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J 147 phofo

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SKU: 1146963-51-0. Category:

AASraw e na le bokhoni ba tlhahiso le tlhahiso ho tloha ho gram ho ea ka taelo ea J 147 powder (1146963-51-0), tlas'a taolo ea CGMP le tsamaiso ea tšebetso ea boleng bo sebetsang.

J147 phofo e ile ea qala ho ntlafatsoa ka 2011, 'me bafuputsi ba entse lipatlisiso tse' maloa tse bontšang hore li ka fetola tahlehelo ea mohopolo 'me ea lieha ho khutlela Alzheimer ho litoeba. Empa ho fihlela thuto ena, ba ne ba sa tsebe hore na e sebetsa joang ka har'a lisele. Ba ile ba khona ho bontša hore phofo ea J147 e sebetsa ka ho hlophisa ATP, protheine mitochondria le mohloli oa matla oa mohloli oa 'mele. Ha phofo ea J147 e ne e le teng, neurons e ne e sirelelitsoe ho chefo e amanang le botsofali. Liteko tse ling li bontšitse hore phofo ea J147 e eketsa maemong a ATP mme e khothalletsa mitochondria e phetseng hantle, e tsitsitseng

Tlhaloso ea Sehlahisoa

J 147 phofo ea video


Raw J 147 phofo ea basebetsi ba motheo

Name: J 147 phofo
CAS: 1146963-51-0
Molecular Formula: C18H17F3N2O2
Boima ba 'mele: 350.3349896
Melt Point: 177-178 ° C
Temp Temp Storage: 4 ° C
Color: Tšoeu kapa u tlohele phofo e tšoeu


Pula ea Raw J 147 ho ntlafatsa boko le boithuto bo eketsehileng

Mabitso

J 147 phofo

J 147 (1146963-51-0) Tekanyo ea ho sebelisa

Ha re sebelisa mokhoa o fumanoeng ke lithethefatsi bakeng sa lefu la Alzheimer (AD) le thehiloeng holim'a mafu a mangata a botsofali, re fumane karolo e matlahali e nang le bokhoni ba ho hopola mekhoa ea liphoofolo le mefuta ea AD liphoofolo. Ho tloha ha motsoako ona, J-147 phofo, e le phenyl hydrazide, ho ne ho e-na le ts'ehetso ea hore e ka ba metsoli e nkhang hamonate ea amine / hydrazine e ka 'nang ea e-ba le kankere. E le ho hlahloba monyetla ona, re ile ra hlahloba metabolites ea J 147 phofo ka microsomes ea motho le ea mouse le mouse plasma. Ho bontšoa hore phofo ea J-147 (1146963-51-0) ha e sebelisetsoe metaboli e nkhang hamonate kapa li-hydrazines, hore scaffold e tsitsitseng haholo, le hore metabolite e nang le lik'hemik'hale e boetse e na leuroprotective. Ho fihletsoe qeto ea hore phofo ea metabolite e kholo ea J 147 (1146963-51-0) e ka kenya letsoho mosebetsing oa eona oa liphoofolo liphoofolong.
J 147, e entsoeng ka lekhetlo le leng le le leng, e na le chefo e fokolang 'me e hlile e fetola tšenyo ea li-neurons tse amanang le Alzheimer's.

J 147 (1146963-51-0) e ne e le protheine ea mitochondrial e tsejoang e le ATP synthase, haholo-holo ATP5A, karoloana ea protheine eo. ATP synthase e ameha molokong oa mitochondrial oa ATP, e leng lisele tse sebelisang matla.

Bafuputsi ba bontšitse hore ka ho fokotsa mosebetsi oa ATP synthase, ba ile ba khona ho sireletsa lisele tsa neuronal ho tse ngata tse chefo tse amanang le botsofali ba boko. Lebaka le leng la phello ena ea phekolo ea meriana e nkoa e le karolo ea excitotoxicity ho neuronal cell senya.

Ho se ts'oanehe ke mokhoa oa ho fokola ha li-neurons tse senyehileng le ho bolaoa ke ho fetoloa ha li-receptor bakeng sa glutamate ea motlakase oa methapo ea pelo. Ak'u nahane hore ho tšoana le senotlolo sa leseli se bulehileng 'me se tima ka potlako hoo se qetellang se etsa hore lebone la lebone le fofone.

Morao tjena, karolo ea ATP synthase e thibelang ho thibela tšireletso khahlanong le tšenyo ea excitotoxic e ile ea bontšoa thupelong ea mouse [4]. Phuputso ea bobeli e bontšitse hore mefuta ea li-mouse e hlalosang mofuta oa motho oa ATPase e thibelang ho thibela ho hlasela 1 (hIF1), e bakang thibelo e tsitsitseng ea ATP synthase, e ne e le matla haholoanyane ho lefu la neuronal ka mor'a tšenyo ea excitotoxic. Lintlha tsena li lumellana le thuto ena e ncha ea J 147, eo ho eona ho eketseha ha IF1 ho litoeba ho fokotsitse mosebetsi oa ATP synthase (haholo-holo ATP5A) mme o ne o se na tšireletso ea mali.

