BPC-157

BPC-157 ke eng?

BPC-157, e khuts'oane bakeng sa "Body Protection Compound 157", ke peptide ea maiketsetso e nkiloeng tatellanong e sa fellang ea Body Protection Compound (BPC) e tsoang lero la motho ka mpeng. E na le ketane ea li-amino acid tse 15 'me ho lumeloa hore e na le matla a ho tsosolosa le ho folisa.BPC-157 e tsejoa ka liphello tsa eona tsa phekolo tse ka' nang tsa e-ba teng ho li-tissue le mekhoa e sa tšoaneng ea 'mele. mekhoa e fapaneng ea 'mele, haholo-holo ho khothalletsa pholiso le tokiso ea lisele. Ho lumeloa hore e na le phello e ntle tsamaisong ea mala, tsamaiso ea mesifa le methapo e bohareng.

Kaha liphuputso li bontšitse hore peptide BPC-157 e ka khothalletsa ho lokisoa le ho tsosolosoa ha mesifa ea mesifa, ho akarelletsa le li-tendon, li-ligaments le mesifa, 'me e bontšitse liphello tse ntle kalafong ea mafu a kang maqeba a Achilles, meokho ea mesifa le fractures. .BPC-157 e hohetse tlhokomelo ea baatlelete, baetsi ba 'mele, le batho ka bomong ba nang le thahasello ea ho khothalletsa ho hlaphoheloa le ho folisa. Millionaire, Dan Bilzerian, o kile a arolelana PED (Performance Enhancing Drugs) eo ae sebelisitseng ho Instagram, ho akarelletsa le BPC-157.

BPC-157 e sebetsa joang?

Mokhoa o nepahetseng oa ts'ebetso ea BPC-157 ha o utloisisoe ka botlalo mme o ntse o le tlas'a lipatlisiso. Mekhoa e reriloeng e kenyelletsa nts'etsopele ea angiogenesis, ho feto-fetoha ha karabelo ea ho ruruha, ho susumetsa tlhahiso ea collagen, tšireletso khahlanong le khatello ea oxidative, le ho sebelisana le mabaka a ho hōla.BPC-157 e bontšitsoe ho khothalletsa ho thehoa ha methapo e mecha ea mali, e thusang ho lokisoa ha lisele. le ho ntlafatsa phallo ea mali. E ka boela ea fokotsa ho ruruha ka ho fetola karabelo ea 'mele ea ho itšireletsa mafung le ho khothalletsa ho lokolloa ha lintho tse khahlanong le ho ruruha. Ho feta moo, BPC-157 e susumetsa tlhahiso ea collagen, e thusang ho lokisoa ha lisele le botšepehi ba sebopeho. E bonts'a thepa ea antioxidant, e sireletsa lisele le lisele ho tsoa tšenyo ea oxidative.

Ho feta moo, AASraw BPC-157 e ka 'na ea sebelisana le lintlha tsa khōlo tse amehang ho lokisoeng ha lisele le ho tsosolosoa, ho khothalletsa ho ata ha lisele, ho arohana, le ho tsosolosoa ha lisele. Ke habohlokoa ho hlokomela hore mekhoa ena e reriloeng e thehiloe lithutong tsa pele-pele tse entsoeng haholo-holo mefuteng ea liphoofolo. Ho hlokahala lipatlisiso tse ling ho utloisisa ka botlalo hore na BPC-157 e sebetsa joang bathong le lits'ebetso tsa eona tsa kalafo tse ka bang teng.

Ho bohlokoa ho reka BPC-157 ho mofani oa thepa ea tsebahalang e le hore boleng ba peptide BPC-157 bo ka netefatsoa. Setsebi sa BPC-157 moetsi le mofani oa thepa AASraw a ka fana ka BPC-157 ka boleng bo phahameng bakeng sa tšehetso ea setsi se ikemetseng sa R&D le fektheri. Haeba u na le litlhoko, BPC-157 wholesale ho tloha AASraw ke khetho e ntle.

