J 147 phofo

1. J147 Powder tsa video-AASraw

2. J147 Powder Litlhaku tsa Motheo

J147 Powder ke eng?

J147 Powder ke motsoako oa maiketsetso oa curcumin, e leng karolo ea curry spice turmeric. J147 Powder ha e le hantle ke motsoako oa Curcumin le Cyclohexyl-Bisphenol A (CBA) o nang le neuroogenic le neuroprotective.

J147 Powder e bontšitsoe ho ntlafatsa haholo ho senyeha ha kelello ho bakuli ba Alzheimer ba tsofetseng. Liphuputso tsena li ipapisitse le mehlala ea liphoofolo tse tsofalang ka potlako. J147 Powder ke moriana o sebetsang ka molomo oa neurotrophic o fetolang ho senyeha ha kelello.

Curcumin ke polyphenol e fumanoang ka turmeric le ginger.

Curcumin e na le melemo e 'maloa e bontšitsoeng ho phekola maloetse a sa tšoaneng, leha ho le joalo, ho na le mefokolo e hlakileng ka lebaka la matla a eona a fokolang a ho fetisa Blood-Brain Barrier (BB).

J147 Powder e ka tšela BBB ka bokong (e matla) 'me e etsa hore ho be le tlhahiso ea lisele tsa neuronal.

J147 Powder, ho fapana le meriana ea hona joale ea lefu la Alzheimer's, ha e na acetylcholinesterase inhibitor kapa phosphodiesterase inhibitor, empa e ntlafatsa kutloisiso ka phekolo ea nako e khutšoanyane.

Nootropic ena e ntse e tsebahala e le kalafo ea lefu la Alzheimer's. J-147 Powder e boetse e hapile thahasello ea basebelisi ba phetseng hantle ka lebaka la bokhoni ba eona ba ho ntlafatsa mohopolo, bokhoni bo eketsehileng ba ho ithuta, le bophelo bo botle ba boko ka kakaretso. Mosebelisi ea batlang ho reka J147 Powder o lokela ho e reka le moetsi oa pele e le hore ba ka fumana fektheri ea J-147 phofo ea theko ho boloka chelete.

J-147 e sebetsa joang?

Tšusumetso ea J-147 liseleng e ne e sa tsejoe ho fihlela Salk Institute neurobiologists e rarolla puzzle ka 2018. J-147 e sebetsa ka ho tlama ho ATP synthase. Protheine ena ea mitochondrial e laola botsofali ka ho fetola tlhahiso ea matla a cellular. Ho ba teng ha Powder ea J-147 tsamaisong ea motho ho qoba chefo e amanang le lilemo e bakoang ke mitochondria e sa sebetseng le tlhahiso e feteletseng ea ATP.

Mokhoa oa ts'ebetso oa J-147 Powder o tla boela o eketse maemo a mefuta e fapaneng ea li-neurotransmitters tse kang NGF le BDNF. Ho feta moo, e fokotsa maemo a beta-amyloid, a lulang a phahame ho bakuli ba Alzheimer le 'dementia'. Liphello tsa J-147 li kenyelletsa ho fokotsa tsoelo-pele ea lefu la Alzheimer, ho fokotsa ho lahleheloa ke mohopolo, le ho eketsa tlhahiso ea lisele tsa neuronal.

Lithuto tse 'maloa ka J-147 Powder li entsoe ka litoeba. Teko ea motho e entsoe ka 2020, leha ho le joalo, liphetho tse felletseng ha li so arolelanoe.

melemo e of J147 Phofo

①E Ntlafatsa Mosebetsi oa Mitochondrial Le Bolele ba bophelo

J147 Powder e sebetsa hantle haholo ho fokotsa khatello ea oxidative le ho ntlafatsa ts'ebetso ea mitochondrial.

Ka mohlala, J147 Powder e eketsa mosebetsi oa mitochondrial ka ho ntlafatsa maemo a ATP (ho thibela ATP synthase, haholo-holo ATP5A).

J147 Powder e ka fokotsa metabolite e kotsi e lebisang ho excitotoxicity ka ho thibela ATP synthase.

