GHRP-6

GHRP-6 ke eng?

GHRP-6, kapa Growth Hormone Releasing Peptide-6, ke hexapeptide ea maiketsetso, e bolelang hore e na le li-amino acid tse tšeletseng. Peptide ena e sebetsa joalo ka secretagogue, e leng ntho e bakang ho ntšoa ha ntho e 'ngoe. Tabeng ea GHRP-6, e khothalletsa ho lokolloa ha li-hormone tsa ho hōla.

GHRP-6 e sebetsa ka ho etsisa liphello tsa hormone ghrelin, e leng hormone e laolang tlala 'me e phetha karolo ea ho aba le tekanyo ea tšebeliso ea matla. Ha GHRP-6 e tlama ho li-ghrelin receptors, e etsa hore ho be le ho lokolloa ha hormone ea ho hōla ho tloha lesela la pituitary. Ho lokolloa hona ha hormone ea ho hōla, hammoho le karolo ea ho etsisa ghrelin, ho lebisa ho eketseha ha takatso ea lijo, e ka bang molemo ho batho ba batlang ho fumana boima ba mesifa.

Ho phaella moo, GHRP-6 e 'nile ea tsejoa ka bokhoni ba eona ba ho ntlafatsa boroko, ho khothalletsa tahlehelo ea mafura, ho tšehetsa tsamaiso ea' mele ea ho itšireletsa mafung, le ho thusa ho sireletsa pelo. Hangata e sebelisoa ke baetsi ba 'mele le baatlelete ka lebaka la phello ea eona ho maemo a hormone ea ho hōla.

GHRP-6 e sebetsa joang?

GHRP-6 (Growth Hormone Releasing Peptide-6) e sebetsa ka ho etsisa ghrelin ea hormone, e bakang keketseho ea endogenous (e hlahisoang ka hare) ho lokolloa ha hormone ea ho hōla 'meleng. Mona ke ho shebisisa mokhoa oa eona oa ts'ebetso.

Ghrelin Stimulation

Ghrelin, eo ka tloaelo e tsejoang e le "hormone ea tlala," ke hormone e hlahisoang ke mpa ka lebaka la ho itima lijo e tsosang takatso ea lijo, e leng se fellang ka ho eketseha ha lijo. GHRP-6 e sebetsa e le ghrelin agonist, e bolelang hore e tlama le ho susumetsa li-receptor tsa ghrelin bokong, ho eketsa maikutlo a tlala.

Ho lokolloa ha Hormone ea Kholo

Ha GHRP-6 e sebelisana le li-ghrelin receptors, lesela la pituitary le ntša hormone ea ho hōla. Hormone ena e thusa ho hola, sebopeho sa 'mele, ho lokisa lisele le metabolism. E matlafatsa mesifa, e eketsa matla a mesifa, 'me e thusa ho hlaphoheloa likotsing le mathata.

Thibelo ea Somatostatin

GHRP-6 e ka boela ea hatella somatostatin, hormone e thibelang tlhahiso ea hormone ea ho hōla. Ka ho thibela somatostatin, GHRP-6 e tiisa hore hormone ea ho hōla ha e thibeloe ho lokolloa, e leng se etsang hore ho be le bongata bo bongata ba hormone ena 'meleng.

Synergistic Effect le GHRH

Ha e nkoa ka hormone ea ho hōla ha hormone (GHRH), GHRP-6 e na le phello ea synergistic. Ha li kopantsoe, li eketsa bongata ba hormone ea ho hōla e lokolloa ke tšoelesa ea pituitary ka holimo ho se neng se tla lokolloa haeba peptide e ka fanoa e le 'ngoe.

Ho bohlokoa ho reka GHRP-6 ho mofani oa thepa ea tsebahalang e le ho netefatsa boleng ba peptide GHRP-6.AASraw, setsebi sa setsebi sa GHRP-6 moetsi le mofani oa thepa, a ka fana ka GHRP-6 ea boleng bo phahameng bakeng sa setsi se ikemetseng sa R ​​& D le fektheri. Haeba u na le litlhoko, GHRP-6 wholesale ho tloha AASraw ke khetho e babatsehang.

Melemo ea GHRP-6

GHRP-6 (Growth Hormone Releasing Peptide 6) ke peptide ea maiketsetso e susumetsang ho lokolloa ha hormone ea ho hōla 'meleng. Melemo ea eona e ka bang teng e hlahlobiloe liphuputsong le lithutong tse fapaneng. Leha ho le joalo, ho bohlokoa ho hlokomela hore bongata ba melemo ena e ka bang teng e thehiloe haholo-holo lithutong tsa liphoofolo le bopaki bo sa tloaelehang bo tsoang ho basebelisi ba batho. Ho hlokahala liteko tse matla tsa kliniki ho netefatsa litlamorao tsena ho batho. mona ke melemo e meng e ka bang teng ea GHRP-6 ho latela lipatlisiso tse teng.

