Tlhaloso ea Sehlahisoa
Cannabidiphorol phofo ke eng?
Cannabidiol (CBDP) phofo ke cannabinoid e fumanoeng mefuteng e itseng ea semela sa cannabis. Ke ea sehlopha se le seng sa metsoako e kang CBD e tsebahalang haholo (cannabidiol) le THC (tetrahydrocannabinol). CBDP e tšoana ka sebopeho sa limolek'hule ho metsoako ea cannabis THC le CBD, empa e matla ho feta makhetlo a 30. Leha ho entsoe lipatlisiso tse nyane ka CBDP, lipatlisiso tsa pele li fana ka maikutlo a hore e kanna ea ba le thepa ea kalafo e ts'oanang le CBD, ho kenyelletsa le melemo e ka bang teng bakeng sa matšoenyeho, khatello ea maikutlo, phomolo ea bohloko le ho ruruha.
Patlisiso ka Cannabidiphorol (CBDP)
Sehlopha sa bo-ramahlale ba Mataliana se etelletse pele boithuto bo matla ba Cannabidiphorol (CBDP), mme liphetho tsa bona li phatlalalitsoe pampiring e bitsoang "Pale ea phytocannabinoid e arohaneng le Cannabis sativa L. e nang le ts'ebetso ea in vivo cannabimimetic e phahameng ho feta 9-tetrahydrocannabinol: 9-Tetrahydrocannabiphorol” koranteng e tumileng ya Scientific Reports mafelong a Tshitwe 2019. Phuputso ena e emetse phetoho ya bohlokwa hobane e fane ka phuputso ya pele e felletseng ya CBDP.
Sebopeho sa sebopeho sa CBDP le litšebelisano tsa eona tse ka khonehang le li-cannabinoid receptors e ne e le libaka tse ka sehloohong tsa thuto, tse lebisang tlhokomelo e khethehileng ho li-receptor tsa 5-HT1A tsa serotonin, tse tsejoang hore li phetha karolo ea ho laola maikutlo le ho tšoenyeha. Bafuputsi ba hakantse hore CBDP le CBD li tla tšoana, ba fana ka maikutlo a litlamorao tse ka bang teng tsa kalafo joalo ka anti-stress, anti-depressant, le litšoaneleho tsa anti-epileptic. Sena se ne se ipapisitse le liphuputso tsa bona tsa pele.
Leha ho le joalo, ke habohlokoa ho hlokomela hore lipatlisiso tsa pele tsa CBDP li ntse li le teng, 'me lithuto tse ling lia hlokahala ho utloisisa ka botlalo liphello tsa eona tsa meriana, mekhoa ea phekolo e ka bang teng, boemo ba tšireletso le litla-morao.
Melemo ea Cannabidiphorol phofo
Ho latela lipatlisiso tse teng hajoale, CBDP e bonahala e na le melemo e ts'oanang ea kalafo ho CBD mme e ka thusa mafu a kang khatello ea maikutlo, khatello ea maikutlo le matšoenyeho. Ho phaella moo, AASraw CBDP e na le monyetla oa ho phekola ho ruruha, ho se phutholohe le lefu la sethoathoa.
- Ho fokotsa ho tšoenyeha, khatello ea maikutlo le khatello ea maikutlo
CBDP e na le monyetla oa ho fokotsa khatello ea maikutlo, matšoenyeho le matšoao a khatello ea maikutlo. CBDP e ka fetola tsela eo li-receptor tsa boko tsa serotonin (5-HT1A) li itšoarang ka eona ho maemo a tlhaho a serotonin ka ho kenya li-receptor tsena. "Molek'hule oa thabo," serotonin, ke ea bohlokoa bakeng sa ho laola matšoenyeho le maikutlo. Ho latela liphuputso, CBD e ka ba le melemo e mengata e khahlanong le khatello ea maikutlo le anti-depressant ka ho sebelisana le li-receptor tsa serotonin.
