Tlhaloso ea Sehlahisoa
CJC-1295 ke eng?
CJCPeptide ea -1295 ke peptide ea maiketsetso ea ho hōla ha hormone-releasing (GHRH) e nang le 30 amino acid. E nkoa e le GHRH e sebetsang ka ho fetisisa e sebelisetsoang ho ntlafatsa hormone ea ho hōla 'me e ka kopanngoa (stacked) le li-peptide tse ling, tse kang Ipamorelin, bakeng sa phello e matla ea synergistic,' me hangata e kenyelelitsoe lenaneong la HRT ho laola botsofali le lenaneo la TRT bakeng sa ts'ebetso e ntlafetseng.CJC-1295 e bontšitse bokhoni ba ho eketsa tahlehelo ea mafura le ho matlafatsa mesifa ea mesifa ha e ntse e nolofalletsa 'mele ho etsa protheine ka katleho. Ntle le ho eketsa tlhahiso ea GH butle-butle, CJC-1295 e boetse e eketsa secretion ea insulin-like growth factor 1 (IGF-1). Haholo-holo e patoa ke sebete, IGF-1 ke hormone ea anabolic e thusang ho khothalletsa khōlo ea motho ho pholletsa le 'mele oohle, haholo-holo mesifa ea masapo.IGF-1 e boetse e thusa ho thibela masapo le ho hloekisa liphio. E 'ngoe ea melemo ea bohlokoa ea CJC-1295 ke hore ha e eketse tlhahiso ea lihomone tse ka 'nang tsa hanyetsanoa tse kang prolactin.CJC-1295 hangata e tsamaisoa ka ente e ka tlas'a letlalo.
CJC-1295 e sebetsa joang?
Peptide ea CJC-1295 e sebetsa ka ho sebetsa ho mokelikeli oa GHRH le ho tlama li-receptor tsa pituitary gland ho susumetsa ho lokolloa ha bobeli ba GH le insulin-like growth factor 1 (IGF-1). E 'nile ea lekoa liphoofolong le lithutong tsa batho.
Phuputso ea liphoofolo ea 2005 e fumane hore CJC-1295 e ile ea susumetsa "keketseho ea makhetlo a 4" maemong a GH ha e fuoa likhoto tse tona tsa Sprague Dawley. Bafuputsi ba hlokometse hore ha CJC-1295 e ne e kenngoa hammoho le hGRF1-29 amide le CJC-1288, e ile ea baka "li-secretions tse matla" ho liphoofolo tsohle 'me ea hlahisa "plasma e kholo ka ho fetisisa AUC ea GH ka nako ea 2-h" ea li-peptide tsohle.
Ho feta moo, lithuto tse peli tsa batho tse amang lithuto tsa liteko tse phetseng hantle li fumane hore tsamaiso ea CJC-1295 DAC e hlahisitse keketseho ea makhetlo a 2 ho isa ho a 10 ka bongata ba plasma ea GH ka matsatsi a ts'eletseng kapa ho feta le keketseho ea 1.5 ho isa ho 3 ho plasma e bolelang IGF-1. mahloriso bakeng sa matsatsi a 9-11.
Melemo ea CJC-1295
①E Ntlafatsa Metabolism & E Eketsa Matla
CJC-1295 ho tloha AASraw e matlafatsa metabolism ea hau ka tsela e sa tobang ka ho romela li-peptide ho lesela la hau la pituitary ho lokolla hormone ea ho hōla le ka ho eketsa phepo ea phepo e nepahetseng. Ka lebaka leo, maemo a hau a matla a tla lula a ntlafatsoa letsatsi lohle; u tla ikutloa u se na mokhathala 'me u be le matla a eketsehileng bakeng sa mesebetsi e tloaelehileng le boikoetliso bo matla.
