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Monomethyl auristatin E (MMAE) phofo

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SKU: 474645-27-7. Category:

AASraw e na le bokhoni ba tlhahiso ea tlhahiso le tlhahiso ho tloha ho gram ho ea ka taolo ea Monomethyl auristatin E (MMAE) powder (474645-27-7), tlas'a taolo ea CGMP le tsamaiso ea boleng bo sebetsang ba boleng.

Tlhaloso ea Sehlahisoa

Monomethyl auristatin E (MMAE) video ea phofo


Monomethyl auristatin E (MMAE) phofo tsebo ea motheo

Name: Monomethyl auristatin E (MMAE) phofo
CAS: 474645-27-7
Molecular Formula: C39H67N5O7
Boima ba 'mele: 717.97858
Melt Point: 238-240 ° C
Temp Temp Storage: Boloka sebakeng sa qalong, pakeng tsa 36 le 46 dirigrama tse F
Color: Pula e tšoeu


Monomethyl auristatin E phofo e le antimitotic agent

Mabitso

Brentuximab vedotin, MMAE phofo

Monomethyl auristatin E Sebeliso ea poud

• Batho ba baholo
Monotherapy, 1.8 mg / kg (e seng ho feta 180 mg / dose) IV libeke tse ling tsa 3; hammoho le chemotherapy, 1.2 mg / kg (e seng ho feta 120 mg / dose) IV libeke tse ling tsa 2.

• Geriatric
Monotherapy, 1.8 mg / kg (e seng ho feta 180 mg / dose) IV libeke tse ling tsa 3; hammoho le chemotherapy, 1.2 mg / kg (e seng ho feta 120 mg / dose) IV libeke tse ling tsa 2.

Monomethyl auristatin E phofo (MMAE powder, vedotin) ke moemeli oa antimitotic o matla haholo o thibelang ho arohana ha selulo ka ho thibela polymerization ea tubulin. Lelapa la auristatine li tšoana le lihlahisoa tsa tlhaho tsa tlhaho Dolastatin 10, ultrapotent cytotoxic microtubule inhibitors tse sebelisoang kalafo e le litefello tsa li-anti-drug-conjugates. Monomethyl auristatin E phofo kapa MMAE powder ke 100-1000 linako tse ling tse matla ho feta doxorubicin (Adriamycin / Rubex) 'me e ke ke ea sebelisoa e le lithethefatsi ka boeona. Leha ho le joalo, e le karolo ea antijection-drug conjugate kapa ADC, MMAE phofo e amahanngoa le anti-monogonal monoclonal (mAb) e amohelang polelo e tobileng ea lisele tsa kankere le ho laela MMAE phofo ho sele e itseng e nang le kankere.

Khokahanyo e kopanya MMAE le phofshoana ea monoclonal e tsitsitse mokelikeli oa extracellular, empa e khomaretsoe ke cathepsin hang ha moriana oa li-antijene-conjugate o lekaneng le kankere ea kankere e hlaselitsoeng mme o kene sele ea kankere, 'me ka mor'a moo ADC e ntša phofo ea MMAE e chefo 'me e etsa hore mokhoa o matla oa ho loantša mitotiki o sebetse. Likokoana-hloko tsa likokoana-hloko li ntlafatsa liphello tsa li-antibodies le ho fokotsa liphello tse mpe tsa tsamaiso ea cytotoxic e matla haholo.