Boemong ba lik'hemik'hale, sena se khothalletsa mitochondria ea bacha / e phetseng hantle (ka ho fetola tsela ea AMPK / mTOR).

② E thibela Lefu la Alzheimer

J147 Powder e phekola bokooa ba kelello ho mofuta oa litoeba tsa lefu la Alzheimer (AD).

J147 Powder e ka khothalletsa metabolism ea Amyloid-Beta (A) le ho fokotsa maemo a bokong ka ho theola -Secretase protein level (BACE).

J147 Powder e ka sireletsa BBB permeability homeostasis le ho ntlafatsa ts'ebetso ea methapo ea mali mefuteng ea liphoofolo ea lefu la Alzheimer's.

J147 Powder e ka boela ea phahamisa haholo maemo a Docosahexaenoic Acid (DHA) bokong.

E ka thusa ho tsosolosa litekanyetso tsa Glutamate bokong (tse hlahisoang ho tloha TCA intermediate -ketoglutarate).

③E ntlafatsa Memori

E ntlafatsa temoho ka bobeli litoeba tsa lefu la Alzheimer le mefuta e tloaelehileng ea liphoofolo.

J147 Powder e ka tsosolosa bokooa ba bohlokoa ba kutloisiso esita le liphoofolong tse tsofetseng ka ho fetisisa.

J-147 e ka boela ea thusa ka mohopolo oa sebaka le Potentiation ea Nako e telele (LTP).

④Khōlo ea Boko

J 147 Powder e na le bokhoni ba ho ntlafatsa le ho susumetsa polasetiki ea synaptic bokong.

J 147 Powder e khothalletsa polasetiki ea synaptic ka ho boloka polelo ea Synaptophysin (protheine ea synaptic vesicle e fokotsehileng ka bobeli botsofaling le AD 'me e nkoa e le biomarker bakeng sa tahlehelo ea synapse).

J-147 Powder e khothalletsa ho hōla ha boko ka ho matlafatsa maemo a Nerve Growth Factor (NGF) le Brain-Derived Neurotrophic Factor (BDNF) (BDNF).

⑤E Sireletsa Li-Neurons

J 147 Powder ha e hloke hore BDNF e be neuroprotective.

J 147 Powder e boetse e sireletsa li-neurone ho tloha khaello ea glutathione (GSH).

J-147 Powder e sireletsa boko khahlanong le khaello ea tsoekere.

Bokong ba AD, 5-Lipoxygenase (5-LOX) e bokella lisele tse ngata tsa 'mele tsa ho itšireletsa mafung ho baka karabelo ea ho ruruha,' me Heme Oxygenase 1 (HO-1) e sebetsa e le pro-oxidant ho e-na le antioxidant.

Curcumin derivative J147 Powder e na le bokhoni ba ho theola maemo a HO-1 hammoho le ho thibela 5-LOX.

⑥E ka Ntlafatsa Lefu la tsoekere

Mehlala ea liphoofolo, Powder ea J147 e bontšitsoe ho fokotsa Glucose ea mali le maemo a HbA1c ka ho eketsa AMPK.

Le hoja e se ea bohlokoa, J147 Powder e ka boela ea ntlafatsa mosebetsi oa lisele tsa beta tse setseng ho lefu la tsoekere.

⑦E Loana le Bohloko le Neuropathy

J-147 Powder e ile ea pakoa e sebetsa ho phekola lefu la tsoekere la mofuta oa 1 lefu la tsoekere.

E ka thusa ho fokotsa ho se sebetse ha methapo ea kutlo e bakoang ke lefu la tsoekere, maikutlo a peripheral, le maemo a bohloko.

⑧E ka Ntlafatsa Matšoenyeho

J147 Powder e na le bokhoni ba ho fokotsa maemo a ho tšoenyeha.

J147 Powder e khonne ho fokotsa maemo a ho tšoenyeha nakong ea liteko tsa maze mefuteng ea liphoofolo tse nang le AD.

