Alprostadil, (PGE1), Prostaglandin E1

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AASraw e na le bokhoni ba tlhahiso ea tlhahiso le tlhahiso ho tloha ho gram ho ea ka taelo e kholo ea Alprostadil, (PGE1), Prostaglandin E1 (745-65-3), tlas'a taolo ea CGMP le tsamaiso ea tšebetso ea boleng bo tsitsitseng.

Prostaglandin E1 (PGE1), eo hape e tsejoang e le alprostadil, ke prostaglandin e tloaelehileng e sebelisoang e le meriana. Ho masea a nang le bokooa ba pelo, o sebelisoa ke ho kenngoa ha moriana o fokolang ho kena monoaneng ho bula li-arteriosus ho fihlela opereishene e ka etsoa. Ka ente e kenang botoneng kapa ho kenngoa hoa mokokotlo, e sebelisoa ho sebetsana le ho se sebetse ha eretile.

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Alprostadil, (PGE1), Prostaglandin video ea E1


I.Aproprodilla, (PGE1), Prostaglandin E1 ea motheo:

Name: Alprostadil, (PGE1), Prostaglandin E1
CAS: 745-65-3
Molecular Formula: C20H34O5
Boima ba 'mele: 354.48
Melt Point: 115-116 ° C
Temp Temp Storage: 2 ° -8 ° C
Color: Pula e tšoeu


II. Alprostadil, (PGE1), tšebeliso ea Prostaglandin E1 (745-65-3) ho potoloho ea steroid

1. Mabitso:

Alprostadil, (PGE1), Prostaglandin E1 (CAS 745-65-3), e bitsoang Avastin le Mvasi.

2. Alprostadil, (PGE1), Prostaglandin E1 Sebeliso:

Bevacizumab e tla le tharollo ea ho tsamaisa butle-butle. Bevacizumab e laoloa ke ngaka kapa mooki setsing sa bongaka, setsing sa ho kenyelletsa metsi, kapa sepetlele. Bevacizumab hangata e fuoa hanngoe ka libeke tsa 2 kapa 3.

E lokela ho nka metsotso ea 90 hore u fumane tekanyo ea hau ea pele ea bevacizumab. Ngaka kapa mooki o tla le shebella haufi ho bona kamoo 'mele oa hau o sebetsang kateng ho bevacizumab. Haeba u se na mathata a tebileng ha u fumana tekanyo ea hau ea pele ea bevacizumab, hangata e nka 30 metsotsoana ea 60 hore u fumane litekanyetso tsa hao tse setseng tsa meriana.

Injection ea Bevacizumab e ka baka likarabo tse tebileng ha ho tšeloa meriana. Haeba u e-na le matšoao a mang a latelang, bolella ngaka hang-hang: ho phefumoloha ho thata kapa phefumoloho e khutšoanyane, ho tsukutleha, ho sisinyeha, ho fufuleloa ke hlooho, hlooho ea sefuba, mokokotlo, ho ikutloa u felloa ke matla, ho fofa, ho hlohlona, ​​ho phatloha kapa mahare. Ngaka ea hau e ka 'na ea hloka ho fokotsa ho theoha ha hao, kapa ho lieha kapa ho emisa phekolo ea hau haeba u e-na le litla-morao tsena kapa tse ling.

3.How Alprostadil, (PGE1), Prostaglandin E1 (745-65-3) e sebetsa?

