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Canrenone phofo (976-71-6)

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AASraw e na le bokhoni ba tlhahiso le tlhahiso ho tloha ho gram ho ea ka taelo e kholo ea Canrenone phofo (976-71-6), tlas'a taolo ea CGMP le tsamaiso ea tšebetso ea boleng bo tsitsitseng.

Canrenone phofo e ne e fanoa ka tekanyo ea 2 × 82 mg le 2 × 164 mg ka letsatsi ka matsatsi a 10 ho bakuli ba lefu la tsoekere ba sa kenye letsoho, sebete kapa liphio. Aldosterone excretion le plasma aldosterone e eketsehile hanyenyane feela nakong ea mebuso ka bobeli.

Tlhaloso ea Sehlahisoa

Canrenone phofo ea video


Canrenone phofo tsebo ea motheo

Name: Canrenone phofo
CAS: 4642-95-9
Molecular Formula: C18H20O2
Boima ba 'mele: 258.36
Melt Point: 138-141 ° C
Temp Temp Storage: Mocheso oa kamore
Color: Phofo e khanyang kapa e bofubelu e khanyang


Potoloho ea phofo ea Canrenone

Mabitso

MOSEBETSI (S): Canrenone phofo
LEBITSO LE QALANG (S): Contaren, Luvion, Phanurane, Spiroletan

Canrenone phofo Tšebeliso

Mahlaseli a Plasma ea Canrenone phofo le 'metabolite eohle' kamora 'metsoako ea hydrolysis e ne e bapisoa le lihlopha tse nyenyane le tsa batho ba hōlileng ka mor'a hore e be e le' ngoe le e mengata ea spironolactone. Ka mor'a tekanyo ea pele ea Letsatsi la 1, mahlaseli a mali a Canrenone le 'metabolite' a mangata a ne a le a mangata ho feta a sehlopha se tsofetseng, 'me phapang e khōlō e fumanoe pakeng tsa lihlopha tse peli tsa AUC bakeng sa pente ea Canrenone le' kakaretso metabolites '. Leha ho le joalo, phapang ena pakeng tsa lihlopha tse peli tsa lilemo e ile ea fokotseha ka mor'a li-dosing tse ngata ka Letsatsi la 8, 'me boemo ba plasma pele ho tekanyo ea mafura a Canrenone phofo e tala le' metabolite eohle 'e ne e phahame haholo ho batho ba hōlileng. Ho bokellana ha kankere ea Canrenone le 'metabolite eohle' ho ne ho phahame haholo ho batho ba hōlileng ho feta lilemong tse nyenyane. Ka lehlakoreng le leng Canrenone e tala le asiti ea canrenoic e ne e kenngoa haholo liprotheine tsa plasma, empa ho ne ho se phapang pakeng tsa lihlopha tse peli tsa li-protein tse tlamang. Ho bona phapang pakeng tsa litebelisuoa tsa mali ka mor'a hore molekane ea se nang molekane le ea nang le lipalo tse ngata a be le liphello tsa lintho tse ngata tse kang ho fetoha ha metabolism ka lilemo; ho senya molomo oa motsoako oa motsoali; le / kapa ho fetoloa boholo ba ho abeloa ha lithethefatsi.

Ke tekanyo efe ea Canrenone phofo

Ka molomo, maemong a mangata, 50-200 mg ka letsatsi e le tekanyo e le 'ngoe kapa metseng e mengata e lekane.
Mathateng a maholo ka ho fetisisa, tekanyo ea pele e ka eketseha ho feta 300 mg kapa ho feta, joale tekanyo e fetotsoe ho karabo ea kliniki le likarolo tsa laboratori.

Canrenone phofo e sebetsa joang

HPLC nts'etsopele ea litebelisuoa tsa boima ba 'mele e ile ea etsoa ka setšoantšo sa TM4 Quantum Discovery sephahla sa triplegratone se nang le Aria CTC HPLC autosampler system. Ka tlase e ntle ea electrospray ionisation, ione e kholo e fumanoang e ne e le ion molecular protonated (M + H) + m / z 341 bakeng sa Canrenone phofo. Alfaxalone (pele ho ion m / z 333; 1 μg) e ne e sebelisoa e le litekanyetso tsa ka hare. Tlas'a ts'ebetso ea ho hlasela, li-ion tse kholo li ne li le m / z 107.1 le 91.1 bakeng sa phofo ea Canrenone e tala le m / z 297.3 le 315.3 bakeng sa alfaxalone. Li-ion tse arohaneng li ne li sebelisoa e le quantifier le lihlopha tse ikhethang ka ho latellana ho kenya kemiso ho teko. Ho arohana ka tsela e nepahetseng ea li-steroid e ne e finyelloa ho sebelisa ammonium acetate (5 mM) / methanol ho (60: 40, 0.3 ml / min) leboteng la C18 T3 Atlantis HPLC (3 μm; 100 × 2.1 mm) ho 25 ° C. Mofuta o tsoileng ho tloha 40 ho ea ho 90% methanol o sebelisitsoe, ka nako eohle ea nako ea 8 metsotso.

