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JW 642 (1416133-89-5)

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SKU: 1416133-89-5. Category:

AASraw e na le bokhoni ba tlhahiso le tlhahiso ho tloha ho gram ho ea ka taelo ea JW 642 (1416133-89-5), tlas'a taolo ea CGMP le tsamaiso ea tšebetso ea boleng bo tsitsitseng.

Tlhaloso ea Sehlahisoa

Video ea JW 642


JW 642 tsebo ea motheo

Name: JW 642
CAS: 1416133-89-5
Molecular Formula: C21H20F6N2O3
Boima ba 'mele: 462.4
Melt Point:
Temp Temp Storage: ho -20 ° C lilemo tse 3 Powder
Color: Tšepe e tšoeu


Potso ea JW 642

Mabitso

Mabitso a Lik'hemik'hale
4 - [(3-Phenoxyphenyl) methyl] -1-piperazinecarboxylic acid 2,2,2-trifluoro-1- (trifluoromethyl) ethyl ester
Li-synonyms:
JW 642;1,1,1,3,3,3-Hexafluoropropan-2-yl 4-(3-phenoxybenzyl)piperazine-1-carboxylate

JW 642 (1416133-89-5) tšebeliso

Mekhoeng ea laboratori, bakeng sa polokelo ea nako e telele, re fana ka maikutlo a hore JW 642be e bolokiloe e ts'oaroe -20 ℃. E lokela ho tsitsa bonyane selemo se le seng.
JW 642 e fanoa e le tharollo methyl acetate. Ho fetola solvent, feela e feto-fetohe mouocha methyl acetate ka tlas'a metsi a nang le nitrojene 'me hang-hang e phaella moo ho khetholloang teng. Lisebelisoa tse kang asethanol, DMSO le dimethyl formamide e hloekisitsoeng ka khase e nang le inerase e ka sebelisoa. Mocheso oa JW 642 matsatsing ana a solvents o haufi le 13,5, le 11mg / ml, ka ho latellana.
JW 642 e na le mocheso o fokolang ka har'a li-buffers tse nang le metsi a mangata. Bakeng sa ho iketsetsa metsi ka ho fetisisa ho li-aqueousbuffers, tharollo ea bohetene ea JW 642Ke lokela ho hlakotsoa ka mochine o fokolang oa maqeba. JW 642 e na le metsi a ka bang 0.3 mg / ml ka 1: 2 tharollo ea ethanol: PBS (pH 7.2) e sebelisa mokhoa ona. Ha re khothaletse ho boloka tharollo e nang le metsi a fetang a le mong.

Ke tekanyo efe ea JW 642

DMSO ho 100 mM
Ethanol ho 100 mM
Keletso ea botsitso le ea mafura: Tse ling li ka ba thata ho fumana tharollo 'me li ka khothatsoa ke ho futhumala ka potlako, moraication kapa ho futhumala hamonate (ka ho sesa metsi a 45-60 ° C). Boitsebiso bo mabapi le ts'ebetso ea sehlahisoa, haholo-holo tharollo, ha hoa ka ha e-ba le tlaleho e sa tloaelehang 'me maemong a mangata re ka fana ka tataiso e akaretsang Melao ea rona e tloaelehileng ke: SOLIDS: Mobu o bolokiloeng o boletsoeng ka lebokoeng la sehlahisoa 'me sekoahelo se bolokiloe ka tieo, sehlahisoa se ka bolokoa ho fihlela likhoeli tsa 6 ho tloha letsatsing la kamohelo. LITLHELO: Re khothaletsa hore tharollo ea li-stock, hang ha e lokiselitsoe, e bolokiloe ka thata ho tiisitsoe vialsat -20 ° C kapa ka tlase mme e sebelisoa ka hare ho khoeli ea 1.Mohle moo ho khonehang tharollo e lokela ho etsoa le ho sebelisoa ka letsatsi le le leng.

Kamoo JW 642 e sebetsang kateng

JW 642 ke monoacylglycerol lipase e matla le e khethileng (MAGL) inhibitor (IC = 3.7 nM). E bontsha> 1000-khekhe selectivity bakeng sa MAGL ka mafura a acid e amidehydrolase (IC = 20.6 μM). Monoacylglycerol lipase (MAGL) e sebetsa serine hydrolase e ikarabellang bakeng sa hydrolysis ea 2-AG ho arachidonic acid le glycerol, e leng ho felisa sebōpeho sa eona. Liphello tsa chefo li ka bakoa joaloka tse ka tlase: Methyl Acetate - Ditaba tsa Toxicity: Oral LD50 (rat):> 5,000 mg / kg; Monyaluoa LD50 (mmutla): 3,705 mg / kg; Letlalo LD50 (mmutla):> 5,000 mg / kg; Inhalation TCLO (motho): 15,000 mg / m3; Methyl Acetate - Irritation Data: Letlalo (mmutla): 500 mg (24h) bonolo; Mahlo (mmutla): 100 mg (24h) e itekanetse.

JW 642 (1416133-89-5) temoso ea

I. Boikarabello le ts'ebetsong

5.1 Reactivity

E tiile tlas'a maemo a khothalletsoang ho tsamaisa kapa ho boloka.

5.2 ts'ebetsong ea lik'hemik'hale

E tiile tlasa maemo a ho boloka a khothalletsoang.