Temoso ho Raw J 147 phofo

Lintlha tse bontšitsoeng mona li bontša hore phofo ea J-147 e na le bokhoni ba ho pholosa mathata a ho utloisisa maikutlo ha e sebelisoa qetellong ea lefu lena. Bokhoni ba J-147 phofo ho ntlafatsa mohopolo oa metsoako ea khale ea AD e amana le ho kenngoa ha metsoako ea neurotrophic NGF (nerve kholo factor) le BDNF (bokooa bo fumanoeng ke neurotrophic factor) hammoho le liprotheine tse ngata tse amohelang BDNF tse bohlokoa bakeng sa thuto le mohopolo. Papiso ea pakeng tsa J-147 (1146963-51-0) phofo le lipapali tse entsoeng ka mohlala oa scopolamine li bontšitse hore le hoja lik'hemik'hale tse peli li ne li tšoana le ho pholosa mohopolo o khutšoanyane, phofo ea J-147 e ne e le ea bohlokoa ho pholosa mohopolo oa sebaka le ho kopana habeli e molemo ka ho fetisisa bakeng sa mohopolo oa liphatlalatso le oa lik'hilo.

Litaelo tse ling

Lefu la Alzheimer ke bothata ba boko bo ntseng bo tsoela pele, bo sa tsoa khethoa e le sesosa sa boraro se bakang lefu la United States le ho ama Maamerika a fetang limilione tse hlano. Hape ke sesosa se tloaelehileng sa 'dementia' ho batho ba baholo, ho ea ka Mekhatlo ea Sechaba ea Bophelo. Le hoja lithethefatsi tse ngata li hlahisitsoe lilemong tsa khale tsa 20 tse nang le letlapa la li-amyloid bokong (e leng se boleloang ke lefu lena), ke ba fokolang ba bonts'itsoeng hantle tleliniking.

"Le hoja lithethefatsi tse ngata li hlahisitsoe lilemong tsa khale tsa 20 tse nang le letlapa la li-amyloid bokong (e leng se boleloang ke lefu lena), ha ho le e 'ngoe e bontšitseng hore e sebetsa hantle tleliniking," ho rialo Schubert, mohlophisi e moholo oa thuto.

Lilemong tse 'maloa tse fetileng, Schubert le basebetsi-'moho le eena ba ile ba qala ho atamela phekolo ea lefu lena ho tloha sebakeng se secha. Ho e-na le ho hlahloba li-amyloid, lab e ile ea etsa qeto ea hore e ka ba kotsi e kholo ea botsofali. U sebelisa li-screens-based screens khahlanong le likokoana-hloko tse amanang le botsofali ba lilemong tsa khale, li entsoe ka phofshoana ea J 147 (1146963-51-0).

Nakong e fetileng, sehlopha se fumane hore phofo ea J-147 e ka thibela esita le ho fokotsa ho lahleheloa ke mohopolo le boloetse ba lefu la Alzheimer ho litoeba tse nang le phetoho ea mofuta oa Alzheimer's, o sebelisoang ka ho fetisisa. Leha ho le joalo, mofuta ona oa lefu lena o na le feela karolo ea 1 ea linyeoe tsa Alzheimer. Bakeng sa motho e mong le e mong, botsofali ke ntho e ka sehloohong ea kotsing, e re Schubert. Sehlopha sena se ne se batla ho hlahloba liphello tsa motho ea nang le lithethefatsi ka mefuta ea litoeba tse fokolang ka nako e telele le ho ba le bothata ba 'dementia' e batlang e tšoana haholo le lefu la motho le amanang le lilemo.

Mofuta o motlakase oa J 147

Ntho e nyenyane 10grams.
Tlhahlobo ka bongata bo tloaelehileng (ka hare ho 1kg) e ka romeloa lihora tse 12 kamora ho lefa.
Bakeng sa tlhahiso e kholo (ka hare ho 1kg) e ka romeloa ka matsatsi a sebetsang a 3 ka mor'a ts'ebetso.

Khoebo ea Rafi J 147

Ho fanoa nakong e tlang.


Joang ho reka phofo ea J 147 ho tloha AASraw

1.To iteanye le rona ka imeile ea rona lenaneo la lipatlisiso, kapa skype ea inthanetengmoemeli oa tšebeletso ea bareki (CSR).
2.To re fane ka lipotso tsa hau le lipotso tsa hau.
3.Our CSR e tla u fa tlhaloso, nako ea ho lefa, nomoro ea ho latela, litsela tsa ho pepa le letsatsi la ho fihla ho fihlela (ETA).
4.Payment e entsoe mme thepa e tla romelloa ka lihora tsa 12 (Ho laela ka hare ho 10kg).
5.Goods e amohetse mme e fana ka litlhaloso.

TLHOKOMELISO LE TLHALOSO:

Boitsebiso bona bo rekisetsoe tšebeliso ea lipatlisiso. Lipehelo tsa thekiso Etsa kopo. Eseng molemong oa tšebeliso ea batho, kapa bongaka, bongaka ba liphoofolo kapa lisebelisoa tsa lapeng.


COA

HNMR

Pfu ea Raw J-147 (1146963-51-0) hplc≥98% | AASraw SARMS powder

Recipes

J 147 Mefuta e Mpe ea Recipe:

Ho botsa bareki ba rona baemeli ba rona (CSR) bakeng sa lintlha tse eketsehileng, bakeng sa boitsebiso ba hau.

Litlhaloso le lihlahisoa tsa lihlahisoa

J-147 Powder Guide ea ho reka le ho hlahloba e feletseng

Meriana ea lithethefatsi J147 (1146963-51-0) Botsofali ba Alzheimer