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Pitoxantrone HCL phofo

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SKU: 70476-82-3. Category:

AASraw e na le bokhoni ba tlhahiso le tlhahiso ho tloha ho gram ho ea ka taelo ea Mitoxantrone HCL powder (70476-82-3), tlas'a taolo ea CGMP le tsamaiso ea tšebetso ea boleng bo sebetsang.

Mitoxantrone hydrochloride powder ke meriana ea kankere e sitisang khōlo le ho ata ha lisele tsa kankere 'meleng. Morixantrone HCL e sebelisoa ho phekola kankere ea tšoelesa ea senya le mefuta e itseng ea kankere ea mali. Morixantrone HCL phofo e boetse e sebelisetsoa ho tšoara matšoao a ho khutla hape ka multiple sclerosis. Meriana ena e ke ke ea phekola multiple sclerosis.

Tlhaloso ea Sehlahisoa

Video ea Mitoxantrone hydrochloride powder


Mitoxantrone hydrochloride powder tsebo ea motheo

Name: Mitoxantrone hydrochloride powder
CAS: 70476-82-3
Molecular Formula: C22H30Cl2N4O6
Boima ba 'mele: 517.4
Melt Point: 160-162 ° C
Temp Temp Storage: Sehatsetsi
Color: Tšoeu kapa u tlohele phofo e tšoeu ea Crystalline


Mitoxantrone hydrochloride phofo e sebelisoang

Mabitso

Lebitso la Lebitso: Novantrone
Lebitso la Lik'hemik'hale: 1,4-dihydroxy-5,8-bis [[2- [2-hydroxyethyl] amino] ethyl] amino] 9,10-anthracenedione dihydrochloride

Sebeliso ea Mitoxantrone hydrochloride powder

Moriana o moholo oa Leyeloemia

Karolo ea lik'hemotherapy e sa tšoaneng e sebetsa bakeng sa ho fokotsa ho fokolloa ha myeloid (myelogenous, nonlymphocytic) kankere ea mali (AML, ANLL). AML e kenyelletsa ho lemalla ho pheta-pheta, monocytic, myelomonocytic, megakaryoblastic, le erythroid leukemias.

Li sebelisoa hammoho le lihlahisoa tse ling tsa mefuta-futa ea likokoana-hloko ka ho kopanya mekhoa ea phekolo ho latela tlhahiso ea phetoho e feletseng.

Kankere ea Prostate
E sebelisoa e le mokhoa o mong oa ho phekola ka lekhetlo la pele la tsoelo-pele e tsoetseng pele, e nang le matšoao (e bolelang, e utloisang bohloko) kankere ea prostate ea khanyang (e kopantseng le prednisone). Mofuta oa pele oa phekolo bakeng sa kankere ea kankere ea prostatic metastatic prostate ke docetaxel hammoho le prednisone.

Multiple Sclerosis (MS)
Kalafo ea MS ea bobeli (e sa foleng) ea tsoelo-pele, ea ho khutlela morao kapa ea ho khutlela morao. E le ho fokotsa bokooa ba neurologic le / kapa lebelo la ho khutlela morao.

E 'nile ea ithutoa ho bakuli ba nang le mekhoa e latelang ea mafu: Ho eketsa butle-butle ho holofala kapa ho se na tšebetso ea ho khutlela litleleniki tsa meriana (lintlheng tsa bobeli tse tsoelang pele le tse tsoelang pele ho khutlela morao) le ho khutla ha meriana ho etsa hore ho be le keketseho ea bokooa, e leng boemo bo sa tloaelehang ba kelello pakeng tsa ho khutlela morao- ho fokotsa lefu).

Ha e khothalletsoe hore e sebelisoe ho bakuli ba nang le ts'ebetso e kholo ea MS.

