Tlhaloso ea Sehlahisoa
Semax ke eng?
Semax ke peptide e ncha ea neuroprotective, e nkiloeng ho sebopeho sa limolek'hule tsa adrenocorticotropic hormone (ACTH), ke ntho ea tlhaho e fumanehang 'meleng oa motho, e tsejoang hape e le MEHFPGP. E ile ea ntlafatsoa ke sehlopha sa lipatlisiso sa Russia se tsoang Setsing sa Molecular Genetics, qalong, se ne se phehelloa e le phekolo bakeng sa mahlatsipa a stroke a nang le tšenyo ea boko. Leha ho le joalo, Semax e boetse e na le nalane e tšoanang, potency, le litlolo tsa lik'hemik'hale ho Noopept phofo. Naheng ea Russia le Ukraine, Semax e lumelletsoe ho sebelisoa ho thibela le ho phekola mathata a potoloho ea mali, hangata e rekisoa e le "nootropic" kapa "sethethefatsi se bohlale" mme ho lumeloa hore e ntlafatsa ts'ebetso ea kelello le mohopolo. Leha ho le joalo, USA, Semax e sebetsa e le karolo ea motheo bakeng sa lihlahisoa tse 'maloa tsa meriana, tse sebelisoang ho phekola kalafo ea mafu a CNS (ischemic brain stroke, dys-circulatory encephalopathy, optic nerve atrophy, jj).
Semax hangata e tsamaisoa joalo ka setlolo sa nko kapa ente ea subcutaneous mme e na le bioavailability e mpe ea molomo. Tšebeliso ea eona le litekanyetso tsa litekanyetso li fapana ho itšetlehile ka boemo bo itseng ba phekolo. Haeba u nahana ho reka peptide ea Semax phofo kapa linkho tse felileng inthaneteng, morekisi ea tsebahalang ke khetho ea bohlokoa haholo, e ka netefatsang hore o fumana boleng ba peptide Semax. Hape, AASraw e ka fana ka li-peptide tsa boleng bo phahameng ka tšehetso ea setsi se ikemetseng sa R & D le fektheri, litaelo tsa Semax tse ngata li amoheleha.
Semax e sebetsa joang
Semax e sebetsa ka mekhoa e mengata ho khothaletsa likarolo tse fapaneng tsa ts'ebetso ea boko le bophelo bo botle, tse latelang ke tse ling tsa mekhoa e reriloeng eo Semax e ka hlahisang litlamorao tsa eona:
(1) Neurotrophic factor modulation
Semax e ntlafatsa maemo le ts'ebetso ea neurotrophic factor (BDNF) e tsoang bokong mme e ka khothaletsa kholo, nts'etsopele, le ho phela ha li-neurone, ho thusa ho ithuta le ho ntlafatsa mohopolo.
(2) Dopaminergic system modulation
Semax e ama sisteme ea dopamine bokong, e ka khothaletsa ho lokolloa ha dopamine, hape e ntlafatsa kutlo ea dopamine receptor, e lebisang ho ntlafatseng mesebetsi ea kelello le taolo ea maikutlo.
(3) Litlamorao tse khahlanong le ho ruruha le li-antioxidant
Semax e bonts'a thepa e khahlanong le ho ruruha ka ho fokotsa tlhahiso ea limolek'hule tsa pro-inflammatory le ho khothaletsa tokollo ea lintho tse thibelang ho ruruha. E boetse e sebetsa joalo ka antioxidant, e sireletsang methapo ea kutlo khatellong ea oxidative le tšenyo e bakiloeng ke li-radicals tsa mahala.
(4) Neuropeptide modulation
Semax e ka ama maemo le ts'ebetso ea li-neuropeptides tse fapaneng, e ka kenya letsoho ho phomotseng bohloko, litlamorao tse khahlanong le ho ruruha, le ho feto-fetoha ha sesole sa 'mele ka ho laola li-neuropeptides tsena.
