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β-Nicotinamide Mononucleotide

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AASraw e na le lengolo la ho fana ka lihlahisoa tse khahlanong le botsofali-Powder ea NMN ka bongata ka taolo ea CGMP le sistimi e laoloang ea boleng bo phahameng. Tlhahiso ea rona ea khoeli le khoeli e ka fihla ho 1500kg. Rea u amohela ho ikopanya le rona bakeng sa tlhaiso-leseling e batsi ea ho reka:
Boemo: E teng setokong

Sehlopha sa Liphutheloana: 1kg / mokotla, 25kg / moqomo

Tlhaloso ea Sehlahisoa

Litšobotsi tsa Motheo

Name Product β-Nicotinamide Mononucleotide (NMN)
Nomoro ea CAS 1094-61-7
Molecular Formula C11H15N2O8P
Boima ba 'mele 334.22
Li-synonyms NMN;

β-D-NMN;

BETA-NMN;

beta-D-NMN;

Phofo ea NMN;

Zwitterion ea NMN;

NICOTINAMIDE RIBOTIDE;

Nicotinamide nucleotide;

Mononucleotide ea Nicotimide.

Ponahalo Pula e tšoeu
Ho Boloka le ho Sebetsana 2-8 ° C sebakeng se ommeng

Ntlha ea Bohlokoa:

AD NAD + ke coenzyme ea bohlokoa e hlokahalang bakeng sa ts'ebetso ea bophelo le lisele.

Methati ea NAD +, haholo-holo mofuta oa eona oa NAD +, ka tlhaho e fokotseha ka lilemo ho lisele tse ngata.

Body 'Mele o theha NMN e le mohato oa lipakeng kapa "selelekela" ho NAD +. Ka mantsoe a bonolo: maemo a phahameng a NMN a bolela maemo a phahameng a NAD +.

E tsejoa: Lihloohong tse latelang, NMN e sebelisitsoeng ho fapana le β-Nicotinamide Mononucleotide (NMN)


 

Semelo sa NMN- NAD + & NMN

NAD + ke motsoako o ikhethang, o tsoelang pele ho etsoa 'meleng oa rona mme o sebelisoa ke li-enzyme tse ngata tsa bohlokoa ho thusa ho khothaletsa tšebetso e ntle ea lisele. Leha ho le joalo, kaha NAD + e sebelisoa molemong oa ho fehla li-enzyme tsena, re qala ho kena likhaello tsa NAD + maemong a fapaneng maphelong a rona, ka maqhubu a ntseng a eketseha ha re ntse re tsofala. Kaha li-enzyme tsena tse nang le matla a NAD + li bapala karolo ea bohlokoa ho boloka matla a sele, le ho khothaletsa bophelo bo botle ba sele, ho theoha ha NAD + ho ka ba kotsi haholo ho bophelo ba rona ka kakaretso.

Ka lebaka la sena, ho entsoe lipatlisiso tse ngata ho khothaletsa maemo a NAD + 'meleng. Khopolo ea ho khothaletsa maemo a NAD + ke hore e tla ba le ts'ehetso e matla bakeng sa mesebetsi e mengata ea bohlokoa ea 'mele, ka hona e ka thusa ho khothaletsa bophelo bo bolelele. Habohlokoa ka ho fetisisa leha ho le joalo, maemo a ntlafalitsoeng a NAD +, ha a lokela ho ts'ehetsa feela ho phela halelele, hape a ka thusa ho khothaletsa bophelo bo betere ha re ntse re tsofala!

Joale re phahamisa maemo a NAD + joang? Sena se bonahala se le bobebe. Leha ho le joalo, lipatlisiso tsa morao-rao li sibollotse motsoako o ikhethileng o bitsoang Nicotinamide Mononucleotide (NMN), oo 'mele o ka o sebelisang e le selelekela se sebetsang hantle sa NAD +. Ka khopolo, sena se bolela hore NMN e ka khothaletsa bophelo bo bolelele le bo phetseng hantle!