Temoso ho Monométhyl auristatin E phofo

• Pneumonitis, lefu la pulmonary, lefu la matšoao la khatello ea kelello
Chefo e se nang tšoaetso ea pulmonary pulmonary (mohlala, pneumonitis, lefu la methapo ea methapo ea mafu, lefu le matla la ho hema le mafu) e tlalehile ka brentuximab therapy; linyeoe tse ling li ne li bolaea. Lekola bakuli bakeng sa matšoao a chefo ea pulmonary e kang ho khohlela le dyspnea. Hlahloba bakuli ba hlahisang matšoao a macha a li-pulmona; tšoara brentuximab ho fihlela matšoao a ntlafala. Tšebeliso e khotsofatsang ea brentuximab le chemotherapy (ntle le letlapa), e kang ABVD (adriamycin, bleomycin, vinblastine, dacarbazine), e hanyetsanoa ka lebaka la kotsi e eketsehileng ea chefo e sa tšoaetseng ea pulmonary. Ho kenella ka sekhahla le / kapa ho ruruha (ho fumanoa sefubeng sa X-ray kapa litšoantšo tsa litšoantšo) ho ne ho etsahala hangata ho bakuli ba Hodgkin lymphoma ba ileng ba fumana brentuximab hammoho le ABVD tekong ea meriana ea lipilisi ho bapisoa le bakuli ba tšohanyetso ba ileng ba amohela ABVD feela. Maemong a mangata a rarolloe ka mor'a lefuba la corticosteroid.

Pheliso ea meriana ea mafu
Phekolo ea meriana ea methapo ea kutlo, haholo-holo kelello ea kelello, e 'nile ea tlalehoa ka phekolo ea brentuximab vedotin; phekolo ea meriana ea phekolo ea kelello e ata. Hlahloba bakuli bakeng sa matšoao a lefu la neuropathy (mohlala, hypoesthesia, hyperesthesia, paresthesia, khathatso, ho chesa maikutlo, bohloko ba pelo, kapa bofokoli). Ho khaotsa ho phekola, ho fokotseha ha tekanyo, kapa ho thibela ho tlohela ho ka 'na ha hlokahala ho bakuli ba hlahisang boloetse ba methapo ea meriana e ncha kapa e ntseng e mpefala.

• Anemia, geriatric, neutropenia, thrombocytopenia
Mathata a hematologic toxicities (mohlala, khaello ea mali, thrombocytopenia, neutropenia) le likotsi tse bolaeang le tse matla tsa febrile neutropenia li tlalehile ka phekolo ea brentuximab vedotin; neutropenia e ka 'na ea e-ba telele (nako e telele ea 1 beke kapa nako e telele). Bakuli ba maiketsetso ba lilemo li 65 le ho feta ba nang le Hodgkin lymphoma ba ileng ba fumana brentuximab vedotin hammoho le chemotherapy ba na le litekanyetso tse phahameng tsa febrile neutropenia ha ba bapisoa le bakuli ba banyenyane. Fumana mali a feletseng ka pele ho tekanyo e 'ngoe le e' ngoe ea brentuximab le ka makhetlo a mangata haeba sehlopheng sa 3 kapa 4 neutropenia se etsahala; hlahloba bakuli bohle bakeng sa feberu. Ho thibela phekolo, ho fokotseha ha tekanyo kapa ho thibela ho tlohela ho ka 'na ha hlokahala ho bakuli ba hlahisang sehlopha sa 3 kapa 4 neutropenia; nahana ka ho phaella ha prophylactic granulocyte-kolone e susumetsang factor (G-CSF) le litebelisuoa tse latelang. Laola G-CSF ho qala ka potoloho 1 ho bakuli ba fumanang brentuximab vedotin hammoho le chemotherapy.

• Ho ruruha lysis syndrome (TLS)
Tumor lysis syndrome (TLS) e tlalehile bakuli ba fumaneng brentuximab vedotin. Bakuli ba nang le lihlahala tse ntseng li eketseha ka potlako le / kapa moroalo o phahameng oa lithethefatsi ba ka ba le kotsing e eketsehileng ea ho hlahisa TLS. Hlahloba bakuli bakeng sa matšoao a TLS (mohlala, serum electrolytes, uric acid, serum creatinine) pele le nakong ea phekolo; ho theha mokhoa o loketseng oa ho phekola le ho phekola (mohlala, hydration, uric acid ho theola therapy) ha ho hlokahala.