②E fokotsa mafura a 'mele
Ho eketseha ha hormone ea ho hōla ho boetse ho khothalletsa ho theola boima ba 'mele le ho fokotsa palo ea mafura a' mele habonolo. Lisele li ka fetisetsa limatlafatsi libakeng tse ling tsa 'mele ka potlako, li chesa mafura a mangata,' me li thusa ho laola boima ba 'mele.E boetse e eketsa ho senyeha ha triglyceride le oxidation ho adipocytes, e leng ho ntlafatsa metabolism ea mafura le ho khothalletsa ho qhibiliha ha mafura a mpeng.
③E eketsa Boima ba mesifa
CJC-1295 e sebelisana le ho kenya tšebetsong li-receptor tse ngata ho pholletsa le 'mele, e susumetsang mefuta e mengata ea mesebetsi ea fisioloji. Ho etsa hore sebete se thehe IGF-1 e eketsehileng ho susumetsa nts'etsopele ea mesifa le protheine synthesis, e leng se etsang hore ho be le mesifa e mengata. Hase feela hoo, empa e boetse e khothalletsa ho lahleheloa ke mafura, ho lumella mesifa ea hao hore e hōle le ho feta.
④E khothalletsa ho thehoa ha masapo
CJC-1295 e boetse e ntlafatsa moloko oa insulin-like growth factor 1 (IGF-1), hormone e tšoanang le proinsulin e susumetsang mosebetsi oa osteoblast le chondrocyte, kahoo e khothalletsa ho thehoa ha masapo.
⑤E matlafatsa 'mele oa ho itšireletsa mafung
Ho feta moo, ha CJC-1295 e kena 'meleng oa hau, e etsa hore sesole sa hau sa 'mele se loantše bahlaseli ba kantle joalo ka livaerase le libaktheria. Haeba o na le immunocompromised, kapa haeba sesole sa hau sa 'mele se sentsoe ke ho kula kapa botsofali, kalafo ea peptide e ka thusa ho khutlisetsa matla a eona. E ka boela ea thusa batho ba nang le sesole sa 'mele se matla.
⑥E matlafatsa Khokahano ea Thobalano
Amino acid ena e tummeng e kokobetsa matšoao a sa tšoaneng a amanang le ho hloka thahasello litabeng tsa thobalano kapa thobalano ka ho eketsa maemo a hormone ea ho hōla ha motho, e ntlafatsang libaka tsohle tseo li sebetsang ho tsona.CJC-1295 e matlafatsa ho thehoa le ho potoloha ha lisele tse khubelu tsa mali, tse bohlokoa bakeng sa ts'ebetso ea erectile. Litla-morao tse ling li kenyelletsa libido e ntlafetseng le boikutlo bo botle ba bophelo bo botle.
⑦ Tokiso e Potlakileng le ho Pholoha Likotsing
Batho ba mafolofolo, haholo-holo baatlelete, hangata ba ikutloa ba sa phutholoha libakeng tse ngata tsa 'mele ka lebaka la likotsi tse bakiloeng nakong ea boikoetliso. Ba boetse ba hloka matla a ho lokisa le ho fola maqeba a bona. Hormone ea ho hōla e matlafatsa tsamaiso ea 'mele ea ho itšireletsa mafung, e leng se etsang hore ho ntlafatsoe ho tsosolosoa ha lisele le ho fola ka potlako le ho hlaphoheloa likotsing.CJC-1295 e khetha ho eketsa protheine ea anabolism meleng e sa tšoaneng, e bolelang hore e ka ntlafatsa ka ho toba matla le ho potlakisa lebelo la ho folisa kotsi le ho hlaphoheloa.
Litla-morao tsa CJC-1295
Monyetla o fokolang oa litla-morao ke e 'ngoe ea mabaka a ka sehloohong a etsang hore peptide ea CJC-1295 e tsoang ho AASraw e amoheloe ke batho ba bangata.CJC-1295 e mamelloa hantle ke batho ba bangata,' me litla-morao hangata li inyenyefatsa, haeba li le teng. kaofela.CJC-1295 Litlamorao tse mpe ka ho fetesisa li kenyelletsa likarabo tsa sebaka sa ente joalo ka ho se phutholohe, bofubelu, edema, ho hlatsa, ho tsekela, hlooho, kapa ho se sebetse hantle.
