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Lapatinib phofo (231277-92-2)

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AASraw e na le bokhoni ba tlhahiso le tlhahiso ho tloha ho gram ho ea ka taelo e kholo ea Lapatinib powder (231277-92-2), tlas'a taolo ea CGMP le tsamaiso ea boleng bo sebetsang ba boleng.

Tlhaloso ea Sehlahisoa

Lapatinib phofo ea video


Lapatinib phofo tsebo ea motheo

Name: Lapatinib phofo
CAS: 231277-92-2
Molecular Formula: C29H26ClFN4O4S
Boima ba 'mele: 581.05
Melt Point: 136-140 ° C
Temp Temp Storage: Sehatsetsi
Color: Tšoeu kapa u tlohele phofo e tšoeu ea Crystalline


Raw Lapatinib phofo ea Antineoplastic Agent cycle

Mabitso

Lebitso la Sehlahahlaha: Lapatinib phofo (la PA tin ib)
Lebitso la Lebitso: Tykerb

Tšebeliso ea phofo ea Raw Lapatinib

Lapatinib phofo ke moriana oa ngaka o sebelisoang ka moriana o mong (capcitabine) ho phekola batho ka kankere ea matsoele e hasaneng libakeng tse ling tsa 'mele e leng HER2 e ntle (lihlahala tse hlahisang liprotheine tse ngata tse bitsoang epidermal growth factor receptor-2) , le ba seng ba ntse ba na le tse ling tsa phekolo ea kankere ea matsoele.

Lapatinib phofo e boetse e sebelisoa ka mofuta oa meriana o bitsoang letrozole bakeng sa phekolo ea basali ba postmenopausal ba nang le li-hormone receptor positive, kankere ea matsoele ea HER2 e nang le methapo ea matsoele eo ho eona ho bontšitsoeng phekolo ea hormone.

Lapatinib phofo ke meriana ea ngaka e sebelisoang ho tšoara kankere ea matsoele. E sebelisoa hammoho le meriana e meng ho phekola mofuta o itseng oa kankere ea matsoele e hasaneng likarolong tse ling tsa 'mele le e sa arabelang kalafo ea meriana e meng.

Lapatinib phofo ke ea sehlopha sa lithethefatsi tse bitsoang kinase inhibitors tse sebetsang ka ho thibela ketso ea protheine e itseng e bontšang hore lisele tsa kankere li ata.

Meriana ena e hlaha ka foromo ea thepa ea thepa 'me e nkiloe hanngoe letsatsi le leng le le leng ka mpeng e se nang letho.

Litla-morao tse tloaelehileng tsa phofo ea Lapatinib li akarelletsa matsoho le maoto a bofubelu, a bohloko, letšollo, leqeba le ho nyefoloha.

Ke litekanyo life tsa Lapatinib phofo

Ho tloaelehile Likoloto tsa Batho ba baholo bakeng sa Kankere ea Bokhachane

-HER2-POSITIVE METASTATIC BREAST CANCER (e kopantsoe le capecitabine): XMUMX mg ka molomo hang ka letsatsi ka Matsatsi 1250 ho 1 ka ho pheta-pheta ho pheta mekhoa ea 21 ho fihlela ho e-ba le mafu kapa chefo e sa amoheleheng.

-HORMONE RECEPTOR-POSITIVE, HER2-POSITIVE METASTATIC BREAST CANCER (e kopantseng le letrozole): XMUMX mg molomo hang ka letsatsi ka nako e tsoelang pele.

Comments:
-Consult moetsi sehlahiswa tlhahisoleseding bakeng sa capecitabine le letrozole dosing maikutlo.
Bakuli ba kankere ea matsoele ba HER2-metastatic ba nang le kankere ba lokela ho ba le ts'oaetso ea mafu ho trastuzumab pele ho qaleha kalafo ka lithethefatsi ena hammoho le capecitabine.

Sebeliso:
-Ke kopane le capecitabine bakeng sa ho phekoloa bakuli ba kankere e tsoetseng pele kapa ea metastatic ea matsoele eo lithethefatsi li hlahisang HER2 le ba amohetseng pele ho phekoloa ho akarelletsa anthracycline, taxane le trastuzumab.
-Ke kopantsoe le letrozole bakeng sa phekolo ea basali ba postmenopausal ea kankere ea matsoele ea metastatic ea letsoele e amohelang li-hormone e amohelang kankere ea HER2 receptor eo ho eona ho bontšitsoeng phekolo ea hormone.

