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acid-Aminobutyric acid (GABA: 56-12-2)

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GABA e nkiloe ka molomo bakeng sa ho imolla matšoenyeho, ho ntlafatsa maikutlo, ho fokotsa matšoao a premenstrual syndrome (PMS), le ho sebetsana le khaello ea khatello ea maikutlo (ADHD) E boetse e sebelisetsoa ho khothaletsa kholo ea mesifa, ho chesa mafura, ho tsitsisa khatello ea mali le ho kokobetsa bohloko.

Tlhaloso ea Sehlahisoa

Litšobotsi tsa Motheo

Name Product acid-Aminobutyric acid (GABA)
Nomoro ea CAS 56-12-2
Molecular Formula C4H9NO2
Boima ba 'mele 103.12
Li-synonyms 4-aminobutyric acid

4-Aminobutanoic acid

asiti ea gamma-aminobutyric

GABA

56-12-2

Ponahalo Pula e tšoeu
Ho Boloka le ho Sebetsana E omme, e lefifi le 0 - 4 C ka nako e khuts'oane, kapa -20 C nako e telele.

 

acid-Aminobutyric acid (GABA)Tlhaloso

γ-aminobutyric acid, kapa gamma-Aminobutyric acid, kapa GABA, ke eona methapo e ka sehloohong e thibelang methapo ea kutlo tsamaisong ea methapo ea mammalian e holileng. Karolo ea eona ea mantlha ke ho fokotsa thabo ea methapo ea kutlo hohle tsamaisong ea methapo.

GABA e rekisoa e le tlatsetso ea lijo linaheng tse ngata. Ka tloaelo ho nahanoa hore GABA e makatsang (ke hore e nkuoa e le tlatsetso) ha e tšele mokoallo oa mali le boko, leha ho le joalo tlhaiso-leseling e fumanoeng lipatlisisong tsa hajoale e bontša hore ho ka khonahala.

 

γ-Aminobutyric acid (GABA) Mokhoa oa Ts'ebetso

Lithethefatsi tse sebetsang joalo ka li-allosteric modulators tsa GABA receptors (tse tsejoang ka hore ke li-analog tsa GABA kapa lithethefatsi tsa GABAergic), kapa li eketsa palo e fumanehang ea GABA, hangata e na le litlamorao tse khathollang, tse loantšang matšoenyeho le tse thibelang ho ferekana. Lintho tse ngata tse ka tlase li tsejoa li baka anterograde amnesia le retrograde amnesia.

Ka kakaretso, GABA ha e tšele tšitiso ea mali le bokong, leha likarolo tse ling tsa boko tse se nang tšitiso e sebetsang ea mali le boko, joalo ka khubu ea periventricular, li ka fihlelleha ka lithethefatsi tse kang GABA e entšitsoeng ka mokhoa o hlophisehileng. Bonyane phuputso e le 'ngoe e fana ka maikutlo a hore GABA e fanoang ka molomo e eketsa palo ea li-hormone tsa kholo ea motho (HGH). GABA e kenngoe ka kotloloho bokong e tlalehiloe e na le litlamorao tse matlafatsang le tse thibelang tlhahiso ea hormone ea kholo, ho latela fisioloji ea motho ka mong. Litlhare tse ling tsa pro-drug tsa GABA (ex. Picamilon) li entsoe hore li kenelle mokoaneng oa mali le bokong, ebe li arohana le GABA le molek'hule e tsamaisang hang kahare ho boko.

GABA e ntlafalitse catabolism ea serotonin ho N-acetylserotonin (selelekela sa melatonin) ka likhoto. Kahoo ho belaelloa hore GABA e kentse letsoho ho qaptjoeng ha melatonin mme ka hona e ka ba le litlamorao tsa taolo litirong tsa boroko le tsa ho ikatisa.

 

acid-Aminobutyric acid (GABA) kopo

Gamma-Aminobutyric Acid ke methapo ea kutlo e hlahang ka tlhaho e nang le tšebetso e thibelang methapo ea kutlo (CNS). Gamma-aminobutyric acid (GABA), e fetotsoeng ho tsoa ho neurotransmitter glutamate ea mantlha bokong, e bapala karolo ea ho laola thabo ea methapo ea kutlo ka ho tlamella li-receptor tsa eona, GABA-A le GABA-B, mme ka hona ea baka ho buloa ha kanale ea ion, hyperpolarization mme qetellong thibelo ea methapo ea kutlo.

