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Peso ea Apixaban

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SKU: 503612-47-3. Category:

AASraw e na le bokhoni ba tlhahiso le tlhahiso ho tloha ho gram ho ea ka taelo e kholo ea phofo ea Apixaban (503612-47-3), tlas'a taolo ea CGMP le tsamaiso ea tšebetso ea boleng bo sebetsang.

Tlhaloso ea Sehlahisoa

Video ea Apixaban phofo


Peso ea Apixaban tsebo ea motheo

Name: Peso ea Apixaban
CAS: 503612-47-3
Molecular Formula: C25H25N5O4
Boima ba 'mele: 459.50
Melt Point: 238-240 ° C
Temp Temp Storage: 20 ° C ho 25 ° C
Color: Ho bolokoa ho tšoeu ho ea mosehla o mosehla


Peso ea Apixaban phofo e tala

Mabitso

Peso ea Apixaban

Apixaban phofo Tšebeliso ea phofo e tala

Liphetoho tsa tekanyo
Tšebelisano le li-inhibitors tse peli tsa CYP3A4 le P-gp

Haeba u nka> 2.5 PO BID, fokotsa tekanyo ea 50%
Haeba o nka 2.5 mg BID, qoba ho tsamaisana le li-inhibitor tse matla tse peli
Li-nonvalvular fibrillation ea lefuba

Fokotsa tekanyo ea 2.5 mg PO BID ho bakuli ba nang le 2 leha e le efe ea litšobotsi tse latelang:
Nako ea lilemo ≥80
Boima ba ≤60 kg
Serum creatinine ≥1.5 mg / dL

  • Ho fokotsa kotsing ea ho otloa ke lefu la Stroke / Systemic ho Fibrillation ea Atrial, ea 5 (Batho ba baholo) habeli ka letsatsi; Leha ho le joalo 2 ea tse latelang: lilemo ≥80 yr, boima ba ≤60 kg, serum creatinine ≥1.5 mg / dL- 2.5 mg habeli ka letsatsi; Tšebeliso e tloaelehileng ea inhibitors e matla ka bobeli CYP3A4 le P-gp- 2.5 mg habeli ka letsatsi; haeba mokuli a se a ntse a nkile 2.5 mg ka makhetlo a mabeli letsatsi le leng le le leng, qoba ho sebelisoa ha motlakase
  • Mathata a Renal, HD- 5 mg (Batho ba baholo) habeli ka letsatsi; HD le lilemo tse ling ≥80 yr kapa boima ba 'mele ≤60 kg- 2.5 mg ka makhetlo a mabeli ka letsatsi.
  • Thibelo ea Sefuba se Tebileng Sefuba Se latela lithethefatsi kapa li-Hip-substitution Surgery, 2.5 mg (Batho ba baholo) habeli ka letsatsi, ba qalile 12-24 hr post-operatively (ha hemostasis e finyelloa) e tsoelapele matsatsing a 35 kamora matsatsi a hip kapa matsatsi a 12 ka mor'a hore motsoako o tlosoe.
  • Kalafo ea DVT kapa PE, 10 mg (Batho ba baholo) habeli ka letsatsi bakeng sa matsatsi a 7, ebe 5 mg habeli ka letsatsi.
  • Ho fokotsa ke kotsi ea ho khutlela ha DVT kapa PE, 2.5 mg (Batho ba baholo) habeli ka letsatsi ka mor'a hore ≥6 mo ea phekolo ea DVT kapa PE.

Temoso ho phofo ea Apixaban phofo e tala

Litla-morao tse tloaelehileng ka ho fetisisa tse tlalehiloeng li tsoa mali 'me li koahetsoe ke sepakapaka, bolella ngaka ea hao kapa u fumane thuso ea bongaka hang-hang haeba u na le matšoao a mang a ka' nang a amana le phello e bohloko haholo:

  • Lipontšo tsa ho itšoara habonolo, joalo ka ho fofa; mangoe; ho hlohlona; ho khubelu, ho ruruha, ho silafatsa kapa ho phunya letlalo ka ntle le feberu; wheezing; ho tiea ka sefubeng kapa molaleng; khathatso ea ho hema, ho emisa, kapa ho bua; hoarseness e sa tloaelehang; kapa ho ruruha ha molomo, sefahleho, molomo, leleme, kapa metso.
  • Lipontšo tsa ho tsoa mali joaloka ho lahla mali kapa ho lahla ho shebahalang joaloka libaka tsa kofi; ho khohlela mali; mali a morong; tse ntšo, tse khubelu, kapa li-stool; ho tsoa mali ho tsoa ka majoe; ho tsoa mali ho tsoa botšehali ho sa tloaelehang; matšoafo ntle le lebaka kapa hore e be khōlō; kapa ho tsoa mali leha e le efe e mpe haholo kapa eo u ke keng ua e emisa.
  • Ho ba le botsoa kapa ho feta.
  • Bohloko bo kopantsoeng kapa ho ruruha.
  • Mahlaba a sefuba kapa khatello.
  • Ho ikutloa u khathetse kapa u fokola.
  • E ikutloa e ferekane.
  • Hlooho ea hlooho.
  • Ho phalla.

Ho phala
Peso ea Apixaban e eketsa kotsi ea ho tsoa mali e ka 'nang ea e-ba e tebileng' me e ka bolaea. Ho sebelisoa ka nako e tšoanang le lithethefatsi tse amang hemostasis ho ka eketsa kotsi ena hape. Sena se akarelletsa lithethefatsi tse kang li-anticoagulants tse ling, heparin, aspirin, li-antiplatelet lithethefatsi, serotonin reuptake inhibitors, serotonin norepinephrine reuptake inhibitors, le lithethefatsi tse seng khahlanong le ho ruruha (NSAIDs).