Leha ho le joalo, NMN ha se feela bophelo bo bolelele bo khabane bo khothalletsang tlatsetso. Ebile, NMN ke tlatsetso e ntle bakeng sa batho ba banyenyane le ba baholo, kaha e na le tšusumetso ea bohlokoa ho sa tsotelehe lilemo tsa hau. Bacha le batho ba baholo ka bobeli ba hloka maemo a phahameng a NAD + bakeng sa 'mele ea bona le likelello ho matha maemong a holimo. Ha maemo a hau a NAD + a phahame, o tla ba le matla a eketsehileng a lisele, 'me mmele le kelello ea hau li tla khona ho sebetsa maemong a boima haholo. Ha re ts'epahalleng, ke mang ea neng a ke ke a sebelisa hanyane lefats'eng lee le potlakileng le le hlokang? Kahoo, haeba u batla ho lefisa lisele tsa hau, 'me u labalabela ho tseba hore na' mele le kelello ea hau li ka fihlella eng ka NAD + e eketsehileng, re tla u khothaletsa ho lula u bala blog ena e phethahetseng e etselitsoeng ho u thusa ho fumana tse ngata tsoa tlatsetsong ea NMN!

 

NMN ke eng?

NMN (Nicotinamide Mononucleotide) ke ea lelapa la li-nucleotide, limolek'hule tse fumanehang lijong tse ngata tseo re li jang. Joalo ka li-nucleotide tsohle, NMN e entsoe ka likarolo tse 3: setsi sa naetrojene, tsoekere le sehlopha sa phosphate.

Ha li-nucleotide tse ngata li sebelisoa ho aha DNA, NMN e sebelisetsoa ho etsa nicotinamide adenine dinucleotide (NAD +) le ho lekanya matla a lekanang hantle. 'Mele o theha NMN e le mohato oa lipakeng kapa "selelekela" ho NAD +. Ka mantsoe a bonolo: maemo a phahameng a NMN a bolela maemo a phahameng a NAD +.

NAD + e eketsa chelete ea mantlha ea matla a 'mele (ATP), e lekanya morethetho oa circadian, mme e nolofalletsa makholo a liphetoho tsa enzymatic - tseo bongata ba tsona li liehisang botsofali. Methati ea NAD +, haholo-holo mofuta oa eona oa NAD +, ka tlhaho e fokotseha ka lilemo ho lisele tse ngata.

 

NMN e Sebetsa Joang? / Hobaneng o Hloka tlatsetso ea NMN?

NR le NMN ka bobeli li na le molemo hobane li phahamisa maemo a NAD +, a fokotsehang ka lilemo. NAD + e bohlokoa ho metabolism ea lisele, ho fetola limatlafatsi matla a cellular, hape e etsa li-sirtuine, sehlopha sa liprotheine tse laolang bophelo bo botle ba lisele. Kaofela re fumana NAD + 'meleng ea rona ka lebaka la lijo tsa rona, ka ho ja lijo tse nang le li-precurs tsa NAD + ho tsona. Le ha NR le NMN li ka fumanoa ka bongata lijong tse fapaneng, leha ho le joalo, motho a ke ke a ja letho le lekaneng ho matlafatsa maemo a NAD +. Ka lebaka leo, ho tlatselletsa ka selelekela sa NAD + ho ka thusa ho fokotsa ho theoha.

 

Melemo ea NMN

  • NMN e matlafatsa phepelo ea matla liseleng tsa botsofali:

Lisele lia kenella ebe li sebetsana le mafura ho matlafatsa mesebetsi ea tsona. Ha ba ntse ba tsofala ba lahleheloa ke bokhoni bona, ba ba qobella ho ba maemong a tsejoang e le senescence ea cellular kapa botsofali ba tlhaho bo tlisoang ke litlamorao tse ling. NAD + eo e leng karolo ea mantlha ea phepelo ea mafura ea sele ho nahanoa hore ke eona feela tsela eo NMN e ka kenyang letsoho ka eona Sena se bolela hore ho tlatselletsa le NMN ho fa lisele tsa hau tsela e potlakileng haholo ea ho eketsa mafura le ho khothaletsa karohano ea lisele le kholo.

