Tlhaloso ea Sehlahisoa
ke eng Selank?
Selank peptide ke peptide ea maiketsetso e nkiloeng ho tuftsin, peptide ea tlhaho e fumanehang 'meleng oa motho. E ile ea ntlafatsoa ka tšebelisano-'moho le Setsi sa Lipatlisiso sa VVZakusov sa Pharmacology Setsing sa Molecular Genetics, Sekolo sa Russia sa Saense ea Bongaka. Naheng ea Russia, e amohetsoe bakeng sa kalafo ea lefu la ho tšoenyeha ka kakaretso (GAD) hape e sebelisoa ka boithapollo joalo ka nootropic.
Tatelano e khethehileng ea peptide ea Selank ke Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP). Tatelano ena e etselitsoe ho etsisa liketso tsa tuftsin, e amehang taolong ea 'mele ea ho itšireletsa mafung' me e na le thepa ea anxiolytic. Selank e ithutoe haholo bakeng sa litlamorao tse ka bang teng tsa kalafo, ho kenyeletsoa ntlafatso ea matšoao a ho tšoenyeha le khatello ea maikutlo, ho ntlafatsa mohopolo le temoho, le ho khothaletsa maikutlo a khutso.
Nts'etsopele ea Selank e ikemiselitse ho sebetsana le mefokolo ea tuftsin peptide ea tlhaho, e nang le nako e khuts'oane ea bophelo 'meleng. Ka ho kopanya Selank, bo-rasaense ba batla ho theha mofuta o tsitsitseng le o tšoarellang halelele oa tuftsin, e lumellang hore ho sebelisoe kalafo e sebetsang le e tšepahalang haholoanyane.
Selank e sebetsa joang?
Selank e hlahisa litlamorao tsa eona 'meleng ka mekhoa e fapaneng. Leha mekhoa e nepahetseng ea ts'ebetso e sa tsejoe, mona ke menahano ea hore na Selank e ka sebetsa joang.
Neurotransmitter modulation: selank ho nahanoa hore e ama bongata ba li-neurotransmitters tsa monoamine tse kang serotonin, dopamine, le norepinephrine. Selank e ka thusa ho laola maikutlo, temoho le maemo a maikutlo ka ho susumetsa metabolism le maemo a li-neurotransmitters tsena.
Tšebelisano le sesole sa 'mele: selank ke analoge ea maiketsetso ea tuftsin e fanang ka maikutlo a hore e kanna ea ba le thepa ea immunomodulatory. Ho nahanoa hore ho na le phello e leka-lekaneng ea T helper cell cytokines le ho fetola polelo ea Interleukin-6 (IL-6), eo ka bobeli e leng ea bohlokoa karabelong ea 'mele ea ho itšireletsa mafung le taolong.
Tšusumetso ho boko bo entsoeng ke neurotrophic factor (BDNF): selank e bontšitsoe ho matlafatsa polelo ea BDNF ho hippocampus, sebaka sa boko se bohlokoa bakeng sa ho ithuta le ho hopola.BDNF ke ea bohlokoa bakeng sa khōlo, ho phela, le polasetiki ea li-neurons.
Thibelo ea enzyme: selank le moriana oa eona o ts'oanang oa peptide Semax e bonts'itsoe hore e thibela li-enzyme tse amehang karohanong ea li-enkephalin le li-peptide tse ling tsa taolo ea endo native. Ketso ena e ka thusa ho laola maemo le ts'ebetso ea peptide, e ka amang maikutlo a bohloko le mekhoa e meng ea 'mele.
Ho bohlokoa ho reka selank ho tsoa ho morekisi ea tsebahalang e le hore boleng ba peptide selank bo ka netefatsoa. Setsebi sa selank moetsi le mofani oa thepa AASraw a ka fana ka selank ka boleng bo phahameng bakeng sa tšehetso ea setsi se ikemetseng sa R&D le fektheri. Haeba u na le litlhoko, selank wholesale ho tloha AASraw ke khetho e ntle.
Melemo ea Selank
Selank peptide e ithutoe bakeng sa melemo ea eona ea kalafo mme e bontšitse litlamorao tse fapaneng tse ntle. Mona ke melemo e meng ea Selank.
Anxiolytic liphello
Selank e bontšitse litlamorao tse khahlanong le ho tšoenyeha litekong tsa bongaka le lithutong tsa liphoofolo. E ka thusa ho fokotsa matšoao a ho tšoenyeha, ho ntlafatsa boleng ba bophelo, le ho fokotsa matšoenyeho a amanang le mathata a fapaneng.