- Anti-epileptic properties
Ho tsieleha khafetsa le ho sa tsitsang, e leng letšoao la lefu la sethoathoa, le tlisoa ke ts'ebetso e sa tloaelehang ea motlakase bokong. Meriana ea setso e thibelang lefu la sethoathoa (AEDs) hangata e sebelisoa ho laola sethoathoa, empa batho ba bang ba ka fumana hore ha e sebetse 'me ba ba le litlamorao tse mpe.
CBDP ho nahanoa hore e sebelisana le 5-HT1A receptor, e leng ea bohlokoa bakeng sa ho laola ho lokolloa ha li-neurotransmitters tse kang serotonin bokong. Serotonin e bapala karolo ea ho laola maikutlo, matšoenyeho le ts'ebetso ea ho tsietsana, har'a lits'ebetso tse ling tsa 'mele.
Liphuputso tse ling tsa pele li fana ka maikutlo a hore li-cannabinoids, tse kang CBD 'me mohlomong CBDP, li ka laola ho lokolloa ha li-neurotransmitter' me tsa ama thabo ea methapo ea kutlo, e ka bang le tšusumetso mosebetsing oa ho tsietsana. Ka lebaka la bokhoni ba eona ba ho ba le litlamorao tse khahlanong le lefu la sethoathoa, CBD ka ho khetheha e entse lipatlisiso tse ngata. Ka lebaka leo, moriana o thehiloeng ho CBD (Epidiolex) o amohetsoe ho phekola mefuta e itseng ea lefu la sethoathoa.
Bafuputsi ba ntse ba etsa lipatlisiso haeba CBDP e kanna ea ba le thepa ea ho thibela lefu la sethoathoa ka lebaka la ho tšoana ho teng lipakeng tsa CBD le CBDP le tšebelisano ea bona e ka bang teng le li-receptor tsa 5-HT1A. Ka lebaka lena, CBDP e ka 'na ea e-ba tlatsetso ea bohlokoa ho mefuta e mengata ea phekolo e fumanehang ho batho ba nang le lefu la sethoathoa, ho fana ka mekhoa e meng e sebetsang bakeng sa ho laola ho tšoaroa ke sethoathoa.
- Ho laola bohloko le ho ruruha
Ho feta moo, CBDP e ka thusa ho fokotsa ho ruruha le bohloko. Liphuputso tse ngata li bontša hore CBD e ka atleha ho phekola matšoao a mafu a kang fibromyalgia, multiple sclerosis le ramatiki. Ka lebaka la hore CBDP le CBD li arolelana lintho tse ngata tse tšoanang, hoa utloahala ho fana ka maikutlo a hore litlamorao tsa tsona li tla tšoana.
Ho bohlokoa ho hlokomela hore lipatlisiso tse mabapi le CBDP li ntse li le maemong a eona a pele, 'me lithuto tse ling lia hlokahala ho utloisisa ka botlalo melemo ea eona le mekhoa ea ts'ebetso. Ho buisana le litsebi tsa bophelo bo botle le litsebi lefapheng lena ho khothaletsoa bakeng sa tlhaiso-leseling e nepahetseng le ea morao-rao mabapi le litlamorao le ts'ebeliso ea CBDP. Ho feta moo, ho reka phofo ea cannabidiphorol (CBDP) ho tsoa mohloling o tšepahalang ho bohlokoa. AASraw, e le setsebi sa cannabidiphorol (CBDP) moetsi oa phofo le mofani oa thepa, a ka fana ka phofo e hloekileng ea cannabidiphorol tlas'a tšehetso ea setsi se ikemetseng sa R & D. Ke khetho e babatsehang ea ho reka kapa ho rekisa phofo ea cannabidiphorol ho tloha AASraw.
U ka reka phofo ea Cannabidiphorol hokae?