5.3 Ho khoneha ha likarabo tse kotsi

Liketsahalo tse kotsi li ke ke tsa etsahala tlas'a maemo a tloaelehileng a lipalangoang kapa tsa ho boloka. Ho senyeha ho ka etsahala ha ho pepesehetse maemo kapa lisebelisoa tse thathamisitsoeng ka tlase.

5.4 Melao ea ho qoba mocheso, mongobo.
Lisebelisoa tsa 5.5 tse sa lumellaneng

Li-acid / alkalis tse matla, li-oxidising tse matla / tse fokolang.

Lihlahisoa tsa 5.6 tse senyang kotsi

Mocheso o ka 'na oa ntša mafura a chefo. Ha ho tsebo e tsejoang ea ho felisoa.

II.Handing le polokelo

Tlhokomelo ea 5.1 bakeng sa ho sebetsana ka bolokolohi

Sebelisa mofuteng oa lik'hemik'hale, moeeng o fanoang ke tsamaiso e ikemetseng. Qoba ho inhalation, ho kopana le mahlo, letlalo le
liaparo. Qoba ho thehoa ha lerōle le li-aerosols. Sebelisa sebakeng se nang le moea o motlakase. Lula hole le mehloli ea ho hloekisa. Qoba
ho pepesa nako e telele kapa ho pheta-pheta.

Melao ea 5.2 bakeng sa polokelo e bolokehileng, ho kenyellets'ana le tse ling tse sa lumellaneng.

Boloka sebakeng se pholileng, se nang le moea o motlakase. Lula hole le letsatsi. Boloka sesebelisoa se tiisitsoeng ho fihlela se loketse ho sebelisoa.
Mocheso o boloketsoeng oa polokelo: Boloka ho -20 ° C

Qetello e khethehileng ea 5.3 e sebelisoa

Sebelisa holong ea maqhubu ea laboratori moo ho ka khonehang.

JW 642 (1416133-89-5) Phiri e Meholo

Ntho e nyenyane 10grams.
Tlhahlobo ka bongata bo tloaelehileng (ka hare ho 1kg) e ka romeloa lihora tse 12 kamora ho lefa.
Bakeng sa taolo e kholo e ka romeloa matsatsing a ts'ebetso ea 3 ka mor'a ts'enyehelo.

JW 642 phofo (1416133-89-5) Marketing

Ho fanoa nakong e tlang.

Na JW 642 e na le Liphello Tse Ntle

Boitsebiso bo ka 'na ba halefisa liphatsa tsa lefutso le pampiri ea ho hema; E ka 'na ea e-ba kotsi ka ho inhalation, ho kenngoa, kapa ho kenngoa ha letlalo; E ka 'na ea etsa hore motho a otsele; E ka etsa hore letlalo kapa ho hema ho halefisoe. Ho pepesa ha motho ka makhetlo ho ka etsa hore letlalo le ome kapa le fokotsehe.
Tlhokomelo ea lipolelo / ts'ireletso ea botho

Lintlha tsa ho laola 9.1

Likarolo tse nang le mekhahlelo ea ho laola mosebetsing
Ha e na lintho tse nang le meeli ea ho pepesa mosebetsing.

Lisolafatso tsa 9.2

Tlhokomelo e nepahetseng ea boenjiniere
Sebelisa holong ea ho chesa moo ho sebetsang teng. Etsa bonnete ba hore mehato eohle ea boenjiniere e hlalositsoeng tlas'a karolo ea 7 ea SDS e ntse e le teng.
Etsa bonnete ba hore laboratory e na le setoro sa polokeho le seteishene sa ho hlatsoa mahlo.
Thepa ea ho itšireletsa

Tšireletso ea mahlo / sefahleho
Sebelisa likhalase tse loketseng tsa polokeho.
Tšireletso ea letlalo
Sebelisa likokoana-hloko tse loketseng tsa lik'hemik'hale (bonyane ho hlokahala hore u sebelise standard BS EN 374: 2003). Lihlopha li lokela ho ba
e hlahlojoe pele e sebelisoa. Hlatsoa 'me u omelle matsoho ka mor'a hore u sebetse.
Tšireletso ea 'mele
Apara liaparo tse loketseng tsa tšireletso.
Tšireletso ea ho hema
Haeba tlhahlobo ea kotsi e bontša hore hoa hlokahala, sebelisa phefumoloho e loketseng.

ngoe har'a ba bang


Joang ho reka phofo ea JW 642 (1416133-89-5) ho tloha AASraw

1.To iteanye le rona ka imeile ea rona lenaneo la lipatlisiso, kapa skype ea inthanetengmoemeli oa tšebeletso ea bareki (CSR).
2.To re fane ka lipotso tsa hau le lipotso tsa hau.
3.Our CSR e tla u fa tlhaloso, nako ea ho lefa, nomoro ea ho latela, litsela tsa ho pepa le letsatsi la ho fihla ho fihlela (ETA).
4.Payment e entsoe mme thepa e tla romelloa ka lihora tsa 12 (Ho laela ka hare ho 10kg).
5.Goods e amohetse mme e fana ka litlhaloso.


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COA

COA 1416133-89-5 JW 642 AASRAW

HNMR

Recipes

Li-Recipe tsa JW 642 tsa Mefuta e Meholo:

Ho botsa bareki ba rona baemeli ba rona (CSR) bakeng sa lintlha tse eketsehileng, bakeng sa boitsebiso ba hau.

Litlhaloso le lihlahisoa tsa lihlahisoa

MAGL inhibitor le FAAH Inhibitor: JW-642 & OL-135 & PF-750