Ho netefatsoa ha mekhahlelo e mengata ho ne ho etsoa ka likarabo tse tšeletseng tse hlahang ka hare le ka hare. Ho fumanoa ka mokhoa o khotsofatsang oa Canrenone phofo le alfaxalone (106.2% (ho latellana ho tloaelehileng ho fapaneng (RSD) 9.5%) le 102.2% (RSD 4.7%)) ho ile ha finyelloa ka mor'a hore metsi a hlahisoe ke metsi a 25 μl e nang le acetate ea ethyl (1: 10). Tekanyo ea ho fumanoa e ne e le 5 ng / ml mme moeli o tlase oa ho nkoa o ne o le 15 ng / ml. Teko e ne e le linear (r = 0.9936) ho feta mefuta e mengata (5 ng / ml ho 5 μg / ml). Litlhapi li ile tsa iponahatsa li loketse ho fumaneha ha Canrenone phofo e kholo sehlopha sa bakuli ba neng ba fumane 400 mg dose, eo ho eona ho neng ho e-na le lipeo tsa plasma tse fapaneng 5-45 μmol / l.

Melemo ea Canrenone phofo

Canrenone phofo ke eona e ka sehloohong e sebetsang metabolite ea spironolactone. Ka papiso ea mohaho, e sebetsa ka katleho le aldosterone ka ho e tlosa ho tswa ho libaka tse amohelang batho ho ea boemong ba karolo ea distal ea tubule ea renal le ea mokhahlelo oa ho bokella; sena se etsa hore ho be le keketseho ea diuresis le natriuresis le ho fokotseha ha kaliuresis. Ha ho bapisoa le spironolactone ho na le monyetla oa nako ea tlaase ea latency. Leha ho le joalo, joaloka spironolactone, ha e na khato ho lihlooho tse ikhethileng kapa litabeng tse tloaelehileng tse nang le secretion e tlaase ea aldosterone.
Ka mor'a ho tsamaisoa ka lentsoe, Canrenone phofo e tala e kenngoa ka potlako, e fihlella maemong a mangata a pele a mali ka har'a lihora tse peli tsa pele. Bophelo ba halofo e ka bang ka lihora tsa 18 mme, ho fapana le spironolactone, e fetotsoe e sa fetohe, ka hare ho lihora tsa 72, ka mochini le likhoele ka palo e lekanang.
Canrenone phofo e bonts'oa maemo a kliniki eo ho feteletseng ha aldosterone ho hlahisang metsi le sodium le ho eketseha hauriuria. E na le thuso ho phekola ascites ka sebete sa sebete, esita le haeba litekanyetso li ntse li feto-fetoha ho arabela boemong bo le bong.

Canrenone phofo

Ntho e nyenyane 10grams.
Tlhahlobo ka bongata bo tloaelehileng (ka hare ho 1kg) e ka romeloa lihora tse 12 kamora ho lefa.
Bakeng sa taolo e kholo e ka romeloa matsatsing a ts'ebetso ea 3 ka mor'a ts'enyehelo.

Canrenone phofo e kholo

Ho fanoa nakong e tlang.

Canrenone tlhahiso e kholo ea phofo

Canrenone phofo e tala ke metabolite e sebetsang ea spironolactone, canrenoic acid, le potassium canrenoate, 'me e nkoa e le e ikarabellang bakeng sa liphello tsa eona. E fumanoe e le tlaleho ea hoo e batlang e le 10 ho 25% ea potassium-sparing effect ea spironolactone, athe e 'ngoe ea metabolite, 7α-thiomethylspironolactone (7α-TMS), e ikarabella ho 80% ea pheliso ea potassium ea meriana.

Canrenone phofo e tlalehoa e le e matla joaloka antimineralocorticoid e amanang le spironolactone, empa e nyenyane haholo ebile e sebetsa e le antiandrogen. Ka mokhoa o tšoanang le spironolactone, Canrenone phofo e tala e thibela li-enzyme tsa steroidogenic tse kang 11β-hydroxylase, k'holeseterole ea lehlakoreng le leng la cholesterol, 17α-hydroxylase, 17,20-lyase, le 21-hydroxylase, empa hape, ha ho bonolo ho etsa joalo.


Ho reka Canrenone phofo ho tloha AASraw

1.To iteanye le rona ka imeile ea rona lenaneo la lipatlisiso, kapa skype ea inthanetengmoemeli oa tšebeletso ea bareki (CSR).
2.To re fane ka lipotso tsa hau le lipotso tsa hau.
3.Our CSR e tla u fa tlhaloso, nako ea ho lefa, nomoro ea ho latela, litsela tsa ho pepa le letsatsi la ho fihla ho fihlela (ETA).
4.Payment e entsoe mme thepa e tla romelloa ka lihora tsa 12 (Ho laela ka hare ho 10kg).
5.Goods e amohetse mme e fana ka litlhaloso.

TLHOKOMELISO LE TLHALOSO:

Boitsebiso bona bo rekisetsoe tšebeliso ea lipatlisiso. Lipehelo tsa thekiso Etsa kopo. Eseng molemong oa tšebeliso ea batho, kapa bongaka, bongaka ba liphoofolo kapa lisebelisoa tsa lapeng.


COA

HNMR

Recipes

Canrenone phofo e tala Recipes

Ho botsa bareki ba rona baemeli ba rona (CSR) bakeng sa lintlha tse eketsehileng, bakeng sa boitsebiso ba hau.

Litlhaloso le lihlahisoa tsa lihlahisoa