• Leukoencephalopathy e tsoelang pele ho feta e mengata
Mafu a bolaeang a multitifocal leukoencephalopathy (PML), a bakoang ke kokoana-hloko ea John Cunningham (kokoana-hloko ea JC), a tlalehile ka phekolo ea brentuximab; linyeoe tse ling li etsahetse nakong ea likhoeli tsa pele tsa 3 tsa ho qala phekolo. Bakuli ba nang le mekhoa ea pele ea phekolo ea ho itšireletsa mafung kapa lefu la immunosuppressive ba ka 'na ba e-ba kotsing e khōloanyane ea tšoaetso ea kokoana-hloko ea JC le PML. Hlahloba bakuli ba hlahisang matšoao a macha a methapo ea kutlo, matšoao, kapa a boitšoaro joalo ka ho fetola maikutlo kapa boitšoaro; pherekano; ho se tsebe ho hopola; liphetoho ponong, lipuo, kapa ho tsamaea; le / kapa fokotsa matla kapa bofokoli ka lehlakoreng le leng la 'mele. Tšoara phekolo haeba PML e belaelloa; tlohela brentuximab ho bakuli ba tiisitsoeng PML.

• Ho fokola ha renal
Qoba tšebeliso ea brentuximab vedotin ho bakuli ba nang le bothata bo matla ba ho ba le tšoaetso ea mali (tlhahiso ea creatinine (CrCl) tlase ho 30 mL / min). Boemo ba kereiti ea 3 kapa liketsahalo tse mpe tse mpe le lefu li ne li le ho feta ho bakuli ba nang le bokooa bo matla ba likokoana-hloko ha bapisoa le bakuli ba nang le ts'ebetso e tloaelehileng ea li-renal (CrCl e kholo ho feta 80 mL / min) thuputsong e nyenyane, e le ngoe ea pharmacokinetic.

• lefu la Hepatic
Qoba tšebeliso ea brentuximab vedotin ho bakuli ba nang le boemo bo leka-lekaneng (Child-Pugh B) kapa lefu le matla (Child-Pugh C) lefu la hepatic / defective; ho fokotsa tekanyo ea tekanyo ea pele ho khothalletsoa ho bakuli ba nang le ho holofala ha hepatic (Child-Pugh A). Boemo ba kereiti ea 3 kapa liketsahalo tse mpe tse mpe le lefu li ne li le ho feta ho bakuli ba nang le bokooa bo feteletseng kapa bo bobebe bo bapisoang le bakuli ba nang le tloaelo e tloaelehileng ea thuto ea pharmacokinetic. Hepatotoxicity (mohlala, kotsi ea hepatocellular, li-enzyme tse phahameng tse phahameng le hyperbilirubinemia) e tlalehiloe ka phekolo ea brentuximab vedotin. Liketsahalo tse ling li ile tsa etsahala ka mor'a tefello ea pele kapa holim'a lisebelisoa tsa lithethefatsi; lefu la li-hepatotoxicity le tlalehile. Hlahloba liteko tsa ts'ebetso ea sebete (LFTs), ho kenyeletsa le bilirubin, pele le nakong ea phekolo. Ho khaotsa ho phekola, ho fokotseha ha tekanyo kapa ho thibela ho tlohela ho ka 'na ha hlokahala ho bakuli ba hlahisang hepatotoxicity e ncha, e ntseng e mpefatsa kapa e tloaelehileng. Bakuli ba nang le mafu a hepatic a neng a e-s'o le teng kapa LFTs e phahameng ho ea pele le bakuli ba fumanang meriana e loantšang meriana ba ka ba kotsing e eketsehileng ea ho ntlafatsa lefu la hepatotoxicity.
• Tšoaetso, sepsis
Matšoao a mangata a tšoaetsanoang le mafu a mang a tebileng, a akarelletsang pneumonia, bacactia, le sepsis (maemong a mang a bolaeang), a tlalehile ka phekolo ea brentuximab vedotin. Atamela bakuli ka hloko nakong ea phekolo bakeng sa lipontšo le matšoao a baktheria, fungal, kapa tšoaetso ea kokoana-hloko.