Ha e nkiloe ka tsela e fosahetseng kapa e fetelletseng, liphello tse mpe li nyolohela ho maemo a sa tšoaneng, ho itšetlehile ka motho ka mong. Keketseho ea takatso ea lijo, molomo o omeletseng, ho tsikinyeha kapa ho tsieleha, khatello e phahameng ea mali, mathata a renal, ho se phutholohe ha manonyeletso, li-moles kapa matheba a eketsehileng, le ho fokotseha ha tsoalo ke tse ling tsa litlamorao tse mpe.
Phapano lipakeng tsa CJC-1295 le DAC le ntle le DAC
Phapang e ka sehloohong pakeng tsa CJC-1295 le DAC le CJC-1295 ntle le DAC e bonoa ka mekhoa ea bona e fapaneng le bophelo ba halofo. Mona ke kakaretso ea liphapang tsa bona:
sebopeho: Ka bobeli CJC-1295 e nang le DAC le CJC-1295 ntle le DAC ke li-peptide tsa maiketsetso tse tsoang ho hormone ea tlhaho ea ho hōla ha hormone (GHRH). Leha ho le joalo, li fapane ka liphetoho tsa tsona tsa lik'hemik'hale.
DAC(Drug Affinity Complex): CJC-1295 e nang le DAC e na le phetoho e eketsehileng e bitsoang Drug Affinity Complex. Motsoako ona ke sebopeho sa limolek'hule se kentsoeng peptide ho matlafatsa botsitso ba eona le ho lelefatsa halofo ea bophelo 'meleng.
Halofo ea bophelo: Ho ba teng ha DAC ho CJC-1295 le DAC ho fella ka halofo ea bophelo e telele haholo ha e bapisoa le CJC-1295 ntle le DAC. Phetoho ea DAC e lumella tokollo e liehang le e tsitsitseng ea peptide, e lebisang ts'ebetsong le ts'ebetsong e telele.
Khafetsa ea Tekanyo: Ka lebaka la halofo ea bophelo bo atolositsoeng, CJC-1295 e nang le DAC e hloka ho noa khafetsa khafetsa. Hangata e tsamaisoa hang kapa habeli ka beke. Ka lehlakoreng le leng, CJC-1295 ntle le DAC e na le halofo ea bophelo bo khutšoanyane 'me hangata e tsamaisoa ka makhetlo a mangata ka letsatsi ho boloka maemo a tsitsitseng.
tsamaiso: Ka bobeli CJC-1295 e nang le DAC le CJC-1295 ntle le DAC hangata e tsamaisoa ka liente tsa subcutaneous. Sebaka sa ente hangata ke sebaka sa mpa kapa serope.
Tšebeliso ea Clinical: CJC-1295 e nang le DAC le CJC-1295 ntle le DAC e na le likopo tse fapaneng.CJC-1295 e nang le DAC e sebelisoa haholo-holo bakeng sa thepa ea eona ea ho hōla ha hormone ho latela mekhoa ea phekolo ea meriana, ho ntlafatsa ts'ebetso, kapa mekhoa ea ho thibela botsofali.CJC-1295 ntle le DAC, ka lehlakoreng le leng, e sebelisoa hangata molemong oa lipatlisiso le lipatlisiso tsa mahlale.
Ka kopo hlokomela hore AASraw e fana ka bobeli ba CJC-1295 ka DAC le CJC-1295 ntle le DAC.
LBH
①Mokhoa o motle oa ho tsamaisa CJC-1295 ke ofe?
Qalong, ente e lumella hore ho be bonolo ho monya ka ho toba maling. Bakeng sa litlamorao tse ntle, enta CJC ka nako e ts'oanang letsatsi le leng le le leng, ka mpeng e se nang letho, ka chelete e boletsoeng.
