Bakeng sa maqephe a mang a fetoleloa ke software mme ha ba nepahale ka ho lekaneng, ka kopo leka ho e hlahloba en English pono ea lintlha tse molemo.

JW 642

Li-endocannabinoids tse kang 2-arachidonoyl glycerol (2-AG) le arachidonoyl ethanolamide li na le li-lipids tse sebetsang ka bongata tse kenyelletsang mekhoa e mengata ea synaptic e kenyeletsang ho amohela li-receptor tsa kankere. JW 642 ke inhibitor e matla ea monoacylglycerol lipase (MAGL) e bontsang litsamaiso tsa IC50 tsa 7.6, 14, le 3.7 nM ho thibela MAGL ka mouse, rat, le liphatsa tsa boko ba motho ka ho latellana. JW642is e khetholla MAGL, e hloka hore ho be le libaka tse phahameng haholo ho thibela ka mokhoa o atlehang motsoako oa mafura a amide hydrolase (IC50s = 31, 14, le 20.6 μM bakeng sa li-mouse, rat, le li-membrane tsa boko ba motho, ka ho latellana).

Tlhaloso ea Sehlahisoa

 

Video ea JW 642

 

 


 

I.JW 642 tsebo ea motheo:

 

Name: JW 642
CAS: 1416133-89-5
Molecular Formula: C21H20F6N2O3
Boima ba 'mele: 462.4
Melt Point:
Temp Temp Storage: ho -20 ° C lilemo tse 3 Powder
Color: Tšepe e tšoeu

 


 

II. Potoloho ea JW 642

 

1. Mabitso:

Mabitso a Lik'hemik'hale
4 - [(3-Phenoxyphenyl) methyl] -1-piperazinecarboxylic acid 2,2,2-trifluoro-1- (trifluoromethyl) ethyl ester
Li-synonyms:
JW 642;1,1,1,3,3,3-Hexafluoropropan-2-yl 4-(3-phenoxybenzyl)piperazine-1-carboxylate

 

2. Mokhoa oa JW 642:

Mekhoeng ea laboratori, bakeng sa polokelo ea nako e telele, re fana ka maikutlo a hore JW 642be e bolokiloe e ts'oaroe -20 ℃. E lokela ho tsitsa bonyane selemo se le seng.
JW 642 e fanoa e le tharollo methyl acetate. Ho fetola solvent, feela e feto-fetohe mouocha methyl acetate ka tlas'a metsi a nang le nitrojene 'me hang-hang e phaella moo ho khetholloang teng. Lisebelisoa tse kang asethanol, DMSO le dimethyl formamide e hloekisitsoeng ka khase e nang le inerase e ka sebelisoa. Mocheso oa JW 642 matsatsing ana a solvents o haufi le 13,5, le 11mg / ml, ka ho latellana.
JW 642 e na le mocheso o fokolang ka har'a li-buffers tse nang le metsi a mangata. Bakeng sa ho iketsetsa metsi ka ho fetisisa ho li-aqueousbuffers, tharollo ea bohetene ea JW 642Ke lokela ho hlakotsoa ka mochine o fokolang oa maqeba. JW 642 e na le metsi a ka bang 0.3 mg / ml ka 1: 2 tharollo ea ethanol: PBS (pH 7.2) e sebelisa mokhoa ona. Ha re khothaletse ho boloka tharollo e nang le metsi a fetang a le mong.

 

3.Ho tekanyo ea JW 642 ke efe?

DMSO ho 100 mM
Ethanol ho 100 mM
Keletso ea botsitso le ea mafura: Tse ling li ka ba thata ho fumana tharollo 'me li ka khothatsoa ke ho futhumala ka potlako, moraication kapa ho futhumala hamonate (ka ho sesa metsi a 45-60 ° C). Boitsebiso bo mabapi le ts'ebetso ea sehlahisoa, haholo-holo tharollo, ha hoa ka ha e-ba le tlaleho e sa tloaelehang 'me maemong a mangata re ka fana ka tataiso e akaretsang Melao ea rona e tloaelehileng ke: SOLIDS: Mobu o bolokiloeng o boletsoeng ka lebokoeng la sehlahisoa 'me sekoahelo se bolokiloe ka tieo, sehlahisoa se ka bolokoa ho fihlela likhoeli tsa 6 ho tloha letsatsing la kamohelo. LITLHELO: Re khothaletsa hore tharollo ea li-stock, hang ha e lokiselitsoe, e bolokiloe ka thata ho tiisitsoe vialsat -20 ° C kapa ka tlase mme e sebelisoa ka hare ho khoeli ea 1.Mohle moo ho khonehang tharollo e lokela ho etsoa le ho sebelisoa ka letsatsi le le leng.

