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Bortezomib phofo (179324-69-7)

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SKU: 179324-69-7. Category:

AASraw e na le bokhoni ba tlhahiso le tlhahiso ho tloha ho gram ho ea ka taelo ea bortezomib phofo (179324-69-7), tlas'a taolo ea CGMP le tsamaiso ea boleng bo sebetsang ba boleng.

Bortezomib ke meriana e khahlanong le kankere le meriana ea pele ea phekolo ea proteasome inhibitor e lokelang ho sebelisoa ho batho. Li-proteasomes ke li-cell complexes tse senyang liprotheine. Litsing tse ling tsa kankere, liprotheine tse atisang ho bolaea lisele tsa kankere lia robeha ka potlako haholo. Bortezomib e sitisa mokhoa ona mme o lumella liprotheine tsena ho bolaea lisele tsa kankere. E amoheloa US le Europe bakeng sa phekolo ea mefuta e mengata ea myeloma le mantle cell lymphoma. Makhetlong a mangata a myeloma, likliniki tse feletseng li fumanehile ho bakuli ba nang le ts'oaetso e fapaneng kapa ba nang le mafu a potlakileng.

Tlhaloso ea Sehlahisoa

Bortezomib phofo video


Bortezomib phofo tsebo ea motheo

Name: Bortezomib phofo
CAS: 179324-69-7
Molecular Formula: C19H25BN4O4
Boima ba 'mele: 384.24
Melt Point: 122-124 ° C
Temp Temp Storage: -20 ° C Freezer
Color: Tšoeu ho ea ho phofo e tšoeu ea Crystalline


Phororo ea Raw Bortezomib e sebelisoang

Mabitso

Boroneic acid, Velcade, Neomib, Bortecad

Sebeliso ea phofo ea Bortezomib

Bortezomib phofo ke lithethefatsi tse khahlanong le kankere 'me kelafo ea pele e phekoloang ea proteasome inhibitor e lokelang ho sebelisoa ho batho. Li-proteasomes ke li-cell complexes tse senyang liprotheine. Litsing tse ling tsa kankere, liprotheine tse atisang ho bolaea lisele tsa kankere lia robeha ka potlako haholo. Phofo ea Bortezomib e sitisa mokhoa ona mme o lumella liprotheine tsena ho bolaea lisele tsa kankere. E amoheloa US le Europe bakeng sa phekolo ea mefuta e mengata ea myeloma le mantle cell lymphoma. Makhetlong a mangata a myeloma, likliniki tse feletseng li fumanehile ho bakuli ba nang le ts'oaetso e fapaneng kapa ba nang le mafu a potlakileng.

Atomone ea boron Borteromib e phofshoana e kopanyang sebaka sa catalytic ea 26S proteasome e nang le kamano e phahameng le tse khethehileng. Lisele tse tloaelehileng, proteasome e laola polelo ea protheine e sebetsa ka ho senyeha ha liprotheine tsa ubiquity, hape e hloekisa sele ea liprotheine tse sa tloaelehang kapa tse sa utloisisoang. Ditshebeletso tsa meriana le ditshebeletso tsa setjhaba tsa lefapha le ts'ehetsoeng ke ditshebeletso tsa lefapha la lefapha la meseloma, mme lisebelisoa tsa lisele le tsa xenograft li fana ka ts'ehetso e tšoanang le ea kankere e matla ea kankere. Le hoja mekhoa e mengata e ka 'na ea ameha, tšireletso ea proteasome e ka thibela ho senyeha ha lisebelisoa tsa pro-apoptotic, ka lebaka leo ho etsa hore seleng e lokiselitsoeng e shoe ka lisele tse sa tsoeleng pele. Morao tjena, ho fumanoe hore phofo ea Bortezomib e bakile phetoho e potlakileng le e tsotehang maemong a li-peptide tse entracellular tse hlahisoang ke proteasome. [8] Li-peptide tse ling tsa li-synthesile li 'nile tsa bontšoa hore li sebetsa ka tsela e phelang,' me kahoo phello ea Bortezomib e tala ka litekanyo tsa li-peptide tsa intracellular li ka tlatsetsa ho likokoana-hloko le / kapa litla-morao tsa moriana.

Peso ea Bortezomib e amahanngoa le phekolo ea meriana ea lefuba ho 30% ea bakuli; ka linako tse ling, ho ka ba bohloko. Sena se ka mpefala ho bakuli ba nang le lefu lena la pelo la pele. Ho phaella moo, myelosuppression e bakang neutropenia le thrombocytopenia e ka boela ea e-ba teng 'me e be tekanyo ea tekanyo. Leha ho le joalo, litla-morao tsena hangata li fokola ka lebaka la ho fetisetsa motsoako oa 'mele le mefuta e meng ea phekolo bakeng sa bakuli ba nang le mafu a tsoetseng pele. Bortezomib phofo e tala e amahanngoa le tekanyo e phahameng ea li-shingle, le hoja prophylactic acyclovir e ka fokotsa kotsi ea sena. Ho na le tlaleho e ntle ea li-nephritis tsa likamano.