Ho lokolloa ha Hormone ea Kholo

GHRP-6 e eketsa ho lokolloa ha hormone ea ho hōla (GH) ho tloha mokokotlong oa pituitary. Hormone ea ho hōla e hlokahala bakeng sa khōlo ea ngoana 'me e thusa batho ba baholo ho boloka sebopeho sa' mele se phetseng hantle le bophelo bo botle. Ho eketseha ha GH ho ka fella ka ho eketseha ha mesifa le matla. Sena se etsahala hobane GH e eketsa tlhahiso ea Insulin-joaloka Growth Factor 1 (IGF-1) sebeteng, e leng hormone ea bohlokoa bakeng sa ho hōla ha mesifa. Ka lebaka la melemo ena, GHRP-6 ke khetho e tsebahalang har'a baetsi ba 'mele le baatlelete ba batlang ho ntlafatsa ts'ebetso ea bona ea' mele le 'mele oa bona.

Bohloko ba ho Shoeloa Weight

GHRP-6 e khothalletsa secretion ea hormone ea ho hōla, e ka thusang ho hōla ha mesifa e boima. Ho eketseha ha mesifa ea mesifa ho ka ntlafatsa sekhahla sa metabolism hobane mesifa e chesa lik'hilojule tse ngata ho feta mafura le ha u phomotse. Ka lebaka leo, ho eketseha ha mesifa ea mesifa ho ka etsa hore ho be le khalori e ntlafetseng le ho theola boima ba 'mele ka nako.

Ho feta moo, liphuputso tse ling li bontša hore ho hōla ha hormone ho ka thusa ho senyeha ha lisele tsa mafura (mokhoa o tsejoang e le lipolysis), e ka thusang boitekong ba ho theola boima ba 'mele. Leha ho le joalo, lipatlisiso tse ling lia hlokahala ho utloisisa mekhoa e itseng le katleho ea mokhoa ona.

Pholiso ea maqeba

GHRP-6 e bontšitsoe ho potlakisa pholiso ea maqeba le tsosoloso ea lisele. Sena se ka 'na sa bakoa ke karolo ea eona ea ho khothalletsa ho lokolloa ha GH, e tsejoang e le karolo ea ho tsosolosoa ha lisele le protheine synthesis - tseo ka bobeli li leng bohlokoa mekhoeng ea phekolo ea' mele. Monyetla ona o ka ba molemo ho batho ba hlaphoheloang ka mor'a ho buuoa, kapa maqeba, kapa ba nang le maqeba a folang butle ka lebaka la mafu a kang lefu la tsoekere.

Litlamorao tse khahlanong le ho ruruha

Liphuputso tse ling li fana ka maikutlo a hore GHRP-6 e ka 'na ea e-ba le litšobotsi tse thibelang ho ruruha, tse ka thusang mafu a sa tšoaneng a bophelo bo botle a khetholloang ke ho ruruha, joalo ka ramatiki, asthma le lefu la ho ruruha ha mala.

Liphello tse sireletsang pelo

Patlisiso e ncha e fana ka maikutlo a hore GHRP-6 e ka ba le thepa e sireletsang pelo. E ka thusa ho fokotsa tšenyo ea lisele tsa pelo, haholo-holo ka mor'a liketsahalo tse kang lefu la pelo. Tšusumetso ena ea tšireletso e na le monyetla oa ho fokotsa kotsi ea lefu la pelo le ho ntlafatsa bophelo bo botle ba pelo, haholo-holo ho batho ba seng ba ntse ba le kotsing.

Ho bohlokoa ho utloisisa hore ho na le bahlahisi ba bangata ba GHRP-6 le barekisi ba fumanehang marang-rang le kantle ho naha; leha ho le joalo, hase bohle ba tšepahalang. Reka GHRP-6 ho moetsi le mofani oa thepa bakeng sa liphello tse ntle ka ho fetisisa.AASraw e sebetsa ka ho khetheha ho hlahiseng le ho fana ka GHRP-6 ho latela litlhoko tsa tlhahiso ea CGMP, le sehlopha ka seng sa lihlahisoa tse tlas'a teko ea boleng pele li rekisoa.

Litla-morao tsa GHRP-6

GHRP-6 (Growth Hormone Releasing Peptide 6) ka kakaretso e mamelloa hantle, empa joalo ka meriana leha e le efe kapa tlatsetso, e ka ba le litla-morao tse ka bang teng. Kamehla ho bohlokoa ho buisana le mofani oa tlhokomelo ea bophelo pele u qala kalafo efe kapa efe e ncha.

