Tlhaloso ea Sehlahisoa
Litlhaku tsa Motheo tsa Powder e tala ea CAD031
| Name Product | CAD031 phofo |
| CAS No. | 2071209-49-7 |
| Molecular Formula: | C18H14F6N2O2 |
| Boima ba 'mele: | 404.312 |
| Qhibiliha Point: | N / A |
| Color: | Pula e tiileng e tšoeu |
| Temp Temp Storage: | -20 ° C bakeng sa nako e telele |
Nootropics bakeng sa lefu la Alzheimer's (AD)
Li-nootropics, tse tsejoang hape e le li-compnitive enhancers kapa lithethefatsi tse bohlale, ke lintho tseo ho lumeloang hore li ntlafatsa ts'ebetso ea kelello, mohopolo, boqapi le ts'ebetso ea boko ka kakaretso. Li ka kenyelletsa metsoako ea tlhaho, lithethefatsi tsa maiketsetso, kapa lisebelisoa tsa lijo. Li-nootropics hangata li sebelisoa ho ts'ehetsa bokhoni ba kelello joalo ka mohopolo, ho tsepamisa maikutlo, le ho hlaka kelellong.
Lefapheng la nts'etsopele ea lithethefatsi tsa AD, ho na le bonkgetheng ba 'maloa ba ts'episang ba bontšitseng bokhoni lithutong tsa pele ho kliniki. E mong oa mokhethoa ea joalo ke J-147, lithethefatsi tsa liteko tse bontšitseng liphello khahlanong le bobeli ba AD le botsofali mefuteng ea litoeba.J-147 e fapane le mekhoa e tloaelehileng ea phekolo ea AD ka ho lebisa tlhokomelo liphellong tse thibelang botsofali ho e-na le ho lebisa tlhokomelo ho li-amyloid plaques, e leng letšoao la AD pathology.
Mokhethoa e mong ke CMS121, motsoako o sebetsang e le mafura a acid synthase inhibitor. Liphuputso li bontšitse hore CMS121 e ka sireletsa khahlanong le lipid peroxidation, ea fokotsa ho ruruha, le ho fokotsa tahlehelo ea kelello mefuteng ea transgenic mouse ea AD. Ka ho shebana le metabolism ea lipid, CMS121 e na le ts'episo ea ho sebetsana le lits'ebetso tse sa sebetseng tsa lipid tse amanang le tsoelo-pele ea AD.
Ho phaella ho J-147 le CMS121, ho na le ba bang ba litlhahlobo tsa AD tse ntseng li etsoa lipatlisiso.CAD031 ke nkgetheng ea novel AD ea lithethefatsi e nang le thepa e matla ea methapo ea kutlo. E 'nile ea bontšoa ho fetola ho ruruha, bophelo bo botle ba synaptic, le metabolism ea lipid.CAD031 e boetse e bontšitse katleho ea ho fokotsa likhaello tsa mohopolo le ho ruruha ha boko mefuteng ea mouse ea AD.
Ka kakaretso, nts'etsopele ea bakuli ba lithethefatsi tsa AD lefapheng la nootropics e na le ts'episo ea ho sebetsana le ho fokotseha ha kelello le mekhoa ea methapo ea methapo e amanang le lefu lena. Mekhoa ena e mecha e fana ka menyetla e mecha ea ho ntlafatsa bophelo ba batho ba anngoeng ke AD. Haeba o hloka ho reka phofo ea CAD031 bakeng sa lipatlisiso, ka kopo khetha mofani oa thepa ea ka tšeptjoang inthaneteng.
CAD031 ke eng?