 

  • NMN e thusa ho loants'a maloetse a ts'oaetso:

Ha u ntse u tsofala, maemo a kang lefu la tsoekere, botenya, dyslipidemia, le lefu la sebete le se nang joala (NAFLD) lea ata. Li bakoa ke phokotso ea maemo a NAD +. NMN e sebetsa ka tsela ea poloko ho matlafatsa maemo a NAD + ka hona e matlafatsa maloetse ana le a mang a ts'oaetso.

 

  • NMN e nchafatsa phallo ea mali e fokolang:

Ha 'mele o ntse o tsofala, palo le mesebetsi ea lisele tsa endothelial (ECs) tse koahelang methapo ea mali lia fokotseha. likepe.

 

  • NMN e hatella leruo le amanang le lilemo:

Ha batho ba ntse ba tsofala, ba nona. Phuputsong ea 2016, ho fumanoe hore lithuto tse fuoeng NMN li bone mafura a tsona a fokotseha le ho eketseha ha boima ba 'mele. Ka ho tlatselletsa le NMN, u ka theola boima ba 'mele' me ua haha ​​mesifa-litsela tse peli tse matla tsa ho ntlafatsa bophelo bo botle ba mesifa le ho shebahala le ho ikutloa u le monyane!

 

  • NMN e matlafatsa metabolism ea matla:

Ka ho tsepamisa mohopolo oa NAD +, NMN e thusa ho senya limatlafatsi ho matla, ho matlafatsa likarolo tsa bohlokoa tsa lisele le ho fokotsa khatello ea maikutlo. Ts'ebetso ena ea biochemical e lieha mme e kanna ea emisa botsofali. NMN ha e matlafatse matla a hau feela empa e thusa ho lokisa lisele tsa hau!

 

Polokeho ea NMN le litlamorao

NMN e nkuoa e bolokehile liphoofolong, 'me liphetho li ts'episa ho lekana hore liteko tsa batho li qalile. Molek'hule ena e nkuoa e bolokehile ebile e se chefo, leha e le maemong a phahameng ho litoeba le thutong ea motho. Tsamaiso ea molomo ea nako e telele (selemo se le seng) litoeba ha e na litlamorao tse chefo. Teko ea pele ea bongaka ho batho e phethetsoe mme bopaki bo tšehetsa mohopolo oa hore ha e na chefo tekanyong e le 'ngoe.

Le ha phuputso e le 'ngoe ea banna ba Majapane e phatlalalitsoeng ka Pherekhong 2019 e hlokometse hore lihlooho li eketsehile ka bongata ba bilirubin maling a bona kamora tsamaiso ea NMN, maemo ana a lula maemong a tloaelehileng. Lithuto tsa nako e tlang li lokela ho shebana le ts'ireletso ea nako e telele le ts'ebetso ea ts'ebeliso. NMN ha e amane le litla-morao tse ling tse tsebahalang.

 

