MMAD (Demethyldolastatin 10)

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AASraw e na le bokhoni ba tlhahiso le tlhahiso ho tloha ho gram ho ea ka taelo ea MMAD (Demethyldolastatin 10) (CAS 203849-91-6), tlas'a taolo ea CGMP le tsamaiso ea boleng bo sebetsang ba boleng.

Ho phaella moo, MMAD ho tlalehoa hore e tla sebelisoa ho hlahisa li-conjugate tse nang le li-anti-drug (NDCs) tsa sebaka sa maqephe. Li-NDC, MMAD e kopantsoe le anti-5T4 antibody kapa anti-Her2 antibody. Ho bontšoa hore li-NDC li bonts'a katleho e ntle le pharmacokinetics.

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MMAD (Demethyldolastatin 10) video


I.MMAD (Demethyldolastatin 10) ea motheo:

Name: MMAD (Demethyldolastatin 10)
CAS: 203849-91-6
Molecular Formula: C41H66N6O6S
Boima ba 'mele: 771.06
Melt Point: N / A
Temp Temp Storage: Phiri -20 ° C lilemo tse 3
4 ° C lilemo tse 2
Ka ho qhibiliha -80 ° C likhoeli tse 6
-20 ° C Khoeli ea 1
Color: Ho soeufala ho fihlela ho soeufala (ho tiile)


II. MMAD (Demethyldolastatin 10) (203849-91-6) tshebeliso ea potoloho ea steroid

1.Names:

Li-synonyms: Demethyldolastatin 10 (203849-91-6); Monomethylauristatin D; Monomethyl Dolastatin 10
Chemical Name: (S)-N-((3R,4S,5S)-3-methoxy-1-((S)-2-((1R,2R)-1-methoxy-2-methyl-3-oxo-3-(((S)-2-phenyl-1-(thiazol-2-yl)ethyl)amino)propyl)pyrrolidin-1-yl)-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamide

2.MMAD (Demethyldolastatin 10) Tšebeliso:

3.Lebella ho MMAD (Demethyldolastatin 10)

Sehlahiswa ha sea ka sa phethahala ka botlalo bakeng sa likopo tsa bongaka. Bakeng sa lipatlisiso sebelisa feela

Bakeng sa ho fumana metsi a mangata, ka kopo o futhumatsa tube ka 37 ℃ mme e sisinyehe ka ho sesa ka nako e telele. Solution ea motlakase e ka bolokoa ka tlase -20 ℃ ka likhoeli tse 'maloa.

4.Hape litaelo:

In Vitro: MMAD (Demethyldolastatin 10) (203849-91-6) e kopanngoa ka mokhoa o tsitsitseng oa oxime-ligation ho hlahisa li-conjugate tse ngata tsa anti-human-antijection (ADCs) tse nang le metsoako ea meriana-to-antibody ea ~ 2.0. Li-conjuguate tse hlahisoang li bontša metsoako e ntle ea pharmacokinetic, mokhoa o matla oa in vitro cytotoxic khahlanong le lisele tsa kankere tsa HER2 +. Ha e bapisoa le ADCs e lokiselitsoeng ke alstelation ea cysteine ​​ka mor'a ho fokotsa li-disulfide tsa sebaka sa tlhaho, libaka tse ling tsa ADCs tse sa tloaelehang tsa libaka tsa tlhaho li bontšitsoe hore li eketsehile ka in vitro cytotoxicity

Li Vivi: Litho tse hlahisoang ke li-anti-drug-conjugates (ADCs) li bonts'a phekolo e feletseng ea lithethefatsi ka litoeba. Ba boetse ba na le pono e ntlafetseng ea toxicology ho likhoto.


III. MMAD (Demethyldolastatin 10) (203849-91-6) HCML

Re li-poure tsa Aprepitant, Prepitant phofo e rekisoang, Raw Aprepitant powder (170729-80-3) hplc≥98% | Ho hlahisa li-Reagents tsa R & D


IV. Joang ho reka MMAD; reka Demethyldolastatin 10 ho tloha AASraw?

1.To iteanye le rona ka imeile ea rona lenaneo la lipatlisiso, kapa skype ea inthanetengmoemeli oa tšebeletso ea bareki (CSR).
2.To re fane ka lipotso tsa hau le lipotso tsa hau.
3.Our CSR e tla u fa tlhaloso, nako ea ho lefa, nomoro ea ho latela, litsela tsa ho pepa le letsatsi la ho fihla ho fihlela (ETA).
4.Payment e entsoe mme thepa e tla romelloa ka lihora tsa 12 (Ho laela ka hare ho 10kg).
5.Goods e amohetse mme e fana ka litlhaloso.


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