CAD031, eo hape e tsejoang e le CAD-31.CAD-31 e tsoa ho sethethefatsi sa liteko J147. Ke motsoako o mocha o hlahisitsoeng e le mokhoa o ka 'nang oa phekoloa bakeng sa lefu la Alzheimer's (AD) .CAD-31 e bonts'a ts'ebetso e matlafalitsoeng ea methapo ea kutlo ho feta J147 liseleng tsa pele tsa methapo ea methapo ea motho, ho bolelang hore e na le matla a matla a ho susumetsa ho ikatisa ha lisele tsena. Ho feta moo, CAD-31 e fumanoe e khothaletsa tšebeliso ea li-acid tse sa lefelloeng tsa mafura bakeng sa tlhahiso ea matla ka ho fetola boemo ba metabolism ea mafura acid ho hlahisa 'mele ea ketone. Mele ea Ketone e sebetsa e le mohloli o mong oa matla bokong ha maemo a tsoekere a le tlase.
Molek'hule e shebiloeng ea CAD-31 ke ATP synthase, protheine e fumanoang mitochondria. Ka ho lebisa tlhokomelo ea ATP synthase, CAD-31 e ikemiselitse ho fetola mosebetsi oa mitochondrial le metabolism ea matla bokong. Phetoho ena ea metabolism ea matla e ka ba le litlamorao tse ka bang teng ho mafu a neurodegenerative joalo ka lefu la Alzheimer's.
Ke habohlokoa ho hlokomela hore CAD-31 e ntse e le tlas'a lipatlisiso 'me lipatlisiso tse ling lia hlokahala ho utloisisa ka botlalo ts'ebetso ea eona, boemo ba polokeho, le bokhoni ba eona e le mokhoa oa ho phekola AD. Phepelo ea phofo ea CAD031 ha e kholo 'marakeng. Ke lik'hamphani tse 'maloa feela tse ka kopanyang thepa ena.CAD031 mofani oa thepa AASRAW e ka fana ka phofo e phahameng ea CAD031 phofo. Ka lab ea rona e ikemetseng le sehlopha sa litsebi tsa R&D, phepelo e akaretsang ea CAD031 ha se bothata.
CAD031 e sebetsa joang?
CAD031 e sebetsa ka ho lebisa tlhokomelo ea ATP synthase, protheine e fumanoang mitochondria ea lisele.ATP synthase e ikarabella ho hlahisa adenosine triphosphate (ATP), e leng chelete ea mantlha ea matla a lisele. Ka ho fetola tšebetso ea ATP synthase, CAD031 e ikemiselitse ho susumetsa ts'ebetso ea mitochondrial le metabolism ea matla bokong.
CAD031 e bontšitsoe ho ntlafatsa ts'ebetso ea methapo ea kutlo liseleng tsa pele tsa methapo ea kutlo ea motho, ho bolelang hore e hlohlelletsa ho ikatisa ha lisele tsena. E boetse e khothalletsa tšebeliso ea li-acid tse sa lefelloeng tsa mafura bakeng sa tlhahiso ea matla ka ho fetola boemo ba metabolism ea mafura a acid ho hlahisa 'mele ea ketone. Mele ea Ketone e sebetsa e le mohloli o mong oa matla bokong ha maemo a tsoekere a le tlase.
Ka ho fetola metabolism ea matla le ho khothaletsa neurogenesis, CAD031 e ka ba le litlamorao tse ka bang teng tsa ts'ireletso ea methapo. Ho nahanoa hore e thusa ho ts'ehetsa ho phela le ho sebetsa ha methapo ea kutlo le ho thibela liketsahalo tse chefo tse amanang le mafu a amanang le neurodegenerative, joalo ka lefu la Alzheimer's.
Leha ho le joalo, ho bohlokoa ho hlokomela hore mekhoa e nepahetseng ea ts'ebetso ea CAD031 le litlamorao tsa eona tse felletseng li ntse li ithutoa le ho utloisisoa. Ho hlokahala lipatlisiso tse ling ho fumana mokhoa o nepahetseng oa ts'ebetso le bokhoni ba eona e le mokhoa oa ho phekola mafu a methapo ea kutlo.
Melemo ea CAD031 ke efe?