Melemo ea BPC-157

BPC-157, kapa Body Protection Compound 157, ke peptide e nkiloeng ho protheine e fumanoang ka mpeng. E 'nile ea e-ba taba ea lithuto tse ngata ka lebaka la liphello tsa eona tsa phekolo. Ho bohlokoa ho hlokomela hore le hoja lipatlisiso tsa pele li ntse li tšepisa, lipatlisiso tse ngata, haholo-holo bathong, lia hlokahala ho utloisisa liphello tsa eona ka botlalo le tšebeliso e ka bang teng. Mona ke melemo e meng e ka bang teng ea BPC-157.

①Ho Nchafatsoa le ho Lokisoa ha Tissue

BPC-157 e tsebahala ka bokhoni ba eona ba ho folisa le ho nchafatsa lisele. Peptide ena e ka 'na ea potlakisa ts'ebetso ea ho hlaphoheloa ha li-tendon tse lemetseng, li-ligamente, mesifa le masapo, e leng se etsang hore e be letlotlo la bohlokoa ho phekola likotsi tsa lipapali, mathata a mesifa, le maemo a mang a amanang le tšenyo ea lisele.

②Thepa e Khahlanong le Tšoaetso

BPC-157 e bonts'a thepa e makatsang ea anti-inflammatory. Ka ho fokotsa ho ruruha le ho fetola karabelo ea 'mele ea ho itšireletsa mafung, e ka ba sesebelisoa sa bohlokoa sa ho laola maemo a khetholloang ke ho ruruha ho sa foleng ho kang lefu la ho ruruha ha mala (IBD), ramatiki le mafu a sa tšoaneng a autoimmune.

③Ho Tsosolosoa ha Gastrointestinal

BPC-157 e ntse e hlahlojoa ka bokhoni ba eona ba ho tsosolosa le ho sireletsa pampitšana ea gastrointestinal (GI). E ka thusa ho lokisa liso tsa ka mpeng, lefu la mala a ho ruruha, tšenyo ea mala, le mathata a mang a GI ka ho khothaletsa nchafatso ea lisele tsa GI, ho fokotsa ho ruruha, le ho matlafatsa ts'ebetso ea thibelo ea mala.

④Bokhoni ba Neuroprotective

BPC-157 e bontšitse thepa ea neuroprotective lithutong tsa pele. E ka fana ka ts'ireletso khahlanong le tšenyo ea boko e bakiloeng ke kotsi e sithabetsang ea boko (TBI), stroke, le mafu a neurodegenerative. Ho feta moo, e ka ntlafatsa ts'ebetso ea methapo le ho matlafatsa ts'ebetso ea methapo.

⑤Angiogenesis le Sebopeho sa Lijana tsa Mali

BPC-157 e fumanoe e susumetsa angiogenesis, kapa ho thehoa ha methapo e mecha ea mali. Sena se ka thusa ho lokisa lisele le ho folisa maqeba ka ho matlafatsa phallo ea mali libakeng tse senyehileng.

⑥Melemo e Meng e ka Khonehang

Liphuputso tsa pele li bontša hore peptide BPC-157 e ka fana ka melemo e eketsehileng, ho kenyelletsa le ho fokotsa bohloko, ho ntlafatsa bophelo bo botle le ho feto-fetoha ha maemo, ho eketsa ts'ebetso ea 'mele ea ho itšireletsa mafung, le ho fetola li-neurotransmitters tse amanang le maikutlo le kutloisiso. Leha ho le joalo, lipatlisiso tse felletseng lia hlokahala ho tiisa litlamorao tsena ka botlalo.

Ho bohlokoa ho tseba hore ho na le bahlahisi le barekisi ba bangata ba BPC-157 inthaneteng kapa kantle ho marang-rang, leha ho le joalo, ha se bohle ba tšepahalang. Bakeng sa liphello tse ntle, etsa bonnete ba hore u reka BPC-157 ho moetsi oa setsebi le mofani oa thepa.AASraw e khethehile tlhahiso le phepelo ea BPC-157 ho latela litlhoko tsa tlhahiso ea CGMP, 'me sehlopha se seng le se seng sa lihlahisoa se tlameha ho etsa tlhahlobo ea boleng pele e rekisoa. .

