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Entecavir hydrate phofo

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SKU: 209216-23-9. Category:

AASraw e na le bokhoni ba tlhahiso le tlhahiso ho tloha ho gram ho ea ka taelo e kholo ea phofo ea Entecavir hydrate (209216-23-9), tlas'a taolo ea CGMP le tsamaiso ea boleng bo sebetsang ba boleng.

Tlhaloso ea Sehlahisoa

Entecavir hydrate phofo video


Pene e entsoeng ka Entecavir hydrate tsebo ea motheo

Name: Entecavir hydrate phofo
CAS: 209216-23-9
Molecular Formula: C12H17N5O4
Boima ba 'mele: 295.29
Melt Point: 220-225 ° C
Temp Temp Storage: -20 ° C Freezer
Color: Tšoeu ho ea ho phofo e tšoeu ea Crystalline


Pene ea Entecavir ea hydrate e sebelisoang haholo

Mabitso

Baraclude

Sebeliso ea phofo ea Entecavir hydrate

Pente ea entecavir ea hydrate ke motsoako o moholo oa deoxyguanosine nucleoside analog e nang le thibelo ea thibelo ea likokoana-hloko (EC50 = 3.7 nM khahlanong le kokoana-hloko ea hepatitis B (HBV) litsong tse tsoetseng pele tsa 2.2.15 sebete). In vitro, mofuta o sebetsang oa intracellular oa Entecavir hydrate phofo e tala, Entecavir hydrate powder triphosphate, e bonts'a ho kopana ho holimo ho HBV DNA polymerase ho feta tlhaho ea guanosine triphosphate substrate 'me e thibela ho pheta-pheta ha HBV DNA ho mehato ea 3 tseleng ea ho pheta-pheta phetolelo, le DNA e itšetlehileng ka DNA. Melemo e ka 'nang ea e-ba le phekolo ea Entecavir ea hydrate e tala e' nile ea bontšoa ka lehong le lehong la HBV. Ketsahalo e ne e fihliloe liphuputsong tsa mehato ea pele ea I / II le Pecedir hydrate powder e amohele tumello ho tswa ho US Food and Drug Administration bakeng sa ho phekoloa batho ba baholo ba nang le lefu la sebete sa lefu le sa foleng.

Entecavir hydrate phofo e tala (ETV), e rekisoang tlas'a lebitso la Baraclude, ke moriana o thibelang ho thibela tšoaetso o sebelisoang ho phekola tšoaetso ea lefu la hepatitis B (HBV). Ho ba nang le meriana e loantšang HIV / AIDS le HBV le eona e lokela ho sebelisoa. Pente ea entecavir ea hydrate e nkoa ka molomo e le letlapa kapa tharollo.

Litla-morao tse tloaelehileng li kenyelletsa hlooho, ho nyefoloa ke pelo, tsoekere e phahameng ea mali le mosebetsi o fokolang oa liphio. Litla-morao tse matla li akarelletsa ho atolosoa ha sebete, maqhubu a phahameng a lactate le ho ruruha ha sebete haeba meriana e emisoa. Ha ho ntse ho bonahala eka ha ho kotsi ho tloha nakong ea bokhachane, mokhoa ona ha o e-s'o ithute hantle. Entecavir hydrate phofo e tala e na le metsoako ea meriana ea nucleoside reverse transcriptase inhibitors (NRTIs). E thibela kokoana-hloko ea hepatitis B ho ata ka ho thibela reverse transcriptase.

Phofo ea entecavir ea hydrate e sebelisoa haholo ho phekola tšoaetso e sa foleng ea lefu la sebete la batho ho batho ba baholo le bana lilemo tse 2 le ho feta ka ho pheta-pheta ha likokoana-hloko le bopaki ba lefu le mafolofolo le nang le likokoana-hloko tsa sebete. E boetse e sebelisetsoa ho thibela HBV ho ts'oaroa hape ka mor'a ho kenngoa ha sebete le ho tšoara bakuli ba HIV ba tšoaelitsoeng ke HBV. Entecavir hydrate e sa sebetse ka mokhoa o fokolang khahlanong le HIV, empa ha e khothalletsoe hore e sebelisoe ho bakuli ba nang le HIV-HBV e nang le tšoaetso ea HIV le HVV e se nang khatello e feletseng ea HIV [9] kaha e ka khethoa bakeng sa ho hanyetsa lamivudine le emtricitabine HIV.

Tšebetso ea matla a entecavir ea hydrate e 'nile ea ithutoa ka mekhoa e' maloa ea li-randomized, tse peli tse foufetseng, tse ngata. Phala ea entecavir ea molate ka molomo e atleha mme ka kakaretso e mamelloa hantle kalafo.

