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2,4-Dinitrophenylhydrazine (DNP) Pula e tala

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AASraw e na le bokhoni ba tlhahiso le tlhahiso ho tloha ho gram ho ea ka taelo e kholo ea 2,4-Dinitrophenylhydrazine (DNP) Raw e phofshoana (51-28-5), tlas'a taolo ea CGMP le tsamaiso ea boleng bo sebetsang.

Tlhaloso ea Sehlahisoa

2,4-Dinitrophenylhydrazine (DNP) Raw powder video


2,4-Dinitrophenylhydrazine (DNP) Pula e mafura (51-28-5) tsebo ea motheo

Name: 2,4-Dinitrophenylhydrazine (DNP) Pula e tala
CAS: 51-28-5
Molecular Formula: C15H32FO2P
Boima ba 'mele: 294.391
Melt Point: 108-112 ° C
Temp Temp Storage: -20 ° C
Color: Phororo e mosehla kapa e mosehla kristalline


Palo ea batho ba batlang ho theola boima ba 'mele e ntse e eketseha. Ba retelehela ho internet ho fumana keletso hammoho le litaelo. DNP (C6H4N2O5) kapa 2, 4-Dinitrophenol 51-28-5 ke motsoako oa motsoako oa tahlehelo o ileng oa fetoha o tloaelehileng 1930. Lipatlisiso li bontša hore haeba motho a nka 300-400 mg ea lithethefatsi letsatsi le leng le le leng, tekanyo ea hae ea metabolic e ka 'na ea eketseha ka 36% ho 95%.

Lihlahisoa tsa lik'hemik'hale tsa 2,4-Dinitrophenylhydrazine Raw e phofshoana

DNP e phetha karolo ea ionophore ea proton ka lisele tsa 'mele tse mafolofolo. Proton ionophore e bolela moemeli ea nang le bokhoni ba ho thibela li-proton, tse tsejoang hape e le lithapo tsa hydrogen ho pholletsa le lihlopha tsa lintho tse phelang. DNP e qhala setsi sa proton ho pholletsa le membrane ea mitochondria kapa chloroplast 'me ka lebaka leo matla a susumetsang a proton, matla a sebelisoang ke lisele tse phelang ho etsa boholo ba lik'hemik'hale tsa bona tsa adenosine triphosphate (ATP), lia oa. Proton gradient e lahleheloa ke matla a eona ka mocheso ho e-na le matla a sebelisoang ho hlahisa ATP. 2,4-Dinitrophenylhydrazine Ho hlahisa phofshoana e matla haholo ka ho etsa lipatlisiso tsa tlhaho ea likokoana-hloko joalokaha bafuputsi ba e sebelisa hangata ka lipatlisiso tsa bona tsa chemiosmotic bioenergetics, har'a mekhoa e meng ea lipalangoang e etsahalang ka lisele tsa sele.

Tlhaloso e bonolo ea DNP Raw powder

DNP, e boetse e bitsoa Dnoc, Dinitro, Nitrophen kapa Dinosan, e bolela motsoako o sebetsang o ikarabellang ka tsela e tloaelehileng eo lisele tse phelang li phefumolohang ka eona. Qalong, sehlahisoa se hlahisitsoe mefuteng e mengata ea liindasteri. Ntle le ho sebelisoa e le ho phatloha, setsi sena se ile sa boela sa sebelisoa e le pesticide, setsebi sa lifoto, setsi sa polokelo ea lifate hammoho le herbicide.

Maurice Tainter, mofuputsi Univesithing ea Stanford, ke eena motho oa pele ea ileng a fumana hore lithethefatsi li ka khona ho fokotsa boima ka potlako. Ho sibolloa ho entsoe ka 1933 'me mofuputsi hamorao a qala ho reka meriana e le tšehetso ea ho ja lijo tse ngata.