CAD031, joalo ka mokhethoa oa lithethefatsi oa lefu la Alzheimer's (AD), e bontšitse melemo e 'maloa e ka bang teng ho latela lipatlisiso tse teng:
Matlotlo a Neuroprotective: CAD031 e fumanoe e na le thepa e matla ea "neuroprotective" litekong tse ngata tsa lisele tsa methapo tse etsisang chefo e bonoang bokong ba botsofali. Sena se fana ka maikutlo a hore CAD031 e na le monyetla oa ho sireletsa li-neurone ho senya le ho senyeha.
Phokotso ea Khaello ea Mehopolo: Ka mohlala oa mouse oa AD, CAD031 e bontšitse katleho ea phekolo ka ho fokotsa likhaello tsa mohopolo. Ha e fuoa litoeba tsa khale, tse nang le matšoao a AD, CAD031 e lebisitse ho fokotseng ho holofala ha mohopolo, e bonts'ang bokhoni ba eona ba ho ntlafatsa ts'ebetso ea kelello.
Ho ruruha ha Boko ho Fokotsehile: CAD031 e hlokometsoe ho fokotsa ho ruruha ha boko ho litoeba tsa AD. Ka ho fokotsa likarabelo tsa ho ruruha bokong, CAD031 e ka thusa ho fokotsa litlamorao tse mpe tse amanang le mafu a neurodegenerative.
Keketseho ea Synaptic Protein Expression: Kalafo ea CAD031 e bontšitsoe ho eketsa polelo ea liprotheine tsa synaptic bokong. Liprotheine tsa Synaptic li bohlokoa bakeng sa ho boloka likamano tse phetseng hantle lipakeng tsa methapo ea kutlo le ho bapala karolo ea bohlokoa ts'ebetsong ea kelello. Keketseho ea polelo ea protheine ea synaptic e fana ka maikutlo a bokhoni ba CAD031 ho ts'ehetsa bophelo bo botle ba synaptic.
Liphello ho Metabolism ea Mafura le Ho ruruha: CAD031 e fumanoe e na le tšusumetso e kholo ho metabolism ea mafura a mafura le litsela tsa ho ruruha. Sena se fana ka maikutlo a hore CAD031 e ka fetola lits'ebetso tsena, tse ka lebisang ho phello e ntle ho bophelo bo botle ba boko le maemo a neurodegenerative.
U ka reka phofo ea CAD031 hokae?
Qetellong, CAD031 e bonts'a bokhoni bo ts'episang joalo ka lithethefatsi tsa nootropic bakeng sa ntlafatso ea kelello. Ho hlokahala lipatlisiso tse ling ho utloisisa ka botlalo katleho, litlamorao tsa nako e telele, le ts'ebeliso e nepahetseng ea CAD031.CAD031 le metsoako e ts'oanang e na le monyetla oa ho kenya letsoho haholo ho ts'ehetsa boiketlo ba kelello le ho notlolla bokhoni ba motho. Lipatlisiso tse tsoelang pele le tlhahlobo e nang le boikarabelo li tla ba tsa bohlokoa ho sebeliseng melemo ea CAD031 bakeng sa ntlafatso ea kelello le ho rarolla mathata a amanang le ho fokotseha ha kelello le mafu a amanang le neurodegenerative. Ho netefatsa polokeho ea lintho tse joalo, ke habohlokoa ho reka phofo ea boleng bo phahameng ba CAD031 ho moetsi ea hlomphehang. Ho na le liphofshoana tse ngata tsa CAD031 tse rekisoang inthaneteng. Ho e reka inthaneteng e ka ba khetho. Ho netefatsa bohloeki, ka kopo etsa bonnete ba hore ba na le litlaleho tse ikemetseng tsa liteko tse kang COA, HPLC, joalo-joalo.