Litla-morao tsa BPC-157

BPC-157 ka kakaretso e nkoa e bolokehile ebile e mamelloa hantle ha e sebelisoa ka nepo. Leha ho le joalo, joaloka ho kenella leha e le efe ea phekolo, ho na le monyetla oa ho ba le litla-morao. Ke habohlokoa ho hlokomela hore lintlha tse teng tsa saense mabapi le litla-morao tsa BPC-157 ho batho li na le moeli, kaha liphuputso tse ngata li entsoe ka mefuta ea liphoofolo. Likarabo tsa motho ka mong li ka 'na tsa fapana,' me litla-morao tse latelang tse ka 'nang tsa e-ba teng li thehiloe litlalehong tse sa tloaelehang le lipatlisiso tse fokolang.

Khalefo ea Sebaka

Basebelisi ba bang ba tlalehile ho utloa bohloko bo fokolang, bofubelu, kapa ho teneha sebakeng sa ente. Hangata sena se ka laoloa ka ho fetola mokhoa oa ente kapa ho sebelisa boholo bo bonyenyane ba nale.

Mathata a tshilong ya dijo

BPC-157 e ka baka bothata ba nakoana ba tšilo ea lijo, joalo ka ho nyekeloa ke pelo, mahlaba ka mpeng, kapa letšollo. Hangata matšoao ana ha a bonolo ebile a feta nakoana.

Liketso tse fokolang

Le hoja e le ntho e sa tloaelehang, batho ba bang ba ka 'na ba e-ba le maikutlo a ho kula ho BPC-157. Matšoao a ka kenyelletsa lekhopho, ho hlohlona, ​​ho ruruha, kapa ho hema ka thata. Haeba matšoao leha e le afe a ho kula a hlaha, tlhokomelo ea meriana e lokela ho batloa hang-hang.

Tšebelisano le Meriana

BPC-157 e ka 'na ea sebelisana le meriana kapa liphekolo tse itseng. Ke habohlokoa ho buisana le setsebi sa tlhokomelo ea bophelo haeba u noa meriana leha e le efe kapa u e-na le maemo a tlase a bongaka pele u qala BPC-157.

Joaloka peptide leha e le efe kapa phekolo ea phekolo, ho khothalletsoa ho buisana le setsebi sa tlhokomelo ea bophelo pele u sebelisa BPC-157. Li ka fana ka tataiso, tsa lekola likotsi tse ka bang teng, le ho beha leihlo tsoelo-pele ea hau ho netefatsa ts'ebeliso e bolokehileng le e nepahetseng. Ho phaella moo, ho reka li-peptide mohloling o nepahetseng ke habohlokoa.AASraw e laola ka thata boleng 'me e hlahisitse sehlopha sa boleng bo phahameng ba BPC-157 e rekisoang. Rea u amohela ho reka peptide BPC-157 ha ho hlokahala.

BPC-157 VS.TB 500 VS.IGF-1 LR3

BPC-157, IGF-1 LR3 (Long arginine 3-IGF-1), le TB500 (Thymosin Beta-4) ke li-peptide tse nkoang haholo tse tsejoang ka tlatsetso ea tsona ea bohlokoa ho folisa, ho hlaphoheloa le ho lokisoa ha lisele. Le ha ba arolelana lipheo tse tšoanang, peptide ka 'ngoe e na le melemo le mesebetsi e fapaneng. Mona ke kakaretso ea li-peptide tsena tse ka thusang ho utloisisa liphapang tsa tsona hantle.