Mokhoa o sebetsang oa 2,4-Dinitrophenylhydrazine Raw e matla

DNP e sebetsa ka ho senya tsela e tloaelehileng eo lisele li hemang ka eona, ka lebaka leo ho etsa hore tekanyo ea tebello ea matla le matla a sebelisoang ea sele e eketsehe ka ~ 11% ka 100mg. E eketsa mocheso o mongata o hlahisoang seleng e phelang ka mokhoa o bitsoang ho hula. Moriana ona o boetse o etsa hore sele e amehang e fokotsehe hantle ho fihlela phefumoloho ea ATP e amehile. ATP ke matla ao 'mele oa motho o itšetlehileng ka oona bakeng sa mesebetsi eohle ea oona.

Lisele tsa 'mele ea rona li na le likarolo tse ikhethang tse tsejoang e le mitochondria eo mosebetsi oa eona oa motheo ke ho fokotsa matla ao re a sebelisang mesebetsing e fapaneng ea boipheliso. 2,4-Dinitrophenylhydrazine powder e sitisa ho sebetsa ha mitochondria ka tsela e atlehang, e leng ho etsang hore ho eketsehe ka potlako mocheso oa 'mele le tekanyo ea metabolism. Ho eketseha ha mefuta e 'meli e fapakaneng ho fella ka boima ba' mele ba hoo e ka bang 1.5kg ka beke.

Ho sebelisa 2,4-Dinitrophenylhydrazine Raw e phofshoana

Tlalehong ea pele ea DNP ka Cutting le Tainter e bonts'ang hore e ka eketsa 'mele oa metsolic acid ka mokhoa o hlollang; moriana oo o ile oa sebelisoa hamorao lipilisong tsa ho ja, haholo-holo ho 1930s. Ka mor'a hore lithethefatsi li be teng 'marakeng ka nako e le' ngoe feela, Tainter o ile a lokolla tlaleho e bontšang hore e 'nile ea sebelisoa ho tšoara batho ba fetang 100,000 United States, har'a ba bang lefatšeng ka bophara.

E sebetsa joaloka protonophore, DNP e lumella ho kenngoa ha proton ka hare ho pambrane ea mitochondria, kahoo ho feta ATP synthase. Ka lebaka leo, katleho ea tlhahiso ea matla ea ATP e fokotsa. Matšeliso a mang a lik'hemik'hale a matla a senya matla a mocheso.

Boholo ba katleho ea tlhahiso ea matla ea ATP e itšetlehile ka tekanyo ea DNP eo motho ae nkang. Palo e eketsehileng ea lithethefatsi e lebisa tlhokomelong e eketsehileng ea matla le ho eketseha ha tekanyo ea lik'hemik'hale tse etsang hore ho be le lihlahisoa tse ngata tsa 'mele. Ka lebaka leo, DNP e khetholloa har'a mekhoa e metle ka ho fetisisa ea ho fokotsa mokelikeli oa phosphorylation ea oxidative.

Tekanyo ea DNP Raw Raw (51-28-5)

Re kgothaletsa titration ho lethal dose letsatsi le leng le le leng ho tloha 200mg ho ea 400 mg. Letsatsi le letsatsi le lokela ho nkoa libeke tse peli.

2,4-Dinitrophenylhydrazine (DNP) Mahlaseli a phofshoana

Liphello tsa 2, 4-DNP hangata li kenyelletsa ho eketseha ha tekanyo ea metabolism, mocheso oa 'mele le mofufutso (ka batho). Ka lebaka leo, 'mele o eketsa lebelo la ho hema e le mokhoa oa ho lefella liphetoho e le ho fana ka lisele tse nang le oksijene e eketsehileng. Ho eketseha ha mocheso oa 'mele ho etsa hore ho be le ponahalo ea meriana e le hore e phophole' meleng ha palo ea likhahla e eketseha e le ho laola ho potoloha.