(5) Liphello tsa Neuroprotective
Semax e bonts'itse thepa ea methapo ea kutlo ka ho ntlafatsa bophelo ba neuronal, ho fokotsa neuronal apoptosis (lefu la sele), le ho khothaletsa pholiso ea methapo le nchafatso. E thusa ho sireletsa li-neurone ts'enyong le ho ts'ehetsa bophelo bo botle le ts'ebetso ea bona ka kakaretso.
(6) Ntlafatso ea kelello
Semax e ka ntlafatsa polasetiki ea synaptic, ea thusa ho matlafatsa kapa ho fokolisa karabelo ea ts'ebetso ea neural mme ea lebisa ho ntlafatseng ts'ebetso ea kelello.
Ho bohlokoa ho hlokomela hore lipatlisiso tsa Semax li ntse li tsoela pele, ho na le mekhoa e mengata ea eona le litlamorao ha li so utloisisoe ka botlalo. Empa, 'marakeng oa hajoale, Semax e rekisoa haholo e le "motlatsi oa kelello" le "neuroprotective agent", e leng e 'ngoe ea litlatsetso tse ntle ka ho fetisisa tsa nootropics.
Melemo e ka bang teng ha o sebelisa Semax
Semax ke sethethefatsi sa nootropic se bontšitsoeng se fana ka melemo le ts'ebeliso e mengata libakeng tse fapaneng, tse latelang ke melemo e tlalehiloeng ke mofuputsi:
① Ntlafatsa tlhokomelo le mohopolo: Basebelisi ba bang ba tlalehile ntlafatso ea nako ea tlhokomelo le bokhoni ba ho hopola ha ba ntse ba sebelisa Semax.
②Ho fokotsa ho tšoenyeha le matšoao a khatello ea maikutlo: Semax e tlalehiloe e na le litlamorao tse laolang maikutlo, tse ka fokotsang matšoao a ho tšoenyeha le khatello ea maikutlo.
③E ntlafalitse ho hlaka kelellong le ho tsepamisa maikutlo: Basebelisi ba hlalositse keketseho ea ho hlaka kelellong le ho tsepamisa maikutlo ka tšebeliso ea Semax.
④Litlamorao tse fokotsehileng tsa khatello ea maikutlo: Semax e kanna ea ba le bokhoni ba ho fokotsa litlamorao tse mpe tsa khatello ea maikutlo 'meleng le ho khothaletsa maikutlo a khutso.
Bakeng sa Maemo a Bongaka ha Semax e sebelisoa bakeng sa kalafo
①Bothata ba ho tšoenyeha: Semax e behiloe bakeng sa kalafo ea mathata a ho tšoenyeha, leha ho hlokahala lipatlisiso tse ling ho netefatsa katleho ea eona.
②Liketsahalo tsa Ischemic le stroke: Semax e 'nile ea etsoa lipatlisiso ka bokhoni ba eona ba ho thusa ho fola le ho fokotsa tšenyo e bakiloeng ke liketsahalo tsa ischemic.
③Ho nchafatsa methapo: Semax e bonts'itse bokhoni ba ho khothaletsa nchafatso ea methapo le tokiso.
④ADHD: Semax e sebelisitsoe e le pheko e 'ngoe bakeng sa ADHD, leha katleho ea eona ntlheng ena e hloka lipatlisiso tse ling.
⑤Ho tlosoa ha Opioid: Semax e hlahlobiloe e le thuso e ka bang teng ho laola matšoao a ho ikhula nakong ea kalafo ea bokhoba ba opioid.
⑥Mafu a sa foleng a kang ALS, Parkinson's Disease, le Alzheimer's: Semax e ithutoe ka mehlala ea preclinical mme e bonts'a ts'episo ea ho ntlafatsa matšoao le tsoelo-pele ea mafu maemong ana, empa lipatlisiso tse ling lia hlokahala.
⑦ Thrombosis: Semax e 'nile ea etsoa lipatlisiso mabapi le bokhoni ba eona ba ho thibela le ho phekola thrombosis, leha ho le joalo ho hlokahala lipatlisiso tse ling ho netefatsa katleho ea eona.
⑧Mathata a mala: Semax e 'nile ea hlahlojoa bakeng sa bokhoni ba eona ba ho phekola mafu a amanang le mpa, empa bopaki ba kliniki bo na le moeli.
