KML29 video


I.KML29 tsebo ea motheo:

Name: KML29
CAS: 1380424-42-9
Molecular Formula: C24H21F6NO7
Boima ba 'mele: 549.42
Melt Point: 204-206 ° C
Temp Temp Storage: Boloka ho -20 ° C
Color: Khristalline e tšoeu e tiile


1.Whats KML29(1380424-42-9) ?

KML29 (1380424-42-9) ke e le tse matla le ka molomo a sebetsang a monoacylglycerol lipase sesitisa hore hlasela MAGL a sebetsang a site ena le ntlafetse haholo selectivity (Rat / toeba ABHD6 IC50 = 1.60 / 4.87; ha ho na mosebetsi inhibitory khahlanong le batho / Rat / toeba mafura acid e amide hydrolase (FAAH) ho fihlela ho 50 μM). KML29(1380424-42-9) ka vivo kalafo diphetho ka upregulation khetha ya 2-arachidonoyl glycerol (2-AG), empa e seng N-arachidonoyl-ethanolamine (AEA) ka litoeba (boko Emax ~20 MG / lik'hilograma po, kapa IP; pherekano Emax ~1 mg / kg po) le likhoto (boko ba Emax ~40 mg / kg ip). KML29 (1380424-42-9) e fokotsa boits'oaro ba ho ruruha ha maikutlo le ho ba le maikutlo a mabeli a likokoana-hloko litabeng tsa liphoofolo ntle le litla-morao tse sa bonahaleng tse bonngoeng ka lebeli la FAAH le MAGL, tsamaiso e sa foleng, leha ho le joalo, e lebisa ho CB1 receptor desensitization joalokaha e hlokometsoe le tse ling tsa MAGL inhibitors.

Lebitso le tloaelehileng KML-29
Nomoro ea CAS 1380424-42-9
limolek'hule C24H21F6NO7
Boima ba 'mele 549.4
Ho hloeka > = 98%
paakanyong Kristalline e tiileng
Shelf Life Joalokaha ho fanoa ka lilemo tse 2 ho tloha letsatsing la QC le fanoeng ka Certificate of Analysis, Ha e bolokoa hantle

Meriana ea KML-29 (1380424-42-9) e sebetsa joang e le inhibitor | AASraw


2.How Stock KML-29 (1380424-42-9)?

Lintlha tse latelang li thehiloe ho sehlahisoa sa limolek'hule tsa 549.42. Litekanyo tse itseng tsa boima ba limolek'hule li ka 'na tsa fapana ho tloha ho batch ho ea ho lihlahisoa ka lebaka la ho qhibiliha ha hydration, e tla ama li-volume tse lekaneng tse lokelang ho lokisetsoa Stock tharollo.

Motsoako oa ho imeloa / Solvent / Mass 1mg 5mg 10mg
1mM 1.82ml 9.1ml 18.2ml
5mM 0.36ml 1.82ml 3.64ml
10mM 0.18ml 0.91ml 1.82ml
50mM 0.04ml 0.18ml 0.36ml


3.KML-29 (1380424-42-9) e sebetsa joang?

re ile ra leka KML29 (1380424-42-9) ka ho ruruha ha murine (ie, carrageenan) le mefuta ea bohloko ea bohloko ba ho ntša kotsi ea methapo ea sistatic, hammoho le mohlala oa diclofenac o bakoang ke lefu la khaello ea mali. KML29 (1380424-42-9) e ile ea boela ea hlahlojoa ka liphello tse sa pheleng, tse kenyelletsang litekanyetso tsa mosebetsi oa boipheliso, mocheso oa 'mele, catalepsy, le liphello tsa ho itšunya-tšunya ha kannete ho tloha ho khethollo ea lithethefatsi paradigm. Ho tloha ha monoacylglycerol lipase (MAGL) e tiisitsoe ka thata joaloka enzyme e matla ka ho fetisisa ea Endocannabinoid 2-arachidonoylglycerol (2-AG), tlhokahalo e kholo e hlahile bakeng sa nts'etsopele ea MAGL inhibitors e khethollang haholo. Mona, re lekoa ka vivo liphello tsa e mong joalo komponeng, KML29 (1,1,1,3,3,3-hexafluoropropan-2-yl 4- (bis (benzo [le d] [1,3] dioxol-5-yl) (hydroxy) methylene) piperidine-1-carboxylate ) Re fumana lintlha tsa bohlokoa: KML29 (1380424-42-9) e entsoeng ka edema e entsoeng ka carrageenan e entsoeng ka carrageenan le allodynia e sebelisoang ka ho feletseng ea carrageenan. liphello tsena ka buuoa ka makhetlo mamello mora repeatedadministration ea phahameng-lethal dose KML29 (1380424-42-9), tse neng li tsamaea le cannabinoid receptor 1 (CB1) receptor desensitization. KML29 (1380424-42-9) e matla haholo kapa e pheta-phetoa palo ea tsamaiso ea 2-AG e bile e fokotseha ka mokhoa o khotsofatsang, empa ntle le ho phahamisa litekanyetso tsa anandamide (AEA) bokong bohle. Ho phaella moo, KML29 allodynia e hanyetsanoang ka mokhoa o fokolang oa meriana ea mahlaba le ho thibela ka ho feletseng diclofenac-induced gastric haemorrhages. Li-CB1 le li-receptor tsa CB2 li bapala ho khetholla lihlahisoa tsena tsa phekolo ea KML29 (1380424-42-9). Ka lehlakoreng le leng, KML29 ha ea ka ea hlahisa liphello tsa cannabimimetic, ho akarelletsa le catalepsy, hypothermia le hypomotility. Leha KML29did se ka nkang sebaka sa Δ (9) -tetrahydrocannabinol (cakir) ka C57BL / 6J litoeba, ho fullyand lethal dose-dependantly ka go engwa legatong bakeng AEA ka mafura acid e amide hydrolase (FAAH) (- / -) litoeba, e lumellana le mosebetsi oa nakong e fetileng e bontšang hore o kopanetsoe FAAH le MAGL inhibition e hlahisa THC-joaloka subjective liphello.