Bakeng sa phekolo ea ho se sebetse ha erectile (ED), alprostadil e khutlisa mesifa e boreleli ea corpus cavernosum; leha ho le joalo, ha ho tsejoe hantle hore na liketso tsa ketso li sebetsa joang. Ho bonahala eka liphello tsena li bakoa ke ho eketsa likhahla tsa intracellular tsa AMP. Alprostadil e amahanya le li-membrane tse nang le lisele tse hlahisang adenylate cyclase le ho phahamisa AMP ea li-cyclic cyclic, e leng ho lebisang ho ts'ebetsong ea protein kinase le ho phomola ha mesifa. Ketso ena e fapane le papaverine e thibelang phosphorylation e kenyelletsoeng ho thibela phallo ea AMP le ho kena-kenana le khaseletso ea khalsiamo nakong ea mesifa ea mesifa. Alprostadil e ka 'na ea boela ea hanyetsa liketso tsa vasoconstrictive tsa norepinephrine ka ho thibela ho lokolloa ha norepinephrine ea neuronal' me ho ka eketsa liketso tsa li-neurotransmitter tse sa sebetsaneng le li-non-nainergic. Ha ho phekoloa ED, alprostadil e etsa hore motho a khaotse ho hlaphoheloa ke methapo e metle le ho theola methapo ea li-cavernosal le makala a tsona. Ho fokotseha ha methapo ea cavernosal ho tsamaisana le ho eketseha ha lebelo la ho theoha ha matla le ho eketseha ha likhahla tsa maqhubu. Ka lebaka leo, li-lacunar libaka li eketseha 'me mali a kenngoa mokokotlong ka bobeli ho tlatsana ha likokoana-hloko khahlanong le tunica albuginea. E le ho finyella tumescence e lekaneng le ho tiea, tunica albuginea e tlameha ho ba thata ka ho lekaneng bakeng sa ho sitisa likokoana-hloko ho kenella le ho thibela phallo ea maqhubu. Ts'ebetso ena e boetse e bitsoa mekhoa e tloaelehileng ea veno-occlusive. Alprostadil ha e ame ka ho toba ho ejaculation kapa orgasm.

Ha phekolo ea ductus arteriosus e itšetlehile ka bokooa ba pelo bo botala, alprostadil e boloka ductal patency ka ho phomola mesifa e boreleli ea ductus arteriosus. Alprostadil e sebetsa feela haeba e fanoe pele ho koaloa ka ho feletseng ha anatomic ea ductus arteriosus. Ts'ebetso ea li-alprostadil ho li-neonate tse nang le bokooa ba pelo bo fokolang (ho thibela mali a phallo ea mali) li fella ka keketseho ea mali a phallo le / kapa keketseho ea ho kopanya pakeng tsa tsamaiso ea metsoako le ea pulmona e lebisang hoketseho ea nakoana ea khatello ea mali e nang le khatello ea mali (PaO2) le saturation ea oksijene. Karabo ea phekolo ea cyanotic neonate ea alprostadil therapy e boetse e amana le ho latellana le poxNUMX. Karabo e kholo ka ho fetisisa e bonahala e le ho li-neonate tse nang le bothata bo tlaase ba pele ho PaO2 (<2 torr), narrowing ductus arteriosus, le bao e leng matsatsing a 20 kapa a le monyenyane. Li-neonates tse nang le maruo a PaO4 a 2 torr kapa ho hangata ha li na karabelo e fokolang ho alprostadil.

Li-neonate tse nang le phekolo ea mali e sa thibeloang, tsamaiso ea alprostadil e ka fella ka ho thibela kapa ho lokisa acidemia, ho eketseha ha pelo ea pelo le ho eketseha ha khatello ea mali ea mali, ho eketseha ha morali oa mocheso oa molumo, ho eketseha ha mali le ho sebetsa, ho theoha ho theoha ha khatello ea mali ea aortic (ka li-neonate tse nang le khohlano ea aorta), le / kapa ho fokotseha ha karolelano ea mochine oa pulmona ho hatella ho theoha khatello ea aortic (ka li-neonates le ho sitisoa ha sefate sa aortic). Ho fapana le li-cyanotic neonates, ts'ebetso ea alprostadil ea li-acyanotic neonates ha e itšetlehe ka lilemo tsa khale kapa ho tlotlisa pele ho PaO2.