Ha ea lokela ho sebelisoa bakeng sa phekolo ea MS ho bakuli ba nang le lintlha tsa motheo LVEF <50% (bonaMyocardial Toxicity in Boxed Warning). Ka kakaretso ha ea buelloa bakeng sa ho sebelisoa ho ba nang le ho holofala ho matla (bona Mathata a Hepatic tlas'a Temoso) kapa ho ba nang le palo ea neutrophil <1500 / mm3.

Lymphoma ea Non-Hodgkin
E sebelisoa e le karolo ea chemotherapy e sebelisoang bakeng sa ho phekoloa ka tlase ea tekanyo e tlase e seng ea Hodgkin's lymphoma †.

Tekanyo ea Mitoxantrone hydrochloride phofo ke efe?

E fumaneha joaloka phofo ea Mitoxantrone hydrochloride; tekanyo e hlalositsoeng ka motsoako oa HCL oa mitoxantrone.

batho ba baholo
Moriana o moholo oa Leyeloemia
Therapy
IV
12 mg / m2 letsatsi le leng le le leng ka matsatsi a 1-3 hammoho le cytarabine 100 mg / m2 letsatsi le leng le le leng (e le tlhahiso ea IV e tsoelang pele ho feta lihora tsa 24) matsatsing a 1-7.

Haeba karabo ea phekolo ea kokoana-hloko nakong ea pele ea tlhahiso ea boipheliso e sa phethoa, thupelo ea bobeli e kenyelletsoeng e na le matsatsi a 2 a mongoxantrone HCL powder (12 mg / m2 letsatsi le leng le le leng) le matsatsi a 5 ea cytarabine (100 mg / m2 letsatsi le leng le le leng) a ka fuoa.

Haeba lefu la nonhematologic le matla kapa le kotsi bophelong, le ka fumanoa thupelong ea bobeli ho fihlela tšebetso ea chefo e rarolloa.

Therapy Consolidation
IV
12 mg / m2 letsatsi le leng le le leng ka matsatsi a 1 le 2 hammoho le cytarabine 100 mg / m2 letsatsi le leng le le leng (e le tlhahiso ea IV e tsoelang pele ho feta lihora tsa 24) matsatsing a 1-5. Laola thupelo ea pele ea ho kopanya libeke tse ka bang 6 ka mor'a thupelo ea ho qetela ea ho koetlisa; tsamaisa thupelo ea bobeli ea ho kopanya ka kakaretso libeke tse 4 ka mor'a thupelo ea pele.

Kankere ea Prostate
IV
12-14 mg / m2 hang ka matsatsi a 21; fana ka tumello ea phekolo ea corticosteroid (mohlala, prednisone 5 mg ka molomo ka makhetlo a mabeli letsatsi le leng le le leng, hydrocortisone 40 mg oralally). Lingaka tse ling li khothalletsa ho khaotsa ho hlahisa phofo ea HCL ea mitoxantrone (le ho phekoloa ha therapy ea corticosteroid feela) ho bakuli ba ntseng ba arabela ka mor'a tekanyo ea merixantrone ea HCL ea phofo ea 140 mg / m2 ka lebaka la kotsi ea chefo ea pelo.

multiple sclerosis
IV
12 mg / m2 hang ka likhoeli tse ling tsa 3.

Ho hlalosa meeli
batho ba baholo
multiple sclerosis
IV
Phomolo e kholo ea bophelo bohle: 140 mg / m2.

Batho ba khethehileng
Mathata a Hepatic
Ho fokotsa maruo; ho ka 'na ha hlokahala hore ho be le phetoho ea tekanyo ea litekanyo, leha ho le joalo, ha ho na litekanyetso tse tobileng tsa phetolo. (Bona Mathata a Hepatic tlas'a Temoso.)

Mathata a Renal
Ho fokotsa tekanyo ha ho hlokehe.

temoso ea

Phihlelo ea Ngaka ea Mohlokomeli

Ho laola feela tlas'a tlhokomelo ea baoki ba nang le boiphihlelo ba nang le phihlelo ea phekolo ea cytotoxic.