• Likarabo tse amanang le ho tšoaetsoa
Liphetoho tse amanang le ho tšoaetsoa ho kopanyelletsa ho akarelletsa le anaphylaxis li tlalehile ka phekolo ea brentuximab vedotin; ka lebaka leo, hlahloba bakuli ba haufi le matšoao a karabelo nakong ea brentuximab infusion. Hang-hang 'me u khaotse ho phekola kalafo haeba anaphylaxis e hlaha. Emisa ho theoleloa 'me u thehe phekolo e loketseng ea bongaka ho bakuli ba hlahisang bohato bo amanang le ho kenngoa ha' mele. Ho itokisetsa pele (mohlala, acetaminophen, antihistamine, le / kapa corticosteroid) pele ho tšoaetso ea mafu ho bakuli ba kileng ba e-ba le tšusumetso e amanang le ho phalla.

• Koetliso, mafu a GI, mafu a GI, thibelo ea GI, ho koetlisa ha GI, leius, boloetse ba seso sa lefuba
Mathata a tebileng a masapo (GI) a kenyeletsang GI perforation, ho tsoa mali a GI, ho nyoloha ha GI, lefu la seso la sesapo, ho thibela GI, lefu la neutropenic, entocolitis le leus e tlalehiloe ka phekolo ea brentuximab vedotin; linyeoe tse ling li ile tsa fella ka lefu. Potlakisa hlahloba le ho tšoara mathata a GI ho bakuli ba hlahisang matšoao a GI a macha kapa a mpefala. Sebelisa brentuximab ka hloko ho bakuli ba nang le histori ea lefu la GI. Bakuli ba nang le histori ea lymphoma le kakaretso ea GI e ka 'na ea e-ba kotsing e eketsehileng ea ho haelloa ke lefu la GI.

• Bokhachane
Brentuximab Vedotin e ka 'na ea baka tšenyo ea lesea ha e etsoa nakong ea bokhachane e itšetlehile ka mohato oa liketso le boitsebiso bo tsoang lithutong tsa liphoofolo. Basali ba nang le bokhoni ba ho ikatisa ba lokela ho eletsoa ho qoba ho ima ha ba ntse ba amohela brentuximab. Haeba mosali a ima nakong ea ha a noa lithethefatsi, o lokela ho tsebisoa ka kotsi e ka 'nang ea e-ba teng ho lesea. Lipatlisisong tsa liphoofolo, li-embryo-fetal toxicities tse kenyeletsang maqhubu a fokolang a ne a bonoa ka litekanyetso tsa brentuximab tse ileng tsa fella ka ho pepeseha ha bakhachane ho neng ho tšoana le ho pepeseha ha batho maemong a khothalletsoang.

• Litlhoko tsa tlhekefetso, ho hloka ts'ebeliso, ts'oaetso ea banna, ho hlahloba bokhachane, kotsi ea ho ikatisa
Bakuli ba nang le kelello mabapi le litlhoko tsa kotsi tsa ho ikatisa le tsa thibelo ea bokhachane nakong ea phekolo ea brentuximab vedotin. Tlhahlobo ea bokhachane e lokela ho etsoa pele ho qala brentuximab ho bakuli ba basali ba nang le bokhoni ba ho ikatisa. Bakuli bana ba lokela ho sebelisa mekhoa e metle ea thibelo ea bokhachane le ho qoba bokhachane nakong ea bonyane likhoeli tsa 6 ka mor'a lefuba la brentuximab. Basali ba nang le bokhachane ha ba ntse ba fumana brentuximab ba lokela ho tsebisoa ka kotsi e ka 'nang ea e-ba teng ho lesea. Ho phaella moo, bakuli ba batona ba nang le basali ba nang le bokhoni ba ho ikatisa ba lokela ho sebelisa thibelo ea bokhachane e sebetsang nakong ea phekolo le bonyane likhoeli tsa 6 ka mor'a hore ba phekoloe ka lebaka la kotsi ea ho ba le bothata ba ho thibela banna. Ho itšetlehile ka lithuto tsa liphoofolo, brentuximab e ka baka ho hloka matla ho banna.