Ka mor'a moo, libaka tse loketseng ho entoa ke karolo e ka tlaase ea mpa, serope kapa letsoho le ka holimo. U lokela ho ema bonyane metsotso e 30 ka mor'a ente ea hau pele u ja kapa u noa eng kapa eng. Haeba u noa ente e fetang e le 'ngoe ka letsatsi, lumella bonyane lihora tse tharo pakeng tsa litekanyetso.
Qetellong, haeba u batla ho fumana liphetho tseo u li lakatsang, u tlameha ho ba le botsitso.
②CJC-1295 e lokela ho bolokoa joang?
Ha ho tluoa bophelong ba sethala, peptide ea CJC-1295 e lokela ho bolokoa ka hloko kamehla le ho sebelisoa. U tlameha ho e sebelisa ka letsatsi le itseng kapa e tla lahleheloa ke ts'ebetso ea eona 'me e be kotsi.
Bophelo ba lishelefo ea linkho bo ka atolosoa ka ho li hatsetsa.CJC-1295 e tla nka libeke tse seng kae feela mochesong oa kamore, leha ho le joalo, ho kenya sehatsetsing ho ka lelefatsa bophelo ba sethala ho fihlela khoeling e le 'ngoe. Ha u fana ka liente, kamehla u khomarele litlhahiso tsa ngaka ea hau.
③ NA CJC-1295 E SEBETSA BATHO E MONG LE E MONG?
Ho lahleheloa ke boima ba 'mele le ho chesa mafura a' mele, u tlameha hape ho etsa liphetoho tsa mokhoa oa bophelo ha ho tluoa tabeng ea ho ja le ho ikoetlisa.
Esita le haeba u latela mokhoa o khothalletsoang oa phekolo, lijo tse mpe le ho se ikoetlise li ka ba le tšusumetso e mpe bophelong ba hao le ho tlatsetsa boima ba 'mele. Leha ho le joalo, ha o kopantsoe le lijo tse nepahetseng le boikoetliso, peptide ena ea CJC-1295 e ka u thusa ho fihlela lipheo tsa hau tsa ho ikoetlisa ka katleho! Haeba ho hlokahala, o amohelehile ho reka CJC-1295.
Ho Reka CJC-1295 Hokae?
Kalafo ea peptide ea CJC-1295 e na le phello e kholo ho bophelo bo botle ka kakaretso. E thusa ho fumana mesifa, ho matlafatsa mafura, ho eketsa matla, le tse ling tse ngata. E finyella lintho tsena kaofela ka ho thusa 'mele oa hau ho eketsa tlhahiso ea lihomone tsa ho hōla. Mona ho AASraw, re inehetse ho Ho fana ka li-peptide tse ngata ho kenyelletsa ho theola boima ba 'mele, kalafo ea bophelo bo botle ba thobalano, le lihomone tse ling. Haeba o khahlehela CJC-1295 kapa li-peptide life kapa life tse ling, tlatsa sebopeho se ka tlase ho hlophisa lipuisano tsa hau le ho bua le basebetsi ba rona ba khethehileng. Re labalabela ho utloa ho tsoa ho uena!
Tlaleho ea Tlhahlobo ea CJC-1295-HNMR
HNMR ke eng hona HNMR spectrum e u bolella eng? H Nuclear Magnetic Resonance (NMR) spectroscopy ke mokhoa oa ho hlahloba k'hemistri o sebelisoang ho laola boleng le lipatlisiso bakeng sa ho fumana likahare le bohloeki ba sampuli hammoho le sebopeho sa limolek'hule. Mohlala, NMR e ka sekaseka ka bongata metsoako e nang le metsoako e tsebahalang. Bakeng sa metsoako e sa tsejoeng, NMR e ka sebelisoa ho bapisa le lilaebrari tsa spectral kapa ho fana ka sebopeho sa motheo ka kotloloho. Hang ha sebopeho sa motheo se tsejoa, NMR e ka sebelisoa ho fumana hore na limolek'hule li lumellana joang le tharollo hammoho le ho ithuta thepa ea 'mele boemong ba limolek'hule joalo ka phapanyetsano ea conformational, liphetoho tsa mohato, solubility le diffusion.
