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Sunifiram (DM235) phofo

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SKU: 314728-85-3. Category:

AASraw e na le bokhoni ba tlhahiso ea tlhahiso le tlhahiso ho tloha ho gram ho ea ka taelo ea tafura ea Sunifiram (DM235) powder (314728-85-3), tlas'a taolo ea CGMP le tsamaiso ea tšebetso ea boleng bo sebetsang.

Tlhaloso ea Sehlahisoa

Sunifiram (DM235) video ea phofo


Sunifiram (DM235) phofo ea motheo ea motheo

Name: Sunifiram (DM235) phofo
CAS: 314728-85-3
Molecular Formula: C15H13F2NO2S
Boima ba 'mele: 309.33
Melt Point: 57-58 ° C
Temp Temp Storage: Boloka mocheso oa mohatsela kapa o pholileng
Color: Phofo e tšoeu kapa e sa tsoe


Sunifiram (DM235) phofo e ntlafatsoang ke boko

Mabitso

Sofiram phofo, DM235 phofo e na le lebitso la khoebo e le BisfluoroModafinil, Flmodafinil.

DM235 phofo ea tšebeliso

DM235 phofo ke buka, e nang le nootropic e matla haholo le e kang AMPAkine e nang le lik'hamphani tse nang le liphello tse matlafatsang litšoantšong tsa liphoofolo.

Peso ea Sunifiram ke piperazine e nang le likarolo tse ling tse tšoanang le tsa piracetam. Piracetam e ile ea hlahisoa bakeng sa mathata a ho qetela a kang lefu la Alzheimer, 'me phofo ea Sunifiram e tsejoa ho ntlafatsa ts'ebetso ea ts'ebetso ho liteko tse ling tsa boitšoaro. Ha ho na le lithuto tsa ho kopanya li-receptor, Sunifiram phofo e tala ha e bontše botsoalle ba batho ba bangata ba amohelang li-neurotransmitter kapa li-channel (ha ho na bonngoe le 1μM bakeng sa serotoninergic, dopaminergic, muscarinic, histaminergic, opioid kapa GABAergic receptors), empa e khothalletsa ho lokolloa ha acetylcholine ho tswa ho cerebral cortex, mohlomong ka katleho e ntle ea karabo ea AMPA.

Sunifiram phofo e thibela amnesia ho bakoa ke scopolamine, ka mor'a ip le po tsamaiso, ka mouse ho feta tlhahlobo e fokolang ea 0.01 mg / kg po Mocheso o matla oa Sunifiram powder o tšoana le o sebelisoang ke lithethefatsi tse tsebahalang tsa nootropic tse kang piracetam (30 mg / kg ip), aniracetam (100 mg / kg po) le rolipram (30 mg / kg po), empa ka nako ea potency 1,000 - 10,000 e feta.

Temoso ea liphello tsa DM235 tsa powder

Peso ea Sunifiram (DM-235) ke lik'hemik'hale tsa lipatlisiso tse entsoeng ka piperazine tse nang le liphello tse khahlanong le amnesiac liphoofolong tsa liphoofolo tse nang le matla a phahameng haholo ho feta piracetam. Sunifiram phofo e tala ke bonolo ho molemi ea unifiram. E itšetlehile ka lithuto tsa li-vitro le liphoofolo, ho bonahala eka phofo ea Sunifiram e sebetsa ka tumellano ea AMPA-receptor.

Sunifiram phofo e tala e sebetsa ka ho etsa li-receptor tsa AMPA; ke hore, li-receptors tse ikarabellang bakeng sa phelisano ea phetisetso ea synaptic tsamaisong ea methapo ea bohareng. Mechine ea eona e boetse e eketsa phosphorylation ea AMPAR le NMDAR ka protheine kinase activation, e leng eona e ntlafatsang bokhoni ba nako e telele-e leng, ho ntlafatsa ho fetisetsa pontšo ea lipontšo pakeng tsa li-neurons tse peli tse bakoang ke ho tsosolosa hang-hang.

Kopo ea kinase e susumelitsoeng ke phofo ea Sunifiram e boetse e ntlafatsa mefokolo ea ho ba le likamano. Ho phaella moo, Sunifiram phofo e tala e sebetsana le lefu la cerebral cortex ea lihlooho tsa tlhahlobo ea liphoofolo ka ho thusa ho lokolloa ha acetylcholine, molek'hule ea mohopolo e sebetsang e le mothapo oa likokoana-hloko o nang le lihloliloeng tse fapa-fapaneng. Mokhoa ona o sebetsang o thusa Sunifiram phofo ho sebelisa thepa ea anti-amnesiac.

Litaelo tse ling

Sunifiram phofo e boetse e khone ho thibela amnesia e bakoang ke mohanyetsi oa micamylamine ea nicotin, GABAB agonist baclofen, α2 agonist clonidine le NBQX ea mamello ea AMPA mofuteng oa tlhahlobo ea ho qoba.

Ka tlhahlobo ea maze ea metsi ea rat Morris, tsamaiso ea scopolamine e thibela ho fokotseha ha latency ea ho baleha ka bobeli boemong ba ho fumana le ho khutlisetsa teko tlhahlobo. Sunifiram phofo e tala, e tsamaisoang ka minara ea 20 pele ho koetliso ea tlhaho ea letsatsi le leng le le leng, e khona ho thibela ho fokola ha mohopolo oa mohopolo oa XMUMX mg / kg ip

Peso ea Sunifiram e hlahisa liphello tse matla haholo tsa tšoaetso le liphetoho tse sa bonahaleng ntle le phetoho e hlakileng ea boitšoaro bo feteletseng ba litoeba kapa likhoto, le 0.1 mg / kg ip, Sunifiram phofo e fokotsa nako ea hypnosis e bakoang ke pentobarbital ho litoeba ntle le ho fetola nako ea ho inkela ea hypnosis. Ho feta moo, litoeba tse tšoaroang ka Sunifiram tse tsoekere e le 'ngoe li boloka motlakase o lekanang le tlhahlobo ea li-rotarod. Motility ea litoeba ka boithatelo, e hlahlojoang ke lisebelisoa tsa Animex, hammoho le boitšoaro ba ho hlahloba, ho hlahlojoa ke teko ea li-board, e lula e tloaelehile ka mor'a tsamaiso ea phofo ea Sunifiram.