Litemoso tsa tsamaiso
Tšoara butle-butle ka tharollo ea bolokolohi ba tšeloetso ea IV. U se ke ua tsamaisa IM, sub-Q, entra-arterial, kapa intrathecal ente.

Matšoao a maholo a methapo ea necrosis haeba ho hlaha extravasation. (Sheba Litlhahiso Tsa Libaka ka Tlhokomeliso.)

Ka nako e telele, neurotoxicity e ke keng ea qojoa e tlalehoa ka morao ho tsamaiso ea boipheliso. (Bona Neurotoxicity tlas'a Temoso.)

Ho fokotsa maikutlo
Myelosuppression e matla e ka etsahala. Ka kakaretso qoba ho sebelisoa ho bakuli ba nang le lintlha tsa motheo tsa neutrophil <1500 / mm3, haese kalafo ea kankere ea myeloid (myelogenous, nonlymphocytic) ea leukemia. Sheba boemo ba hematologic hantle. (Sheba Litlhahiso Tsa Hematologic tlas'a Temoso.)

Toxicity Toxicity
Ho na le lefu la cardiotoxicity le CHF e ka bolaeang ka nako kapa likhoeli ho fihlela lilemo tse ngata ka mor'a phekolo; kotsi e eketseha ka tekanyo e eketsehileng ea tekanyo.

Matšoao a kotsi (histori ea hona joale kapa lefu la pelo ea methapo ea meriana, mokokotlo oa pele kapa o khotsofatsang sebakeng sa lipakeng tsa 'mele, lipilisi tse fetileng le tse ling tsa anthracyclines kapa li-anthracenediones, kapa ho sebelisoa ha lithethefatsi tse ling tsa cardiotoxic) li ka eketsa kotsi ea cardiotoxicity. Leha ho le joalo, chefo e ka 'na ea etsahala ho sa tsotellehe hore na lintho tse kotsi tsa pelo li teng kapa che. (Bona Cardiotoxicity tlas'a Temoso.)

Kotsi ea CHF e ntseng e e-na le bakuli ba kankere e hakanngoa hore e na le 2.6% ho tekanyo ea tekanyo ea ho fihlela 140 mg / m2.

Pele ho qala ts'oaetso, hlahloba bakuli bohle bakeng sa matšoao a lefu la pelo ka histori le ho hlahloba 'mele le ho hlahloba karolo e ka tlaase ea karoloana ea ejection ea ventricular (LVEF) ka echocardiogram kapa multigated radionuclide angiography (MUGA).

U se ke ua qala phekolo ho bakuli ba nang le multiple sclerosis haeba motheo oa LVEF o le <50%.

Bakeng sa bakuli ba nang le multiple sclerosis, hlahloba LVEF ka echocardiogram kapa MUGA pele ho tekanyo e 'ngoe le e' ngoe; u se ke ua fana ka tekanyo e eketsehileng haeba LVEF e fokotseha ho <50% kapa haeba ho fokotseha ha bohlokoa holima LVEF ho etsahala.

Bakuli ba nang le multiple sclerosis ha baa lokela ho fumana tekanyo ea lipalo> 140 mg / m2.

Sepheo sa Bobeli sa Myelogenous Leukemia (AML)
AML ea bobeli e tlaleha ho bakuli ba tšoaroang ka phofo ea mitoxantrone HCL; kotsi ea ho hanyetsa lik'hemik'hale tse eketsehileng tsa leukemia e eketseha ha li-anthracycline li kopantsoe le likokoana-hloko tse ling tse bakang DNA, ka mor'a hore li be le lithethefatsi tse ngata tsa cytotoxic kapa ha li-anthracycline li lekanngoa. (Sheba Carcinogenicity tlas'a Temoso.)