Litlamorao tsa Semax ke life?
Joalo ka ha lipatlisiso tse ling le litlaleho tsa basebelisi, Semax hangata e nkuoa e bolokehile ebile e mamelloa hantle. Leha ho le joalo, joalo ka ntho efe kapa efe, Semax e ka ba le litlamorao tse ka bang teng. Ho bohlokoa ho hlokomela hore likarabo tsa motho ka mong ho Semax li ka fapana, mme ha se motho e mong le e mong ea ka bang le litlamorao tsena. Mona ke litlamorao tse ling tse amanang le Semax:
▪ Ho hlotheha ha moriri
▪ Nausea
▪ Ho hlatsa
▪ Ho opeloa ke hlooho
▪ Ho khathala ho fokolang
▪ Ho hloka botsitso
▪ Ho hlohlona nko
▪ Lintho tse hananang le tsona
▪ Litšitiso tsa boroko
▪ Ho fetoha ha takatso ea lijo
▪ Keketseho ea tsoekere maling
Ho bohlokoa ho hlokomela hore Semax e ithutile haholo Russia mme e sebelisitsoe boikoetlisong ba bongaka ka lilemo tse 'maloa, e nang le boemo bo botle ba polokeho. Empa, haeba u mosebelisi e mocha ea nang le Semax, hangata ha u eletse mosebetsi oa Semax stack ka li-nootropic tse ling kapa li-supplement, tse ka eketsang kotsi ea litlamorao tse mpe. Haeba u tsitlallela ho etsa ntho ena, ho molemo ho buisana le setsebi sa tlhokomelo ea bophelo pele u e sebelisa.
Semax VS Selank: Ho Tšoana le Liphapang
Semax le Selank ka bobeli ke lithethefatsi tsa peptide tse nang le litlamorao tse ka ntlafatsang mohopolo le maikutlo, empa li na le mekhoa e fapaneng ea ts'ebetso le ts'ebeliso. Mona ke papiso lipakeng tsa Semax le Selank:
(1)Mokhoa oa Ts'ebetso:
Semax: Semax e tsoa ho peptide e bitsoang adrenocorticotropic hormone (ACTH). E sebetsa ka ho fetola maemo a li-neurotransmitters tse kang dopamine, serotonin, le norepinephrine bokong. Semax haholo-holo e sebetsa e le moemeli oa methapo ea kutlo le ea kelello.
Selank: Selank ke peptide ea maiketsetso e thehiloeng ho sekhechana sa peptide Tuftsin. E sebetsa joaloka anxiolytic le antidepressant ka ho laola maemo a lihomone tse amanang le khatello ea kelello, joalo ka cortisol. Selank e boetse e ama maemo a li-neurotransmitters, ho kenyelletsa le serotonin.
(2)Liphello le Melemo
Semax: Semax e tsejoa ka melemo ea eona e ka bang teng ho ntlafatseng mesebetsi ea kelello joalo ka tlhokomelo, mohopolo le ho tsepamisa maikutlo. E ka boela ea thusa ho fokotsa matšoao a ho tšoenyeha, khatello ea maikutlo le khatello ea maikutlo. Semax e ithutoe maemong a kang stroke, ADHD, le mafu a neurodegenerative.
Selank: Selank e sebelisoa haholo-holo bakeng sa litlamorao tsa eona tse tšoenyang le tse thibelang ho imeloa kelellong. E ka thusa ho fokotsa matšoao a ho tšoenyeha, ho khothalletsa ho phomola, le ho ntlafatsa maikutlo. Selank e ithutoe ka mathata a ho tšoenyeha, khatello ea maikutlo le lefu la khatello ea maikutlo ka mor'a ho sithabela maikutlo (PTSD).
(3) Tsamaiso
Semax: Semax e fumaneha hangata joalo ka setlolo sa nko mme e tsamaisoa ka intranasally.
Selank: Selank e fumaneha hape e le sefafatsi sa nko, empa e ka enteloa ka tlas'a letlalo.