Ntlafatso ea kelello
Selank e fumanoe e ntlafatsa ts'ebetso ea kelello le ho ntlafatsa bokhoni ba ho ithuta le mohopolo. E ka khothaletsa tlhokomelo e ntlafetseng, ho ithuta, le mekhoa ea ho hopola, e ka thusang batho ba nang le bokooa ba kelello kapa ba batlang ho ntlafatsa ts'ebetso ea bona ea kelello.
Taolo ya maikutlo
Selank e kanna ea ba le thepa e laolang maikutlo, e ka kenyang letsoho litlamoraong tsa eona tsa matšoenyeho. E ithutile ka bokhoni ba eona ba ho fetola polelo ea "brain-derived neurotrophic factor" (BDNF), e bapalang karolo ea bohlokoa taolong ea maikutlo le kholong le tlhokomelong ea methapo ea kutlo.
Ho feto-fetoha ha 'mele oa ho itšireletsa mafung
Selank e bontšitsoe hore e na le liphello tsa immunomodulatory, tse kenyelletsang ho susumetsa ho lokolloa ha li-interferon le ho ntlafatsa tlhahiso ea lisele tsa T mothusi oa mofuta oa 1 (Th1). Liphello tsena li ka kenya letsoho ho matla a eona a matla a ho itšireletsa mafung.
Tšireletso ea sebete
Selank e bonts'itse ts'ebetso ea antioxidant mme e bonts'itse hore e fokotsa maemo a li-radicals tsa mahala sebeteng. E ka boela ea thusa ho tsosolosa sebōpeho sa lisele tsa sebete, tse ka 'nang tsa kenya letsoho bophelong bo botle ba sebete.
Pele o sebelisa selank, joalo ka peptide efe kapa efe kapa kalafo ea kalafo, ho molemo ho buisana le setsebi sa tlhokomelo ea bophelo. Ba ka fana ka likeletso, ba lekola likotsi tse ka bang teng, 'me ba latela tsoelo-pele ea hau ho netefatsa ts'ebeliso e bolokehileng le e nepahetseng. Ho feta moo, ho reka li-peptide mohloling o nepahetseng ke habohlokoa.AASraw e boloka taolo e thata ea boleng 'me e entse sehlopha sa selank sa boleng bo phahameng se rekisoang. Haeba ho hlokahala, o amohelehile ho reka peptide selank.
Selank vs Semax
Selank le Semax ka bobeli ke li-peptide tsa maiketsetso tse ntlafalitsoeng bakeng sa litlamorao tsa tsona tse ka bang teng tsa kalafo. Ha ba ntse ba arolelana lintho tse ling tse tšoanang, ba boetse ba na le liphapang tse ikhethang tatellanong ea bona ea peptide, mehloli e nkiloeng, tšebeliso ea kalafo le mekhoa ea tsamaiso. Mona ke papiso lipakeng tsa Selank le Semax:
· Tatelano ea Peptide
Selank: Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP)
Semax: Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP)
· E nkiloeng ho
Selank:Selank e tsoa ho tuftsin, peptide ea tlhaho e amehang taolong ea 'mele ea ho itšireletsa mafung le thepa ea ho tšoenyeha.
Semax:Semax e tsoa sekhechana sa ACTH, e leng hormone ea peptide e amehang taolong ea tlhahiso ea cortisol.
· Tšebeliso ea phekolo
Selank: Selank e amohetsoe Russia bakeng sa kalafo ea lefu la ho tšoenyeha ka kakaretso (GAD). E boetse e sebelisoa bakeng sa ho tepella maikutlong, anhedonia (tahlehelo ea thabo), ho feto-fetoha ha 'mele oa ho itšireletsa mafung, matšoao a ho tlohela joala, le ho ntlafatsa kutloisiso.
Semax: Semax e sebelisoa haholo bakeng sa ntlafatso ea kelello, ho kenyelletsa le ho ntlafatsa tlhokomelo, mohopolo le mesebetsi ea kelello. E boetse e ithutoe bakeng sa litlamorao tsa neuroprotective mme e na le ts'ebeliso e ka bang teng kalafong ea stroke, kotsi e sithabetsang ea boko, le mafu a mahlo a kang optic nerve neuropathy le glaucoma.
