EA-121-CMS

Litlhaku tsa Motheo tsa Powder tse tala tsa CMS121

CMS121 phofo ke eng?

CMS121 phofo ke motsoako o sebetsang e le mafura a acid synthase inhibitor. Fatty acid synthase ke enzyme e amehang ho qaleng ha mafura acid, e leng likarolo tsa bohlokoa tsa lera la lisele mme e bapala karolo lits'ebetsong tse fapaneng tsa lisele. Ho thibela mafura a acid synthase ho ka ama metabolism ea lipid mme ho ka ba le litlamorao ho mafu a kang lefu la Alzheimer's.

Ho feta moo, CMS121 e bonts'a litlamorao tse khahlanong le ho ruruha, ho bolelang hore e ka thusa ho fokotsa ho ruruha 'meleng. Ho ruruha ho sa foleng ho amahanngoa le maemo a 'maloa a bophelo bo botle, ho kenyelletsa mafu a autoimmune, mafu a pelo le mefuta e meng ea mofetše. Ka ho fokotsa ho ruruha, CMS121 e ka 'na ea e-ba le mekhoa e ka sebelisoang ho phekola maemo ana a amanang le ho ruruha.

Ntho e 'ngoe e hlokomelehang ea CMS121 ke ts'ebetso ea eona ea antioxidative. Khatello ea oxidative, e bakoang ke ho se leka-lekane pakeng tsa tlhahiso ea mefuta ea oksijene e sebetsang (ROS) le tsamaiso ea 'mele ea ho itšireletsa ea antioxidant, e ka lebisa ho senyeha ha lisele le ho kenya letsoho ho nts'etsopele ea mafu a sa tšoaneng, ho akarelletsa le mafu a neurodegenerative le mafu a pelo.CMS121's antioxidative activity e nolofalletsa ho loantša khatello ena ea oxidative, e ka 'nang ea sireletsa lisele hore li se ke tsa senyeha.

Ho feta moo, CMS121 e bontšitse liphello tsa ho tsosolosa, ho bontša bokhoni ba eona ba ho sireletsa liphio ho tsoa likotsi kapa ho se sebetse. Mafu a liphio, a kang lefu le sa foleng la liphio kapa kotsi e matla ea liphio, a ka ba le liphello tse tebileng bophelong bo botle ka kakaretso. Ka ho fana ka litlamorao tsa ts'ireletso, CMS121 e na le ts'episo ea ho ba moemeli oa kalafo bakeng sa maemo a amanang le liphio.

CMS121 e sebetsa joang?

Lefu la Alzheimer ke lefu la neurodegenerative le khetholloang ke ho bokellana ha li-plaque tsa beta-amyloid le li-tangles tsa neurofibrillary bokong. E amahanngoa le ho fokotseha ha kelello, ho ruruha, le khatello ea oxidative. Nts'etsopele ea maano a kalafo ho lebisa likarolo tsena tsa pathological ke sebaka se sebetsang sa lipatlisiso.

Boemong ba lefu la Alzheimer, liphuputso li batlisisitse melemo e ka bang teng ea ho thibela mafura a acid synthase ho sebelisa metsoako e kang CMS121. Boithuto ba preclinical bo sebelisang mefuta ea litoeba tsa transgenic tsa lefu la Alzheimer bo bonts'itse hore CMS121 e ka sireletsa khahlanong le lipid peroxidation e feteletseng, ea fokotsa ho ruruha, le ho fokotsa tahlehelo ea kelello.

Ho fetella ha lipid peroxidation ho bolela tšenyo e bakiloeng ke mefuta ea oksijene e sebetsang ho li-membrane tsa lisele. Ts'ebetso ena e ka lebisa ho se sebetseng ha lisele le ho kenya letsoho ho tsoeleng pele ha mafu a neurodegenerative. Ka ho thibela mafura a acid synthase, CMS121 e ka thusa ho khutlisetsa lipid homeostasis le ho fokotsa lipid peroxidation.

Ho feta moo, ho ruruha ho tsebahala ho phetha karolo ea bohlokoa ho ata ha lefu la Alzheimer's. Mekhoa ea ho ruruha bokong e ka tlatsetsa ho senyeha ha neuronal le ho fokotseha ha kelello. Boithuto bo bonts'itse hore CMS121 e na le litlamorao tse thibelang ho ruruha, tse ka bang molemo ho fokotsa karabelo ea ho ruruha e amanang le lefu la Alzheimer's.