(4)Tlhahiso ea Tšireletso
Semax: Semax ka kakaretso e nkuoa e bolokehile ebile e mamelloa hantle, e na le litlamorao tse fokolang tse tlalehiloeng. Litla-morao tse atisang ho tlalehoa li kenyelletsa ho se phutholohe ha nko, ho opeloa ke hlooho, le ho teneha ha nakoana.
Selank: Selank e boetse e nkuoa e na le boemo bo botle ba polokeho, e nang le litlamorao tse fokolang tse tlalehiloeng. Basebelisi ba bang ba ka 'na ba utloa bohloko bo fokolang ba nko kapa ba tšoaroa ke hlooho.
Ho bohlokoa ho hlokomela hore litlamorao le melemo ea Semax le Selank li ntse li ithutoa, 'me bopaki bo teng bo na le moeli. Katleho le ts'ebeliso e nepahetseng ea li-peptide tsena li ka fapana ho ea ka batho ka bomong. Ho bohlokoa hore u buisane le setsebi sa tlhokomelo ea bophelo pele u nahana ka tšebeliso ea Semax, Selank, kapa meriana efe kapa efe e thehiloeng ho peptide, kaha ba ka fana ka likeletso tse ikhethileng ho latela litlhoko tsa hau le nalane ea bongaka.
Moo u ka rekang Semax Inthaneteng?
Ehlile ho bohlokoa ho ba hlokolosi ha u batla ho reka Semax kapa tlatsetso efe kapa efe ea nootropic inthaneteng, kaha lihlahisoa tsa maiketsetso li ka tšoenya. Ho netefatsa hore o reka Semax ea boleng bo holimo e bolokehileng hape e matla, ho molemo ho reka ka kotloloho fekthering e tsebahalang ea Semax, morekisi ea lumelletsoeng oa Semax, kapa k'hamphani ea Semax e nang le litlhahlobo tse tšepahalang tsa bareki. Pele o laela Semax, o lokela ho etsa lipatlisiso tse ling mabapi le barekisi ba Semax, lits'ebetso tsa tlhahiso, le mehato ea taolo ea boleng.
Re khothaletsa haholo AASraw, e leng moetsi ea tsebahalang le setsebi le mofani oa thepa ea khethehileng ka ho fana ka mefuta e mengata ea phofo e tala ea peptide le li-vials. Ka boitseanape le boiphihlelo ba rona indastering, re fana ka lihlahisoa tsa boleng bo holimo ho fihlela litlhoko tsa bafuputsi, lik'hamphani tsa meriana, le batho ba amehang ts'ebetsong le nts'etsopele ea peptide. Haeba u batla ho fumana morekisi ea tšepahalang oa Semax, AASraw ke khetho e ntle.
Tlaleho ea Tlhahlobo ea Semax-HNMR
HNMR ke eng hona HNMR spectrum e u bolella eng? H Nuclear Magnetic Resonance (NMR) spectroscopy ke mokhoa oa ho hlahloba k'hemistri o sebelisoang ho laola boleng le lipatlisiso bakeng sa ho fumana likahare le bohloeki ba sampuli hammoho le sebopeho sa limolek'hule. Mohlala, NMR e ka sekaseka ka bongata metsoako e nang le metsoako e tsebahalang. Bakeng sa metsoako e sa tsejoeng, NMR e ka sebelisoa ho bapisa le lilaebrari tsa spectral kapa ho fana ka sebopeho sa motheo ka kotloloho. Hang ha sebopeho sa motheo se tsejoa, NMR e ka sebelisoa ho fumana hore na limolek'hule li lumellana joang le tharollo hammoho le ho ithuta thepa ea 'mele boemong ba limolek'hule joalo ka phapanyetsano ea conformational, liphetoho tsa mohato, solubility le diffusion.
U ka reka Semax joang ho AASraw?
❶Ho ikopanya le rona ka sistimi ea rona ea ho botsa ka lengolo-tsoibila, kapa ho re siela nomoro ea hau ea WhatsApp, moemeli oa rona oa litšebeletso tsa bareki(CSR) o tla ikopanya le uena ka mor'a lihora tse 12.
❷ Ho re fa palo le aterese eo u e botsitseng.