Pontšo ea nakoana

Haeba ka monyetla leha e le ofe o o phefumoloha, kapa o kene letlalong la hao, Dinitrophenol e ka u ama hampe. Ho toba letlalo kapa ho sheba mahlo ka lithethefatsi ho ka bakela khalefo e matla. Lithethefatsi li ka ama metabolism e tloaelehileng ea 'mele, e lebisang ho phahama mocheso oa' mele.

Ntle ho moo, phello ea Dinitrophenol tsamaisong ea methapo ea methapo e ka etsa hore u ikutloe u se na mesifa kapa "lipane le lisebelisoa" maikutlo. U ka 'na ua ba le bofokoli ba matsoho le maoto ka lebaka la lithethefatsi.

Litla-morao tse ling tsa ho pepesehela lithethefatsi li kenyeletsa bluing ea melomo le letlalo, feberu, hlooho e bohloko, ho ferekana, ho sithabela le ho se tsebe letho ka nako e telele. Boemong bo bobe bo amanang le litekanyetso tse phahameng tsa lithethefatsi, matšoafo a ka 'na a bokella metsi a mangata a ka lebisang lefung. Ho hlahisa maikutlo ho ka etsa hore motho a halefisoe ke matšoafo a ka lebisang ho khohlela le ho phefumoloha mathata.

Tlhaloso ea nako e telele

Haeba letlalo la hao le kenella ho kopana le Dinitrophenol ka makhetlo a mangata kapa ka nako e telele, u ka 'na ua fumana:

  • Dermatitis
  • Letlalo la letlalo
  • Ho omisa letlalo
  • Lera la mahlo
  • Tšenyo ea sebete
  • Ho ntša kotsi ea lefuba liphio
  • Ho halefa hamonate
  • Bronchitis e khetholloang ke ho khohlela le ho phefumoloha mathata
  • Tsamaiso ea methapo e senya
  • Ho senyeha ha bakhachane ho basali ba nang le bakhachane
  • Phokolo ea mali ka lebaka la tšenyo ea lisele tsa mali ka 2, sekhahla sa 4 (haeba se hlahella hangata)
  • Mokhathala
  • Malaise
  • Lefu, haholo ka hare ho lihora tsa 24 bakeng sa nyeoe e matla

Haeba motho ea hlokofalitsoeng a phela nakong e boima ea chefo ea lithethefatsi, o ka khona ho mamella mathata a kang ho haelloa ke lesela kapa lefu la lefu la sebete hamorao bophelong ba hae.

Ka lehlakoreng le leng, batho ba bang ba 'nileng ba pepesoa hangata tlalehong ea lithethefatsi ke boikutlo bo monate, ka mohlala, ba ikutloa ba matlafalitsoe ebile ba thabile.

2,4-Dinitrophenylhydrazine (DNP) Phofo e kholo (51-28-5) Mantsoe a ho Qetela

Le hoja e le lithethefatsi tse atlehang ho lahleheloa ke lithethefatsi, DNP e ka lebisa ho mefuta e mengata ea liphello tse bohloko tse ling tsa tsona tse ka bolaeang ha li sebelisoa ka ho hlokomoloha mangolo a eona a ngotsoeng le litaelo tsa ho sebelisa. Ka hona, o lokela ho ba hlokolosi haholo ha u ntse u sebetsana le lithethefatsi.


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Recipes

Litlhaloso le lihlahisoa tsa lihlahisoa

Ho lahleheloa ke tefo ea lithethefatsi tsa 2,4-Dinitrophenol (DNP) melemo ea ho haha ​​'mele

bibiliokerafi

  • Journal ea toxicology ea bongaka: Koranta ea molao ea American College ea Medical Toxicology 7 (3): 205-12
  • Tara, ML le al. Tšebeliso ea dinitrophenol ka botenya le maemo a amanangTlaleho ea tsoelo-pele. JAMA. 1933; 101: 1472-1475.
  • Dunlop, DM. Tšebeliso ea 2: 4-dinitrophenol e le tšusumetso ea lik'hemik'hale. Br Med J. 1934; 24 (1): 524-527

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