 

4.Ho JW 642 e sebetsa joang?

JW 642 ke monoacylglycerol lipase e matla le e khethileng (MAGL) inhibitor (IC = 3.7 nM). E bontsha> 1000-khekhe selectivity bakeng sa MAGL ka mafura a acid e amidehydrolase (IC = 20.6 μM). Monoacylglycerol lipase (MAGL) e sebetsa serine hydrolase e ikarabellang bakeng sa hydrolysis ea 2-AG ho arachidonic acid le glycerol, e leng ho felisa sebōpeho sa eona. Liphello tsa chefo li ka bakoa joaloka tse ka tlase: Methyl Acetate - Ditaba tsa Toxicity: Oral LD50 (rat):> 5,000 mg / kg; Monyaluoa LD50 (mmutla): 3,705 mg / kg; Letlalo LD50 (mmutla):> 5,000 mg / kg; Inhalation TCLO (motho): 15,000 mg / m3; Methyl Acetate - Irritation Data: Letlalo (mmutla): 500 mg (24h) bonolo; Mahlo (mmutla): 100 mg (24h) e itekanetse.

 

5.Tlhahlobo:

I. Boikarabello le ts'ebetsong

5.1 Reactivity

E tiile tlas'a maemo a khothalletsoang ho tsamaisa kapa ho boloka.

5.2 ts'ebetsong ea lik'hemik'hale

E tiile tlasa maemo a ho boloka a khothalletsoang.

5.3 Ho khoneha ha likarabo tse kotsi

Liketsahalo tse kotsi li ke ke tsa etsahala tlas'a maemo a tloaelehileng a lipalangoang kapa tsa ho boloka. Ho senyeha ho ka etsahala ha ho pepesehetse maemo kapa lisebelisoa tse thathamisitsoeng ka tlase.

5.4 Melao ea ho qoba mocheso, mongobo.
Lisebelisoa tsa 5.5 tse sa lumellaneng

Li-acid / alkalis tse matla, li-oxidising tse matla / tse fokolang.

Lihlahisoa tsa 5.6 tse senyang kotsi

Mocheso o ka 'na oa ntša mafura a chefo. Ha ho tsebo e tsejoang ea ho felisoa.

II.Handing le polokelo

Tlhokomelo ea 5.1 bakeng sa ho sebetsana ka bolokolohi

Sebelisa mofuteng oa lik'hemik'hale, moeeng o fanoang ke tsamaiso e ikemetseng. Qoba ho inhalation, ho kopana le mahlo, letlalo le
liaparo. Qoba ho thehoa ha lerōle le li-aerosols. Sebelisa sebakeng se nang le moea o motlakase. Lula hole le mehloli ea ho hloekisa. Qoba
ho pepesa nako e telele kapa ho pheta-pheta.

Melao ea 5.2 bakeng sa polokelo e bolokehileng, ho kenyellets'ana le tse ling tse sa lumellaneng.

Boloka sebakeng se pholileng, se nang le moea o motlakase. Lula hole le letsatsi. Boloka sesebelisoa se tiisitsoeng ho fihlela se loketse ho sebelisoa.
Mocheso o boloketsoeng oa polokelo: Boloka ho -20 ° C

Qetello e khethehileng ea 5.3 e sebelisoa

Sebelisa holong ea maqhubu ea laboratori moo ho ka khonehang.

 

6.JW Phiri e Ntle ea 642:

Ntho e nyenyane 10grams.
Tlhahlobo ka bongata bo tloaelehileng (ka hare ho 1kg) e ka romeloa lihora tse 12 kamora ho lefa.
Bakeng sa taolo e kholo e ka romeloa matsatsing a ts'ebetso ea 3 ka mor'a ts'enyehelo.

