USA Tsamaiso ea malapeng, Canada Tlhabollo ea malapeng, Tlhabollo ea malapeng ea Europe

BMS-564929 phofo

Rating:
5.00 tsoa 5 ho ipapisitsoe le 1 moreki tekanyetso
SKU: 627530-84-1. Category:

AASraw e na le bokhoni ba tlhahiso le tlhahiso ho tloha ho gram ho ea ka taelo ea BMS-564929 powder (627530-84-1), tlas'a taolo ea CGMP le tsamaiso ea tšebetso ea boleng bo sebetsang.

BMS-564929 phofo ke lisebelisoa tsa lipatlisiso le androgen receptor modulator, e ntseng e hlahisoa ke Bristol-Myers Squibb bakeng sa kalafo ea matšoao a ho theoha ha lilemong tsa lilemo le li-androgen maemo a banna ("andropause"). Matšoao ana a ka 'na a kenyelletsa khatello ea maikutlo, ho lahleheloa ke mesifa le matla, ho fokotseha ha libido le ho fokola ha masapo. Ho latela liphuputso tsena, phofo ea BBMS-564929 e bonahala eka ke SARM e ntle ea anabolic

Tlhaloso ea Sehlahisoa

Video ea phofo ea BMS-564929


I.BMS-564929 phofo tsebo ea motheo:

Name: BMS-564929 phofo
CAS: 627530-84-1
Molecular Formula: C14H12ClN3O3
Boima ba 'mele: 305.71638
Melt Point: 175-184 ° C
Temp Temp Storage: E omileng, e lefifi le ka 0 - 4 ° C ka nako e khutšoanyane (matsatsi ho isa ho a libeke) kapa -20 ° C ka nako e telele (likhoeli le lilemo)
Color: Pula e tšoeu


BMS-564929 phofo (627530-84-1) ho potoloha 'mele

Mabitso a phofo ea BMS-564929

BMS-564929 phofo

Mokhoa o sebelisoang o moholo oa BMS-564929

BMS-564929 phofo ke modulator e matla haholo, e sebetsang ka molomo, e sa sebeliseng methapo ea moriana e hlahisang androgen receptor (AR). BMS-564929 phofo ke subnanomolar AR agonist in vitro, e khetholla haholo ho AR le li-receptor tse ling tsa steroid, mme lipontšo ha li sebelisane haholo le SHBG kapa aromatase. Liphuputso tsa likhahla lipakeng tsa banna tse hlahisitsoeng li bontša hore BMS-564929 phofo e tala e na le matla haholo ho feta testosterone (T) ho susumetsa ho hōla ha mesifa ea li-ani, mme ho fapana le T, e khethollang haholo mesifa le prostate.

BMS-564,929 ke e 'ngoe ea lik'hemik'hale tse seng li ntse li le litsing tsa pele tsa kliniki ea motho, e leng li-agonist tse sebetsang ka molomo, tse matla le tse khethileng bakeng sa li-androgen receptors (Ki 2.1nM, 20x e sebetsang hantle bakeng sa lisele tsa mesifa ka ho fetisisa ea prostate) ho thibela ho fokotseha ha mesifa ho feta nako, 'me ha tekanyo e phahameng e ntse e eketseha le mesifa e mengata, e sa ame haholo mahlaseli a senya. Leha ho le joalo, ho na le li-hormone tse fokolang haholo tsa luteinizing, e leng 33x e makatsang haholoanyane ho feta testosterone, e ka' nang ea e-ba bothata ho batho tšebeliso ea meriana.
BMS-564929 phofo e tala e tlama hantle ho amoheleha ea androgen mme eseng ho e meng e amohelang steroid. BMS-564929 phofo ha e na ho sebelisana le SHBG ebile ha e thibele aromatase. Liteko tsa likhoto li bontša mosebetsi o motle oa banabolic, e leng testosterone propionate ka tekanyo e le 'ngoe, le mosebetsi o tlaase oa androgenic. Ka tekanyo e phahameng ea BMS-564929 phofo e tala e thibela hypothalamus le \ kapa pituary 'me ka tsela ena e theola secretion ea LH le FSH.

X-ray ea sesebelisoa sa phofshoana ea BMS-564929 le LBD ea amohelehang ea androgen e bontša phapang pakeng tsa phofo e tala ea BMS-564929 le dihydrotestosterone ha ba sebelisana le LBD ea mokamoli. Ho se tšoane hona ho bonahala ho lekana ho lekaneng hore ho be le phetisano ea phello ea anabolic ka har'a mesifa mme eseng phello ea androgenic ho prostate. Ha e e-s'o hlake ka ho feletseng hore na re ka hlalosa phapang efe.

BMS-564929 phofo e fumaneha molomong 'me liphetoho tsa metabolism li fokotseha ka nakoana ho proionamide SARM's. Nako ea halofo ea bophelo e fapana le 8 ho ea ho lihora tsa 14, mme tekanyo e tlase e ka khoneha.