• Tšebeliso ea Metsi
• Keketseho ea Lijo
• Hypoglycemia
• Liketso tsa sebaka sa ente
• Carpal Tunnel Syndrome
• Gynecomastia

Hopola, lena ha se lethathamo le felletseng, mme litla-morao li ka fapana ho ea ka motho ho latela lintlha tse ngata, ho kenyeletsoa bophelo bo botle ka kakaretso, litekanyetso, le karabelo ea motho kalafong. Kamehla buisana le mofani oa tlhokomelo ea bophelo ho utloisisa likotsi le melemo e ka bang teng pele u qala GHRP-6 kapa mofuta ofe kapa ofe o mocha oa phekolo.

Pele o sebelisa GHRP-6, joalo ka peptide leha e le efe kapa phekolo ea phekolo, ho molemo ho buisana le setsebi sa tlhokomelo ea bophelo. Ba ka fana ka likeletso, ba lekola likotsi tse ka bang teng, 'me ba latela tsoelo-pele ea hau ho netefatsa ts'ebeliso e bolokehileng le e nepahetseng. Ho feta moo, ho reka li-peptide mohloling o nepahetseng ke habohlokoa.AASraw e boloka taolo e tiileng ea boleng 'me e entse sehlopha sa GHRP-6 ea boemo bo holimo e rekisoang. Haeba ho hlokahala, o amohelehile ho reka peptide GHRP-6.

GHRP-6 vs GHRP-2

GHRP-6 le GHRP-2 ka bobeli ke li-peptide tsa maiketsetso tse leng tsa sehlopha sa li-peptide tse hlahisang li-hormone (GHRPs). Li susumetsa tlhahiso ea 'mele ea hormone ea ho hōla (GH), e ka lebisang ho eketseha ha mesifa le matla, hammoho le ho hlaphoheloa hantle le ho lahleheloa ke mafura. Mona ke papiso ea li-peptide tsena tse peli.

Li-GHRP-6 li na le li-peptide tse ling

GHRP-6, mofuta oa peptide e lokollang hormone ea ho hōla, e atisa ho sebelisoa hammoho, kapa "stacked," le li-peptide tse ling ho ntlafatsa katleho ea eona. Sena ke hobane GHRP-6 e sebetsa ka mokhoa o ts'oanang le li-peptide tsena, ho bolelang hore phello e kopantsoeng e kholo ho feta kakaretso ea liphello tsa bona. Mona ke li-peptide tse 'maloa tse atisang ho kenngoa ka GHRP-6.

Ka kopo hlokomela hore lintlha tsena ke tsa litšupiso feela, eseng tlhahiso ea litsebi tsa bongaka. Hopola, le hoja mekotla ena e sebelisoa hangata, e lokela ho sebelisoa tlas'a tlhokomelo ea mofani oa tlhokomelo ea bophelo kapa setsebi sa meriana ea lipapali. Tšebeliso e mpe e ka baka liphello tse mpe tsa bophelo bo botle, 'me melemo le likotsi tse ka bang teng li lokela ho hlahlojoa ka hloko.

Tlhokomeliso: Ha u reka GHRP-6 ho mofani oa thepa, ho bohlokoa ho beha boleng le polokeho ea sehlahisoa pele. Etsa bonnete ba hore mofani oa thepa oa GHRP-6 o na le botumo bo botle ebile o hlahlobiloe hantle, le hore ba fana ka tlhahisoleseding e feletseng mabapi le mekhoa ea ho fumana, ho etsa le ho laola boleng ba lihlahisoa tsa bona. Li boetse li lokela ho ba pepeneneng mabapi le metsoako le mahloriso a peptide. Kamehla buisana le setsebi sa tlhokomelo ea bophelo pele u qala tlatsetso leha e le efe e ncha kapa meriana, 'me u hopole hore lintho tsena li lokela ho sebelisoa feela tlas'a tlhokomelo ea bongaka.

Tlaleho ea Tlhahlobo ea GHRP-6-HNMR

HNMR ke eng hona HNMR spectrum e u bolella eng? H Nuclear Magnetic Resonance (NMR) spectroscopy ke mokhoa oa ho hlahloba k'hemistri o sebelisoang ho laola boleng le lipatlisiso bakeng sa ho fumana likahare le bohloeki ba sampuli hammoho le sebopeho sa limolek'hule. Mohlala, NMR e ka sekaseka ka bongata metsoako e nang le metsoako e tsebahalang. Bakeng sa metsoako e sa tsejoeng, NMR e ka sebelisoa ho bapisa le lilaebrari tsa spectral kapa ho fana ka sebopeho sa motheo ka kotloloho. Hang ha sebopeho sa motheo se tsejoa, NMR e ka sebelisoa ho fumana hore na limolek'hule li lumellana joang le tharollo hammoho le ho ithuta thepa ea 'mele boemong ba limolek'hule joalo ka phapanyetsano ea conformational, liphetoho tsa mohato, solubility le diffusion.