 

7.JW 642 Pherefatsi e Meholo Recipes:

Ho botsa bareki ba rona baemeli ba rona (CSR) bakeng sa lintlha tse eketsehileng, bakeng sa boitsebiso ba hau.

 

8.JW 642 Marketing:

Ho fanoa nakong e tlang.

 

9.Does JW 642 Na o na le Liphello Tse Ntle?

Boitsebiso bo ka 'na ba halefisa liphatsa tsa lefutso le pampiri ea ho hema; E ka 'na ea e-ba kotsi ka ho inhalation, ho kenngoa, kapa ho kenngoa ha letlalo; E ka 'na ea etsa hore motho a otsele; E ka etsa hore letlalo kapa ho hema ho halefisoe. Ho pepesa ha motho ka makhetlo ho ka etsa hore letlalo le ome kapa le fokotsehe.
Tlhokomelo ea lipolelo / ts'ireletso ea botho

Lintlha tsa ho laola 9.1

Likarolo tse nang le mekhahlelo ea ho laola mosebetsing
Ha e na lintho tse nang le meeli ea ho pepesa mosebetsing.

Lisolafatso tsa 9.2

Tlhokomelo e nepahetseng ea boenjiniere
Sebelisa holong ea ho chesa moo ho sebetsang teng. Etsa bonnete ba hore mehato eohle ea boenjiniere e hlalositsoeng tlas'a karolo ea 7 ea SDS e ntse e le teng.
Etsa bonnete ba hore laboratory e na le setoro sa polokeho le seteishene sa ho hlatsoa mahlo.
Thepa ea ho itšireletsa

Tšireletso ea mahlo / sefahleho
Sebelisa likhalase tse loketseng tsa polokeho.
Tšireletso ea letlalo
Sebelisa likokoana-hloko tse loketseng tsa lik'hemik'hale (bonyane ho hlokahala hore u sebelise standard BS EN 374: 2003). Lihlopha li lokela ho ba
e hlahlojoe pele e sebelisoa. Hlatsoa 'me u omelle matsoho ka mor'a hore u sebetse.
Tšireletso ea 'mele
Apara liaparo tse loketseng tsa tšireletso.
Tšireletso ea ho hema
Haeba tlhahlobo ea kotsi e bontša hore hoa hlokahala, sebelisa phefumoloho e loketseng.

ngoe har'a ba bang

 


 

III. JW 642 HNMR

 

Re li-poure tsa Aprepitant, Prepitant phofo e rekisoang, Raw Aprepitant powder (170729-80-3) hplc≥98% | Ho hlahisa li-Reagents tsa R & D

 


 

IV. Joang ho reka JW 642 ho tloha AASraw?

 

1.To iteanye le rona ka imeile ea ronalenaneo la lipatlisiso, kapa skype ea inthanetengmoemeli oa tšebeletso ea bareki (CSR).
2.To re fane ka lipotso tsa hau le lipotso tsa hau.
3.Our CSR e tla u fa tlhaloso, nako ea ho lefa, nomoro ea ho latela, litsela tsa ho pepa le letsatsi la ho fihla ho fihlela (ETA).
4.Payment e entsoe mme thepa e tla romelloa ka lihora tsa 12 (Ho laela ka hare ho 10kg).
5.Goods e amohetse mme e fana ka litlhaloso.

 


 

Nahana hore u rata sehlahisoa sa hau sa blog:

 

 Phofo ea Basali? Ntho e 'ngoe le e' ngoe e buang ka ho ntlafatsa thobalano ho Flibanserin phofo Mokhoa oa ho sebelisa Clenbuterol bakeng sa tahlehelo ea boima ba 'mele Namrolone phofo e sebeliselitsoeng bakeng sa melemo ea / nandrolone ke efe?

 


 

Lintlha tse ling tse mabapi le lihlahisoa tsa bohlokoa,amohela ho tobetsa mona.


Bakeng sa lipotso, ka kopo ikopanye imeile , Ka tloaelo re arabela nakong ea lihora tsa 8.
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