Tlhaloso ea Sehlahisoa
Retatrutide ke eng?
Retatrutide, moriana o mocha, o bonts'a monyetla o moholo oa ho phekola lefu la tsoekere le botenya. FDA e mothating oa ho amohela moriana ona, o tsejoang hape e le GGG Tri-agonist, GLP-1/GIP/glucagon tri-agonist, kapa LY3437943. E lekana le meriana e meng ea tahlehelo ea boima ba 'mele e kang tirzepatide le semaglutide, le hoja e sebetsa haholoanyane. Ha e nkoa hammoho le lijo tse matlafatsang, boikoetliso bo tsitsitseng, le liphetoho tsa mokhoa oa bophelo (khatello e phahameng ea mali), retatrutide e ka phekola mafu a amanang le botenya a kang lefu la tsoekere kapa khatello ea mali.
Retatrutide e shebahala e atlehile ho feta meriana e meng e teng ea ho fokotsa boima ba 'mele. E finyella melemo ea eona ea phekolo ka mekhoa e meraro e meholo:
GIPR Agonism: Retatrutide e hatella takatso ea lijo 'me e fokotsa mafura a mafura ka ho sebetsa e le GIP receptor agonist.Sena se fella ka ho ja lik'halori tse fokolang le ho sebelisa matla a mangata.
Retatrutide e sebetsa joalo ka glucagon-joaloka peptide 1 receptor agonist. Ketso ena e khothalletsa ho lokolloa ha insulin ho manyeme ha e ntse e fokotsa tlhahiso ea glucagon, hormone e phahamisang tsoekere ea mali.
GR Agonism: Ka ho sebetsa joalo ka glucagon receptor agonist, retatrutide e fokotsa ho lokolloa ha glucagon. Sena se fella ka maemo a ntlafetseng a tsoekere ea mali, ho fokotseha ha lijo, le ho eketseha ha tšebeliso ea matla, e qetellang e lebisa ho theola boima ba 'mele.
Mekhoa ena e kopantsoeng e etsa hore retatrutide e be moriana o atlehang oa ho fokotsa boima ba 'mele o ka boela oa ruisa li-comorbidities tse amanang le botenya bo kang lefu la tsoekere kapa khatello ea kelello.
Retatrutide e sebetsa joang?
Liphetho tse ts'episang tsa retatrutide, e ka fetolang papali sebakeng sa bophelo bo botle ba sechaba, li bakoa ke tšebelisano ea eona ea ho bala le lihomone tse laolang takatso ea rona ea lijo.
Retatrutide e etsa ketso ea ho leka-lekanya ka ho etsisa lihomone tse 'maloa. Joalo ka Wegovy e etsisa GLP-1, hormone e thusang taolong ea tsoekere ea mali ka ho tsosa tlhahiso ea insulin kamora ho ja. Empa ha e felle moo.
Retatrutide e boetse e etsisa tirzepatide e le ho etsisa GIP, hormone ea bobeli e amanang le tlhahiso ea insulin. Se khethollang retatrutide ke ho susumetsa ha eona homone ea boraro, e leng glucagon receptor, e fumanoang haholo-holo sebeteng. Matla ana a eketsehileng e ka ba senotlolo sa melemo e meng e tebileng ea lithethefatsi e fetang hole ho theola boima ba 'mele.
Lintlha tsa mantlha tsa moriana ona ke lihlooho tsa litaba ka lebaka la melemo e meng e ka bang teng. Kalafo ea retatrutide e ile ea fella ka phokotso ea 20 ka boitsebahatso ba LDL, kapa "cholesterol" e "mpe", e leng ntlafatso e habeli e bonoang le lithethefatsi tse ling tsa GLP-1.
Melemo ea Retatrutide
①Ntšetsapele ho Theola 'Mele
Retatrutide e atlehile ho feta lithethefatsi tse ling tsa ho fokotsa boima ba 'mele ka lebaka la motsoako o ikhethang oa mekhoa ea ts'ebetso. Hobane ke agonist ea GIPR, e matlafatsa taolo ea takatso ea lijo le ho thibela ho bokellana ha mafura. E theola maemo a tsoekere ea mali ka ho eketsa tlhahiso ea insulin ea pancreatic ha e ntse e fokotsa ho lokolloa ha glucagon joalo ka agonist ea GLP-1. Joaloka GR agonist, e ntlafatsa secretion ea insulin ha e ntse e fokotsa ho lokolloa ha glucagon. Litsamaiso tsena li thusa ho theola boima ba 'mele ka ho fokotsa ho ja lik'hilojule le ho phahamisa litšenyehelo tsa matla.