· Litla-morao
Selank: Litla-morao tse sa tloaelehang le tse sa tloaelehang tse amahanngoang le Selank li ka kenyelletsa ho tsekela, mokhathala, ho lahleheloa ke moriri, hlooho e opang, ho hlohlona ha nko, ho nyekeloa ke pelo le 'metso. Leha ho le joalo, litla-morao tsena ha li tlalehoe hangata.
Semax: Semax hangata e nkuoa e bolokehile ebile e mamelloa hantle, ka litlamorao tse sa tloaelehang le tse sa tloaelehang tse tlalehiloeng.
· Liphello tsa kelello
Selank: Selank e ithutile ka bokhoni ba eona ba ho ntlafatsa temoho, mohopolo le bokhoni ba ho ithuta.
Semax: Semax e tsejoa ka litlamorao tsa eona tse matlafatsang kelello, haholoholo ho ntlafatseng tlhokomelo, mohopolo le mesebetsi ea kelello.
· Liphello tsa Anxiolytic
Selank: Selank e bonts'itse litlamorao tse khahlanong le ho tšoenyeha 'me e sebelisetsoa ho phekola mathata a ho tšoenyeha.
Semax: Le ha Semax e shebane haholo le ntlafatso ea kelello, e kanna ea ba le litlamorao tse ling tsa matšoenyeho, leha e se ts'ebeliso ea eona ea mantlha ea kalafo.
· Liphello tsa Neuroprotective
Selank: Selank e bonts'itse litlamorao tse ka bang teng tsa neuroprotective lithutong.
Semax: Semax e ithutoe ka thepa ea eona ea methapo ea kutlo, haholo maemong a stroke le kotsi e bohloko ea boko.
Ho bohlokoa ho hlokomela hore tlhahisoleseling e fanoeng ke kakaretso e akaretsang, mme thepa le ts'ebeliso e ikhethileng ea Selank le Semax li ka fapana ho latela maemo a motho ka mong le ho fumaneha ha libaka. Kamehla ho eletsoa ho buisana le setsebi sa tlhokomelo ea bophelo bakeng sa tlhaiso-leseling e nepahetseng le ea motho ka mong mabapi le li-peptide tsena.
U ka reka Selank hokae?
Ho na le barekisi ba fapaneng ba marang-rang le barekisi ba ikhethileng ka ho rekisa li-peptide le lihlahisoa tse amanang le tsona. Li-platform tsena tsa marang-rang li ka fana ka Selank e rekisoang. Ho bohlokoa ho etsa bonnete ba hore u khetha morekisi ea tšepahalang le ea tšepahalang ha u reka inthaneteng. Bala maikutlo a bareki, hlahloba litifikeiti, 'me u netefatse bonnete le boleng ba sehlahisoa.
AASraw ke moetsi ea nang le botumo bo botle le setsebi le mofani oa thepa ea khethehileng ka ho fana ka mefuta e mengata ea phofo e tala ea peptide le li-vials. Ka boitseanape le boiphihlelo ba rona indastering, re fana ka lihlahisoa tsa boleng bo holimo ho fihlela litlhoko tsa bafuputsi, lik'hamphani tsa meriana, le batho ba amehang ts'ebetsong le nts'etsopele ea peptide. Haeba u batla ho fumana mofani oa Selank ea tšepahalang, AASraw ke khetho e ntle.
Tlaleho ea Tlhahlobo ea Selank-HNMR
HNMR ke eng hona HNMR spectrum e u bolella eng? H Nuclear Magnetic Resonance (NMR) spectroscopy ke mokhoa oa ho hlahloba k'hemistri o sebelisoang ho laola boleng le lipatlisiso bakeng sa ho fumana likahare le bohloeki ba sampuli hammoho le sebopeho sa limolek'hule. Mohlala, NMR e ka sekaseka ka bongata metsoako e nang le metsoako e tsebahalang. Bakeng sa metsoako e sa tsejoeng, NMR e ka sebelisoa ho bapisa le lilaebrari tsa spectral kapa ho fana ka sebopeho sa motheo ka kotloloho. Hang ha sebopeho sa motheo se tsejoa, NMR e ka sebelisoa ho fumana hore na limolek'hule li lumellana joang le tharollo hammoho le ho ithuta thepa ea 'mele boemong ba limolek'hule joalo ka phapanyetsano ea conformational, liphetoho tsa mohato, solubility le diffusion.