4.Hape litaelo:

Alprostadil (Prostglandin E1) e sebelisoa ho sebetsana le ho se sebetse ha erectile (ED) ho banna ba baholo. Ts'ebetso ea alprostadil ho phekola ED e fapana le sesosa; tekanyo ea likarabo hangata e fokotseha ho bakuli ba nang le ED ka lebaka la li-etiologies tse tsoakaneng ha li bapisoa le ba nang le ED ka lebaka la methapo ea methapo ea pelo, ea psychogenic, kapa mabaka a vasculogen. Mefuta e 'meli ea litekanyetso e rekisoa bakeng sa ho phekola ED: sehlahisoa sa transurethral (Muse) se sebelisang pellet e nang le meriana e tsamaisoang ho urethra le ente (Caverject kapa Edex) e kenngoa ka ho toba ka corpus cavernosa. Mefuta e meng ea litekanyetso tse kang gelisi ea lihlooho le lenaneo la ho fana ka liposomal tse sa hlaselang li ntse li hlahlojoa. Ho ea ka tataiso ea phekolo ea ED, mofuta oa liphosphodiesterase oa mofuta oa 5 inhibitors (PDE5 inhibitor) o nkoa e le phekolo ea meriana ea pele. Methati ea phekolo ea meriana ea bobeli e kenyeletsa entracavernous injection le phekolo ea intra-urethral. Kalafo ea Intracavernous e entsoeng ke phekolo e sa sebetseng ka ho fetisisa ea ED, ka karabo e sa tsejoeng le e tsitsitseng. Leha ho le joalo, e hlasela ebile e na le litla-morao tse bonahalang tse kenyelletsang ho akarelletsa le priapism le penile fibrosis. Litumello tsa FDA ke tse latelang: Caverject ka July 1995, MUSE ka October 1996, le Edex ka June 1997.

Alprostadil le prostaglandine tse ling lihloohong tsa E ka tlhaho li teng ka placenta le ductus arteriosus ea fetus. E-type prostaglandins vasodilate arterioles ka ho phomola ka ho toba ha mesifa e boreleli e boreleli. Liphello tse ling tsa pharmacologic li kenyeletsa keketseho ea lik'hemik'hale tsa pelo, ho hlahisa lijana tsa systemic le tsa pulmonary, ho theola li-ductus arteriosus, ho thibela sekhahla sa li-platelet, ho ba le khatello ea mesifa ea bolulo, ho eketseha ha ho tsoa mali ea mali, le ho lieha ha lesapo ho senya nako. Intravenous alprostadil e sebelisetsoa li-neonate tse thibelang ho tsoa ka ntle kapa ho le letšehali ho tsoa holimo ho boloka botumo ba ductus arteriosus ho fihlela nako ea ho buuoa kapa ho buuoa ka palliative. Hangata Alprostadil e atleha haholo ho li-neonate tse nang le mali a fokolang mali a 'maloa PO2 le bao e leng matsatsi a 4 kapa a seng makae. Linakong tse kholo ho feta matsatsi a 4, ho na le ho fokotseha ha meriana e fokolang ea mesifa e tsitsitseng ka lebaka la liphetoho tsa morao-rao leboteng la ductus arteriosus. Intravenous alprostadil e hloka tlhokomelo ea ho phefumoloha nakong ea tsamaiso hobane apnea e qala ho 10-12% ea lihlahisoa. Alprostadil ke FDA e amohelehang ho bakuli ba bana ba sa le monyenyane. Prostin VR Pediatric e ile ea amoheloa ke FDA ho 1981.


III. Alprostadil, (PGE1), Prostaglandin E1 (745-65-3) HCML

Re li-poure tsa Aprepitant, Prepitant phofo e rekisoang, Raw Aprepitant powder (170729-80-3) hplc≥98% | Ho hlahisa li-Reagents tsa R &amp; D


IV. Joang ho reka Alprostadil, (PGE1), Prostaglandin E1 ho tloha AASraw?

1.To iteanye le rona ka imeile ea rona lenaneo la lipatlisiso, kapa skype ea inthanetengmoemeli oa tšebeletso ea bareki (CSR).
2.To re fane ka lipotso tsa hau le lipotso tsa hau.
3.Our CSR e tla u fa tlhaloso, nako ea ho lefa, nomoro ea ho latela, litsela tsa ho pepa le letsatsi la ho fihla ho fihlela (ETA).
4.Payment e entsoe mme thepa e tla romelloa ka lihora tsa 12 (Ho laela ka hare ho 10kg).
5.Goods e amohetse mme e fana ka litlhaloso.


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