuhan, Wuhan 430060, Hubei, PR China
2. Sidar Copur
Lefapha la Bongaka, Sekolo sa Bongaka sa Koc University, Istanbul 34010, Turkey
3. Rouchan Ali
Lefapha la Pharmaceutical Chemistry and Analysis, ISF College of Pharmacy, Moga 142001, Punjab, India
4. V. Thieu
Eli Lilly, Litaba tsa Bongaka, Indianapolis, USA
Ha ho ka tsela leha e le efe ngaka/saense ena e buellang kapa ho buella ho rekoa, thekiso, kapa tšebeliso ea sehlahisoa sena ka lebaka lefe kapa lefe. Aasraw ha e na kamano kapa kamano, ho boleloa kapa ho seng joalo, le ngaka ena. Sepheo sa ho qotsa ngaka ena ke ho ananela, ho ananela le ho babatsa lipatlisiso tse felletseng le mosebetsi oa nts'etsopele o entsoeng ke bo-ramahlale ba sebetsanang le ntho ena.

References

[1] Lilly :Mokhahlelo oa 3 oa Liphetho tsa Tirzepatide li Bontša ho Phahameng ka ho Fetisisa A1C le Phokotso ea Boima ba 'Mele ho Mofuta oa 2 oa lefu la tsoekere”.Business Insider.RTTNews.19 October 2021.E bolokoa ho tloha qalong ka la 28 Mphalane 2021.E khutlisitsoe 28 October 2021.

[2] Tirzepatide e fokolitse haholo A1C le boima ba 'mele ho batho ba nang le lefu la tsoekere la mofuta oa 2 litekong tse peli tsa mohato oa 3 ho tsoa lenaneong la Lilly's SURPASS” (Tlhaloso ea Phatlalatso).Eli Lilly and Company.17 February 2021.Archived from the original on 28 October 2021.Retrieved 28 October 2021 - ka PR Newswire.

[3] Kellaher,Colin (28 Mmesa 2022).”Eli Lilly's Tirzepatide e Kopana le Mafelo a Maholo a Mokhahlelo oa 3 oa Boithuto ba Botenya”.MarketWatch.Dow Jones Newswires.E bolokoa ho tloha ea mantlha ka la 29 Mmesa 2022.E Khutlisitsoe ka la 29 Mmesa 2022.

[4] Willard FS,Douros JD,Gabe MB,Showalter AD,Wainscott DB,Suter TM,et al.(Lwetse 2020).”Tirzepatide ke moamoheli ea amohelang GIP-1 a sa leka-lekanang le a leeme”.JCI Insight.5 (17) .doi:10.1172/jci.insight.140532.PMC 7526454.PMID 32730231.

[5] Frederick MO,Boyse RA,Braden TM,Calvin JR,Campbell BM,Changi SM,et al.(2021)."Kilogram-Scale GMP Manufacture of Tirzepatide Using a Hybrid SPPS/LPPS Approach with Continuous Manufacturing”.Organic Process Research & Development & Development .25 (7):1628–1636.

[6] Frías JP, Davies MJ, Rosenstock J, Pérez Manghi FC, Fernández Landó L, Bergman BK, et al.(August 2021)."Tirzepatide vs Semaglutide Hang ka Beke ho Bakuli ba nang le Mofuta oa 2 lefu la tsoekere ".The New England Journal of Medicine.385 (6): 503–515.doi:10.1056/NEJMoa2107519.


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