Entecavir hydrate phofo e tala e nkoa ka molomo e le letlapa kapa tharollo. Meriana e thehiloe boima ba motho. Tharollo e khothalletsoa bana ho feta lilemo tse 2 tse lekanyang ho 30 kg. Peso ea entecavir ea hydrate e khothalletsoa ho se na letho ka mpeng bonyane lihora tsa 2 pele kapa ka mor'a lijo, ka kakaretso ka nako e le 'ngoe letsatsi ka leng. Ha e sebelisoe ho bana ba ka tlaase ho lilemo tse 2. Liphetoho tsa likhahla li boetse li khothalletsoa ho batho ba nang le ts'ebetso ea liphio e fokotsehileng.

Temoso ea phofo ea Entecavir hydrate

Boholo ba batho ba sebelisang phofo ea Entecavir hydrate ha ba na litla-morao tse fokolang. Litla-morao tse tloaelehileng haholo li kenyelletsa hlooho, mokhathala, mokoloko, le ho nyeheloa ke pelo. Liphello tse sa tloaelehang li kenyelletsa bothata ba ho robala le matšoao a matšoao a kang mala a bolila, letšollo le ho hlatsa.

Litla-morao tse matla tsa Entecavir hydrate phofo e tala li akarelletsa lactic acidosis, mathata a sebete, ho eketsa sebete, le mafura sebeteng.

Liteko tsa laborateng li ka bontša keketseho ea alanine transaminase (ALT), hematuria, glycosuria, le ho eketseha ha lipase. Ho hlahlojoa ka nako e telele mosebetsi oa hepatic le hematology.

Litaelo tse ling

Pente ea entecavir ea hydrate ke analog ea maiketsetso ea 2-deoxyguanosine e nang le thibelo ea ho thibela kokoana-hloko ea hepatitis B (HBV). Entecavir hydrate e tsoekere ea phofo e sebelisoang ka ho hlaka ho 5-triphosphate metabolite. Ka lehlakoreng le leng, foromo ea triphosphate e ikopanya le substrate deoxyguanosine triphosphate (dGTP) bakeng sa ho kenngoa ka vireleng ea DNA. Ho kenngoa ha methaphoate e entsoeng ka triphosphate ea entecavir ea hydrate e thibela ho fokotsa likokoana-hloko tsa RNA tse itšetlehileng ka HBV DNA polymerase, ka hona, ho pheta-pheta ha DNA ea kokoana-hloko le ho ngolisoa ha eona.

Entecavir hydrate phofo e tala ke guanosine nucleoside analogue e sebelisoang ho phekola tšoaetso ea kokoana-hloko e sa foleng ea lefu la sebete (HBV). Phekolo ea pouche ea entecavir ea hydrate e ka amahanngoa le li-flares tsa lefu la sebete la B nakong kapa kamora 'meriana, empa ha lia amahanngoa le lisosa tsa ho hlaseloa ke sebete se hlahisitsoeng ke lingaka.

Phydrate ea Entecavir hydrate

Ntho e nyenyane 10grams.
Tlhahlobo ka bongata bo tloaelehileng (ka hare ho 1kg) e ka romeloa lihora tse 12 kamora ho lefa.
Bakeng sa tlhahiso e kholo (ka hare ho 1kg) e ka romeloa ka matsatsi a sebetsang a 3 ka mor'a ts'ebetso.

Khamphani ea Entecavir ea Hydrate ea Peso

Ho fanoa nakong e tlang.


Ho reka phofo ea Entecavir hydrate ho tloha AASraw

1.To iteanye le rona ka imeile ea rona lenaneo la lipatlisiso, kapa skype ea inthanetengmoemeli oa tšebeletso ea bareki (CSR).
2.To re fane ka lipotso tsa hau le lipotso tsa hau.
3.Our CSR e tla u fa tlhaloso, nako ea ho lefa, nomoro ea ho latela, litsela tsa ho pepa le letsatsi la ho fihla ho fihlela (ETA).
4.Payment e entsoe mme thepa e tla romelloa ka lihora tsa 12 (Ho laela ka hare ho 10kg).
5.Goods e amohetse mme e fana ka litlhaloso.


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COA

HNMR

Peso ea entecavir ea hydrate (209216-23-9) ≥98% | Ho hlahisa li-Reagents tsa R & D

Recipes

Mohatla oa Entecavir hydrate Recipes:

Ho botsa bareki ba rona baemeli ba rona (CSR) bakeng sa lintlha tse eketsehileng, bakeng sa boitsebiso ba hau.

Litlhaloso le lihlahisoa tsa lihlahisoa

9 lintho tse ka entecavir hydrate

1 tekolo botjha bakeng Entecavir hydrate phofo

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