NMN joalo ka NAD + Supplement-E tsebahala haholo

Lits'ebetso tsa li-Intracellular tsa NAD + li fokotseha ho tloha botsofaling joalo ka ha mesebetsi e tloaelehileng ea lisele e felisa thepa ea NAD + ka nako. Maemo a phetseng hantle a NAD + ho nahanoa hore a ka khutlisoa ka tlatsetso le li-precurs tsa NAD +. Ho ea ka lipatlisiso, li-precursors tse kang NMN le nicotinamide riboside (NR) li nkuoa e le litlatsetso tsa tlhahiso ea NAD +, li eketsa maemo a NAD +. David Sinclair, mofuputsi oa NAD + ea tsoang Harvard, o re, "Ho fepa kapa ho fepa NAD + ka kotloloho linthong tse phelang ha se khetho e sebetsang. Molek'hule ea NAD + e sitoa ho tšela lisele tsa lisele habonolo ho kena liseleng, ka hona e ke ke ea fumaneha ho ama metabolism. Ho fapana le moo, limolek'hule tsa pele ho NAD + li tlameha ho sebelisoa ho eketsa maemo a NAD + a sa fumaneheng. ” Sena se bolela hore NAD + e ke ke ea sebelisoa e le tlatsetso e otlolohileng, hobane ha e kenelle habonolo. Lits'oants'o tsa NAD + li ananeloa habonolo ho feta NAD + ebile li tlatsetsa ka katleho.

 

O tlameha ho tseba pele o reka phofo ea NMN inthaneteng

 

Sebopeho se sa tsitsang.

Moloko oa pele oa NMN o nang le letsoalo le tlase o ne o sena fluidity e ntle haholo. Phetolelo e ntlafalitsoeng ea AASraw ea NMN e tla theola litšenyehelo tsa tlhahiso ka phallo e ntle ea phofshoana e lebisang ho eketsa bokhoni ba tlhahiso kaha ho tla ba bonolo ho feta ka mechini. Ho feta moo, mofuta ona o tla lebisa litekong tse tšoanang tsa li-capsules kaha mofuta o tlase oa letsoalo o thata ho o kopanya ka mokhoa o ts'oanang. Kamora nako, phofo e nyane ea NMN e petelitsoeng ka sebopeho sa letlapa e ka hasana habonolo nakong ea leeto.

Bareki ba bangata ba leka ho rarolla sena ka litlatsetso tse ling empa seo se lebisa ho matlapa a maholo, a sa nepahalang bakeng sa bareki ho batho ba baholo ba shebiloeng. Kahoo, letsoalo le tlase la NMN le loketse feela lihlahisoa tsa sehlahisoa sa phofo.

 

Ingredients Lisebelisoa tsa NMN tse kentsoeng ka bongata.

Ka bomalimabe 'maraka o koahetsoe ke NMN ea bohata le e silafalitsoeng. Ho tloha ha NMN e kena 'marakeng selemong se fetileng lihlahisoa tse ngata tse ncha tsa NMN li hlahile ka tatellano. Ho thata haholo bakeng sa baetsi le bareki ba rona ho bolela lisebelisoa tsa 'nete tsa boleng bo holimo tse tsoang mekhoeng e seng ea nnete le e hloekileng e rekisoang inthaneteng.

Lihlahisoa tse ling tsa NMN tse rekisitsoeng li na le bohloeki bo ka tlase ho 80%. Bareki le bareki ha ba tsebe feela hore na ke lintho life tse tlatsang kapa tse silafatsang tse fumanehang ho tse ling tse 20% tsa sehlahisoa.

Re hlile ra fumana hore barekisi ba bangata ba NMN ba rekisa nicotinamide (vithamine B3 e tloaelehileng e theko e tlaase) kapa nicotinamide riboside sebakeng sa NMN. Barekisi ba eketsehileng ba eketsa phofo ho hlapolla NMN le ho qhekella bareki ba bona. Lihlahisoa tsena hangata li theko e tlase empa hape ha li na litlamorao tse ntle.

 

Ho hloka polokeho le tlhaiso-leseling e sebetsang.

NMN e ntse e tsebahala le ho feta US, Europe, Japane le China, jj, empa polokeho le lintlha tse ngata tse sebetsang li ntse li haella. Batho ba bangata ba ntse ba sa tšepe sehlahisoa sena, kahoo mmaraka oa NMN o lula o lekantsoe. Haele hantle NMN e ne e le teng 'meleng oa motho le meroho e meng e kang broccoli, ka hona ha e na mathata a polokeho. Empa ke nako e holimo ea hore lintlha li netefatse ho sebetsa ha eona.

 

[Reference]

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