J147 Phofo dose le stack

Liphuputso tse fapaneng li sebelisitse litekanyo tse fapaneng ho litoeba, empa e 'ngoe ea lithuto tse ntlafalitsoeng hantle e file litoeba 10 mg / kg ea boima ba' mele ka letsatsi. Phuputso e 'ngoe e sebelisitse litekanyetso tsa 1, 3 kapa 9 mg / kg, mme ea fumana litlamorao tse itšetlehileng ka tekanyetso, ka litekanyo tse phahameng tse sebetsang hantle.

Leha ho le joalo, ho fetolela sena ho litekanyetso tsa motho ho hloka hore ho lokisoe sebakeng sa 'mele. Ho ea ka mokhoa o sebelisoang haholo oa phetoho, tekanyo e lekanang le motho e lokela ho lekana le tekanyo ea mouse e arotsoeng ka 12.3-kapa .81 mg k'hilograma ea boima ba 'mele ka letsatsi.

E meng ea melemo e tla bonahala hang ha u qala ho e sebelisa. Esita le ka phekolo ea nako e khutšoanyane, J-147 e hlahisa liphello tse potlakileng tsa ho imeloa kelellong ho likhoto ka nako ea matsatsi a 3 ntle le ho theha mamello ea lithethefatsi kapa ho eketseha ha tsebo. Ho na le J147 Powder e ngata e rekisoang inthaneteng, ke habohlokoa ho reka lihlahisoa tsa sebele le tsa boleng bo phahameng. O ka reka J147 Powder Wholesale le mofani oa thepa AASRAW.

J147 ha e e-s'o tloaelehe har'a batho ba phelang hantle ka nako e telele e lekaneng hore re ka khothaletsa ka kholiseho li-stacks leha e le life. Ha se li-nootropic tsohle tse ka 'tsoang le ho ts'oaroa' ka mokhoa o sireletsehileng.

J147 Phofo hmonna trials and uditshebeletso eliphihlelo

Thuto ea pele ea batho ea J147 Powder e ngolisitsoe 'me e lebelletsoe ho phethoa ka 2020. Ho bonahala eka e entsoe e le teko ea mohato oa 1 ho batho ba phelang hantle ba 64, ka sepheo sa mantlha sa ho hlahloba polokeho le pharmacokinetics (half-life, side). liphello, metsoako ea lisele) ea J147 Powder, ho e-na le ho thusa ha eona ho phekola boemo leha e le bofe.

Le hoja liphuputso tsa phuputso ena li e-s'o phatlalatsoe, rea tseba hore e bonahala e phethetsoe ntle le mathata a maholo.

Le hoja J147 Powder e le k'hemik'hale ea lipatlisiso 'me e 'nile ea tšohloa metseng e mengata ea nootropics, ha ho e-s'o be le litlaleho tse ngata tsa basebelisi tse fanoeng ho fihlela joale,' me batho ba bangata ba emetse ho bona thuto e eketsehileng pele ba e sebelisa. Ho ea ka basebelisi ba Powder ea J-147, Ho bonolo ho reka phofo ea J147 inthaneteng, ho fumana mofani oa J147 Powder ea ka tšeptjoang o tla qeta nako e itseng. Mofani oa AASRAW o fana ka Powder ea boleng bo holimo ea J-147. Haeba u etsa li-supplement tsa J-147, u ka reka bongata ba J147 Powder ho thabela theko e ntle.

Bongata ba batho bo bonahala bo sa bone litlamorao ho tsoa ho liphihlelo tse 'maloa tsa basebelisi tse tlalehiloeng. Le hoja basebelisi ba atisa ho ba bacha ba bile ba phetse hantle 'me nako ea tšebeliso e tloaelehile haholo ho feta lithutong, curcumin derivative J147 Powder e ka' na ea se ke ea e-ba le liphello tsa bohlokoa tsa nootropic ho bacha ba phetseng hantle.

Re ka etsa likhakanyo tse rutehileng tsa hore na Powder ea J147 e ka ba molemo hakae ha ho se na lipatlisiso tsa batho kapa li-anecdotes tse tsebahalang. Ka khopolo, ntho leha e le efe e eketsang metabolism ea matla a neuronal e lokela ho ba le liphello tsa nootropic, leha ho le joalo, mosebetsi oa hau oa kelello o ka 'na oa se ke oa fokotsoa ke tšebeliso ea matla. E ka itšetleha ka hore na limatlafatsi li ka kena kapele hakae le ho tsoa bokong ba hau kapa hore na mehopolo ea hau e kopantsoe hantle hakae.

