N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide

AASraw e na le bokhoni ba tlhahiso le tlhahiso ho tloha ho gram ho ea ka taelo ea N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-681136-29, tlas'a taolo ea CGMP le tsamaiso e tsitsitseng ea boleng ba boleng.

N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamid powder ke piperazinyl phenyl urea eo mohaho oa eona o fapaneng le li-alkyl carbamates le li-alpha-keto heterocyclic metsoako 'me ke motsoako o matla le o khethollang mafura a amide hydrolase (FAAH) (IC50s = 34 le 33 nM phakong le batho ka ho latellana) ho tšela thibelo ea mali le boko. 1 Ha 20 mg / kg, e kopanya ka mokhoa o ts'oanang le sebaka sa mafolofolo sa FAAH ka ho ts'oanela ho sebetsa ha urea ho hlahisang aniline le FAAH-poperazinyl carbamate.

Tlhaloso ea Sehlahisoa

N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide video


I.N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide basic Characters:

Name: N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
CAS: 681136-29-8
Ho hloeka: ≥99% (HPLC)
Li-synonyms: JNJ 1661010;N-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinecarboxamide;Takeda-25;1-Piperazinecarboxamide, N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-;JNJ 1661010, >=98%
Molecular Formula: C19H19N5OS
Boima ba 'mele: 365.459
Ntlha e qhibilihisang: 240.48
Ntlha e belang: 559.69 ° C ho 760 mmHg
Botenya: ~ 1.3 g / cm3
Temp Temp Storage: Boloka ho + 4 ° C
Solubility: DMSO: ≥28mg / mL
Index ea ts'ebetso: N20D 1.68
Color: Kristalline e tiileng
InChI: InChI=1S/C19H19N5OS/c25-18(20-16-9-5-2-6-10-16)23-11-13-24(14-12-23)19-21-17(22-26-19)15-7-3-1-4-8-15/h1-10H,11-14H2,(H,20,25)
InChI Key: BHBOSTKQCZEAJM-UHFFFAOYSA-N


II. N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid Tšebeliso ea poula ka potoloho:

1.Name:

N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid powder, JNJ 166101 Poda

2. Mosebetsi oa N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid e sebelisoa joang?

FAAH e etselitsoeng pele ka JNJ-1661010 e fana ka ts'ebetso e fokolang ea ho sebelisana pakeng tsa JNJ1661010 le sebaka se sebetsang, se potlakileng licheso tse phahameng. JNJ-1661010 ke substrate inhibitor e tsitsitseng, e sebetsanang le LC-ESI-MS. JNJ-1661010 laolloang thepa le phenylthiadiazole ka kotopo hydrophobic le phenylurea ka pokothong hydrophilic tsa FAAH, JNJ-1661010 (20 mg, / lik'hilograma IP) thibela FAAH ke bonyane 85% ya ho fihlela ho 4 H mora dosing, sephetho le bokella lipid li-ethanolamides ka boko ba rat. JNJ-1661010 e itšetlehile ka tekanyo ea meriana e hlalosang allodynia e tactile e nang le katleho e ka holimo ho 90% ho 30 min kamora 'me ka bobeli likarolo tse bobebe tsa ho futhumala ha metsi (MTI) litoeba le mekhoa ea boleng. JNJ-1661010 (20 mg / kg) e fetola allodynia ea tactile ka 60.8% ho 30 min mokhoeng oa kotsi oa mokokotlo oa lesapo la mokokotlo. JNJ-1661010 (50 mg / kg ip) e bonts'a tlhokomelo e kholo ea hyperalgesia ho 30 min ka mor'a hore e be mohlala oa rat carrageenan oa bohloko ba ho ruruha.
Li-rats tse nang le JNJ-1661010 (20 mg / kg ip) li na le plasma Cmax ea 26.9 μM ho Tmax ea 0.75 h le Cmax bokong ba 6.04 μM Tmax ea 2 h. JNJ-1661010 (20 mg / kg ip) e thibela boko ba FAAH ebile e phahamisa lekala la AEA likarolong tsa boko ba rat.

3.Tlatsoa ka N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid powder

4.Hape litaelo:

5. N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamid Powder:

Ntho e nyenyane 10grams.
Tlhahlobo ka bongata bo tloaelehileng (ka hare ho 1kg) e ka romeloa lihora tse 12 kamora ho lefa.
Bakeng sa tlhahiso e kholo (ka hare ho 1kg) e ka romeloa ka matsatsi a sebetsang a 3 ka mor'a ts'ebetso.

6. N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid Powder Recipes:

Ho botsa bareki ba rona baemeli ba rona (CSR) bakeng sa lintlha tse eketsehileng, bakeng sa boitsebiso ba hau.

7. N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid powder Marketing:

Ho fanoa nakong e tlang.


III. N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamide phofo ea HNMR


IV. Joang ho reka N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamide powder ho tloha AASraw?

1.To iteanye le rona ka imeile ea ronalenaneo la lipatlisiso, kapa skype ea inthanetengmoemeli oa tšebeletso ea bareki (CSR).
2.To re fane ka lipotso tsa hau le lipotso tsa hau.
3.Our CSR e tla u fa tlhaloso, nako ea ho lefa, nomoro ea ho latela, litsela tsa ho pepa le letsatsi la ho fihla ho fihlela (ETA).
4.Payment e entsoe mme thepa e tla romelloa ka lihora tsa 12 (Ho laela ka hare ho 10kg).
5.Goods e amohetse mme e fana ka litlhaloso.


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