Mathata a Gastro-intestinal (GI) le asthenia ke liketsahalo tse bohloko ka ho fetisisa.

Liphello tsa likokoana-hloko tsa Bortezomib phofo e tala e le moemeli o le mong li 'nile tsa bontšoa mefuteng ea xenograft ea mefuta e mengata ea myeloma, T-cell e kholo ea leukemia, matšoafo, matsoele, sefate sa prostate, pancreatic, hlooho le molaleng, le kankere ea colon le melanoma. Oral Bortezomib phofo 1.0 mg / kg letsatsi le leng le le leng bakeng sa matsatsi a 18 e etsa hore kholo ea tatso e fokotsehe, hammoho le ho fokotseha ha palo ea metastases mehlala ea kankere ea lung ea Lewis. Bortezomib phofo e lekaneng le le leng ho fihlela ho 5 mg / kg haholo e fokotsa karolo e setseng ea lisele tse hlahisang matsoele. Bortezomib phofo 1.0 mg / kg e laoloang beke le beke bakeng sa libeke tsa 4 e fokotsa kholo ea hlahala ka 60% mekhoeng ea murine xenograft ea kankere ea prostate. 1.0 mg / kg Ho tsamaisa phofshoana ea phofo ea bortezomib bakeng sa libeke tsa 4 ho fella ka ho fokotsa 72% kapa 84% ho kankere ea pancreatic murine ea li-xenografts e hōlang, hammoho le keketseho ea tumor cell cell apoptosis. 1.0 mg / kg Phekolo ea phofo ea Bortezomib e etsa hore ho thibeloe ha plasmacytoma ea batho ho eketseha ha xenograft ho eketseha, ho eketseha ha lisele tsa tumor apoptosis le ho phela ka kakaretso, le ho fokotseha ha tumor angiogenesis.

Temoso ho Bortezomib phofo e tala

Ho shebella tsela ea ubiquitin-proteasome ho hlahile e le mokhoa o utloahalang oa ho phekola kankere ea motho. Ho itšetlehile ka lithuto tse nepahetseng tsa meriana le litsing tsa bophelo, Bortezomib phofo e tala e ile ea amoheloa ka nako e telele bakeng sa tšebeliso ea lithethefatsi e le phekolo ea pele bakeng sa bakuli ba bangata ba myeloma ba sa tsoa fumanoa le bakeng sa phekolo ea meriana e mengata ea myeloma le mantle cell lymphoma, eo meriana ena e nang le eona fetoha sethoathoa sa phekolo. Ho amoheloa ha phofo ea Bortezomib ke US Food and Drug Administration (FDA) ho ne ho e-na le ketsahalo ea bohlokoa ka ho fetisisa ea hore inhibitor ea pele ea proteasome e sebelisoe ho phekola lefu le bolaeang. Bortezomib phofo e tala e bonts'itse molemo o nepahetseng oa meriana o le mong kapa e le karolo ea phekolo e kopanetsoeng ho kenyelletsa chemo- / radio-sensitization kapa ho hlōla ho hanyetsa lithethefatsi. E 'ngoe ea mekhoa e meholo ea phofo ea Bortezomib e tsamaisanang le mosebetsi oa eona oa li-antibody ke ka ho fokotsa NOXA, e leng proapoptotic protheine,' me NOXA e ka sebelisana le liprotheine tse khahlanong le apoptotic tsa Bcl-2 kamoreng ea Bcl-XL le Bcl-2, le phello ka seleng ea apoptotic lefu lisele tse bolaeang. Tsela e 'ngoe ea bohlokoa ea Bortezomib phofo e tala ke ka ho tlosoa ha tsela ea ho etsa lipontšo tsa NF-κB e etsang hore ho theohe-taolo ea likokoana-hloko tsa eona tse khahlanong le apoptotic. Le hoja boholo ba katleho e finyelitsoeng ka phofo ea Bortezomib e 'nile ea e-ba liphatseng tsa mahlaba a hematological, phello ea eona ho li-tumor e tiileng e se e sa khothatse. Ho phaella moo, ho sebelisoa kliniki e ngata ea Bortezomib phofo e tsoela pele ho sitisoa ke ponahalo ea tekanyo ea tekanyo ea tekanyo ea lithethefatsi, ho hanyetsa lithethefatsi le ho kena-kenana le lik'hemik'hale tse ling tsa tlhaho. Liphuputso tsena li ka thusa ho tataisa lingaka ho ntlafatsa tšebeliso ea meriana ea phofo ea Bortezomib, le ho khothaletsa bo-rasaense ba mantlha hore ba hlahise likokoana-hloko tsa proteasome tse nang le katleho e kholoanyane le ho hlahisa karabo e kholo ea bakuli ba kankere. Mefuta e meng e lakatsehang ea tšebeliso ea proteasome inhibitors e kenyeletsa nts'etsopele ea li-inhibitors khahlanong le E3 ligase e khethehileng, e sebetsang ka potlako tseleng ea ubiquitin-proteasome, le ho sibolloa ha likokoana-hloko tse nyenyane tse nang le chefo le lenane le lihlahisoa tsa tlhaho le meriana ea setso, e leng e ka fana ka batho ba bangata ba nang le lithethefatsi tse khonehang bakeng sa phekolo ea kankere ea kankere le phekolo ea bakuli ba kankere nakong e tlang.