• Ho fepa masea
Ha ho tlhahisoleseding e fumanehang mabapi le boteng ba brentuximab vedotin lebese la motho, liphello ho lesea le anyesitsoeng, kapa liphello tsa tlhahiso ea lebese. Ka lebaka la monyetla oa ho ba le tšusumetso e tebileng ho masea a anyesang (mohlala, cytopenias le neurologic kapa moriana oa toxicities), ho anyesa ha ho khothalletsoe nakong ea phekolo ea brentuximab. Nahana ka melemo ea ho anyesa, kotsi ea ho ba le lithethefatsi tsa bokhachane, le kotsi ea ho se tšoaroe kapa ho se tšoanelehe ho phekoloa. Haeba lesea le anyesang le e-na le phello e mpe e amanang le lithethefatsi tse laoloang ke bakhachane, bafani ba tlhokomelo ea bophelo ba khothalletsoa ho tlaleha liphello tse bohloko ho FDA.

Litaelo tse ling

Monomethyl auristatin E powder (MMAE powder) e lokolloa hantle ho SGN-35 ka har'a lisele tsa kankere ea CD30 + 'me, ka lebaka la ho itšireletsa ha eona, e khona ho etsa mosebetsi oa cytotoxic lisele tsa mahlo. MMAE phofo e nolofatsa lisele tsa kankere le li-pancreatic ho IR nakong ea kemiso le mokhoa o itšetlehileng ka tekanyo e amanang le mitotic ea ho tšoaroa. Radiosensitization e bonahatsoa ke ho fokotseha ha li-clonogenic le ho eketseha ha DNA ka makhetlo a mabeli lisele tse hanyelitsoeng.

Monomethyl auristatin E E Pha

Ntho e nyenyane 10grams.
Tlhahlobo ka bongata bo tloaelehileng (ka hare ho 1kg) e ka romeloa lihora tse 12 kamora ho lefa.
Bakeng sa tlhahiso e kholo (ka hare ho 1kg) e ka romeloa ka matsatsi a sebetsang a 3 ka mor'a ts'ebetso.

Monomethyl auristatin E E Mmele e Feteletseng ea Recipe

Ho botsa bareki ba rona baemeli ba rona (CSR) bakeng sa lintlha tse eketsehileng, bakeng sa boitsebiso ba hau.

Monomethyl auristatin E Khoebo ea Puse

Ho fanoa nakong e tlang.


IV. Ho reka monomethyl auristatin E phofo; reka MMAE phofo ho tloha AASraw?

1.To iteanye le rona ka imeile ea rona lenaneo la lipatlisiso, kapa skype ea inthanetengmoemeli oa tšebeletso ea bareki (CSR).
2.To re fane ka lipotso tsa hau le lipotso tsa hau.
3.Our CSR e tla u fa tlhaloso, nako ea ho lefa, nomoro ea ho latela, litsela tsa ho pepa le letsatsi la ho fihla ho fihlela (ETA).
4.Payment e entsoe mme thepa e tla romelloa ka lihora tsa 12 (Ho laela ka hare ho 10kg).
5.Goods e amohetse mme e fana ka litlhaloso.

TLHOKOMELISO LE TLHALOSO:

Boitsebiso bona bo rekisetsoe tšebeliso ea lipatlisiso. Lipehelo tsa thekiso Etsa kopo. Eseng molemong oa tšebeliso ea batho, kapa bongaka, bongaka ba liphoofolo kapa lisebelisoa tsa lapeng.


COA

COA 474645-27-7 Monoméhyl auristatin E (MMAE) AASRAW

HNMR

Re monométhyl auristatin e pouder supplie, MMAE phofo e rekisoang, Monomethyl auristatin E (MMAE) powder (474645-27-7) ≥98% | AASraw

Recipes

Monomethyl auristatin E Mokhukhu a Metsoako Recipes:

Ho botsa bareki ba rona baemeli ba rona (CSR) bakeng sa lintlha tse eketsehileng, bakeng sa boitsebiso ba hau.

Litlhaloso le lihlahisoa tsa lihlahisoa

Antineoplastic Agent Monomethyl auristatin E (MMAE)