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Alfaxalone

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Alfaxalone ke molek'hule ea neuroactive steroid e nang le thepa ea moriana o thethefatsang kutlo. Alfaxalone e hlalosoa ka lik'hemik'hale e le 3-α-hydroxy-5-α-pregnane-11, 20-dione, 'me e na le boima ba limolek'hule 332.5…

Tlhaloso ea Sehlahisoa

Litšobotsi tsa Motheo

Name Product Alfaxalone
Nomoro ea CAS 23930-19-0
Molecular Formula C21H32O3
Boima ba 'mele 332.48
Li-synonyms Alphaxalone;

Alfaxalone;

23930-19-0;

5-alpha-Pregnan-3alpha-ol-11,20-dione;

Alfaxalonum.

Ponahalo Pula e tšoeu
Ho Boloka le ho Sebetsana Boloka ka mocheso oa kamore e laoloang -20 ° C

 

Tlhaloso ea Alfaxalone

Alfaxalone ke molek'hule ea neuroactive steroid e nang le thepa ea moriana o thethefatsang kutlo. Alfaxalone e hlalosoa ka lik'hemik'hale e le 3-α-hydroxy-5-α-pregnane-11, 20-dione, 'me e na le boima ba limolek'hule 332.5. Mochini o ka sehloohong oa ketso e thethefatsang kutlo ea alfaxalone ke ho feto-fetoha ha methapo ea methapo ea methapo ea methapo ea methapo ea methapo ea methapo, e hlohlelletsoang ke ho tlama alfaxalone ho GABAA (gamma-aminobutyric acid) cell receptors.

 

Mokhoa oa ketso oa Alfaxalone

Alfaxalone e hlahisa ho akheha ka ho sebetsa ho li-receptor tsa gamma aminobutyric acid subtype A (GABAA) tsamaisong ea methapo e bohareng (CNS). Li-receptor tsena ke liteishene tse nang le li-ionotropic tse nang le ligand, mme GABA ke ligand ea tsona e sa feleng. GABA ke methapo ea kutlo e ka sehloohong e thibelang methapo ea kutlo ho CNS. Kamora hore mokelikeli o kenngoe tšebetsong, mocha o bula le ho khothaletsa ho kenella ha chloride ka seleng, ho baka ho fetella ha lera la postynaptic. Ha e le maemong a tlase, alfaxalone e tsamaisa hantle li-chloride hajoale ka mocha oa chloride; empa maemong a phahameng, e sebetsa joalo ka agonist ea GABA, ka tsela e ts'oanang le barbiturates. Sephetho ke sedation e tebileng kapa ho kenoa ha anesthesia, ho latela tekanyetso le tsela ea tsamaiso.

 

Kopo ea Alfaxalone

Alfaxalone, eo hape e tsejoang e le alphaxolone kapa alphaxalone 'me e sebelisoa tlasa lebitso la khoebo Alfaxan, ke neuroactive steroid le moriana o thethefatsang kutlo o sebelisoang lintja le likatse. E ka sebelisoa e le moemeli oa induction kapa bakeng sa thethebatso e akaretsang.

 

Alfaxalone Melemo le Likotsi

  • le menyetla:

Alfaxalone e baka phetoho e nyane lipehelong tsa pelo kapa khatello ea mali ha litekanyetso tse amehang tsa bongaka li fuoa bakuli ba phetseng hantle. Alfaxalone e na le lethathamo le phahameng la kalafo, e sebetsa ka bokhutšoanyane ebile ha e bokelle letho. Litšobotsi tsena li etsa hore alfaxalone e loketse ho sebelisoa e le moemeli oa induction kapa bakeng sa ho fana ka anesthesia e nang le kankere.

Alfaxalone e ka boela ea fuoa methapo ea methapo, ka hona e ka sebelisoa ho kokobetsa bakuli ba sa sebelisaneng. Ha alfaxalone e sebelisetsoa ho kokobetsa mokuli lethal dose ke 1-3mg / kg IM 'me hangata e tsamaisoa' moho le opioid bakeng sa sedation e nepahetseng.

Ha alfaxalone e sebelisoa bakeng sa likaroloana tsa masea, malinyane a falimehile ebile a phetse hantle ka lintlha tse ntlafalitsoeng tsa AGPAR ha li bapisoa le propofol.

 

  • go tlhoka mesola:

Alfaxalone e baka khatello ea maikutlo e amanang le ho hema, 'me apnea e kanna ea etsahala kamora ho entoa ka potlako ea IV. Itokisetse ho intubate, ho fana ka tšehetso ea oksijene, le ho hema moea ha o sebelisa alfaxalone bakeng sa ho kenella kapa ho phomola.

Tsamaiso e fetelletseng ea alfaxalone e ka baka khatello ea maikutlo e itšetlehileng ka pelo, mme phokotso e kholo ea tlhahiso ea pelo le khatello ea mali. Tekanyo ea alfaxalone e lokela ho ngoloa ka hloko ho bakuli ba fokotsang methapo ea pelo kapa methapo e sa tsitsang ea hemodynamically.

Alfaxalone ha e fane ka li-analgesia, ka hona e lokela ho sebelisoa hammoho le opioid e nepahetseng bakeng sa lits'ebetso tse bohloko.

Ha alfaxalone e sebelisoa ka intramuscularly, bophahamo ba ente bo ka ba boholo, mme bo ka baka bohloko ho ente. Molumo o moholo o ka etsa hore tsamaiso e be thata ha ho na le fensetere e fokolang ea ente ka lebaka la bohale ba mokuli. Tsamaiso ea Alfaxalone e kanna ea fella ka ho hlaphoheloa hampe ho khetholloang ka mekhahlelo e fapaneng ea ho soka, ho bitsa mantsoe le / kapa myoclonus.

 

Reference

[1] Whittem T, Pasloske KS, Heit MV le al. (2008) Pharmacokinetics le pharmacodynamics ea alfaxalone ka likatseng kamora taolo e le 'ngoe le e mengata ea methapo ea Alfaxan litekong tsa bongaka le tsa bongaka. J Vet Pharmacol Ther 31 (6), 571-579.

[2] Ferre PJ, Pasloske K, Whittem T le al. (2006) Plasma pharmacokinetics ea alfaxalone lintja kamora bolus ea methapo ea Alfaxan-CD. Vet Anaesth Analg 33, 229-236.

[3] Muir W, Lerche P, Wiese A le al. (2009) Liphello tsa pelo le pelo e thethefatsang moriana oa alfaxalone likatseng. Vet Anaesth Analg 36, 42-54.

[4] Clarke KW, Trim CM, Hall LW, lingoliloeng. (2014). "Khaolo ea 15: Anesthesia ea ntja". Anesthesia ea bongaka ba liphoofolo (11th ed.). Oxford: WB Saunders. maq. 135-153.

[5] Varga M (2014). "Khaolo ea 4: Anesthesia le Analgesia". Buka ea sengoloa ea Rabbit Medicine (2nd ed.). Butterworth-Heinemann. maq. 178-202.

[6] Nieuwendijk H (Hlakubele 2011). "Alfaxalone". Sehlopha sa Ts'ehetso sa Bongaka ba Bongaka ba Bongaka. E khutlisitsoe ka la 14 Phupu, 2017.

[7] Zeltzman P (Pherekhong 17, 2014). "Hobaneng ha ho tsamaisa Alfaxalone ho hloka thuto e nyane". Litaba tsa Boithuto ba Bongaka ba Liphoofolo. E khutlisitsoe ka la 14 Phupu, 2017.