Temoso ea phofshoana ea BMS-564929

BMS-564929 phofo ke khetho ea lipatlisiso le androgen receptor modulator (SARM) e ntseng e hlahisoa ke Bristol-Myers Squibb bakeng sa ho phekoloa matšoao a ho fokotseha ho amanang le lilemo ka maemo a androgen ho banna ("andropause"). Matšoao ana a ka kenyelletsa ho tetebela maikutlong, ho lahleheloa ke mesifa le matla, ho fokotseha ha libido le ho fokola ha masapo. Kalafo e nang le testosterone e feteletseng e atleha ho loantša matšoao ana empa e amahanngoa le mefuta e mengata ea litla-morao, e kholo ka ho fetisisa ea eona ke ho atolosa ha prostate gland, e ka lebisang ho benign prostatic hypertrophy esita le kankere ea prostate. Sena se bolela hore ho na le tlhokahalo ea kliniki ea li-electro-receptor modulator tse khethiloeng, tse hlahisang liphello tsa anabolic liphatseng tse ling tse kang mesifa le lesapo, empa li sa amohele li-androgen receptors ka prostate.

Litaelo tse ling

BMS-564929 phofo ke modulator e khethiloeng ke androgen receptor (AR) e nang le K bohlokoa ba 2.11 ± 0.16 nM.
AR e na le mofuta oa nuclear nuclear receptor e susumelitsoeng ke lihomone tsa androgenic, testosterone, kapa dihydrotestosterone. Mosebetsi oa bohlokoa o laola mokhoa oa liphatsa tsa lefutso.
BMS-564929 phofo e tala ke mesifa ea mesifa ea agonist ea AR le mohaho oa bicyclic hydantoin. BMS-564929 phofo e ka bang le 400 e khethollang AR vs. PR le ho feta 1000-khetho ea AR le GR, MR le ERα le β. Meleng ea C2C12 cell myoblast, phofo e tala ea BMS-564929 e bontša palo ea 0.44 ± 0.03 nM ha e bapisoa le 2.81 ± 0.48 nM e lekanyelitsoeng bakeng sa testosterone.
Li-rats tse ratoang tsa banna, tlhaho e tala ea BMS-564929 e na le matla ho feta testosterone (T) ho khothalletsa ho hōla ha mesifa ea li-ani, 'me e khetha haholo mesifa khahlanong le Prostate. Ka lebaka la tšebetso ea eona ea molomo le likheo tse khethiloeng, 'mele oa BMS-564929 o lebeletsoe hore o hlahise liphello tse ntle tsa kliniki meleng le meleng e meng e nang le tsela e sireletsehileng e sireletsehileng.

Powder ea Raw ea BMS-564929

Ntho e nyenyane 10grams.
Tlhahlobo ka bongata bo tloaelehileng (ka hare ho 1kg) e ka romeloa lihora tse 12 kamora ho lefa.
Bakeng sa tlhahiso e kholo (ka hare ho 1kg) e ka romeloa ka matsatsi a sebetsang a 3 ka mor'a ts'ebetso.

Khamiso e kholo ea BMS-564929 ea phofo

Ho fanoa nakong e tlang.


Joang ho reka phofo ea BMS-564929 ho tloha AASraw

1.To iteanye le rona ka imeile ea rona lenaneo la lipatlisiso, kapa skype ea inthanetengmoemeli oa tšebeletso ea bareki (CSR).
2.To re fane ka lipotso tsa hau le lipotso tsa hau.
3.Our CSR e tla u fa tlhaloso, nako ea ho lefa, nomoro ea ho latela, litsela tsa ho pepa le letsatsi la ho fihla ho fihlela (ETA).
4.Payment e entsoe mme thepa e tla romelloa ka lihora tsa 12 (Ho laela ka hare ho 10kg).
5.Goods e amohetse mme e fana ka litlhaloso.

TLHOKOMELISO LE TLHALOSO:

Boitsebiso bona bo rekisetsoe tšebeliso ea lipatlisiso. Lipehelo tsa thekiso Etsa kopo. Eseng molemong oa tšebeliso ea batho, kapa bongaka, bongaka ba liphoofolo kapa lisebelisoa tsa lapeng.


COA

COA 627530-84-1 BMS-564929 phofo AASRAW

HNMR

Re BMS-564929 powder supplie, phofo ea BMS-564929 e rekisoang, phofo ea BMS-564929 (627530-84-1) hplc≥98% | Ho hlahisa li-Reagents tsa R & D

Recipes

BMS-564929 Mefuta e Meholo ea Likhopo:

Ho botsa bareki ba rona baemeli ba rona (CSR) bakeng sa lintlha tse eketsehileng, bakeng sa boitsebiso ba hau.

Litlhaloso le lihlahisoa tsa lihlahisoa

SARMS e ncha ka ho fetisisa ea BMS-564929 Powder Powder Online