Powder Raw Mitoxantrone

Ntho e nyenyane 10grams.
Tlhahlobo ka bongata bo tloaelehileng (ka hare ho 1kg) e ka romeloa lihora tse 12 kamora ho lefa.
Bakeng sa taolo e kholo e ka romeloa matsatsing a ts'ebetso ea 3 ka mor'a ts'enyehelo.

Mitoxantrone hydrochloride powder Marketing

Ho fanoa nakong e tlang.

Na phofo ea Mitoxantrone HCL e na le liphello tse mpe

Tloaelo e ile ea tlaleha liphello tse ya mitoxantrone kenyeletsa: tšoaetso, tshwaetso e ka holimo respiratorytract, tšoaetso ea pampitšana mosese, tshwaetso fungal, tshwaetso fungal letlalo, sepsis, alopecia, amenorrhea, arrhythmia cardiac, pipitlelano, letšollo, ecg sa tloaelehang, gastrointestinal hemorrhage, e ile ea eketseha ea gamma-glutamyl transferase, leukopenia, lefu matsatsing, ho nyekoa ke pelo, stomatitis, moroto sa tloaelehang, bohloko mpeng, aphthous stomatitis, asthenia, tukang a ikutloa joang pampitšaneng gastrointestinal, khohlela, fokotseha haemoglobin, fokotseha tšoeu mali count ya seleng, dyspnea, edema, epigastric bohloko, mokhathala, feberu, hematuria, hyperglycemia, hypocalcemia, hypokalemia, e ile ea eketseha serum tsoekere, lymphocytopenia, mucositis, pharyngitis, rhinitis, bohloko mpeng, thrombocytopenia, ho hlatsa, ho nona, e sa tloaelehang ka ho feletseng neutrophil count ya, ho ipolaisa tlala, malaise, le nailbedchanges. litla tse ling lehlakoreng kenyeletsa: serame sa matšoafo, renal ho hloleha lefu, inkela ka mahahapa, skininfection, khaello ea mali, ho opeloa ke mokokotlo, granulocytopenia, hlooho e opang, sinusitis, ho tšoenyeha arthralgia, conjunctivitis, ho tepella maikutlo, dyspepsia, boima mali matsatsing, hemorrhage, kgatelelo ya madi, hyponatremia, ho hloka matla, e ile ea eketseha serum alanine aminotransferase, e ile ea eketseha serum aspartate aminotransferase, lefu ischemic pelo, myalgia, bohloko petechia, proteinuria, nyopa, khoba, chills, diaphoresis, le ecchymoses. Sheba ka tlase bakeng sa lenane le sa utloisiseng la liphello tse bohloko.


Ho reka phofo ea Mitoxantrone hydrochloride ho tloha AASraw

1.To iteanye le rona ka imeile ea rona lenaneo la lipatlisiso, kapa skype ea inthanetengmoemeli oa tšebeletso ea bareki (CSR).
2.To re fane ka lipotso tsa hau le lipotso tsa hau.
3.Our CSR e tla u fa tlhaloso, nako ea ho lefa, nomoro ea ho latela, litsela tsa ho pepa le letsatsi la ho fihla ho fihlela (ETA).
4.Payment e entsoe mme thepa e tla romelloa ka lihora tsa 12 (Ho laela ka hare ho 10kg).
5.Goods e amohetse mme e fana ka litlhaloso.


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COA

COA 70476-82-3Mitoxantrone HCL phofo AASRAW

HNMR

Re Mitoxantrone hydrochloride phofo supplie, Mitoxantrone HCL phofo bakeng sa sale, Tala Mitoxantrone HCL phofo supplie (70476-82-3) hplc≥98% | AASraw

Recipes

Mitoxantrone hydrochloride Raw Powder Recipes

Ho botsa bareki ba rona baemeli ba rona (CSR) bakeng sa lintlha tse eketsehileng, bakeng sa boitsebiso ba hau.

Litlhaloso le lihlahisoa tsa lihlahisoa