❸ CSR ea rona e tla u fa khotheishene, nako ea ho patala, nomoro ea morao-rao, litsela tsa ho fihla, le letsatsi la ho fihla (ETA).
❹Ho lefa 'me thepa e tla romelloa ka mor'a lihora tse 12.
❺Lintho tse amohetsoeng le ho fana ka maikutlo.
Mongoli oa sengoloa sena:
Ngaka Monique Hong o fumane lengolo UK Imperial College London Faculty of Medicine
Sengoli sa pampiri sa Scientific Journal:
1.Nataliya Yu.Glazova
Institute of Molecular Genetics,RAS,2 Akademika Kurchatova square,Moscow 123182,Russia
2.D.Khukhareva
Lomonosov Moscow State University, Biological- Human and Animal phisiology, Moscow, Russia Federation
3. Antonio Magri
Istituto di Biostrutture e Bioimmagini,Consiglio Nazionale delle Ricerche (CNR),Via P.Gaifami 18,95126 Catania,Italy
4.TYAgapova
Laboratori ea Liphatsa tsa lefutso tsa Molek'hule ea Mafu a Lefa, Lefapha la Motheo oa Molek'hule oa Liphatsa tsa lefutso tsa Batho, Setsi sa Molecular Genetics RAS, 2 Kurchatov Sq.,Moscow 123182, Russia
Ha ho ka tsela leha e le efe ngaka/saense ena e buellang kapa ho buella ho rekoa, thekiso, kapa tšebeliso ea sehlahisoa sena ka lebaka lefe kapa lefe. Aasraw ha e na kamano kapa kamano, ho boleloa kapa ho seng joalo, le ngaka ena. Sepheo sa ho qotsa ngaka ena ke ho ananela, ho ananela le ho babatsa lipatlisiso tse felletseng le mosebetsi oa nts'etsopele o entsoeng ke bo-ramahlale ba sebetsanang le ntho ena.
Reference
[1] Sciacca MFM, Naletova I, Giuffrida ML, Attanasio F.” Semax, Synthetic Regulatory Peptide, E Ama Aggregation ea Abeta ea Copper-Induced Abeta le Amyloid Formation ho Artificial Membrane Models.” ACS Chem Neurosci.2022 Feb 16; 13 (4): 486-496.PMID: 35080861.
[2] Sudarkina OY,Filippenkov IB”Boko ba Pontšo ea Pontšo ea Protheine ea Boko bo Tiisa Phello ea Tšireletso ea ACTH(4-7)PGP Peptide (Semax) ka Rat Model ea Cerebral Ischemia-Reperfusion”.Int J Mol Sci.2021 Jun 8;22(12(6179) ): 34201112.PMID: XNUMX
[3] Dergunova LV,Dmitrieva VG”The Peptide Drug ACTH(4-7)PGP (Semax) Suppresses mRNA Transcripts Encoding Proinflammatory Mediators Induced by Reversible Ischemia of the Rat Brain”.Mol Biol (Mosk) .2021 May-Jun;55 (3): 402-411.PMID: 34097675.
[4] Panikratova YR,Lebedeva KE”Mokhoa o sebetsang oa Connectomic oa ho Ithuta Selank le Semax Effects”.Dokl Biol Sci.2020 Jan; 490(1):9-11.PMID: 32342318.
[5] Slominsky PA, Shadrina MI”Peptides semax le selank e ama boitšoaro ba likhoto tse nang le 6-OHDA induced PD-like parkinsonism”.Dokl Biol Sci.2017 May; 474(1): 106-109.PMID: 28702721.
[6] Kaplan AY,Kochetova AG,Nezavibathko VN,Rjasina TV,Ashmarin IP (Lwetse 1996)."Synthetic acth analogue semax displays nootropic-like activity in people”.Neuroscience Research Communications.19 (2): 115–123.doi :10.1002.
[7] Tabbì G,Magrì A”Semax,analoge ea peptide ea ACTH4-10 e nang le kamano e phahameng bakeng sa ion ea koporo(II) le bokhoni ba ho itšireletsa khahlanong le chefo ea sele e bakoang ke tšepe”J Inorg Biochem.2015 Jan;142:39-46.doi: 10.1016.PMID: 25310602.