Ntho e 'ngoe e amehang ka tšebeliso ea phofo ea Apixaban le li-anticoagulants tse ling tse ncha ke ho ba sieo ha protocol e tsitsitseng ea ho fetola mosebetsi oa bona (ha ho na antidote e fumanehang). Ena ke bothata bo bohlokoa mabapi le warfarin ha mathata a tsoang mali a tsoa, ​​kapa ha batho ba noa meriana ba hloka ho buuoa ka tšohanyetso.

Pente ea mokokotlo
Ha lefu la mokokotlo le lejoe la sekholo le sebelisoa, bakuli ba ntseng ba phekoloa ka lithibela-mafu ho thibela mathata a mabeli ba kotsing ea ho hlasela hematoma, e ka bakang nako e telele kapa e sa feleng ea ho holofala. Kotsi ea sena e ka eketseha ka ho sebelisa li-catheters tsa epidural kapa tsa intrathecal ka mor'a ho buuoa kapa ho sebelisoa ka nako e le 'ngoe ea meriana e amang hemostasis.

Litaelo tse ling

Peso ea Apixaban ke anticoagulant ea molomo le inhibitor e tobileng ea Factor Xa e sebelisetsoang ho fokotsa kotsi ea maloetse a bakoang ke mokokotlo, tlhahiso ea tsamaiso le ts'oaetso ho bakuli ba nang le mafura a atrial, le ho fokotsa kotsi ea bothata bo tebileng ba vein thrombosis le pulmonary embolus ka mor'a ho buuoa ka mangole kapa ka mokokotlo oa phekolo . Peso ea Apixaban e 'nile ea amahanngoa le tekanyo e fokolang ea matla a serum aminotransferase nakong ea phekolo le makhetlong a sa tloaelehang a kotsi ea sebete.

Tšebeliso ea bongaka:
Peso ea Apixaban e bontšoa bakeng sa tse latelang:

Ho fokotsa kotsi ea ho otloa ke lefu le ho ruruha ho bakuli ba se nang maqhubu a atrial fibrillation.
Tšoaetso e tebileng ea lesea (DVT) prophylaxis. Li-DVTs li ka lebisa ho embolism pulmonary (PE) ka meriana kapa mahlaku a bakuli ba buuoang.
Kalafo ea DVT le PE.
Ho fokotsa kotsi ea ho pheta-pheta DVT le PE ka mor'a phekolo ea pele.

Peso ea Apixaban

Peso ea Apixaban ke e tsoeu e le 'mala o mosehla. Nakong ea tlhaho ea pH (1.2-6.8), phofo ea Apixaban ha e hloke; 'mele oa eona o nang le metsi a fokolang pH ke ~ 0.04 mg / mL.

Matlapa a ELIQUIS a fumaneha bakeng sa tsamaiso ea molumo ka matla a 2.5 mg le 5 mg ea phofo ea Apixaban ka lisebelisoa tse sa sebetsang tse latelang: lactose anhydrous, microcrystalline cellulose, croscarmellose sodium, sodium lauryl sulfate le magnesium stearate. Ho roala filimi ho na le lactose monohydrate, hypromellose, titanium dioxide, triacetin, le yellow iron oxide (lipilisi tsa 2.5 mg) kapa matlapa a khubelu a tšepe (5 mg lipilisi).

Ntho e nyenyane 10grams.
Tlhahlobo ka bongata bo tloaelehileng (ka hare ho 1kg) e ka romeloa lihora tse 12 kamora ho lefa.
Bakeng sa tlhahiso e kholo (ka hare ho 1kg) e ka romeloa ka matsatsi a sebetsang a 3 ka mor'a ts'ebetso.

Apixaban powder Marketing

Ho fanoa nakong e tlang.


Ho reka phofo ea Apixaban ho AASraw

1.To iteanye le rona ka imeile ea rona lenaneo la lipatlisiso, kapa skype ea inthanetengmoemeli oa tšebeletso ea bareki (CSR).
2.To re fane ka lipotso tsa hau le lipotso tsa hau.
3.Our CSR e tla u fa tlhaloso, nako ea ho lefa, nomoro ea ho latela, litsela tsa ho pepa le letsatsi la ho fihla ho fihlela (ETA).
4.Payment e entsoe mme thepa e tla romelloa ka lihora tsa 12 (Ho laela ka hare ho 10kg).
5.Goods e amohetse mme e fana ka litlhaloso.

TLHOKOMELISO LE TLHALOSO:

Boitsebiso bona bo rekisetsoe tšebeliso ea lipatlisiso. Lipehelo tsa thekiso Etsa kopo. Eseng molemong oa tšebeliso ea batho, kapa bongaka, bongaka ba liphoofolo kapa lisebelisoa tsa lapeng.


COA

HNMR

Peso ea Apixaban (503612-47-3) hplc≥98% | AASraw HNML

Recipes

Apixaban Raw Powder Recipes:

Ho botsa bareki ba rona baemeli ba rona (CSR) bakeng sa lintlha tse eketsehileng, bakeng sa boitsebiso ba hau.

Litlhaloso le lihlahisoa tsa lihlahisoa

Apixaban (Eliquis): o sebelisa, ho sebelisana, litla-morao, litemoso