Boitsebiso bo fanoeng mona ha boa lokela ho nkoa e le keletso ea bongaka. Melemo le mekhoa ea ts'ebetso ea IGF-1 LR3, TB500, le BPC 157 e boletsoeng ka holimo e thehiloe haholo-holo lithutong tsa pele le palo e lekanyelitsoeng ea liteko tsa meriana. Le hoja lintho tsena li bontšitse monyetla oa ho folisa le ho tsosolosoa maemong a itseng, tšebeliso ea tsona e lokela ho lula e le tlas'a tataiso ea setsebi sa tlhokomelo ea bophelo ka lebaka la litla-morao tse ka 'nang tsa e-ba teng, liphello tse sa tsejoeng tsa nako e telele, le ho fapana ha motho ka mong ho arabela.

 Na BPC-157 e thusa ka ho aha 'mele?

BPC-157 e fumane tlhokomelo sechabeng sa kaho ea 'mele ka lebaka la melemo ea eona e ka bang teng bakeng sa ho hlaphoheloa ha mesifa, pholiso ea likotsi le bophelo bo botle bo kopanetsoeng. Le hoja ho na le lipatlisiso tse fokolang tsa saense tse lebisang tlhokomelo ka ho khetheha liphellong tsa BPC-157 mabapi le ho haha ​​​​'mele, litlaleho tse ling tsa li-anecdotal li fana ka liphello tse ntle.

Pholiso ea mesifa

BPC-157 e ka thusa ka ho tsosolosa mesifa ka ho khothalletsa ho lokisoa ha lisele le ho fokotsa ho ruruha. Ho 'nile ha bontšoa ho potlakisa ho hlaphoheloa ha likotsi tsa mesifa, mathata le meokho.BPC-157 e ka thusa baetsi ba' mele hore ba hlaphoheloe ka potlako ho tloha ho ikoetlisa ka matla ka ho eketsa mokhoa oa ho folisa, ho ka fokotsa phomolo pakeng tsa lithupelo.

Pholiso ea Kotsi

Ho haha ​​​​'mele, haholo-holo ho phahamisa boima, ho ka ba le khatello ea mesifa, li-tendon le li-ligamente, ho eketsa menyetla ea ho tsoa kotsi.BPC-157 e bontšitse tšepiso ea ho thusa ho hlaphoheloa ha lisele, haholo-holo li-tendon le li-ligaments. E ka thusa ho hlaphoheloa likotsing tse amanang le koetliso ka ho khothalletsa ho lokisoa ha lisele le ho fokotsa ho ruruha.

Bophelo bo Botle bo Kopanetsoeng

Lihahi tsa 'mele li hloka manonyeletso a phetseng hantle hobane li khothalletsa sebopeho se setle, mefuta e mengata ea ho sisinyeha, le ts'ebetso e akaretsang.BPC-157 e na le litšobotsi tse khahlanong le ho ruruha' me e 'nile ea etsoa e le phekolo ea bohloko ba manonyeletso le ho ruruha. E ka kenya letsoho ntlafatsong ea koetliso le ts'ebetsong ka kakaretso ka ho khothaletsa bophelo bo botle bo kopanetsoeng le ho fokotsa ho se phutholohe.

Ke habohlokoa ho hlokomela hore liphihlelo tsa motho ka mong ka BPC-157 li ka fapana, 'me lipatlisiso tsa saense tse batlisisang ka ho khetheha liphello tsa eona ho haha' mele li lekanyelitsoe. Ho phaella moo, BPC-157 ha ea lokela ho nkoa e le sebaka sa koetliso e nepahetseng, phepo e nepahetseng, le khetho ea bophelo ka kakaretso ea bohlokoa bakeng sa katleho ea ho haha ​​​​'mele.

Haeba u nahana ho sebelisa BPC-157 bakeng sa merero ea ho haha ​​​​'mele, ho kgothaletswa ho buisana le setsebi sa tlhokomelo ya bophelo se nang le tsebo ka dikalafo tsa peptide. Ba ka fana ka keletso ea motho ka mong, ba nahanela lipakane le maemo a hao a khethehileng, 'me ba u tataisa mabapi le tšebeliso e nepahetseng ea BPC-157 hammoho le likarolo tse ling tsa mokhoa oa hau oa ho haha' mele.