Mokhoa oa ho reka GHRP-6 ho tloha AASraw?

❶Ho ikopanya le rona ka sistimi ea rona ea ho botsa ka lengolo-tsoibila, kapa ho re siela nomoro ea hau ea WhatsApp, moemeli oa rona oa litšebeletso tsa bareki(CSR) o tla ikopanya le uena ka mor'a lihora tse 12.

❷ Ho re fa palo le aterese eo u e botsitseng.

❸ CSR ea rona e tla u fa khotheishene, nako ea ho patala, nomoro ea morao-rao, litsela tsa ho fihla, le letsatsi la ho fihla (ETA).

❹Ho lefa 'me thepa e tla romelloa ka mor'a lihora tse 12.

❺Lintho tse amohetsoeng le ho fana ka maikutlo.

Mongoli oa sengoloa sena:
Ngaka Monique Hong o fumane lengolo UK Imperial College London Faculty of Medicine

Sengoli sa pampiri sa Scientific Journal:
1. Miriam Granado
Lefapha la Endocrinology, Sepetlele sa Infantil Universitario Niño Jesús, Madrid, Spain
2. Liz Hernández
Sepetlele sa Univesithi ea St. James, Leeds, UK,
3. Geneviève Frégeau
Faculty of Pharmacy, Université de Montréal, Montreal, Québec, Canada4.
4. Andrea Giustina
Karolo ea Endocrine, Lefapha la Meriana ea ka hare, Brescia, Italy
Ha ho ka tsela leha e le efe ngaka/saense ena e buellang kapa ho buella ho rekoa, thekiso, kapa tšebeliso ea sehlahisoa sena ka lebaka lefe kapa lefe. Aasraw ha e na kamano kapa kamano, ho boleloa kapa ho seng joalo, le ngaka ena. Sepheo sa ho qotsa ngaka ena ke ho ananela, ho ananela le ho babatsa lipatlisiso tse felletseng le mosebetsi oa nts'etsopele o entsoeng ke bo-ramahlale ba sebetsanang le ntho ena.

References

[1]  Liu,Q.,Lei,T.,Adams,EF,Buchfelder,M.,& Fahlbusch,R. (1997) .Kamano pakeng tsa GHRP-6 le TPA taolong ea tlhahiso ea hormone ea ho hōla ka pituitary somatotrophinomas ea motho. Journal of Tongji Medical University,17(3),132-135.

[2] Cabrales A,Gil J,Fernández E,Valenzuela C,Hernández F,García I,Hernández A,Besada V,Reyes O,Padrón G,Berlanga J,Guillén G,González LJ (2013). "Thuto ea Pharmacokinetic ea Growth Hormone-Releasing Peptide 6 (GHRP-6) ho baithaopi ba robong ba phetseng hantle". Eur J Pharm Sci. 48 (1–2): 40–6.

[3] Argente,J.,García-Segura,LM,Pozo,J.,& Chowen,JA (1996). Li-peptide tse lokollang li-hormone tsa kholo: likarolo tsa bongaka le tsa mantlha. Patlisiso ea Hormone,46(4-5),155-159.

[4] Chen,C.,Pullar,M.,Loneragan,K.,Zhang,J.,& Clarke,IJ (1998). Phello ea ho hōla ha hormone-release peptide-2 (GHRP-2) le GH-releasing hormone (GHRH) maemong a cAMP le ho lokolloa ha GH ho tsoa lihlahala tsa acromegalic. Journal of Neuroendocrinology, 10 (6), 473-480.

[5] Peñalva,A; Carballo,A; Pombo,M; Casanueva,FF; Dieguez, C (1993). "Phello ea hormone ea ho hōla (GH) -e lokollang hormone (GHRH), atropine, pyridostigmine, kapa hypoglycemia ho GHRP-6-induced GH secretion ho motho". Journal of Clinical Endocrinology le Metabolism. 76 (1): 168–71.

[6] McGirr,R; McFarland,MS; McTavish,J; Luyt,LG; Dhanvantari,S (2011). "Moqapi le sebopeho sa analog ea fluorescent ghrelin bakeng sa ho nahana ka hormone ea kholo ea secretagogue receptor 1a". Li-peptide tse laoloang. 172 (1–3): 69–76.

[7] Ghigo,E.,Arvat,E.,Muccioli,G.,& Camanni,F. (1997). Li-peptide tse lokollang li-hormone tsa kholo. European Journal of Endocrinology, 136 (5), 445-460.

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