Cannabidiphorol (CBDP) phofo ke cannabinoid e batlang e le ncha ebile e sa batlisisoa e fumanehang mefuteng e itseng ea cannabis. Ka lebaka la ho fumaneha ha eona ho fokolang le ho sibolloa ha morao tjena, CBDP ha e fumanehe hangata joalo ka li-cannabinoids tse tsebahalang joalo ka THC le CBD. Ka lebaka leo, tlhokomeliso e lokela ho sebelisoa ha ho nahanoa ka theko ea lihlahisoa tsa CBDP, haholo-holo inthaneteng.
AASraw ba fana ka phofo e hloekileng ea Cannabidiphorol, e entsoeng ka tlas'a litekanyetso tse thata tsa taolo ea boleng ho netefatsa bohloeki le matla. AASraw e fana ka thomello e potlakileng le e masene ho bareki lefatšeng ka bophara, e etsa hore ho be bonolo ho fumana lihlahisoa tseo u li hlokang kapele le ka mokhoa o bonolo.
Mokhoa oa ho reka phofo ea Cannabidiphorol ho tloha AASraw?
❶Ho ikopanya le rona ka sistimi ea rona ea ho botsa ka lengolo-tsoibila, kapa ho re siela nomoro ea hau ea WhatsApp, moemeli oa rona oa litšebeletso tsa bareki(CSR) o tla ikopanya le uena ka mor'a lihora tse 12.
❷ Ho re fa palo le aterese eo u e botsitseng.
❸CRS ea rona e tla u fa khotheishene, nako ea ho patala, nomoro ea ho e sala morao, litsela tsa ho fihla, le letsatsi la ho fihla (ETA).
❹Ho lefa 'me thepa e tla romelloa ka mor'a lihora tse 12.
❺Lintho tse amohetsoeng le ho fana ka maikutlo.
Mongoli oa sengoloa sena:
Ngaka Monique Hong o fumane lengolo UK Imperial College London Faculty of Medicine
Sengoli sa pampiri sa Scientific Journal:
1. Alexandra E. Golliher
Lefapha la Khemistri le Biochemistry, Univesithi ea New Mexico State, United States
2. Pasquale Linciano
Lefapha la Life Sciences, Univesithi ea Modena le Reggio Emilia, Modena, Italy
3. Fred Shahbazi
Lefapha la Khemistri le Biochemistry, Univesithi ea Windsor, Canada
4. Mohsen Hesami
Gosling Research Institute for Plant Preservation, Lefapha la Temo ea Limela, Univesithi ea Guelph, Canada
5. Jason Wallach
Lefapha la Saense ea Meriana, Philadelphia College of Pharmacy, Univesithi ea Saense, Philadelphia, PA, United States
Ha ho ka tsela leha e le efe ngaka/saense ena e buellang kapa ho buella ho rekoa, thekiso, kapa tšebeliso ea sehlahisoa sena ka lebaka lefe kapa lefe. Aasraw ha e na kamano kapa kamano, ho boleloa kapa ho seng joalo, le ngaka ena. Sepheo sa ho qotsa ngaka ena ke ho ananela, ho ananela le ho babatsa lipatlisiso tse felletseng le mosebetsi oa nts'etsopele o entsoeng ke bo-ramahlale ba sebetsanang le ntho ena.
Reference
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[8] Verrico CD, Wesson S, Konduri V, Hofferek CJ, Vazquez-Perez J, Blair E, et al. (Lwetse 2020). "Phuputso e sa sebetseng, e foufetseng habeli, e laoloang ke placebo ea letsatsi le letsatsi cannabidiol bakeng sa phekolo ea bohloko ba canine osteoarthritis". Bohloko. 161 (9): 2191–2202.
[9] Maa E, Figi P (June 2014). "Nyee ea matekoane a bongaka a lefu la sethoathoa". Epilepsia. 55 (6): 783–786.
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Fumana mantsoe a mangata