Curcumin derivative J147 Powder e boetse e hlahisa lintlha tse ngata tsa neurotrophic, ho bolelang hore e ka khona ho thusa boko ba hau ho hlahisa li-synapse tse ngata le lisele tsa boko. Empa hopola hore ho ka ba le li-synapse tse ngata le lisele tsa boko.

Hona joale ha ho na lebaka la ho lumela hore J147 Powder e tla ba le phello e kholo ea nootropic ho bacha, batho ba baholo ba phetseng hantle. Ho ba nang le 'dementia', ho ka etsahala hore e molemo. Ho batho ba seng ba hōlile hanyenyane ba hlokomelang hore 'dementia' e matha malapeng a bona, e ka 'na ea thusa joaloka nootropic kaha e ka emisa kapa ea fetola tahlehelo ea kelello pele e fetoha 'dementia' ea bongaka. Leha ho le joalo, ho tla nka nako pele re ka kholiseha.

J-147 Phofo risks le sho joalo emafu

J147 Powder e 'nile ea hlahlojoa ka bongaka' me ea fumanoa e sireletsehile bakeng sa tšebeliso ea nako e telele ke li-laboratory tse ikemetseng. E fetisitse tlhahlobo ea chefo lithutong tsa liphoofolo tseo Tsamaiso ea Lijo le Lithethefatsi (FDA) e li hlokang, 'me ha ho litlamorao tse mpe tse tlalehiloeng ho batho ha li nkuoa ka tekanyo e khothaletsoang (e tšohloa hamorao).

Where ho reka Phofo ea J-147?

Ho ba le molao oa nootropic ena ho ntse ho phehisana khang, leha ho le joalo, ho ke ke ha u thibela ho reka lintho tse amohelehang. Ntle le moo, liteko tsa bongaka tsa J-147 Alzheimer's li se li ntse li tsoela pele. U ka reka phofo ho tloha mabenkeleng a marang-rang kaha u ka bapisa litheko tsa J-147 Powder ho tsoa ho barekisi ba bangata. Leha ho le joalo, u lokela ho sheba ho pota-pota bakeng sa moetsi ea hlomphehang ea nang le liteko tsa laboratori tse ikemetseng.

Haeba u batla ho rekisoa Powder ea J-147, kena ho fektheri ea rona. Re fana ka mefuta e mengata ea li-nootropic tlas'a taolo e thata ea boleng. Ho itšetlehile ka sepheo sa hau sa psychonautic, u ka reka ka bongata kapa ka bomong. Hlokomela hore, theko ea J-147 Powder e na le botsoalle ha feela u reka ka bongata.

J147 Powder Tlaleho ea Tlhahlobo-HNMR

HNMR ke eng hona HNMR spectrum e u bolella eng? H Nuclear Magnetic Resonance (NMR) spectroscopy ke mokhoa oa ho hlahloba k'hemistri o sebelisoang ho laola boleng le lipatlisiso bakeng sa ho fumana likahare le bohloeki ba sampuli hammoho le sebopeho sa limolek'hule. Mohlala, NMR e ka sekaseka ka bongata metsoako e nang le metsoako e tsebahalang. Bakeng sa metsoako e sa tsejoeng, NMR e ka sebelisoa ho bapisa le lilaebrari tsa spectral kapa ho fana ka sebopeho sa motheo ka kotloloho. Hang ha sebopeho sa motheo se tsejoa, NMR e ka sebelisoa ho fumana hore na limolek'hule li lumellana joang le tharollo hammoho le ho ithuta thepa ea 'mele boemong ba limolek'hule joalo ka phapanyetsano ea conformational, liphetoho tsa mohato, solubility le diffusion.

J-147 Phofo(1146963-51-0)-COA

J-147(1146963-51-0)-COA

Joang ho reka J147 Powder ho tsoa ho AASraw?

