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MMAD (Demethyldolastatin 10)

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SKU: 203849-91-6. Category:

AASraw e na le bokhoni ba tlhahiso le tlhahiso ho tloha ho gram ho ea ka taelo ea MMAD (Demethyldolastatin 10) (CAS 203849-91-6), tlas'a taolo ea CGMP le tsamaiso ea boleng bo sebetsang ba boleng.

Ho phaella moo, MMAD ho tlalehoa hore e tla sebelisoa ho hlahisa li-conjugate tse nang le li-anti-drug (NDCs) tsa sebaka sa maqephe. Li-NDC, MMAD e kopantsoe le anti-5T4 antibody kapa anti-Her2 antibody. Ho bontšoa hore li-NDC li bonts'a katleho e ntle le pharmacokinetics.

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MMAD (Demethyldolastatin 10) video


MMAD (Demethyldolastatin 10) ea Bohlokoa

Name: MMAD (Demethyldolastatin 10)
CAS: 203849-91-6
Molecular Formula: C41H66N6O6S
Boima ba 'mele: 771.06
Melt Point: N / A
Temp Temp Storage: Phiri -20 ° C lilemo tse 3
4 ° C lilemo tse 2
Ka ho qhibiliha -80 ° C likhoeli tse 6
-20 ° C Khoeli ea 1
Color: Ho soeufala ho fihlela ho soeufala (ho tiile)


MMAD (Demethyldolastatin 10) (203849-91-6) tshebeliso ea potoloho ea steroid

Mabitso

Li-synonyms: Demethyldolastatin 10 (203849-91-6); Monomethylauristatin D; Monomethyl Dolastatin 10
Chemical Name: (S)-N-((3R,4S,5S)-3-methoxy-1-((S)-2-((1R,2R)-1-methoxy-2-methyl-3-oxo-3-(((S)-2-phenyl-1-(thiazol-2-yl)ethyl)amino)propyl)pyrrolidin-1-yl)-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamide

Temoso ho MMAD (Demethyldolastatin 10)

Sehlahiswa ha sea ka sa phethahala ka botlalo bakeng sa likopo tsa bongaka. Bakeng sa lipatlisiso sebelisa feela

Bakeng sa ho fumana metsi a mangata, ka kopo o futhumatsa tube ka 37 ℃ mme e sisinyehe ka ho sesa ka nako e telele. Solution ea motlakase e ka bolokoa ka tlase -20 ℃ ka likhoeli tse 'maloa.

Litaelo tse ling

In Vitro: MMAD (Demethyldolastatin 10) (203849-91-6) e kopanngoa ka mokhoa o tsitsitseng oa oxime-ligation ho hlahisa li-conjugate tse ngata tsa anti-human-antijection (ADCs) tse nang le metsoako ea meriana-to-antibody ea ~ 2.0. Li-conjuguate tse hlahisoang li bontša metsoako e ntle ea pharmacokinetic, mokhoa o matla oa in vitro cytotoxic khahlanong le lisele tsa kankere tsa HER2 +. Ha e bapisoa le ADCs e lokiselitsoeng ke alstelation ea cysteine ​​ka mor'a ho fokotsa li-disulfide tsa sebaka sa tlhaho, libaka tse ling tsa ADCs tse sa tloaelehang tsa libaka tsa tlhaho li bontšitsoe hore li eketsehile ka in vitro cytotoxicity

Li Vivi: Litho tse hlahisoang ke li-anti-drug-conjugates (ADCs) li bonts'a phekolo e feletseng ea lithethefatsi ka litoeba. Ba boetse ba na le pono e ntlafetseng ea toxicology ho likhoto.


Joang ho reka MMAD; reka Demethyldolastatin 10 ho tloha AASraw

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