U ka reka CJC-1295 joang ho AASraw?
❶Ho ikopanya le rona ka sistimi ea rona ea ho botsa ka lengolo-tsoibila, kapa ho re siela nomoro ea hau ea WhatsApp, moemeli oa rona oa litšebeletso tsa bareki(CSR) o tla ikopanya le uena ka mor'a lihora tse 12.
❷ Ho re fa palo le aterese eo u e botsitseng.
❸ CSR ea rona e tla u fa khotheishene, nako ea ho patala, nomoro ea morao-rao, litsela tsa ho fihla, le letsatsi la ho fihla (ETA).
❹Ho lefa 'me thepa e tla romelloa ka mor'a lihora tse 12.
❺Lintho tse amohetsoeng le ho fana ka maikutlo.
Mongoli oa sengoloa sena:
Ngaka Monique Hong o fumane lengolo UK Imperial College London Faculty of Medicine
Sengoli sa pampiri sa Scientific Journal:
1. Bernd Peschke
Health Care Chemistry, Novo Nordisk A/S, Novo Nordisk Park, 2760 Måløv, Denmark
2. Peter B. Johansen
Lefapha la Pharmacological Research, Novo Nordisk A/S, Bagsværd, DK-2880, Denmark
3. NB Andersen
Lefapha la Connective Tissue Biology, Institute of Anatomy, Univesithi ea Aarhus, Aarhus C, DK-8000, Denmark
Ha ho ka tsela leha e le efe ngaka/saense ena e buellang kapa ho buella ho rekoa, thekiso, kapa tšebeliso ea sehlahisoa sena ka lebaka lefe kapa lefe. Aasraw ha e na kamano kapa kamano, ho boleloa kapa ho seng joalo, le ngaka ena. Sepheo sa ho qotsa ngaka ena ke ho ananela, ho ananela le ho babatsa lipatlisiso tse felletseng le mosebetsi oa nts'etsopele o entsoeng ke bo-ramahlale ba sebetsanang le ntho ena.
References
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[2] Hartvig RA, Holm NB, Dalsgaard PW, Reitzel LA, Müller IB, Linnet K (2014). "Ho tsebahatsa metsoako ea lithethefatsi e amanang le peptide le protheine e amanang le doping e nkiloeng Denmark pakeng tsa 2007-2013". Scandinavian Journal of Forensic Science. 20 (2): 42–49. doi:10.2478/sjfs-2014-0003. ISSN 2353-0707.
[3] Ionescu M, Frohman LA (December 2006). "Pulsatile secretion of growth hormone (GH) e ntse e tsoela pele nakong ea ts'usumetso e tsoelang pele ke CJC-1295, analoge ea nako e telele ea GH e lokollang ". Journal of Clinical Endocrinology le Metabolism. 91 (12): 4792–7. doi:10.1210/jc.2006-1702. PMID 17018654.
[4] Thorner MO (June 2008). "Ho sibolloa ha hormone ea kholo e lokollang hormone: ntlafatso". Journal of Neuroendocrinology. 20 (6): 653–4. doi:10.1111/j.1365-2826.2008.01740.x. PMID 18601685. S2CID 29788809.
[5] Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA (March 2006). "Ho tsosoa ha nako e telele ea hormone ea ho hōla (GH) le insulin-like growth factor I secretion by CJC-1295, analog ea nako e telele ea GH-releasing hormone, ho batho ba baholo ba phetseng hantle". Journal of Clinical Endocrinology le Metabolism. 91 (3): 799–805. doi:10.1210/jc.2005-1536. PMID 16352683.