Sunifiram e phofshoana e le 'ngoe e etsa hore ho be le phekolo ea ho bolaoa ha likokoana-hloko tse sa tšoaneng. Joalokaha ho bontšoa ke liteko tsa microdialysis, phofo ea Sunifiram e khona ho eketsa ho lokolloa ha ACh ka tekanyo ea 0.01 mg / kg, e nang le potency e fetang Unifiram.

Ho hlahisa likarolo tsa rat tsa hippocampal ho 100 μM NMDA e etsa hore ho be le keketseho ea [3H] NE (48). Phello ea NMDA e haneloa haholo ke 100 μM kynurenic acid (KYNA). Ho phaella ho nanomolar concentrations ea Sunifiram e tala phofo e fetola haholo KYNA tse hanyetsanang. Phello ea phofo ea Sunifiram e itšetlehile ka mahloriso (EC50 0.1 μM) mme e batla e phethehile ho 1 μM.

Ho ameha ha li-receptor tsa AMPA ho ka hlahlojoa ka ho sebelisoa ha NBQX ea mohanyetsi oa AMPA ea khethiloeng. Ha e sebelisoa ho 5 μM, NBQX e thibela [3H] NE ho lokolloa ho susumelitsoe ke AMPA (100 μM), empa ha e lokolloe ke 100 μM NMDA-mediated tritium tse tsoang lithong tsa hippocampal (48). NBQX, e sa sebetse ka boeona, e hanyetsa letsatsi la Sunifiram la phetoho ea phofshoana ea KYNA e hanyetsanang le ho lokolloa ha NMDA-evoked tritium, e fana ka maikutlo a ho kenngoa ha li-receptor tsa AMPA liphellong tsa lero la Sunifiram.

Hoa thahasellisa hore, tlasa maemo a mabeli, mefuta e mengata ea Sunifiram ea phekolo ea phofo e eketsehile PKCa (Ser-657) le mesebetsi ea Src (Tyr-416) e nang le lekhalo le lekanang le lekaneng la likarolo joaloka lekala la LTP, le ts'oanang le 10 nM. Keketseho ea phosphorylation ea PKCa (Ser-657) le Src (Tyr-416) e susumelitsoeng ke phofo ea Sunifiram e ne e thibeloa ke phekolo ea 7-ClKN. Matlafatso a LTP ke Sunifiram phofo e tala e thibelitsoe haholo ke PP2, lelapa la Src inhibitor.

Qetellong, ha ho ne ho e-na le metsoako e matla ea glycine (300 lM), litlhare tsa Sunifiram tsa phofo li ile tsa hlōleha ho fumana LTP sebakeng sa CA1.

Ho fumanoa hammoho, bopaki bo ka holimo bo bontša hore Sunifiram phofo e tala e susumetsa sebaka sa glycine-binding ea NMDAR ka tumellano ea PKCa e sebetsang ka Src kinase. Ntlafatso ea mesebetsi ea PKCa e etsang hore ho be le monyetla oa hippocampal LTP ka ho etsa kopo ea CaMKII.

Sunifiram (DM235) Phiri e Meholo

Ntho e nyenyane 10grams.
Tlhahlobo ka bongata bo tloaelehileng (ka hare ho 1kg) e ka romeloa lihora tse 12 kamora ho lefa.
Bakeng sa tlhahiso e kholo (ka hare ho 1kg) e ka romeloa matsatsing a ts'ebetso ea 3 ka mor'a ts'enyehelo.

Tlhahiso ea phofo ea DM235

Ho fanoa nakong e tlang.


Mokhoa oa ho reka phofo ea DM235: reka phofo ea Sunifiram ho tloha AASraw

1.To iteanye le rona ka imeile ea rona lenaneo la lipatlisiso, kapa skype ea inthanetengmoemeli oa tšebeletso ea bareki (CSR).
2.To re fane ka lipotso tsa hau le lipotso tsa hau.
3.Our CSR e tla u fa tlhaloso, nako ea ho lefa, nomoro ea ho latela, litsela tsa ho pepa le letsatsi la ho fihla ho fihlela (ETA).
4.Payment e entsoe mme thepa e tla romelloa ka lihora tsa 12 (Ho laela ka hare ho 10kg).
5.Goods e amohetse mme e fana ka litlhaloso.

TLHOKOMELISO LE TLHALOSO:

Boitsebiso bona bo rekisetsoe tšebeliso ea lipatlisiso. Lipehelo tsa thekiso Etsa kopo. Eseng molemong oa tšebeliso ea batho, kapa bongaka, bongaka ba liphoofolo kapa lisebelisoa tsa lapeng.


COA

HNMR

Sunifiram (DM235) phofo (314728-85-3) hplc≥98% | Basebetsi ba AASraw HNMR

Recipes

Sunifiram (DM235) Li-Recipes tsa Meroho e Meholo:

Ho botsa bareki ba rona baemeli ba rona (CSR) bakeng sa lintlha tse eketsehileng, bakeng sa boitsebiso ba hau.

Litlhaloso le lihlahisoa tsa lihlahisoa

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