Melemo ea phofo ea CMS121

CMS121 phofo ke motsoako oa quinoline o nkeloang sebaka o nang le thepa e 'maloa e molemo. E fumanoe e bontša mesebetsi ea neuroprotective, anti-inflammatory, antioxidative, le renoprotective. Litlamorao le liketso tsa CMS121 ke tsena:

Neuroprotection: CMS121 e bontšitsoe ho sireletsa lisele tsa hippocampal tsa mouse tsa HT22 ho tloha tšenyo e bakoang ke glutamate in vitro.E thusa ho boloka maemo a glutathione (GSH), e leng antioxidant ea bohlokoa, liseleng tsena. Ho phaella moo, CMS121 e bontša tšireletso khahlanong le ischemia le oxytocin (lefu la lisele tse bakoang ke glutamate) liseleng tsa HT22.

-Ba khahlanong le a hlabang: CMS121 e bonts'a litlamorao tse khahlanong le ho ruruha ka ho thibela ts'ebetso ea N9 microglia, mofuta oa sele ea 'mele ea ho itšireletsa mafung bokong. Boteng ba lipopolysaccharide (LPS), CMS121 e fokotsa ts'ebetso ea microglial ka 82% ho N9 microglia. Thepa ena e khahlanong le ho ruruha e ka ba molemo maemong a fapaneng a neuroinflammatory.

Antioxidant: CMS121 e qhekella li-radicals tsa mahala, joalo ka ha ho bonts'itsoe tekong ea ts'ebetso e ts'oanang ea Trolox (TEAC). Li-radicals tsa mahala ke limolek'hule tse sebetsang haholo tse ka bakang tšenyo ea lisele le ho kenya letsoho mafu a sa tšoaneng. Ka ho hlakola li-radicals tsa mahala, CMS121 e sebetsa joalo ka antioxidant mme e thusa ho sireletsa lisele khatellong ea oxidative.

Tlhahiso ea phapang: CMS121 e etsa hore ho be le phapang ea lisele tsa PC12. Lisele tsa PC12 li atisa ho sebelisoa e le mokhoa oa mohlala oa ho ithuta phapang ea neuronal le mosebetsi. Bokhoni ba CMS121 ba ho etsa hore ho be le phapang liseleng tsena bo fana ka maikutlo a karolo e ka bang teng ho nts'etsopele le ho lokisoa ha neuronal.

Tšireletso e ncha: CMS121 e bonts'a litlamorao tsa ts'ireletso, haholo mohlala oa toeba oa SAMP8 oa lefu le sa foleng la liphio le amanang le botsofali bo potlakileng. Ha e sebelisoa ka tekanyo ea 10 mg / kg ka letsatsi ho qala ka likhoeli tse robong, CMS121 e fokotsa ho lahleheloa ke boima ba liphio le ho fokotsa polelo ea TNF-α, caspase-1, le inducible nitric oxide synthase (iNOS). Liphello tsena li bontša karolo e ka bang teng ea phekolo bakeng sa CMS121 ho sireletsa liphio ho tsoa tšenyo e amanang le lefu le sa foleng la liphio.

Ka kakaretso, CMS121 ke motsoako o ts'episang o nang le lisebelisoa tse ngata tse molemo, ho kenyelletsa le neuroprotection, anti-inflammatory effects, antioxidative activity, le renoprotection. Liketso tsa eona tse fapaneng li e etsa motho ea ka khonang ho phekola mafu a fapaneng a methapo, maemo a amanang le ho ruruha le mafu a liphio.

U ka reka phofo ea CMS121 hokae?

AASraw ke sebaka se setle ka ho fetisisa sa ho reka CMS121 ka kakaretso. Lihlahisoa tsohle tsa rona li tla le Setifikeiti sa Tlhahlobo se ikemetseng, se fanoeng ke motho oa boraro bakeng sa boitsebahatso, bohloeki le ho tsepamisa maikutlo. 'Me re na le CMS121 e ngata e rekisoang setokong!

AASraw ke mofani oa CMS121 le moetsi oa CMS121 ea nang le lab e ikemetseng le fektheri e kholo e le ts'ehetso, tlhahiso eohle e tla etsoa tlas'a taolo ea CGMP le tsamaiso ea ho laola boleng ba trackable. Sistimi ea phepelo ea CMS121 e tsitsitse, 'me liodara tsa mabenkele le tse rekisoang lia amoheleha. Haeba u batla ho reka CMS121 inthaneteng, rea u amohela ho etela sebaka sa rona sa Marang-rang(aasraw.com).