Litaelo tse ling

Bortezomib phofo ke lithethefatsi tse thibelang protheasome ea mammalian 26S. Tsela ea ubiquitin-proteasome e phetha karolo ea bohlokoa ho laola mohopolo oa li-proteine ​​tse itseng, 'me kahoo li boloka homeostasis ka har'a lisele. Ho thibela ha 26S proteasome ho thibela proteolysis ena e hlaselitsoeng, e ka amang marang-rang a mangata ka har'a sele. Ho ferekanya ha mekhoa e tloaelehileng ea homeostatic ho ka lebisa seleng lefu. Liteko li bontšitse hore Bortezomib phofo e tala ke cytotoxic ho mefuta e fapa-fapaneng ea kankere ea lisele tsa kankere. Bortezomib phofo e tala e etsa hore ho lieha ho hlahisa hlahala e holimo ho vivo ka mekhoa e meng e sa hlabang, ho akarelletsa le myeloma e mengata. Lisele tsa mokokotlo, ke hore, ho arohana ka lisele ka potlako, ho bonahala eka e na le tšenyo e matla ho proteasome inhibition.

Peso ea Bortezomib ke inhibitor e ts'oanelang ho ts'oaroa ea liketso tsa mofuta oa chymotrypsin tsa proteasome ea 26S lisele tsa mammalian. The proteasome ea 26S ke karolo e khōlō ea protheine e silafatsang liprotheine tse sa tloaelehang. Sebaka se sebetsang sa proteasome se na le chymotrypsin-joaloka, trypsin-like, le postglutamyl peptide hydrolysis. Proteasome ea 26S e silafatsa liprotheine tse sa tšoaneng tse nyatsitseng ho boloka lefu la kankere, joalo ka li-cyclins, likokoana-hloko tse thibelang lefuba, BCL-2 le li-cyclin-dependent kinase inhibitors. Ho thibela litšila tsena ho matlafatsa lisele ho ea ho apoptosis. Bortezomib phofo e tala ke inhibitor e matla ea 26S proteasome, e leng se susumetsang ts'ebetso ho arola lisele tse ngata tsa myeloma le leukemia, ka hona ho etsa hore ho be le apoptosis. Ho phaella moo, phofo ea Bortezomib e bonahala e eketsa kutloisiso ea lisele tsa kankere ho metsoako ea li-antiticancer (mohlala, gemcitabine, cisplatin, paclitaxel, irinotecan le radiation).

Phororo ea Bortezomib Raw

Ntho e nyenyane 10grams.
Tlhahlobo ka bongata bo tloaelehileng (ka hare ho 1kg) e ka romeloa lihora tse 12 kamora ho lefa.
Bakeng sa tlhahiso e kholo (ka hare ho 1kg) e ka romeloa ka matsatsi a sebetsang a 3 ka mor'a ts'ebetso.

K'hamphani ea Raw Bortezomib ea phofo

Ho fanoa nakong e tlang.


Ho reka phofo ea bortezomib ho tloha AASraw

1.To iteanye le rona ka imeile ea rona lenaneo la lipatlisiso, kapa skype ea inthanetengmoemeli oa tšebeletso ea bareki (CSR).
2.To re fane ka lipotso tsa hau le lipotso tsa hau.
3.Our CSR e tla u fa tlhaloso, nako ea ho lefa, nomoro ea ho latela, litsela tsa ho pepa le letsatsi la ho fihla ho fihlela (ETA).
4.Payment e entsoe mme thepa e tla romelloa ka lihora tsa 12 (Ho laela ka hare ho 10kg).
5.Goods e amohetse mme e fana ka litlhaloso.

TLHOKOMELISO LE TLHALOSO:

Boitsebiso bona bo rekisetsoe tšebeliso ea lipatlisiso. Lipehelo tsa thekiso Etsa kopo. Eseng molemong oa tšebeliso ea batho, kapa bongaka, bongaka ba liphoofolo kapa lisebelisoa tsa lapeng.


COA

HNMR

Bortezomib phofo (179324-69-7) hplc≥98% | Ho hlahisa li-Reagents tsa R & D

Recipes

Bortezomib Raw Powder Recipes:

Ho botsa bareki ba rona baemeli ba rona (CSR) bakeng sa lintlha tse eketsehileng, bakeng sa boitsebiso ba hau.

Litlhaloso le lihlahisoa tsa lihlahisoa

Sena ke Ntho e 'ngoe le e' Ngoe eo U Lokelang ho e Tseba ka Bortezomib