Cortexolone 17α-propionate phofo (19608-29-8) hplc≥98% | AASraw
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Cortexolone 17α-propionate phofo

Rating: SKU: 19608-29-8. Category:

AASraw e na le bokhoni ba tlhahiso le tlhahiso ho tloha ho gram ho ea ka taelo ea Kortexolone 17A-propionate powder (19608-29-8), tlas'a taolo ea CGMP le tsamaiso ea boleng bo sebetsang ba boleng.

Tlhaloso ea Sehlahisoa

 

Video ea phote ea Cortexolone 17α-propionate

 

 


 

Cortexolone 17α-propionate phofo tsebo ea motheo

 

Name: Cortexolone 17α-propionate phofo
CAS: 19608-29-8
Limolek'hule Mokgwa wa ho Nahana: C24H34O5
Boima ba limolek'hule: 402.52
Melt Point:
Temp Temp Storage: Mocheso oa kamore
Color: E tsoeu ho fihlela phofo e tšoeu ea phofo

 


 

Kortexolone 17α-propionate potoloho

 

Mabitso

CAS: 19608-29-8
Lebitso la Lik'hemik'hale: cortexolone-17α-propionate,
Mabitso a mang: CB-03-01, Winlevi phofo, Breezula phofo, 11-deoxycortisol 17α-propionate, Cortexolone 17α-propionate phofo

 

Sebeliso ea Cortexolone 17α-propionate

Cortexolone 17A-propionate ke steroidal antiandrogen e entsoeng ka metsoako-haholo-holo, mohanyetsi oa li-androgen-e leng tlas'a nts'etsopele ea Cassiopea le Intrepid Therapeutics ho sebelisoa e le meriana ea litlhapi ho phekola maemo a torogen a itšetlehileng ka acne vulgaris le alopecia ea androgenic ho lahleheloa ke moriri)

 

Tekanyo ea Cortexolone 17α-propionate ke efe?

Cortexolone 17α-propionate 1% tranelate, e leng antiandrogen e ncha e matla bakeng sa phekolo ea li-acne vulgaris. Mofofisi oa lifofane, thuto ea ho bapisa habeli le sefofu ho latela li-placebo le tretinoin 0 · 05% tranelate.

MOSEBETSI

Acne vulgaris ke bothata ba lits'ebetso tse tšollang mali tseo li-androgens li kenellang ho tsona le ho phehella. Ka hona, tšebeliso ea antiandrogens e ka atleha; Leha ho le joalo, li-antiandrogens tsa tšebeliso ea litlhapi ha li fumanehe 'marakeng. Cortexolone 17α-propionate ke ntho e ncha ea antiandrogen e ka sehloohong e ka sebelisoang ke acne vulgaris.

LIPOTSO

Ho hlahloba polokeho le lihlooho tsa puisano bohlokwa ba tsamaiso ea Cortexolone 17α-propionate 1% tranelate ka maqoqomete vulgaris ka bapisoa le placebo le le tretinoin 0 · 05% tranelate.

METHODA

Banna ba mashome a supileng a metso e supileng ba nang le makhopho a sefahleho ba hapileng 2-3 ho latela Investigator's Global Assessment (IGA) ba ile ba fuoa li-cream tsa placebo (n = 15), kapa Cortexolone 17α-propionate 1% cream (n = 30), kapa tretinoin 0 · 05 % tranelate (n = 32) hang ka letsatsi nakong ea ho robala libeke tse 8. Ts'ebetso ea bongaka e ile ea hlahlojoa libeke tse ling le tse ling tsa 2 ho kenyeletsoa palo ea lisosa (TLC), palo ea ho ruruha ha lesion (ILC), li-acne severity index (ASI) le IGA. Tekolo ea polokeho e kenyelelitse lintlha tsa lehae tsa ho teneha, liteko tsa laboratori, tlhahlobo ea 'mele, matšoao a bohlokoa le ho rekota liketsahalo tse mpe.

LIPOTSO

CB-03-01 tranelate ile hantle haholo mameletse, 'me e ne e haholo molemo ho feta placebo mabapi TLC (P = 0 · 0017), ILC (P = 0 · 0134) le ASI (P = 0 · 0090),' me hape ea bongaka atlehang haholoanyane ho feta ho bapisa. Sehlahisoa sena se boetse se entse hore ho be le katleho e fokolang ea 50% ntlafatso mefuteng ena e ka holimo. CB-03-01

CONCLUSIONS

Thuto ena ea lifofane e tšehetsa moelelo oa tšebeliso ea li-antiandrogens tsa lihlooho tsa meriana kalafo ea acne vulgaris. Cortexolone 17A-propionate 1% tranelate e bonahala e lumellana le boemo ba antiandrogen e ntle bakeng sa tšebeliso ea lipapali.

