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N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide

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SKU: 681136-29-8. Category:

AASraw e na le bokhoni ba tlhahiso le tlhahiso ho tloha ho gram ho ea ka taelo ea N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-681136-29, tlas'a taolo ea CGMP le tsamaiso e tsitsitseng ea boleng ba boleng.

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N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide video


N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide basic Characters

Name: N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
CAS: 681136-29-8
Ho hloeka: ≥99% (HPLC)
Li-synonyms: JNJ 1661010;N-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinecarboxamide;Takeda-25;1-Piperazinecarboxamide, N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-;JNJ 1661010, >=98%
Molecular Formula: C19H19N5OS
Boima ba 'mele: 365.459
Ntlha e qhibilihisang: 240.48
Ntlha e belang: 559.69 ° C ho 760 mmHg
Botenya: ~ 1.3 g / cm3
Temp Temp Storage: Boloka ho + 4 ° C
Solubility: DMSO: ≥28mg / mL
Index ea ts'ebetso: N20D 1.68
Color: Kristalline e tiileng
InChI: InChI=1S/C19H19N5OS/c25-18(20-16-9-5-2-6-10-16)23-11-13-24(14-12-23)19-21-17(22-26-19)15-7-3-1-4-8-15/h1-10H,11-14H2,(H,20,25)
InChI Key: BHBOSTKQCZEAJM-UHFFFAOYSA-N


N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid Tšebeliso ea poula ka potoloho

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N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid powder, JNJ 166101 Poda

Mosebetsi oa N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid e sebelisoa joang

FAAH e etselitsoeng pele ka JNJ-1661010 e fana ka ts'ebetso e fokolang ea ho sebelisana pakeng tsa JNJ1661010 le sebaka se sebetsang, se potlakileng licheso tse phahameng. JNJ-1661010 ke substrate inhibitor e tsitsitseng, e sebetsanang le LC-ESI-MS. JNJ-1661010 laolloang thepa le phenylthiadiazole ka kotopo hydrophobic le phenylurea ka pokothong hydrophilic tsa FAAH, JNJ-1661010 (20 mg, / lik'hilograma IP) thibela FAAH ke bonyane 85% ya ho fihlela ho 4 H mora dosing, sephetho le bokella lipid li-ethanolamides ka boko ba rat. JNJ-1661010 e itšetlehile ka tekanyo ea meriana e hlalosang allodynia e tactile e nang le katleho e ka holimo ho 90% ho 30 min kamora 'me ka bobeli likarolo tse bobebe tsa ho futhumala ha metsi (MTI) litoeba le mekhoa ea boleng. JNJ-1661010 (20 mg / kg) e fetola allodynia ea tactile ka 60.8% ho 30 min mokhoeng oa kotsi oa mokokotlo oa lesapo la mokokotlo. JNJ-1661010 (50 mg / kg ip) e bonts'a tlhokomelo e kholo ea hyperalgesia ho 30 min ka mor'a hore e be mohlala oa rat carrageenan oa bohloko ba ho ruruha.
Li-rats tse nang le JNJ-1661010 (20 mg / kg ip) li na le plasma Cmax ea 26.9 μM ho Tmax ea 0.75 h le Cmax bokong ba 6.04 μM Tmax ea 2 h. JNJ-1661010 (20 mg / kg ip) e thibela boko ba FAAH ebile e phahamisa lekala la AEA likarolong tsa boko ba rat.

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N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamid Powder

Ntho e nyenyane 10grams.
Tlhahlobo ka bongata bo tloaelehileng (ka hare ho 1kg) e ka romeloa lihora tse 12 kamora ho lefa.
Bakeng sa tlhahiso e kholo (ka hare ho 1kg) e ka romeloa ka matsatsi a sebetsang a 3 ka mor'a ts'ebetso.

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