Li-Renal Dose Liphetoho
Litaba ha li fumanehe mabapi le liphetoho tsa litekanyetso; leha ho le joalo, pharmacokinetics ea lithethefatsi ena ha e na tšebetso ea ho ameha hobane ho fokotsoe ho feta 2% ea tekanyo e fanoang ke liphio.

Lefu la sebete Liphetoho
MOSEBETSI OA HO ETSA HORE O TSETSE MOSEBETSI OA HEPATIC (CHILD-PUGH A / B): Ditaba ha di fumanehe.

MOTHO OA HO ETSA HEPATIC (APIL-PUGH C): E fokotsa lethal dose:
-HER2-Positive Metastatic Cancer ea Breast (e kopantsoe le capecitabine): 750 mg / letsatsi.
-Hormone Receptor-Positive, HER2-Positive Metastatic Kankere ea Breese (hammoho le letrozole): 1000 mg / letsatsi

HEPATOTOXICITY E HLATSOXICITY E MONGATA KA THERAPY: Ho khaotsa ho phekoloa ka ho sa feleng.

Maikutlo: Liphetoho tsa liphetoho tsa likhahla li thehiloe lithuputsong tsa pharmacokinetic; ha ho na ditaba tsa kliniki tse teng.

Liphetoho tsa likhahla
MOSEBETSI OA SEBELISA KA MANGATA A MANGATA A CYP450 3A4 LE / KAPA MOTSOALLE OA CYP450 3A4 BANG: Qoba ho sebelisa habonolo ha ho khoneha. Litlhahiso tsa liphetoho tsa likhahla li thehiloe lithuputsong tsa pharmacokinetic; ha ho na ditaba tsa kliniki tse teng.
MOTHO OA SEBELE O SEBELISA MOTSOALLE OA CYP450 3A4 MOKHETSI: Fokotsa lethal ho lekola 500 mg / letsatsi; lumella phomolo ea nako e ka bang beke ea 1 pele ho etsoa phetoho ea lithethefatsi ena ho feta tekanyo e tloaelehileng e khothalletsoang haeba inhibitor e khaotsa.
MOSEBETSI OA SEBELISA KA MOTSOALLE OA CYP450 3A4 INDUCER: Mothati o fokolang haholo o thehiloeng holellong; fokotsa lethal dose ho tloaelehileng tekanyo ea khoeli haeba mochine o fokolang o khaotsa.
-HER2-Positive Metastatic Cancer ea Breast (e kopantsoe le capecitabine): Eketsa tekanyo ea ho fihlela 4500 mg / letsatsi.
-Hormone Receptor-Positive, HER2-Positive Metastatic Kankere ea Breast (e kopantswe le letrozole): Eketsa tekanyo ea ho fihlela 5500 mg / letsatsi.

GRADE 2 kapa KHAOLO E KHETHO EA HO HLAHALA KA LITŠOANTŠISO (LVEF) KAPA LVEFU E KHETHA MOSEBETSI OA MESEBETSI EA LITABA TSE KOPITSOENG: Khaotsa ho phekoloa; e ka qala hape ka tekanyo e fokotsehileng ka mor'a libeke tse ka tlase tsa libeke tse 2 haeba LVEF e hlaphoheloa ho tloaelehileng mme mokuli o na le matla a ho itšireletsa.
Mokhoa o fokotsehileng:
-HER2-Positive Canast Metastatic Cancer (e kopantseng le capecitabine): 1000 mg / letsatsi
-Hormone Receptor-Positive, HER2-Positive Metastatic Kankere ea Breese (hammoho le letrozole): 1250 mg / letsatsi

GRADE 3 kapa GRADE 1 kapa 2 DIARRHEA KA LIPHELO TSE KHETHA (ho fokotsa mpa ho ea ka mpeng, Grade 2 kapa ts'oaetso e khōlō kapa ho hlatsa, ho fokotseha boemo ba ts'ebetso, feberu, sepsis, neutropenia, mali a tsoang fatše, kapa ho felloa ke metsi): E ka boela ea tsosolosa tekanyo e tlaase ha letšollo o rarolla sehlopheng sa 1 kapa ka tlasa.
Mokhoa o fokotsehileng:
-HER2-Positive Metastatic Breast Cancer Patients (hammoho le capecitabine): 1000 mg / letsatsi
-Hormone Receptor-Positive, HER2-Positive Metastatic Breast Cancer Bakuli: 1250mg / letsatsi
GRADE 4 DIARRHEA: Ho khaotsa ho phekoloa ka ho sa feleng.