❶Ho ikopanya le rona ka mokhoa oa rona oa ho botsa ka lengolo-tsoibila, kapa ho re siela nomoro ea hau ea WhatsApp, moemeli oa rona oa litšebeletso tsa bareki (CSR) o tla ikopanya le uena ka mor'a lihora tse 12.

❷ Ho re fa palo le aterese eo u e botsitseng.

❸ CSR ea rona e tla u fa khotheishene, nako ea ho patala, nomoro ea morao-rao, litsela tsa ho fihla, le letsatsi la ho fihla (ETA).

❹Ho lefa 'me thepa e tla romelloa ka mor'a lihora tse 12.

❺Lintho tse amohetsoeng le ho fana ka maikutlo.

Mongoli oa sengoloa sena:
Ngaka Monique Hong o fumane lengolo UK Imperial College London Faculty of Medicine

Sengoli sa pampiri sa Scientific Journal:
1. Paul A. Lapchak
Rasaense le mofuputsi lefapheng la lipatlisiso tsa methapo ea kutlo le stroke.
2. David Schubert
The Salk Institute for Biological Studies, Cellular Neurobiology Laboratory, La Jolla, California, USA.
Ha ho ka tsela leha e le efe ngaka/saense ena e buellang kapa ho buella ho rekoa, thekiso, kapa tšebeliso ea sehlahisoa sena ka lebaka lefe kapa lefe. Aasraw ha e na kamano kapa kamano, ho boleloa kapa ho seng joalo, le ngaka ena. Sepheo sa ho qotsa ngaka ena ke ho ananela, ho ananela le ho babatsa lipatlisiso tse felletseng le mosebetsi oa nts'etsopele o entsoeng ke bo-ramahlale ba sebetsanang le ntho ena.

References

[1] Pan X, Chen L, Xu W, Bao S, Wang J, Cui X, Gao S, Liu K, Avasthi S, Zhang M, Chen R. “Ho kenya tšebetsong tsamaiso ea monoaminergic ho tlatsetsa ho antidepressant- le anxiolytic-like. liphello tsa J147.” Behav Brain Res. 2021 Aug 6;411:113374. doi: 10.1016/j.bbr.2021.113374. Epub 2021 May 21. PMID: 34023306

[2] Li J, Chen L, Li G, Chen X, Hu S, Zheng L, Luria V, Lv J, Sun Y, Xu Y, Yu Y. "Sub-Acute Treatment of Curcumin Derivative J147 Ameliorates Depression-Joe Behavior Ka 5-HT1A-Mediated CAMP Signaling. "Front Neurosci. 2020 Jul 8;14:701. doi: 10.3389/fnins.2020.00701. eCollection 2020.PMID: 32733195

[3] Jin R, Wang M, Zhong W, Kissinger CR, Villafranca JE, Li G. "J147 E Fokotsa Tšimoloho ea Boko e bakoang ke tPA-Induced Brain in Acute Experimental Stroke in Rats."Neurol e ka Pele. 2022 Mar 2;13:821082. doi: 10.3389/fneur.2022.821082. eCollection 2022. PMID: 35309561

[4] Emmanuel IA, Olotu FA, Agoni C, Soliman MES. "Ho Silico Repurposing ea J147 bakeng sa Kalafo ea Neonatal Encephalopathy: Ho Hlahloba Mekhoa ea Limolek'hule ea Mutant Mitochondrial ATP Synthase." Curr Pharm Biotechnol. 2020;21(14):1551-1566. doi: 10.2174/1389201021666200628152246. PMID: 32598251

[5] Lian L, Xu Y, Zhang J, Yu Y, Zhu N, Guan X, Huang H, Chen R, Chen J, Shi G, Pan J. "Liphello tse khahlanong le ho imeloa kelellong tsa buka e nkiloeng ea curcumin J147: Kenyeletso ea 5-HT1A receptor. Neuropharmacology. 2018 Jun;135:506-513. doi: 10.1016/j.neuropharm.2018.04.003. Epub 2018 Apr 5. PMID: 29626566

Fumana mantsoe a mangata