② Ntlafatsa Maemo a Tsoekere ea Mali
Retatrutide e theola maemo a tsoekere ea mali ka ho fetola lihomone tsa glucagon le insulin. Glucagon e eketsa tsoekere ea mali ha insulin e ba fokotsa ho theha homeostasis kapa ho leka-lekana. Hobane ke GLP-1 le GR agonist, e ntlafatsa tokollo ea insulin ea pancreatic ha e ntse e theola tokollo ea glucagon. Ka lebaka leo, maemo a tloaelehileng a tsoekere ea mali a finyelloa.
③ Ntlafatsa Khatello ea Mali
Retatrutide e ka thusa ho theola boima ba 'mele le ho fokotsa khatello ea mali. E ka thusa ho theola boima ba 'mele ka ho fokotsa lijo tsa khalori ha o ntse o eketsa tšebeliso ea matla a hau. Ho na le bopaki ba hore ho theola boima ba 'mele ho ka thusa ho fokotsa khatello ea mali. Sena se bontša hore retatrutide e ka ba molemo ho bakuli ba nang le khatello e phahameng ea mali.
Litla-morao tsa Retatrutide
Litla-morao tsa retatrutide li fumaneha seoelo haholo. Ho bile le maemo ao mokuli a nkang retatrutide a ileng a ba le e 'ngoe ea litla-morao tse thathamisitsoeng ka tlase ha a ntse a noa meriana. Maikutlo ana a mabe a ne a sa amahanngoa le phekolo; e ka 'na eaba li bile teng ka tsietsi le tse sa amaneng le tšebeliso ea retatrutide. Leha ho le joalo, e ne e thathamisitsoe e le litla-morao tse ka bang teng le hoja litla-morao tse ka bang teng li sa tloaeleha haholo.
Tsena ke tse ling tsa litla-morao tse ka bang teng tsa retatrutide:
- Mahlaba a sefuba
- ho tepella maikutlo
- Ho phefumoloha ho thata
- Sehlōhō
- Molomo o omileng
- Mokhathala
- Hlooho ea hlooho
- Ho otlolla pelo ho sa tloaelehang
- Ho ruruha matsohong le maotong
Retatrutide khahlano le li-peptide tse ling
Retatrutide VS Semaglutide
Semaglutide le Retatrutide ke meriana e 'meli e fapaneng e sebelisoang ho phekola lefu la tsoekere la mofuta oa 2. Ka bobeli li sebetsa ka ho fokotsa maemo a tsoekere ea mali empa li na le mekhoa e fapaneng ea ho etsa joalo. Semaglutide (e tsejoang hape e le Wegovy le Ozempic ) ke ente ea GLP-1 receptor agonist e thusang lisele tsa 'mele ho hlahisa insulin e ngata, e lebisang ho theola maemo a tsoekere ea mali ha ho hlokahala.
Retatrutide, ka lehlakoreng le leng, ke analog e kang glucagon-like peptide-1 (GLP-1) e sebetsang ho susumetsa lisele tsa beta manyeme tse bakang ho lokolloa ha insulin le ho lokolloa ha pancreatic polypeptide, tseo ka bobeli li theolang boemo ba tsoekere maling.
Retatrutide VS Tirzepatide
Retatrutide le Tirzepatide ke liente tse peli tse khahlanong le botenya tse sa tsoa hlaha lefatšeng la bophelo bo botle le mokhoa oa bophelo. Retatrutide ke sethethefatsi se nkiloeng ho glucagon-joaloka peptide 1 receptor, e thusang batho ho fokotsa lijo tsa bona tsa khalori ka ho liehisa tšilo ea lijo le ho matlafatsa maikutlo a botlalo, ha Tirzepatide e le GLP-1 / glucose e itšetlehileng ka insulinotropic receptor agonist e etselitsoeng ho fokotsa takatso ea tlala.
Retatrutide VS Liraglutide
Retatrutide (eo hape e tsejoang e le MK-8349) le liraglutide (eo hape e tsejoang e le Victoza) ke lihomone tsa maiketsetso tse kentsoeng ka tlas'a letlalo letsatsi le letsatsi bakeng sa kalafo ea lefu la tsoekere la Mofuta oa 2. Leha meriana ka bobeli e na le matšoao a ts'oanang, ho na le bopaki ba hore Retatrutide e ka fana ka taolo e phahameng ea tsoekere ea mali ha e bapisoa le liraglutide.