Tlaleho ea Tlhahlobo ea CMS121-HNMR

HNMR ke eng hona HNMR spectrum e u bolella eng? H Nuclear Magnetic Resonance (NMR) spectroscopy ke mokhoa oa ho hlahloba k'hemistri o sebelisoang ho laola boleng le lipatlisiso bakeng sa ho fumana likahare le bohloeki ba sampuli hammoho le sebopeho sa limolek'hule. Mohlala, NMR e ka sekaseka ka bongata metsoako e nang le metsoako e tsebahalang. Bakeng sa metsoako e sa tsejoeng, NMR e ka sebelisoa ho bapisa le lilaebrari tsa spectral kapa ho fana ka sebopeho sa motheo ka kotloloho. Hang ha sebopeho sa motheo se tsejoa, NMR e ka sebelisoa ho fumana hore na limolek'hule li lumellana joang le tharollo hammoho le ho ithuta thepa ea 'mele boemong ba limolek'hule joalo ka phapanyetsano ea conformational, liphetoho tsa mohato, solubility le diffusion.

U ka reka CMS121 joang ho AASraw?

❶Ho ikopanya le rona ka sistimi ea rona ea ho botsa ka lengolo-tsoibila, kapa ho re siela nomoro ea hau ea WhatsApp, moemeli oa rona oa litšebeletso tsa bareki(CSR) o tla ikopanya le uena ka mor'a lihora tse 12.

❷ Ho re fa palo le aterese eo u e botsitseng.

❸ CSR ea rona e tla u fa khotheishene, nako ea ho patala, nomoro ea morao-rao, litsela tsa ho fihla, le letsatsi la ho fihla (ETA).

❹Ho lefa 'me thepa e tla romelloa ka mor'a lihora tse 12.

❺Lintho tse amohetsoeng le ho fana ka maikutlo.

Mongoli oa sengoloa sena:
Ngaka Monique Hong o fumane lengolo UK Imperial College London Faculty of Medicine

Sengoli sa pampiri sa Scientific Journal:
1.Gamze Ates
Cellular Neurobiology Laboratory, The Salk Institute for Biological Studies,La Jolla,CA,USA.
2.Sveinn Olafsson
Faculty of Physical Sciences, Univesithi ea Iceland, Reykjavik, Iceland
3.Diana Garibo
Univesithi ea Tomsk Polytechnic, Lenin Ave.No 30,6634050 Tomsk, Russia
4.Rodrick Wallace
New York State Psychiatric Institute, United States
Ha ho ka tsela leha e le efe ngaka/saense ena e buellang kapa ho buella ho rekoa, thekiso, kapa tšebeliso ea sehlahisoa sena ka lebaka lefe kapa lefe. Aasraw ha e na kamano kapa kamano, ho boleloa kapa ho seng joalo, le ngaka ena. Sepheo sa ho qotsa ngaka ena ke ho ananela, ho ananela le ho babatsa lipatlisiso tse felletseng le mosebetsi oa nts'etsopele o entsoeng ke bo-ramahlale ba sebetsanang le ntho ena.

Reference

[1] Schneider LS,Mangialasche F.,Andreasen N.,Feldman H.,Giacobini E.,Jones R.Clinical liteko le nts'etsopele ea morao-rao ea lithethefatsi bakeng sa lefu la Alzheimer's: tlhahlobo ho tloha 1984 ho ea 2014.J.Intern.Med. 2014;275: 251–283.doi: 10.1111/joim.12191.

[2] Ashraf A.,Jeandriens J.,Parkes HG,So P.-W.Iron dysshomeostasis,lipid peroxidation and perturbed expression of cystine/glutamate antiporter in Alzheimer's disease: bopaki ba ferroptosis.Redox Biol.2020;32:101494. doi: 10.1016/J.REDOX.2020.101494.

[3] Trares K., Gào X., Perna L., Rujescu D., Stocker H., Möllers T. Mekhatlo ea maemo a moroto a 8-iso-prostaglandin F2α a nang le 'dementia' e bakoang ke tsohle, lefu la Alzheimer's, le liketsahalo tsa 'dementia' ea methapo: liphetho ho tsoa ho batho ba lebelletsoeng ho ithuta.Alzheimers Dement.2020;16(5): 804–813.doi: 10.1002/alz.12081.

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