IDFP

AASraw e na le bokhoni ba tlhahiso le tlhahiso ho tloha ho gram ho isa taolong e kholo ea IDFP (615250-02-7), tlas'a taolo ea CGMP le tsamaiso ea tšebetso ea boleng bo sebetsang.

IDFP ke setho sa organophosphorus se thibelang MAGL le FAAH ka litekanyetso tsa IC50 tsa 0.8 le 3 nM, ka ho latellana.1 Ho 10 mg / kg, IDFP e phahamisa boko ba 2-AG le AEA ho feta 10, mme e fokotsa litekanyetso tsa acidic acidic acid e na le boholo bo tšoanang. Li-endocannabinoids, 2-arachidonoyl glycerol (2-AG) le arachidonoyl ethanolamide (AEA), li na le li-lipids tse sebetsang ka tsela ea tlhaho tse sebetsang ka mefuta e fapa-fapaneng ea likokoana-hloko le metabolism ka ho etsa li-receptor tsa kannete, li-cannabinoid (CB1) le phallo ea cannabinoid (CB2). Monoacylglycerol lipase (MAGL) le mafura a mafura a amidehydrolase (FAAH) hydrolyze 2-AG le AEA, ka ho latellana, kahoo ba khaotsa ho sebetsa ha bona.

Tlhaloso ea Sehlahisoa

Video ea IDFP


I.IDFP tsebo ea motheo:

Name: IDFP
CAS: 615250-02-7
Molecular Formula: C15H32FO2P
Boima ba 'mele: 294.391
Melt Point:
Temp Temp Storage: -20 ° C
Color:


II. Potso ea IDFP

1.Names:

Mabitso a Lik'hemik'hale: ISOPROPYL DODECYLFLUOROPHOSPHONATE
Senyesemane:
IDFP; ISOPROPYL DODECYLFLUOROPHOSPHONATE; P-DODECYL-1-METHYLETHYL ESTER-PHOSPHONOFLUORIDIC ACID

2. Sebeliso ea IDFP:

IDFP ke motsoako oa organophosphorus o amanang le moemeli oa methapo ea sarine. Joaloka sarin, IDFP ke sesitisa etsolloa bakeng sa 'maloa a potlakisang tsebetso ea lik'hemik'hale e fapaneng eo ka tloaelo sebeletsa ho heletsa neurotransmitters Leha ho le joalo ka nako e telele alkyl ketane ea IDFP etsa hore ka tsela e hlollang se fokolang haholo e le sesitisa tsa acetylcholinesterase (AChE), ka IC50 ya feela 6300nM, ha ke sesitisa matla ea enzyme tse peli monoacylglycerol lipase (MAGL), le potlakisang tsebetso ea lik'hemik'hale mathomo le boikarabelo ba ho e hlephileng ea endocannabinoid 2-arachidonoylglycerol (2-AG), le tse mafura acid e amide hydrolase (FAAH), le potlakisang tsebetso ea lik'hemik'hale mathomo hore degrades e mong ka sehloohong endocannabinoid anandamide . IC50 ea IDFP ke 0.8nM ho MAGL, le 3.0nM ho FAAH. Thibelo ea enzyme tsena tse peli e etsa hore haholo eketseha maemo la bobeli anandamide le 2-AG bokong, sephetho le inincreased cannabinoid a bontsa ho le tloaelehileng cannabinoid litla boitshwaro ka lithuto tsa liphoofolo, ha a haelloa ke lona la potency ka AChE bolela hore ha ho na matšoao a cholinergic etsoa. ​​[1 ] [2] [3] [4] Ho sa tsotellehe lik'hemik'hale tse tšoanang le tsa methapo ea thibelo e thibetsoeng, ketane e telele ea alkyl ea IDFP e etsa hore e tsoe ka ntle ho tlhaloso ea "lik'hemik'hale tse chefo" tlas'a Tumellano ea Lihlomo Tsa Lik'hemik'hale, [5] le ho tloha ha e boetse ha e bontše matla a thibelo ea ACHE a metsoako e amanang le organophosphorus, IDFP ha e sebetsane le melao e lekaneng ea taolo ea molao.

3.Ho tekanyo ea IDFP ke efe?

Bakeng sa polokelo ea nako e telele, re fana ka maikutlo a hore IDFP e bolokehe joalokaha e fanoe ka -20 ℃. E lokela ho tsitsa bonyane selemo se le seng.
IDFP e fanoa e le tharollo methyl acetate. Ho fetola solvent, feela e fetole mouoane methyl acetate tlas'a metsi a nang le nitrogen 'me hang-hang e kenye letsoho le khethollang.Sollo e kang ethanol, DMSO, le dimethyl formamide e hloekisitsoeng ka khase ea inerase e ka sebelisoa. Ho iketsetsa ha IDFP li-solvents ke hoo e batlang e le 10mg / ml.
Haeba lihlahisoa tsa likokoana-hloko li hlokahalang bakeng sa liteko tsa likokoana-hloko, li ka ba li lokiselitsoe ka ho fetisisa ka ho hlapolla mokelikeli o lekaneng oa lihlahisoa tse nang le metsi a mongobo kapa saline ea isotonic. Ho netefatsa hore bongata ba lihlahisoa tsa 'mele ha bo na thuso, kaha metsoako ea lintho tse phelang e ka ba le liphello tsa mmele maemong a fokolang. u se ke ua khothalletsa ho boloka tharollo e nang le metsi a fetang a le mong.

4.How IDFP e sebetsa joang?