Mokhoa oa ho reka Selank ho tloha AASraw?
❶Ho ikopanya le rona ka mokhoa oa rona oa ho botsa ka lengolo-tsoibila, kapa ho re siela nomoro ea hau ea WhatsApp, moemeli oa rona oa litšebeletso tsa bareki (CSR) o tla ikopanya le uena ka mor'a lihora tse 12.
❷ Ho re fa palo le aterese eo u e botsitseng.
❸ CSR ea rona e tla u fa khotheishene, nako ea ho patala, nomoro ea morao-rao, litsela tsa ho fihla, le letsatsi la ho fihla (ETA).
❹Ho lefa 'me thepa e tla romelloa ka mor'a lihora tse 12.
❺Lintho tse amohetsoeng le ho fana ka maikutlo.
Mongoli oa sengoloa sena:
Ngaka Monique Hong o fumane lengolo UK Imperial College London Faculty of Medicine
Sengoli sa pampiri sa Scientific Journal:
1.Timur Kolomin
Laboratori ea liphatsa tsa lefutso tsa limolek'hule tsa mafu a lefutso, Lefapha la Motheo oa Limolek'hule tsa Liphatsa tsa lefutso tsa Batho, Setsi sa Liphatsa tsa lefutso tsa Molek'hule, Academy of Sciences ea Russia, Russia.
2.T. Syunyakov
Lefapha la Borderline Psychiatry, FSBI "Setsi sa Sechaba sa Lipatlisiso sa Serbsky sa Social and Forensic Psychiatry", Moscow, Russia.
3.TN Sollertinskaja
IMSechenov Institute of Evolutionary Physiology le Biochemistry ea RAS, Russia
4.Marina Morozova
Lefapha la Biomedical le Theknoloji ea Meriana, Lefapha la Biotechnology le Organic Synthesis, Lomonosov Moscow University of Fine Chemical Technology, Russia.
Ha ho ka tsela leha e le efe ngaka/saense ena e buellang kapa ho buella ho rekoa, thekiso, kapa tšebeliso ea sehlahisoa sena ka lebaka lefe kapa lefe. Aasraw ha e na kamano kapa kamano, ho boleloa kapa ho seng joalo, le ngaka ena. Sepheo sa ho qotsa ngaka ena ke ho ananela, ho ananela le ho babatsa lipatlisiso tse felletseng le mosebetsi oa nts'etsopele o entsoeng ke bo-ramahlale ba sebetsanang le ntho ena.
Reference
[1] Inozemtseva LS, Karpenko EA, Dolotov OV, Levitskaya NG, Kamensky AA, Andreeva LA, Grivennikov IA (2008). "Tsamaiso ea Intranasal ea peptide Selank e laola polelo ea BDNF ho rat hippocampus ka vivo". Doklady Biological Sciences. 421:241–243 .
[2] SEMAX: sethethefatsi se pharalletseng se sebetsang hantle sa tsamaiso ea methapo. Institute of Molecular Genetics (ka Serussia).Moscow.E bolokoa ho tloha qalong ka 2011-07-22.
[3] Solov'ev VB,Gengin MT,Sollertinskaia TN,Latynova IV,Zhivaeva LV (2012).“[Phello ea selank ho li-carboxypeptidase tse ka sehloohong mofuteng oa methapo ea likhoto]”. Zhurnal Evoliutsionnoi Biokhimii I Fiziologii (ka Serussia). 48 (3):254–257.
[4] Uchakina ON,Uchakin PN,Miasoedov NF,Andreeva LA,Shcherbenko VE,Mezentseva MV,et al.(2008)."[Immunomodulatory effects of selank in patients with depression-asthenic disorders]". Zhurnal Nevrologii I Psikhiatrii Imeni SSKorsakova. 108 (5):71–75.
[5] Kost NV, Sokolov OI, Gabaeva MV, Grivennikov IA, Andreeva LA, Miasoedov NF, Zozulia AA (2001). "Semax le selank li thibela li-enzyme tse senyang enkephalin ho serum ea motho". Bioorganicheskaia Khimiia (ka Serussia). 27 (3):180–183.
[6] Semenova TP,Kozlovskiĭ II,Zakharova NM,Kozlovskaia MM (Phato 2010).“[Katoloso ea liteko ea mekhoa ea ho ithuta le ea ho hopola ka selank]”. Eksperimental'naia le Klinicheskaia Farmakologia. 73 (8):2–5.