Le hoja ka bobeli li etselitsoe ho thusa batho ho theola boima ba 'mele, li sebetsa ka litsela tse fapaneng. Retatrutide e bontša litšoaneleho tse thibelang takatso ea lijo ha Tirzepatide e fana ka tekanyo ea tsoekere ea mali, e thusang basebelisi ho laola maemo a bona a tlala. Ka hona, ho bohlokoa ho motho ea batlang ho sebelisa ente ho fumana hore na ke efe e tla lumellana hantle le litlhoko tsa bona e le hore a fumane molemo o moholo ho eona.
U ka reka Retatrutide hokae?
Phekolo ea Retatrutide peptide e na le phello e kholo ho bophelo bo botle ka kakaretso. E thusa ho theola boima ba 'mele, ho ntlafatsa maemo a tsoekere ea mali, ho ntlafatsa khatello ea mali le tse ling tse ngata. Mona ho AASraw, re inehetse ho fana ka li-peptide tse ngata ho kenyeletsa ho lahleheloa ke boima ba 'mele, phekolo ea bophelo bo botle ba thobalano, le lihomone tse ling. Haeba u thahasella Retatrutide kapa li-peptide life kapa life tse ling, tlatsa foromo e ka tlase ho hlophisa lipuisano tsa hau mme moemeli oa rona oa litšebeletso tsa bareki o tla ikopanya le uena. Re labalabela ho utloa ho tsoa ho uena!
Tsela ea ho reka Retatrutide ho tloha AASraw?
❶Ho ikopanya le rona ka mokhoa oa rona oa ho botsa ka lengolo-tsoibila, kapa ho re siela nomoro ea hau ea WhatsApp, moemeli oa rona oa litšebeletso tsa bareki (CSR) o tla ikopanya le uena ka mor'a lihora tse 12.
❷ Ho re fa palo le aterese eo u e botsitseng.
❸ CSR ea rona e tla u fa khotheishene, nako ea ho patala, nomoro ea morao-rao, litsela tsa ho fihla, le letsatsi la ho fihla (ETA).
❹Ho lefa 'me thepa e tla romelloa ka mor'a lihora tse 12.
❺Lintho tse amohetsoeng le ho fana ka maikutlo.
Mongoli oa sengoloa sena:
Ngaka Monique Hong o fumane lengolo UK Imperial College London Faculty of Medicine
Sengoli sa pampiri sa Scientific Journal:
1.Julio Rosenstock MD
Patlisiso ea Velocity Clinical ho Medical City, Dallas, TX, USA
2.Thinzar Min
Boto ea Bophelo ea Univesithi ea Swansea Bay le Sekolo sa Bongaka sa Univesithi ea Swansea,Swansea SA2 8PP,UK
3.Clifford J.Bailey
Lisaense tsa Bophelo le Bophelo bo Botle, Univesithi ea Aston, Birmingham B4 7ET, UK
Ha ho ka tsela leha e le efe ngaka/saense ena e buellang kapa ho buella ho rekoa, thekiso, kapa tšebeliso ea sehlahisoa sena ka lebaka lefe kapa lefe. Aasraw ha e na kamano kapa kamano, ho boleloa kapa ho seng joalo, le ngaka ena. Sepheo sa ho qotsa ngaka ena ke ho ananela, ho ananela le ho babatsa lipatlisiso tse felletseng le mosebetsi oa nts'etsopele o entsoeng ke bo-ramahlale ba sebetsanang le ntho ena.
Reference
[2]Liphetho tsa Lilly's phase 2 retatrutide tse phatlalalitsoeng ho The New England Journal of Medicine li bonts'a molek'hule ea lipatlisiso e fihletsoeng ho fihla ho 17.5% e bolela phokotso ea boima ba libeke tse 24 ho batho ba baholo ba nang le botenya le boima bo feteletseng.
[3] "Sethethefatsi sa liteko sa Eli Lilly sa botenya se ka otla batho ba qothisanang lehlokoa le bona ka kakaretso ea tahlehelo ea boima ba 'mele bakeng sa bakuli".CNBC.26 June 2023.Retrieved 3 July 2023.
[4]Jastreboff AM,Kaplan LM,Frías JP,Wu Q,Du Y,Gurbuz S,et al.(June 2023).”Triple-Hormone-Receptor Agonist Retatrutide for Obesity – A Phase 2 Trial”.The New England Journal ea Meriana.doi: 10.1056/NEJMoa2301972.PMID 37366315.
Fumana mantsoe a mangata