Tlaleho ea Tlhahlobo ea BPC-157-HNMR

HNMR ke eng hona HNMR spectrum e u bolella eng? H Nuclear Magnetic Resonance (NMR) spectroscopy ke mokhoa oa ho hlahloba k'hemistri o sebelisoang ho laola boleng le lipatlisiso bakeng sa ho fumana likahare le bohloeki ba sampuli hammoho le sebopeho sa limolek'hule. Mohlala, NMR e ka sekaseka ka bongata metsoako e nang le metsoako e tsebahalang. Bakeng sa metsoako e sa tsejoeng, NMR e ka sebelisoa ho bapisa le lilaebrari tsa spectral kapa ho fana ka sebopeho sa motheo ka kotloloho. Hang ha sebopeho sa motheo se tsejoa, NMR e ka sebelisoa ho fumana hore na limolek'hule li lumellana joang le tharollo hammoho le ho ithuta thepa ea 'mele boemong ba limolek'hule joalo ka phapanyetsano ea conformational, liphetoho tsa mohato, solubility le diffusion.

Mokhoa oa ho reka BPC-157 ho tloha AASraw?

❶Ho ikopanya le rona ka mokhoa oa rona oa ho botsa ka lengolo-tsoibila, kapa ho re siela nomoro ea hau ea WhatsApp, moemeli oa rona oa litšebeletso tsa bareki (CSR) o tla ikopanya le uena ka mor'a lihora tse 12.

❷ Ho re fa palo le aterese eo u e botsitseng.

❸ CSR ea rona e tla u fa khotheishene, nako ea ho patala, nomoro ea morao-rao, litsela tsa ho fihla, le letsatsi la ho fihla (ETA).

❹Ho lefa 'me thepa e tla romelloa ka mor'a lihora tse 12.

❺Lintho tse amohetsoeng le ho fana ka maikutlo.

Mongoli oa sengoloa sena:
Ngaka Monique Hong o fumane lengolo UK Imperial College London Faculty of Medicine

Sengoli sa pampiri sa Scientific Journal:
1. Andrea Zemba Cilic
Mafapha a Pharmacology le Pathology, Sekolo sa Bongaka, Univesithi ea Zagreb, Zagreb, Croatia
2. Anita Zenko Sever
Lefapha la Pathology, Sekolo sa Bongaka, Univesithi ea Zagreb, Zagreb, Croatia
3. Sanja Masnec
Lefapha la Univesithi ea Ophthalmology, Setsi sa Sepetlele sa Univesithi ea Zagreb, Zagreb, Croatia
4. Vedran Cesarec
Lefapha la Pharmacology, Lefapha la Bongaka, Univesithi ea Zagreb, Zagreb, Croatia
Ha ho ka tsela leha e le efe ngaka/saense ena e buellang kapa ho buella ho rekoa, thekiso, kapa tšebeliso ea sehlahisoa sena ka lebaka lefe kapa lefe. Aasraw ha e na kamano kapa kamano, ho boleloa kapa ho seng joalo, le ngaka ena. Sepheo sa ho qotsa ngaka ena ke ho ananela, ho ananela le ho babatsa lipatlisiso tse felletseng le mosebetsi oa nts'etsopele o entsoeng ke bo-ramahlale ba sebetsanang le ntho ena.

References

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[2] Gwyer D,Wragg NM,Wilson SL.Gastric pentadecapeptide body protection compound BPC 157 le karolo ea eona ho potlakisa pholiso ea mesifa le masapo a bonolo.Cell Tissue Res.2019

[3] Amic F,Drmic D,Bilic Z,Krezic I,Zizek H,Peklic M,et al.Ho feta ho koaleha ha venous le maqeba a duodenal ho likhoto,le kalafo ka gastric pentadecapeptide e tsitsitseng BPC 157,L-NAME le L-arginine. J Gastroenterol.2018;24: 5366-5378.

[4] Sikiric P,Seiwerth S,Rucman R,Turkovic B,Rokotov DS,Brcic L,et al.Toxicity by NSAIDs.Counteraction by stable gastric pentadecapeptide BPC 157.Curr Pharm Des.2013;19: 76–83.

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