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Dolastatin 10 (110417-88-4)

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SKU: 110417-88-4. Category:

AASraw e na le bokhoni ba tlhahiso le tlhahiso ho tloha ho gram ho ea ka taelo ea Dolastatin 10 (CAS 110417-88-4), tlas'a taelo ea CGMP le tsamaiso ea mokhoa oa ho laola boleng.

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Dolastatin 10 video


I.Dolastatin 10 ea motheo:

Name: Dolastatin 10
CAS: 110417-88-4
Molecular Formula: C42H68N6O6S
Boima ba 'mele: 785.09g / mol
Melt Point: 94-95oC
Temp Temp Storage: Boloka sebakeng se phodileng le se omeletseng le ka 0 - 4 ℃ ka nako e khutšoanyane (matsatsi ho isa ho libeke) kapa -57 ℃ ka nako e telele (likhoeli le lilemo)
Color: Ho soeufala ho fihlela ho soeufala-sollid


II. Dolastatin 10 (110417-88-4) ts'ebetsong ho potoloha

1. Mabitso:

Lebitso la k'hemik'hale
Dolastatin 10 (CAS 110417-88-4), Dolastatin-10, Neuro_000215, CCRIS 7310, CID100208, NSC376128,NSC 376128, C11280, L-Valinamide, N,N-dimethyl-L-valyl-N-(2-methoxy-4-(2-(1-methoxy-2-methyl-3-oxo-3-((2-phenyl-1-(2-thiazolyl)ethyl)amino)propyl)-1-pyrrolidinyl)-1-(1-methylpropyl)-4-oxobutyl)-N-methyl-, (2S-(1(1R*(R*),2S*),2R*(1S*,2S*,3(R*))))-

Sesebelisoa sa 2.Dolastatin 10:

Morero: Rasaense oa bongaka o ile a etsa lipatlisiso ka katleho le toxicity ea novel ea anti-microtubule agent dolastatin-10 ho bakuli ba nang le kankere ea matsoele e tsoetseng pele.

Mekhoa: Bakuli ba mashome a mabeli a metso e 'meli ba nang le kankere ea matsoele e lekantsoeng ea metastatic ba ne ba tšoaroa ka dolastatin-10 ka tekanyo ea 400 mcg / m2 ka li-intravenous bolus hang ka libeke tse ling tsa 3.

Phello: E mong ho bakuli ba 21 (5%; 95% CI: 0-24%) o finyelitsoe ho fokotsa karolo e itseng ka nako ea matsatsi a 113. Bakuli ba bane ba ile ba boloka mafu a tsitsitseng bakeng sa matsatsi a mabeli a 87. Mokuli o fumanoe o lekanang le metso e 'meli ea dolastatin-10. Hematologic toxicity e ne e le tekanyo, mme bakuli ba 8 ba hlahisa grade 4 neutropenia, le 5 le sehlopha sa 3 neutropenia; Sehlopha se seng sa 3 febrile neutropenia se ne se hlokomeloa. Likarolo tsena tsa grade 3 le 4 neutropenia li bile le phihlelo ho 36% ea mekoloko ea phekolo. Ho se tloaelehe ha chefo ea mali ho ne ho sa tloaeleha.

Qetello: Le hoja setšoantšo sa chefo ea dolastatin-10 se amoheleha, se ne se e-na le mosebetsi o fokolang thupelong ena ea kankere ea matsoele e tsoetseng pele.

In Vitro: Dolastatin 10 ke sebaka se ikhethang sa pentapepde se ka thōko ho leoatle hare Dolabella auricularia. Ho fumanoa hore lintlha tsena tsa in vitro li tšoana haholo le tsa Dolastatin 10 le Auristatin PE, e 'ngoe le e' ngoe e nang le litekanyetso tsa GI50 tsa 10-5-10-6 μg / mL (10-2-10-3 nM) khahlanong le se tšoanang minipanel ea lisele tsa motho. An antibody-drug conjugate (ADC) e na le anti-CD30 monoclonal antibody cAC10 e kopanetsoeng ho cytotoxic moemeli monomethyl auristatin E (MMAE), sehlahisoa sa maiketsetso sa tubulin polymerization inhibitor Dolastatin 10 (110417-88-4).

3.Lebella ho Dolastatin 10

Sehlahisoa sena ke sa ho etsa lipatlisiso feela, eseng bakeng sa tšebeliso ea batho kapa ea bongaka.

Bakeng sa ho fumana metsi a mangata, ka kopo o futhumatsa tube ka 37 ℃ mme e sisinyehe ka ho sesa ka nako e telele. Solution ea motlakase e ka bolokoa ka tlase -20 ℃ ka likhoeli tse 'maloa.

4.Hape litaelo:

Dolastatin 10 pele
Kakaretso ea Dolastatin 10 (110417-88-4) e phethiloe ka ho ntlafatsa metsoako e 'meli ea motsoako oa amino acid, Dil (6) le Dap (11), le ho kopanngoa ha li-amino acid tse hlano ho tloha ho C-terminal Doe .

Tlhahlobo le Tlhaloso ea Dolastatin 10 Li-analogue tse nang le Heteroatom lihlahisoa tsa mahlakoreng a Amino.
Litšoantšo tse ling tsa tlhaho tse etsahalang dolastatin 10 li thahasella haholo kankere ka lebaka la liketso tsa tsona tse matlahali 'me li sebelisoa e le tefo ea li-anti-drug conjugates (ADCs). Ho fetoloa ha dolastatin 10 core scaffold e tsepamisitse maikutlo haholo ka liphetoho tsa P1, N-terminus, le P5, C-terminus, e sa ele hloko karoloana ea P2.

Sethaleng sa cellular, Dolastatin 10 (110417-88-4) e bonts'oa khahlanong le kankere ea motho, lymphoma le lisele tse matla tse hlahisang lisele (tse kang OVCAR-3 le NSCLC) ka litekanyetso tsa IC50 ho tloha 0.1nM ho 10nM. Hona joale e lekoa litsing tsa kliniki.


III. Dolastatin 10 (110417-88-4) HCML

Re li-poure tsa Aprepitant, Prepitant phofo e rekisoang, Raw Aprepitant powder (170729-80-3) hplc≥98% | Ho hlahisa li-Reagents tsa R & D


IV. Joang ho reka Dolastatin 10 ho tloha AASraw?

1.To iteanye le rona ka imeile ea rona lenaneo la lipatlisiso, kapa skype ea inthanetengmoemeli oa tšebeletso ea bareki (CSR).
2.To re fane ka lipotso tsa hau le lipotso tsa hau.
3.Our CSR e tla u fa tlhaloso, nako ea ho lefa, nomoro ea ho latela, litsela tsa ho pepa le letsatsi la ho fihla ho fihlela (ETA).
4.Payment e entsoe mme thepa e tla romelloa ka lihora tsa 12 (Ho laela ka hare ho 10kg).
5.Goods e amohetse mme e fana ka litlhaloso.

TLHOKOMELISO LE TLHALOSO:

Boitsebiso bona bo rekisetsoe tšebeliso ea lipatlisiso. Lipehelo tsa thekiso Etsa kopo. Eseng molemong oa tšebeliso ea batho, kapa bongaka, bongaka ba liphoofolo kapa lisebelisoa tsa lapeng.