Tlaleho ea Tlhahlobo ea Phofo ea CAD031-HNMR
HNMR ke eng hona HNMR spectrum e u bolella eng? H Nuclear Magnetic Resonance (NMR) spectroscopy ke mokhoa oa ho hlahloba k'hemistri o sebelisoang ho laola boleng le lipatlisiso bakeng sa ho fumana likahare le bohloeki ba sampuli hammoho le sebopeho sa limolek'hule. Mohlala, NMR e ka sekaseka ka bongata metsoako e nang le metsoako e tsebahalang. Bakeng sa metsoako e sa tsejoeng, NMR e ka sebelisoa ho bapisa le lilaebrari tsa spectral kapa ho fana ka sebopeho sa motheo ka kotloloho. Hang ha sebopeho sa motheo se tsejoa, NMR e ka sebelisoa ho fumana hore na limolek'hule li lumellana joang le tharollo hammoho le ho ithuta thepa ea 'mele boemong ba limolek'hule joalo ka phapanyetsano ea conformational, liphetoho tsa mohato, solubility le diffusion.
Mokhoa oa ho reka Powder ea CAD031 ho AASraw?
❶Ho ikopanya le rona ka sistimi ea rona ea ho botsa ka lengolo-tsoibila, kapa ho re siela nomoro ea hau ea WhatsApp, moemeli oa rona oa litšebeletso tsa bareki(CSR) o tla ikopanya le uena ka mor'a lihora tse 12.
❷ Ho re fa palo le aterese eo u e botsitseng.
❸ CSR ea rona e tla u fa khotheishene, nako ea ho patala, nomoro ea morao-rao, litsela tsa ho fihla, le letsatsi la ho fihla (ETA).
❹Ho lefa 'me thepa e tla romelloa ka mor'a lihora tse 12.
❺Lintho tse amohetsoeng le ho fana ka maikutlo.
Mongoli oa sengoloa sena:
Ngaka Monique Hong o fumane lengolo UK Imperial College London Faculty of Medicine
Sengoli sa pampiri sa Scientific Journal:
1.Trieu-Duc Vu
Laboratori ea Genomics ea Bophelo bo Botle le Bophelo bo Bolelele, Sekolo sa Pharmacy, Univesithi ea Kitasato, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0373, Japan
2.Naoki Ito
Oriental Medicine Research Center, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8642, Japan
3.Devin Kepchia
Cellular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd., La Jolla, CA 92037, USA
4.Marguerite Pele
The Salk Institute for Biological Studies, Cellular Neurobiology, La Jolla, CA, USA.
Ha ho ka tsela leha e le efe ngaka/saense ena e buellang kapa ho buella ho rekoa, thekiso, kapa tšebeliso ea sehlahisoa sena ka lebaka lefe kapa lefe. Aasraw ha e na kamano kapa kamano, ho boleloa kapa ho seng joalo, le ngaka ena. Sepheo sa ho qotsa ngaka ena ke ho ananela, ho ananela le ho babatsa lipatlisiso tse felletseng le mosebetsi oa nts'etsopele o entsoeng ke bo-ramahlale ba sebetsanang le ntho ena.
Reference
[1]Currais A,Huang L,Petrascheck M,Maher P,Schubert D.”Mokhoa oa baeloji ea lik'hemik'hale oa ho khetholla litsela tsa limolek'hule tse amanang le botsofali."Geroscience.2021 Feb;43(1):353-365.doi: 10.1007/ s11357-020-00238-5.Epub 2020 Jul 23.PMID: 32705410
[2]Pele ho M,Goldberg J,Chiruta C,Farrokhi C,Kopynets M,Roberts AJ,Schubert D.”Ho khetha bakeng sa bokhoni ba methapo ea kutlo e le mokhoa o mong oa ho sibolla lithethefatsi tsa lefu la Alzheimer."Alzheimers Dement.2016 Jun;12(6): 678-86.doi: 10.1016/j.jalz.2016.03.016.Epub 2016 May 2.PMID: 27149904
[3] Ruth Beckervorderandforth, Chiara Rolando. https://doi.org/10.1016/j.coph.2019.12.002
[4] David Schubert, Antonio Currais, Joshua Goldberg, Kim Finley, Michael Petrascheck, Pamela Maher.” Ho theola neurogenesis ea motho ho utloisisa le ho loantša mathata a boko. ”https://doi.org/10.1016/j.coph.