Gamma-aminobutyric acid ke gamma-amino acid eo e leng butanoic acid e nang le sebaka sa amino se fumanehang ho C-4. E na le karolo ea ho bontša molek'hule, metabolism ea motho, Saccharomyces cerevisiae metabolite le neurotransmitter. Ke gamma-amino acid le monocarboxylic acid. E tsoa ho asiti ea butyric. Ke asiti ea conjugate ea gamma-aminobutyrate. Ke tautomer ea gamma-aminobutyric acid zwitterion.

 

Melemo ea γ-Aminobutyric acid (GABA)

GABA e nkiloe ka molomo bakeng sa ho imolla matšoenyeho, ho ntlafatsa maikutlo, ho fokotsa matšoao a premenstrual syndrome (PMS), le ho sebetsana le khaello ea khatello ea maikutlo (ADHD) E boetse e sebelisetsoa ho khothaletsa kholo ea mesifa, ho chesa mafura, ho tsitsisa khatello ea mali le ho kokobetsa bohloko.

 

Reference

1, Chapouthier G, Venault P (Mphalane 2001). "Khokahano ea litlama pakeng tsa lefu la sethoathoa le matšoenyeho?". Mekhoa ea Pharmacol. Sci. 22 (10): 491–3. doi: 10.1016 / S0165-6147 (00) 01807-1. PMID 11583788.

2, Campagna JA, Miller KW, Forman SA (Mots'eanong 2003). "Mekhoa ea liketso tsa li-anesthetics tse hetsitsoeng". N. Engl. J. Med. EA-348 (21): 2110–24. doi: 10.1056 / NEJMra021261. PMID 12761368.

3, Müller EE, Locatelli V, Cocchi D (Mmesa 1999). "Taolo ea Neuroendocrine ea kholo ea sephiri sa" hormone ". Physiol. Tšen. 79 (2): 511-607. doi: 10.1152 / physrev.1999.79.2.511. PMID 10221989.

4, Matla ME, Yarrow JF, McCoy SC, Borst SE (Pherekhong 2008). "Hormone ea kholo ea kholo e arabela ho kenella ha GABA nakong ea phomolo le kamora ho ikoetlisa". Bongaka le Saense lipapaling le ho ikoetlisa. 40 (1): 104-10. doi: 10.1249 / mss.0b013e318158b518. PMID 18091016.

5, Balemans MG, Mans D, Smith I, Van Benthem J (1983). "Tšusumetso ea GABA ho tswakana ha N-acetylserotonin, melatonin, O-acetyl-5-hydroxytryptophol le O-acetyl-5-methoxytryptophol ka tšoelesa ea phaene ea Rist e tona ea Wistar". Ho ikatisa, phepo e nepahetseng, Nts'etsopele. 23 (1): 151-60. doi: 10.1051 / rnd: 19830114. PMID 6844712.

6, Sato S, Yinc C, Teramoto A, Sakuma Y, Kato M (2008). "Modulation ea thobalano ea GABA (A) ea maqhubu a melatonin ka likhoto gonadotropin-e lokollang li-hormone neurons". J Physiol Sci. 58 (5): 317--322. doi: 10.2170 / physiolsci.rp006208. PMID 18834560.

7, Kuriyama K, Sze PY (Pherekhong 1971). "Tšitiso ea mali-bokong ho H3-γ-aminobutyric acid liphoofolong tse tloaelehileng le tse amino oxyacetic acid". Neuropharmacology. 10 (1): 103-108. doi: 10.1016 / 0028-3908 (71) 90013-X. PMID 5569303.

8, Foster AC, Kemp JA (Hlakubele 2006). "Phekolo ea CNS ea Glutamate- le GABA". Curr Opin Pharmacol. 6 (1): 7-17. doi: 10.1016 / j.coph.2005.11.005. PMID 16377242.