 

Kamoo Cortexolone 17α-propionate e sebetsang kateng

Cortexolone 17A-propionate (CAS 19608-29-8), kapa 11-deoxycortisol 17α-propionate, ke steroidal antiandrogen ea maiketsetso - haholo-holo, mohanyetsi oa li-androgen-e leng tlas'a nts'etsopele ea Cassiopea le Intrepid Therapeutics ho sebelisoa e le meriana ea lihlooho phekolo ea maemo a itšetlehileng ka androgen ho akarelletsa le acne vulgaris le alopecia ea androgenic (ho lahleheloa ha moriri-mekhoa ea botho). Ke ester ea C17A propionate ea 11-deoxycortisol (cortexolone); C17α esters tsa 11-deoxycortisol ne ho sa lebelloa fumanoa ho rua mosebetsi antiandrogen, le cortexolone 17α-propionate o ile a khethoa bakeng sa ntshetsopele e thehiloeng profil lona Optimum lithethefatsi.

Likokoanyana, lithethefatsi li fumanoe li e-na le tšebetso e matla ea antiandrogen sebakeng sa moo, empa e sa hlokomelehe tsamaiso ea antiandrogen ha e tsamaisoa ka ho kenya meriana e nyenyane. Ho phaella moo, cortexolone 17α-propionate ha e tsoe pele, e fana ka maikutlo a hore e khetha ka hohle-hohle. Sebakeng sa tlhaho ea liphoofolo tse phelang, pheko ea moriana e ne e le khōlō ho feta progesterone, flutamide, le finasteride 'me e ne e lekana le ea cyproterone acetate.

A motsamaisi ea tleleniki qoso 2011 tsa banna tšoaroa ka ea lihlooho tsa puisano cortexolone 17α-propionate 1% tranelate bakeng sa maqoqomete fumane hore lithethefatsi e ne e haholo hantle mameletse 'me haholo fokotswa matšoao a maqoqomete a makhopho. Ho feta moo, katleho ea eona e ne e le khōlō haholo ho feta ea setšoantšo se sebetsang, tretinoin 0.05% tranelate. Ha e le ea 2017, meriana ena e le litekong tsa lik'hemik'hale tsa phalline ea phalline bakeng sa liteko tsa acne vulgaris le liteko tsa bobeli ba lik'hemik'hale bakeng sa alopecia ea androgenic.

 

temoso ea

Cortexolone 17α-proprionate, phofo ea Breezula ka mefuta ea eona ea polymorphic: lelapa la pele la patent, le felang United States ka 2022/23 le 2022 lefats'eng lohle, le akaretsa ts'ebeliso ea bongaka ea komporo bakeng sa kalafo ea makhopho, alopecia le mafu a mang; lelapa la bobeli la litokelo tsa molao le koahela mefuta eohle e tsebahalang ea kristale ea API, lipina tse nang le API e tšoanang le ts'ebeliso ea bongaka e amanang le eona ho phekola makhopho, AGA le mafu a mang: lelapa lena la litokelo tsa molao le se le fanoe United States, Europe, Canada, Japane le linaha tse ling, li tla felloa ke nako ka 2030 United States le 2028 lefats'eng lohle.Breezula powder

 

Kortexolone 17A-propionate Mofuthu o Phoroselang

Ntho e nyenyane 10grams.
Tlhahlobo ka bongata bo tloaelehileng (ka hare ho 1kg) e ka romeloa lihora tse 12 kamora ho lefa.
Bakeng sa taolo e kholo e ka romeloa matsatsing a ts'ebetso ea 3 ka mor'a ts'enyehelo.

 

Cortexolone 17A-propionate Raw Powder Recipes

Ho botsa bareki ba rona baemeli ba rona (CSR) bakeng sa lintlha tse eketsehileng, bakeng sa phofshoana ea hau ea phofo ea winlevi

 

Kortexolone 17α-propionate Marketing

Ho fanoa nakong e tlang.

 

Na Cortexolone 17A-propionate e na le liphello tse mpe

Cortexolone 17α-propionate ke motjha steroidal-Ester, peripherally khetha androgen-antagonist, re filoe mosebetsi o bonolo antiinflammatory, eo ho bonahalang ho ikhethang loketseng bakeng sa kalafo ya maqoqomete vulgaris. CB-03-01 e sebetsana le boemo ba motho le myrogen-receptor ntle le ho thibela 5-ho fokotsa letlalo. Steroid e kenella ka hare ho letlalo la motho mme e potlakela ho fetola motsoako oa motsoako oa cortexolone, o se nang metsoako. Ntho ea bohlokoa, ho fihlela joale, ha e bontšitse litla-morao tsa lehae kapa tsa systemic steroid.

 


 

Ho reka phofo ea Cortexolone 17A-propionate ho tloha AASraw

 

1.To iteanye le rona ka imeile ea rona Sisteme ea lipotso, kapa skype ea inthanetengmoemeli oa tšebeletso ea bareki (CSR).
2.To re fane ka lipotso tsa hau le lipotso tsa hau.
3.Our CSR e tla u fa tlhaloso, nako ea ho lefa, nomoro ea ho latela, litsela tsa ho pepa le letsatsi la ho fihla ho fihlela (ETA).
4.Payment e entsoe mme thepa e tla romelloa ka lihora tsa 12 (Ho laela ka hare ho 10kg).
5.Goods e amohetse mme e fana ka litlhaloso.