IDFP ke inhibitor e ke keng ea senngoa bakeng sa li-enzyme tse fapa-fapaneng tseo ka tloaelo li sebetsang ho senya methapo ea li-neurotransmitters, leha ho le joalo ketane ea alkyl e telele ea IDFP e etsa hore e fokotsehe haholo joaloka mothapo oa acetylcholinesterase (AChE), ha e ntse e le inhibitor e matla ea li-enzyme tse peli monoacylglycerol lipase ( MAGL), enzyme e ka sehloohong e ikarabellang bakeng sa ho silafatsa lefu la 2-arachidonoylglycerol (2-AG), le mafura a mafura a amide hydrolase (FAAH), e leng enzyme e ka sehloohong e silafatsang e meng ea mainendocannabinoid anandamide. Karolo ea organophosphorus e thibelang MAGL le FAAH ka likarolo tsa IC50 tsa 0.8 le 3 nM, ka ho latellana.1 Ka 10 mg / kg, IDFP e phahamisa boko ba likarolo tsa 2-AG le AEA ho feta 10, mme e fokotsa maemo a arachidonic acid ka 10.

5.Tlhahlobo:

Sehlahisoa sena ha se bakeng sa tšebeliso ea batho kapa ea bongaka ba liphoofolo, temoso e ntse e tsoela pele ho etsa lipatlisiso. Qoba ho ikopanya le letlalo, mahlo, phefumoloho, ho sa tsotellehe letho, mo bitsa ngaka hang-hang.

Pompo ea Raw 6.IDFP:

Ntho e nyenyane 10grams.
Tlhahlobo ka bongata bo tloaelehileng (ka hare ho 1kg) e ka romeloa lihora tse 12 kamora ho lefa.
Bakeng sa taolo e kholo e ka romeloa matsatsing a ts'ebetso ea 3 ka mor'a ts'enyehelo.

7.IDFP Mefuta e Mpe ea Recipe:

Ho botsa bareki ba rona baemeli ba rona (CSR) bakeng sa lintlha tse eketsehileng, bakeng sa boitsebiso ba hau.

Khamphani ea 8.IDFP:

Ho fanoa nakong e tlang.

9.Does IDFP E na le Liphello Tse Ntle?

The renal medulla, eo ho nkoang e le ea bohlokoa bakeng sa taolo ea letsoai le ea metsi le ho laola khatello ea mali ea nako e telele, e ntlafatsoa ka anandamide le li-enzyme tse peli tse khōlō tsa metabolizing, cyclooxygenase-2 (COX-2) le fatone acidide amide hydrolase (FAAH) . Ho tšeloa ha anandamide (15, 30, le 60 nmol · min-1 · kg-1) ho renal medulla ea C57BL / 6J litoeba li tsositse diuresis le letsoai excretion ka COX-2-empa e seng COX-1 mokhoa o itšetlehileng ka oona. Ho fumana hore na li-endocannabinoids tse ke keng tsa lekanngoa nakong ea renal medulla li ka etsa liphello tse tšoanang, liphello tsa intramedullary isopropyl dodecyl fluorophosphate (IDFP), e thibelang li-hydrolases tse peli tse kholo tsa endocannabinoid, li ile tsa ithutoa. Tlhokomelo ea IDFP e ekelitse palo ea moralo oa motso le ho fetela ha sodium ka COX-2-empa e se ka tsela e itšetlehileng ka COX-1. Hase anandamide kapa IDFP e ileng ea ama glomerular filtration rate. Hase mokhoa oa ho etsa lintho ka tsela e tloaelehileng (0.625 mg · kg-1 · 30 min-1 iv) kapa intramedullary (15 nmol · min-1 · kg-1 · 30 min-1) Phatlalatso ea IDFP pele ho intramedullary anandamide (15-30 nmol · min-1 · kg-1) liphello tse thibelitsoeng tsa anandamide, ho fana ka maikutlo a hore hydrolysis ea anandamide e ne e sa hlokahale bakeng sa phello ea eona ea diuretic. Intramedullary IDFP e ne e se na phello ea phekolo ea mali ea tšollo ea mali empa e ile ea tsosolosa ho phalla ha mali ka mali. Liphello tsa IDFP ka tekanyo ea ho phalla ha motso le ho phalla ha mali ho ne ho e-na le FAAH-ho itšetlehile ka kamoo ho sebelisitsoeng litoeba tsa khokahano tsa FAAH. Ho hlahlojoa ha moriri oa khohlopo oa PGE2 ka HPLC-electrospray ionisation tandem mass spectrometry e bontšitse hore phekolo ea IDFP e fokotsehile ho ntša metsi PGE2 Litaba tsena li lumellana le karolo ea FAAH le anandamide e sa feleng e sebetsang ka metabolite e nang le COX-2 ho laola diuresis le salt excretion mousekidney.


III. HNMR ea IDFP

Re li-poure tsa Aprepitant, Prepitant phofo e rekisoang, Raw Aprepitant powder (170729-80-3) hplc≥98% | Ho hlahisa li-Reagents tsa R & D


IV. Joang ho reka IDFP ho tloha AASraw?

1.To iteanye le rona ka imeile ea rona lenaneo la lipatlisiso, kapa skype ea inthanetengmoemeli oa tšebeletso ea bareki (CSR).
2.To re fane ka lipotso tsa hau le lipotso tsa hau.
3.Our CSR e tla u fa tlhaloso, nako ea ho lefa, nomoro ea ho latela, litsela tsa ho pepa le letsatsi la ho fihla ho fihlela (ETA).
4.Payment e entsoe mme thepa e tla romelloa ka lihora tsa 12 (Ho laela ka hare ho 10kg).
5.Goods e amohetse mme e fana ka litlhaloso.


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