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MMAF (Hydrochloride) (1415246-68-2)

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SKU: 1415246-68-2. Category:

AASraw e na le bokhoni ba tlhahiso le tlhahiso ho tloha ho gram ho ea ka taelo ea MMAF (Hydrochloride) (CAS 1415246-68-2), tlas'a taolo ea CGMP le tsamaiso ea boleng bo sebetsang ba boleng.

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Tlhaloso ea Sehlahisoa

Video ea MMAF (Hydrochloride)


MMAF (Hydrochloride) Boitsebiso ba motheo

Name: MMAF (Hydrochloride)
CAS: 1415246-68-2
Molecular Formula: C39H66ClN5O8
Boima ba 'mele: 768.42
Melt Point: 314.3 ° C ho 760 mmHg (Ho boletsoe esale pele)
Temp Temp Storage: Phiri -20 ° C lilemo tse 3
4 ° C lilemo tse 2
Ka ho qhibiliha -80 ° C likhoeli tse 6
-20 ° C Khoeli ea 1
Color: Phosente e tšoeu ea kristale


Tšebeliso ea MMAF (Hydrochloride) ka potoloho ea steroids

Mabitso

MMAF (Hydrochloride) (1415246-68-2) e boetse e bitsa Monomethylauristatin F Hydrochloride, MMF HCL

Sebeliso ea MMAF (Hydrochloride)

Setsebi sa bongaka se etsa reseach e ngata ho MMAF, mona ka tlase ke litlhaloso tsa ho buella:
In Vitro: MMAF e bonts'a in vitro cytotoxicity khahlanong le karolo ea lisele tsa sele. Melao ea IC50 bakeng sa Karpas 299, H3396, 786-O le Caki-1 ke 119, 105, 257, le 200 nM, ka ho latellana. MMAF e lebisitsoeng e matla haholo ho feta lithethefatsi tse sa lefelloeng, le hore likhokahano tsa CAC10 tsa MMAF li phatlalatsa liketso. Ka molar, motheo oa cAC10-L1-MMAF4 ke karolelano ea 2200 e matla ho feta MMAF e sa lefelloeng 'me e sebetsa mafapheng' ohle a lisele tsa CD30 a lekiloeng

Li-Vivo: Maqhubu a mamelloang ka ho fetisisa meleng ea MMAF (1415246-68-2) (> 16 mg / kg) e phahametse MMAE (1 mg / kg). CAC10-L1-MMAF4 e na le MTD ea 50 mg / kg ka litoeba le 15 mg / kg ka likhoto. CAC10-L4-MMAF4 ADC e ne e le chefo e nyenyane haholo, e nang le li-MTDs likhopong le likhoto tsa> 150 mg / kg le 90 mg / kg ka likhoto, ka ho latellana

Temoso ho MMAF (Hydrochloride)

Bakeng sa lipatlisiso tse sebelisoang feela

Litaelo tse ling

Ho tlalehiloe hore Monomethylauristatin F Hcl (MMF Hcl) ke moemeli oa antitubulin o thibelang ho arohana ha sele ka ho thibela polymerization ea tubulin; 'me mosebetsi oa thecytotoxic o tlase ho feta MMAE; 'me ke cytotoxin ea anti-drug.

Cell Assay
Lisele li tšoaroa ka li-molecule tsa tlhahlobo tsa limolek'hule tsa tlhahlobo mme li kenngoa matsatsing a 4-6 ho itšetlehile ka lisele tsa sele. Tlhahlobo ea ho hōla ha lisele le ho fokotseha ha data ho hlahisa litekanyetso tsa IC50 ho etsoa ho sebelisa tekanyetso ea ho fokotsa tee ea Alamar Blue
MCE ha e e-s'o ikemisetse ho tiisa ho nepahala ha mekhoa ena. Li fumaneha bakeng sa boitsebiso feela.

Tsamaiso ea liphoofolo
Litoeba: liphuputso li bontša hore ha karolo e nyenyane ea Karpas 299 e fihla ho 300 mm3, liphoofolo tse tharo ka sehlopha li amohela ente e le 'ngoe ea 10 mg antibody component / kg boima ba' mele ea cAC10-L1-MMAF4 kapa cBR96-L1-1415246 ) 68 ka hare. Joale li-moriri li tlosoa ebe li kenngoa mofuteng oa mocheso o motle, mme 2 μm-mekhabiso e metsoako ea maqheku e silafatsoa ka ho hlahloba immunohistochemistry
MCE ha e e-s'o ikemisetse ho tiisa ho nepahala ha mekhoa ena. Li fumaneha bakeng sa boitsebiso feela.


Tsela ea ho reka MMAF; reka Hydrochloride ho tloha AASraw

1.To iteanye le rona ka imeile ea rona lenaneo la lipatlisiso, kapa skype ea inthanetengmoemeli oa tšebeletso ea bareki (CSR).
2.To re fane ka lipotso tsa hau le lipotso tsa hau.
3.Our CSR e tla u fa tlhaloso, nako ea ho lefa, nomoro ea ho latela, litsela tsa ho pepa le letsatsi la ho fihla ho fihlela (ETA).
4.Payment e entsoe mme thepa e tla romelloa ka lihora tsa 12 (Ho laela ka hare ho 10kg).
5.Goods e amohetse mme e fana ka litlhaloso.

TLHOKOMELISO LE TLHALOSO:

Boitsebiso bona bo rekisetsoe tšebeliso ea lipatlisiso. Lipehelo tsa thekiso Etsa kopo. Eseng molemong oa tšebeliso ea batho, kapa bongaka, bongaka ba liphoofolo kapa lisebelisoa tsa lapeng.


COA

HNMR

Recipes

Litlhaloso le lihlahisoa tsa lihlahisoa