4.A Tseba ka KML-29 (1380424-42-9)

Thutong ea hona joale, re ile ra lekoa KML29 ka ho ruruha ha murine (e.g. carrageenan) le mefuta ea bohloko ea bohloko ba ho ntša kotsi ea methapo ea sistatic, hammoho le mohlala oa diclofenac o bakoang ke lefu la khaello ea mali. KML29 e ile ea boela ea hlahlojoa ka liphello tsa mefuta e mengata, ho kenyelletsa le litekanyo tsa mosebetsi oa likhoheli, mocheso oa 'mele, catalepsy, le liphello tsa ho itšireletsa ka kannete ka lebaka la khethollo ea lithethefatsi paradigm.

LIPOTSO TSA SEHLOOHO:

KML29 (1380424-42-9) e betenuated carrageenan-induced edem edema le ho fetoha ka ho feletseng carrageenan-moduced allodynia mechine. Liphetoho tsena li ile tsa e-ba le mamello ka mor'a ho laola khafetsa ea tekanyo e phahameng ea KML29 (1380424-42-9), e neng e tsamaea le cannabinoid receptor 1 (CB1 ) ho amohela lesensitization. Puso ea KML29 e boima kapa e pheta-phetoang e ile ea eketseha ka mahlakore a 2-AG 'me ka mokhoa o khotsofatsang o fokotsa li-acid tsa arachidonic, empa ntle le ho phahamisa anandamide (AEA) lintlheng tsa bokong bohle. Ho feta moo, KML29 (1380424-42-9) e feto-fetoha karolo e 'ngoe ea allodynia e hlahisitsoeng ke sciatic nerve injection model le ho thibela ka ho feletseng diclofenac-induced gastric haemorrhages. Li-CB1 le li-receptor tsa CB2 li bapala karolo e fapaneng le liphellong tsena tsa meriana ea KML29. Ka lehlakoreng le leng, KML29 (1380424-42-9) ha ea ka ea hlahisa liphello tsa kannabimimetic, ho akarelletsa le catalepsy, hypothermia le hypomotility. Leha KML29 ba ne ba sa ka nkang sebaka sa Δ (9) -tetrahydrocannabinol (cakir) ka C57BL / 6J litoeba, ho ka botlalo le lethal dose-dependantly ka go engwa legatong bakeng AEA ka mafura acid e amide hydrolase (FAAH) (- / -) litoeba, tsela e lumellanang le Ho bontša mosebetsi fetileng tse peli FAAH le MAGL ho thibela ho hlahisa liphello tse joalo tsa THC.

LIPOTSO TSA BOHLOKOA:

Liphetho tsena li bontša hore KML29, MAGL inhibitor e khethollang haholo, e fokotsa boitšoaro bo bakoang ke ho ruruha le mokhoa oa ho itšoara habonolo oa lik'hemik'hale ntle le tšebetso ea litla-morao tsa kannete.


5Nka fumana boitsebiso bo eketsehileng hokae?

Hopola, boloka sena le meriana e meng kaofela hore bana ba se ke ba e fumana, le ka mohla u se ke ua arolelana meriana ea hau le ba bang, 'me u sebelise meriana ena feela bakeng sa pontšo e laetsoeng.
Boiteko bo bong le bo bong bo entsoe ho tiisa hore tlhahisoleseding e fanoeng ke AASraw ho fihlela joale, mme e phethehile, empa ha ho tiisetso e entsoeng ho seo. Tlhahisoleseding e nang le lithethefatsi e fanoeng mona e ka 'na ea e-ba nako e utloahalang Litaba tsa AASraw li ngotsoe bakeng sa tšebeliso ea litsebi tsa bophelo bo botle le bareki United States ka hona, AASraw ha e lumelle hore e sebelisoang ka ntle ho United States e loketse, ntle le haeba e hlalositsoe ka ho toba.AASrawtlhahisoleseding ea lithethefatsi ha e lumelle lithethefatsi, ho hlahloba bakuli kapa ho khothalletsa phekolo. AASraw ya lithethefatsi lesedi ke mohlodi informational etselitsoeng ho thusa lingaka bophelo bo botle ka laesense ea ho hlokomela bakuli ba tsona le ho / kapa ho sebeletsa bareki sheba tšebeletso ena ka tlatsetsa ho, 'me ha e le ka nkang sebaka sa, ho bokgoni, bokhoni, tsebo le kahlolo ea lingaka bophelo bo botle. Ho se be le temoso bakeng sa motsoako o fanoeng ke lithethefatsi kapa lithethefatsi ka tsela leha e le efe ho lokela ho etsoa ho bonts'a hore motsoako oa lithethefatsi kapa oa lithethefatsi o sireletsehile, o sebetsa kapa o nepahetse bakeng sa mokuli ea fuoeng. AASrawha e nke boikarabelo leha e le bofe bakeng sa karolo efe kapa efe ea tlhokomelo ea bophelo e tsamaisoang ka thuso ea tlhahisoleselingAASraw. Tlhahisoleseding e fanoeng mona ha e reretsoe ho koahela mekhoa eohle e ka sebelisoang, litaelo, litemoso, litemoso, litšebelisano tsa lithethefatsi, ts'ebetso ea khatello, kapa liphello tse bohloko. Haeba u na le lipotso mabapi le lithethefatsi tseo u li nkang, hlahloba ngaka ea hau, mooki kapa setsebi sa metsoako.


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