LITŠOANTŠISO TSE LING, GRADE 2 kapa GREATER: E ka 'na ea nahana ka ho khaotsa kapa ho sitisoa ha dosing; e ka qala hape ka tekanyo e tloaelehileng ea menyetla ha chefo e ntlafala ho ea ho Grade 1 kapa ka tlase.
HAEBA TOXICITY RECURS: Fokotsa lethal dose:
-HER2-Positive Canast Metastatic Cancer (e kopantseng le capecitabine): 1000 mg / letsatsi
-Hormone Receptor-Positive, HER2-Positive Metastatic Breast Cancer Bakuli: 1250mg / letsatsi

Joang ha pale e tala ea Lapatinib e sebetsa

Lapatinib phofo e sebelisoa le capecitabine (Xeloda) ho phekola mofuta o itseng oa kankere ea matsoele e tsoetseng pele ho batho ba seng ba ntse ba phekoloa ka meriana e meng ea chemotherapy. Lapatinib phofo e ka sehlopheng sa meriana e bitsoang kinase inhibitors. E sebetsa ka ho thibela ketso ea protheine e sa tloaelehang e bontšang hore lisele tsa kankere li ata. Sena se thusa ho emisa kapa ho liehisa ho ata ha lisele tsa kankere.

temoso ea

Bolella bafani bohle ba tlhokomelo ea bophelo hore u nke phofo ea Lapatinib. Sena se kenyeletsa lingaka tsa hau, baoki, litsebi tsa meriana le lingaka tsa meno.
Haeba u halefisitsoe ke mpa, u lahleheloa, u laola (letšollo), kapa u sa lapile, buisana le ngaka ea hau. Ho na le litsela tsa ho theola litla-morao tsena.
Li-stools (letšollo) li etsahetse ka phofo ea Lapatinib. Ka linako tse ling, letšollo le bile le bobe haholo 'me ba shoele ba hlahile. Bua le ngaka ea hau.
Haeba u na le li-setulo (letšollo), buisana le ngaka ea hau. U se ke ua leka ho phekola letšollo ntle le ho hlahloba ngaka ea hau pele.
Etsa hore mosebetsi oa mali o hlahlojoe joalokaha u boleletsoe ke ngaka. Bua le ngaka.
U tla hloka ho ba le liteko tsa mosebetsi oa pelo ha u ntse u nka phofo ea Lapatinib. Bua le ngaka.
Qoba litholoana tsa morara le lero la morara.
Haeba u nka digoxin, buisana le ngaka ea hau. U ka 'na ua hloka hore mosebetsi oa hao oa mali o hlahlojoe haufi-ufi ha o ntse o o nka ka phofo ea Lapatinib.
Meriana ena e ka baka kotsi ho lesea le e-s'o tsoaloe haeba le e nka ha le ntse le imme.
Sebelisa thibelo ea bokhachane eo u ka e tšepang ho thibela bokhachane ha u ntse u nka phofo ea Lapatinib.
Haeba u imme kapa u ima nakong ea ha u nka phofo ea Lapatinib, founa ngaka ea hao.

Phiri ea Raw ea Lapatinib

Ntho e nyenyane 10grams.
Tlhahlobo ka bongata bo tloaelehileng (ka hare ho 1kg) e ka romeloa lihora tse 12 kamora ho lefa.
Bakeng sa taolo e kholo e ka romeloa matsatsing a ts'ebetso ea 3 ka mor'a ts'enyehelo.

Khoebo ea phofo ea Lapatinib

Ho fanoa nakong e tlang.

Na phofo ea Lapatinib e tala e na le liphello tse mpe

Hammoho le liphello tsa eona tse hlokahalang, phofo ea Lapatinib e ka baka liphello tse sa batleheng. Le hoja litla-morao tsena kaofela li ka etsahala, haeba li ka etsahala li ka hloka tlhokomelo ea meriana.

Kopa ngaka hang-hang haeba ho na le litla-morao tse latelang tse hlahang ha u ntse u nka phofo ea Lapatinib:

Tse sa tloaelehang
Ho phefumoloha ho thata kapa ho sebetsa hantle
ho tepella
ka potlako kapa ka mokhoa o sa tloaelehang oa pelo
letšollo le matla
ho tiea ka sefubeng
khatello e sa tloaelehang kapa bofokoli
Rare

Bohloko ba mpa kapa mpa kapa bonolo
lipalo tsa letsopa tsa letsopa
motsoako o lefifi
fokotseha takatso ea lijo
feberu
hlooho
ho hlatsoa kapa ho phatloha ka letlalo
ho lahleheloa ke takatso ea lijo
ho nyefutsa le ho hlatsa
ho ruruha maotong kapa maoto a tlaase
mosehla mahlo kapa letlalo
Kotsi e sa tsejoeng
Ho phalla, ho senya, ho lokoloha ha letlalo
bohloko ba sefuba
ho tsuba
khohlela
letšollo
bothata ka ho metsa
botsoa
boikutlo bo tloaelehileng ba ho se utloise bohloko kapa bokuli
mehaho
bohloko bo kopantsoeng kapa ba mesifa
ho ikhohomosa kapa ho ruruha ha mahlo kapa ho pota-pota mahlo, sefahleho, molomo kapa leleme
letlalo le lefubelu la letlalo, hangata le nang le setsi se pherese
e khubelu, e halefile
'metso o bohloko
liso, liso, kapa matheba a masoeu molomong kapa molomong
ho koaloa ha liphiri tse senyang
Tse ling tsa litla-morao tsa Lapatinib phofo e ka 'na ea hlaha hangata ha e hloke thuso ea meriana. Litla-morao tsena li ka fela nakong ea phekolo ha 'mele oa hao o fetola meriana. Hape, ngaka ea hao ea tlhokomelo ea bophelo e ka khona ho u bolella ka litsela tsa ho thibela kapa ho fokotsa tse ling tsa litla-morao tsena. Sheba ngaka ea hau ea bophelo bo botle haeba ho na le litla-morao tse latelang tse tsoelang pele kapa tse khathatsang kapa haeba u e-na le lipotso tse mabapi le tsona:

E tloaelehileng haholoanyane
Matsoalo a 'mala kapa a bolila
bohloko ba morao
belching
melomo e sothehileng
letšollo (bonolo)
letlalo omileng
ho otloa ke pelo
indigestion
bohloko maotleng kapa maotong
bofubelu, ho ruruha, kapa letlalo le bohloko
ho phahama ha letlalo matsohong le maotong
liso, liso, kapa matheba a masoeu molomong, lelemong, kapa ka har'a molomo
ho se khotsofale ke mpa, ho halefa kapa bohloko
ho ruruha kapa ho ruruha ha molomo
ho sisinya matsoho le maoto
khathatso ea ho robala


Ho reka phofo ea Lapatinib ho tloha AASraw

1.To iteanye le rona ka imeile ea rona lenaneo la lipatlisiso, kapa skype ea inthanetengmoemeli oa tšebeletso ea bareki (CSR).
2.To re fane ka lipotso tsa hau le lipotso tsa hau.
3.Our CSR e tla u fa tlhaloso, nako ea ho lefa, nomoro ea ho latela, litsela tsa ho pepa le letsatsi la ho fihla ho fihlela (ETA).
4.Payment e entsoe mme thepa e tla romelloa ka lihora tsa 12 (Ho laela ka hare ho 10kg).
5.Goods e amohetse mme e fana ka litlhaloso.


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COA

COA 231277-92-2 Lapatinib phofo AASRAW

HNMR

Re phofshoana ea Lapatinib, phepelo ea Lapatinib, phofo e kholo ea Lapatinib (231277-92-2) hplc≥98% | Ho hlahisa li-Reagents tsa R & D

Recipes

Li-Recipe tsa Raw ea Raw ea Raw:

Ho botsa bareki ba rona baemeli ba rona (CSR) bakeng sa lintlha tse eketsehileng, bakeng sa boitsebiso ba hau.

Litlhaloso le lihlahisoa tsa lihlahisoa

Tykerb (231277-92-2) -Molai oa sefuba sa matsoele